Curated hyperbaric oxygen therapy evidence, organised by indication and graded by study design. Every entry comes from Dr Gregory Weir's maintained HBOT clinical wiki — positive and null trials both included — and, where the source is indexed, links to its PubMed record and DOI.
How these appraisals were produced. The critical appraisals on this site — the risk-of-bias ratings, the GRADE and OCEBM judgements and the summaries — were generated by automated tooling (Anthropic Claude) working from the source documents, under Dr Weir's editorial direction and within his clinical wiki. They were not written up individually by hand. Each card names its appraiser. We publish this because a reader should learn it here rather than infer it: machine appraisal at this scale is what makes a library of this size possible, and it carries the failure modes of machine appraisal. Treat every rating as a starting point for your own reading of the paper, not as a substitute for it. What was checked, and how.
https:// fails with a certificate error, http:// returns the page. These links therefore point at http and your browser will mark them Not Secure — correctly, because the connection is not encrypted. It is a third-party, public, read-only wiki that asks for no credentials, and the citation printed on each card is there so you never have to follow the link to know what was appraised. Where a paper appears in both, the two appraisals are independent and may disagree — which is why they are kept apart.Last updated 2026-11-01 · built from the clinical wiki at commit 4c3afc1 · corrections to wiki@hbo.co.za
The SAUHMA/UHMS-recognised indications this unit treats. Select one to see its evidence.
How to read the tiles and cards:
Authorship, stated plainly. These appraisals were generated by automated tooling — Anthropic
Claude — reading the source documents, inside Dr Gregory Weir's clinical wiki and under his
editorial direction. No claim is made that any individual appraisal was composed, or independently
re-derived, by a clinician reading that paper. Where a card is stamped as reviewed or signed off,
that is an editorial decision recorded on a date, not a re-appraisal. The appraiser named on
each card is the truthful answer to "who wrote this?".
What follows from that, and what a reader should do with it: the instrument selection, the domain
judgements and the certainty ratings are reproducible and each is shown with the sentence from the
paper it rests on, so they can be checked. They are also subject to the failure modes of machine
reading — a design can be misread from an ambiguous methods section, a direction of effect can be
taken from an abstract that contradicts its own tables, and a paper can be summarised confidently
and wrongly. Several such errors have been found and corrected here, and the corrections are dated
in the wiki. Cite the paper, not this page. Where a rating matters to a decision, read the
methods yourself.
This library holds 2612 records, of which 2610 are citable sources. 2 are held deliberately and labelled do not cite — one retracted, one withdrawn — because a reader who meets the paper elsewhere is better served by finding it here with the reason attached than by not finding it at all. They are shown, and they are excluded from the counts below. The records are not uniform, and the badge on each card says which kind it is.
Tools/concordance_adjudicated.tsv); a value in neither
place fails the page. That re-check is
automated, and it tests concordance, not clinical judgement: it confirms a number was copied
correctly, not that it was the right number to report or that it was interpreted correctly.Positive and null results are both included by design. Where a source contradicts another, both are kept and the tension is stated rather than resolved silently.
American Academy of Underwater Sciences, Academy of Underwater Arts and Sciences, American Board of Wound Healing, American College of Emergency Physicians, American College of Hyperbaric Medicine, American College of Surgeons, et al. Access to emergent hyperbaric oxygen (HBO2) therapy: an urgent problem in health care delivery in the United States. Undersea Hyperb Med 2020;47(4):652-657.
Abdelhakim H, Hebishy A, Shune L, McGuirk J, Baran A, Allin D, Mina A, Aljitawi OS. Impact of hyperbaric oxygen on post-UCB transplant blood transfusion and growth factor support. Transfus Apher Sci 2025;64(4):104176.
Abid C, Gassara Z, Feki A, Benjemaa S, Kallel MH, Baklouti S, Fourati H. Carbon Monoxide Poisoning-Induced Myositis. Eur J Case Rep Intern Med 2025;12(12):005874.
Abidia A, Laden G, McCollum PT. Hyperbaric oxygen therapy improves reflex vasoconstriction induced by leg dependency in patients with diabetic neuropathy. Undersea Hyperb Med 2000;27(Suppl):44.
Abidia A, Kuhan G, Laden G, Bahia H, Chetter I, McCollum PT. The placebo effect of hyperbaric oxygen therapy - fact or fiction? Undersea Hyperb Med 2001;28(Suppl):57-58.
Abidia A, Laden G, Kuhan G, Johnson BF, Wilkinson AR, Renwick PM, Masson EA, McCollum PT. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: A double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg 2003;25(6):513–518.
Complete healing (epithelialisation): 5/8 ulcers (HBO) vs 1/8 (air). Median wound-area reduction at 6 weeks: 100% (HBO) vs 52% (air), P=0.027. By 6 months the difference in area reduction was not significant (100% vs 95%) — HBO produced
Ablin JN, Lang E, Catalogna M, Aloush V, Hadanny A, Doenyas-Barak K, Finci S, Polak N, Fishlev G, Korin C, Tzidky RY, Meir Genuth O, Efrati S. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: a randomized, controlled trial. PLoS One 2023;18(3):e0282406.
Abraini JH. Oxygen for the ischemic organ: Much more than an oxygen provider. Undersea Hyperb Med 2013;40(2):211-2.
Abrard S, Brenac C, Jacquet L, Catella J, Joffre T. Laser speckle contrast imaging for assessment of cutaneous perfusion and treatment response during hyperbaric oxygen therapy in chronic wounds: a case series. Int Wound J 2026;23(10):e71075.
Açiksari K, Eğin S, Hepgül G, Mirasoğlu B, Tanriverdi G, Kanber DS, Demirci S, Doğan H, Özüçelik DN, Toklu AS, Seçkin İ, Yanar HT. Protective effect of hyperbaric oxygen treatment on rat intestinal mucosa after mesenteric ischaemia and reperfusion. Diving Hyperb Med 2019;49(4):253-258.
Ackerman NB, Brinkley FB. Oxygen tensions in normal and ischemic tissues during hyperbaric therapy: studies in rabbits. JAMA 1966;198(12):1280.
Adachi K, et al. Procedure-related cerebral air embolism: Systematic review and individual participant data meta-analysis. Clin Neurol Neurosurg 2025;255:108982.
Adamina M, Minozzi S, Warusavitarne J, Buskens CJ, Chaparro M, Verstockt B, et al. ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment. J Crohns Colitis 2024;18(10):1556-1582.
Adams B, Templeton A, Tsouras T, Sheldrake J, Roberts L, Lin ZC, Millar I, Orosz J, Birthisel T, Devaney B. The process, logistics and governance behind a high-stakes novel intervention: the use of extracorporeal membrane oxygenation (ECMO) in the hyperbaric chamber. Diving Hyperb Med 2025;55(4):315-322.
Adir Y, Bitterman N, Katz E, Melamed Y, Bitterman H. Salutary consequences of oxygen therapy on the long-term outcome of hemorrhagic shock in awake, unrestrained rats. Undersea Hyperb Med 1995;22(1):23-30.
Rouleau G, Moqadem K, Pineau G. Indications de l'oxygénothérapie hyperbare. Mise à jour (Indications for hyperbaric oxygen therapy: update). ETMIS 2008;4(5). Montréal: Agence d'évaluation des technologies et des modes d'intervention en santé (AETMIS) 2008:123 pp (French); 5 pp English summary (now INESSS; URL https://www.inesss.qc.ca/publications/repertoire-des-publications/publication/indications-de-loxygenotherapie-hyperbare-mise-a-jour.html).
Afifah S, Ulfa M, Zunaedi R. Hubungan kepatuhan terapi hiperbarik oksigen dengan fungsi pendengaran pada pasien sudden sensorineural hearing loss (SSNHL) di Klinik Hiperbarik RS Bhayangkara Hasta Brata Batu [The relationship between hyperbaric oxygen therapy compliance and hearing function in patients with sudden sensorineural hearing loss at the Hyperbaric Clinic, Bhayangkara Hasta Brata Batu Hospital]. Medic Nutricia (Jurnal Ilmu Kesehatan Cahaya Ilmu Bangsa) 2026;23(4).
Agrawal S, Sharma N. Complete recovery following hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss--a report of two cases. Undersea Hyperb Med 2016;43(2):161–165.
Ahijón-Lana M, Baragaño-Ordóñez E, Veiga-Cabello R, de la Cruz-Tapidor C, Carreira PE. Treatment of Raynaud phenomenon and ischemic ulcers associated to systemic sclerosis with hyperbaric oxygen. Reumatol Clin 2022;18(4):246-248.
Ajayi OD, Gaskill Z, Kelly M, Logue CJ, Hendricksen SM. A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4 ATA for 90 minutes in treating radiation-induced cystitis. Are these regimens equivalent? Undersea Hyperb Med 2020;47(4):581-589 (PMID 33227834; DOI 10.22462/10.12.2020.7).
Akbar YM, Maskoen AM, Mardiati E, Wandawa G, Setiawan AS. Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies. Eur J Dent 2022;17(1):16-23.
Akcali G, Uzun G, Arziman I, Aydin I, Yildiz S. The relationship between intoxication severity and blood interleukin 6, interleukin 10 and CRP levels in carbon monoxide-poisoned patients. Undersea Hyperb Med 2018;45(6):646-652.
Akgün M, Nemery B. Inhalation Injury: Update on Pathogenesis, Emerging Hazards, and Management. Balkan Med J 2026;not yet assigned — published online ahead of issue on 25 Sep 2026. Re-check.(not yet assigned. Re-check.):not yet assigned; the held PDF runs to 16 pages. Re-check.
Akın İE, Özay M. A Rare Case Report of Penile Necrosis Successfully Treated With Early Hyperbaric Oxygen Treatment. Undersea Hyperb Med 2026;53(2):291-294.
Aktaş S, Toklu AS, Yildiz S, Uzun G. Development of underwater and hyperbaric medicine as a medical specialty in Turkey. Undersea Hyperb Med 2013;40(1):63-7.
Aktas S. Advances in the treatment of earthquake victims in Turkey: An editorial perspective. Undersea Hyperb Med 2015;42(1):1-3.
Al Abri SA, ALqartoobi H, Al Farsi B, AlBalushi Y, Hazra D. Clinical Outcomes of Carbon Monoxide Poisoning Managed with Hyperbaric Oxygen Therapy in Oman. Oman Medical Journal 2026.
Al Balushi A, Smart D. Safety and performance of intravenous pumps and syringe drivers in hyperbaric environments. Diving Hyperb Med 2023;53(1):42-50.
Al Bazzal H, Hassan F, Tlais M, Tlaiss Y. Advancements in the Treatment of Necrotizing Otitis Externa with Hyperbaric Oxygen: A Systematic Review. Int Arch Otorhinolaryngol 2025;29(3):s00451809432.
No effect estimate of any kind is produced. There is no meta-analysis, no pooled proportion, no HBOT protocols across the included studies were inconsistent "with variations in pressure, duration, Quality assessment is asserted but not shown. The Cochrane Risk of Bias tool (RoB 1) and the
Al-Seraihi A, Ayas M. Hyperbaric oxygen should not be used in the management of hemorrhagic cystitis in patients with Fanconi anemia. Pediatr Blood Cancer 2007;49(6):854-6.
ALBalawi HB, Magliyah MS, Alali NM, Alshehri MM, Alhewiti A, Almarek F, Shajry I, Hazzazi MA, Alotaibi YA. Therapeutic Efficacy of Hyperbaric Oxygen in Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. J Clin Med 2026;15(9):3530.
Pooled efficacy favoured HBOT: OR 0.47 (95% CI 0.26–0.87, p=0.02) — but substantial heterogeneity Timing: studies initiating HBOT <12 h consistently reported greater visual improvement; delayed/ Safety: adverse-event rates not significantly different between HBOT and non-HBOT (OR 0.70, 95% CI
Alberta Provincial Gynecologic Oncology Tumour Team. Hyperbaric oxygen therapy for late radiation tissue injury in cervical and other gynecological malignancies (Clinical Practice Guideline GYNE-003). Alberta Health Services, CancerControl Alberta 2011;GYNE-003:1-16.
Aldè M, Cantarella G, Piatti G, Ambrosetti U. Sudden hearing loss and early hyperbaric oxygen therapy: a preliminary study. Undersea Hyperb Med 2023;50(2):145-153.
Alekseeva O, Zaripov K, Vasilev D, Demchenko I. Distinct Roles of NMDA and AMPA Receptors in the Pathogenesis of Hyperbaric Oxygen-Induced Seizures. Biomedicines 2026;14(8):1807.
Alexander JL, Shulman MD, Sethuraman K. Acute direct traumatic optic neuropathy treated with steroids, minocycline and hyperbaric oxygen: a case report. Undersea Hyperb Med 2019;46(5):709-712.
Allashem HM, Sward DG, Sethuraman K, Matthews MK. Hyperbaric oxygen therapy for perioperative posterior ischemic optic neuropathy: a case report. Undersea Hyperb Med 2019;46(5):701–707 (PubMed lists the first author as 'Allashem HM' and the last as 'Matthews MK'; the PDF byline prints 'Hussain M. Alhashem' and 'Michaela K. Mathews').
Alhumaid MS. Efficacy of hyperbaric oxygen therapy in post-mastectomy wound healing: a systematic review. Acta Innov 2026;(63):1430–1442 (No. 63: 2s; ISSN 2300-5599; no DOI printed in the PDF; not indexed in PubMed (title search 26 Oct 2026)).
- A single-author review that separates acute postoperative ischaemia from chronic radiation injury and refuses to pool them, a distinction stated as predetermined (p.1431). - Search: PubMed, Scopus, Web of Science and Cochrane Library are named only as having been searched "in the original manuscript", with no dates, strings or yield (p.1431). The 2026 update "focused on updating, rather than re-
Aljinović J, Pivalica D, Marinović I, Poljičanin A, Vlak T, Stipančević H, Martinović-Kaliterna D, Čarić D. Hyperbaric Oxygen Therapy as a Therapy Option in the Early Phase of Avascular Necrosis of the Femoral Head. Int J Physiatry 2016;2(2):010.
Alleman T. UHMS Guidelines For Multiplace Inside Attendants: Medical Fitness to Work 1st edition. Undersea Hyperb Med 2018;45(2):231-247.
Allen KD, Danforth JS, Drabman RS. Videotaped modeling and film distraction for fear reduction in adults undergoing hyperbaric oxygen therapy. J Consult Clin Psychol 1989;57(4):554-8.
Allen MW, Golembe E, Gorenstein S, Butler GJ. Protective effects of hyperbaric oxygen therapy (HBO2) in cardiac care — a proposal to conduct a study into the effects of hyperbaric pre-conditioning in elective coronary artery bypass graft surgery (CABG). Undersea Hyperb Med 2015;42(2):107–114.
Alleva R, Nasole E, Di Donato F, Borghi B, Neuzil J, Tomasetti M. α-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun 2005;333(2):404–410.
In chronic-wound patients undergoing HBO, α-lipoic acid reduced HBO-induced lipid and DNA oxidation (directly scavenging free radicals and recycling vitamin E) and lowered pro-inflammatory IL-6; the authors propose LA as an adjuvant to attenuate HBO's oxidative side-effects and support impaired wound healing.
Almomany M, Rawashdeh Z, Alshyyab M, Alnabulsi A, Alodat L, Alshamaly S, et al. Effects of Hyperbaric Oxygen Therapy on Myocardial Injury and Inflammatory Biomarkers: A Systematic Review With Qualitative Synthesis. Cureus 2026;18(4):e106468 (PMID 42093774).
Alp BF, Cebi G, Özdemir A, Irkilata HC, Uzun G. Hyperbaric oxygen therapy for unilateral testicular torsion in a child. Diving Hyperb Med 2014;44(3):161.
Alqasmi H, Jawich B, Jarrah R, Ibrahim S, Khanji H, et al. The role of hyperbaric oxygen therapy for treating spinal cord injury: Mechanisms, considerations, and research outcomes. eNeurologicalSci 2026;43:100608.
Alter IL, Hamiter M, Han J, Leu CS, Usseglio J, Lalwani AK (Columbia University). Hyperbaric Oxygen and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. Laryngoscope 2026;136(1):91–101 (Epub 2025 Aug 1).
HBOT + MT vs MT alone: OR 2.61 (95% CI 1.86–3.68, p<0.001) for hearing recovery. Holds in subgroups: HBOT+systemic steroids vs SS (OR 2.54, 1.63–3.97) and HBOT+SS+intratympanic
Altomare M, Benuzzi L, Molteni M, Virdis F, Spota A, Cioffi SPB, Reitano E, Renzi F, Chiara O, Sesana G, Cimbanassi S. Negative pressure wound therapy for the treatment of Fournier's gangrene: a rare case with rectal fistula and systematic review of the literature. J Pers Med 2022;12(10):1695.
Altun BD, Sümen SG, Dumlu A. A diving physician's experience of dental barotrauma during hyperbaric chamber exposure: case report. Diving Hyperb Med 2022;52(1):63-65.
Altun BD, Sümen SG, Öçbe M, Dumlu A. Effect of hyperbaric oxygen therapy on diabetes-related oral complications. Undersea Hyperb Med 2024;51(2):101-106 (DOI 10.22462/664).
Altunay I, Kucukunal A, Sarikaya S, Tukenmez Demirci G. A favourable response to surgical intervention and hyperbaric oxygen therapy in pyoderma gangrenosum. Int Wound J 2014;11(4):350-353.
Alvarez Villela M, Wever-Pinzon O, Parikh M, Deru K, Muhlestein JB, Anderson JL, et al. Patterns of cardiac dysfunction after carbon monoxide poisoning. Undersea Hyperb Med 2020;47(3):477-485.
Amamri A, Miliani A, Boudour R, Mellal Y, Dib M, Medaouar M, et al. Dysbaric osteonecrosis: Case series osteonecrosis in divers. Undersea Hyperb Med 2026;53(1):83-89.
Amonic RS, Cockett AT, Lorhan PH, Thompson JC. Hyperbaric oxygen therapy in chronic hemorrhagic shock. JAMA 1969;208(11):2051-4.
Single case report. A 26-year-old man of the Jehovah's Witness denomination, admitted with painless rectal bleeding, who refused all blood and blood products. A bleeding gastric leiomyoma was excised at eventual laparotomy; the haemoglobin fell to 2.2 gm/100 cc and on the third postoperative day he showed evidence of severe cerebral and myocardial ischaemia with congestive cardiac failure. He was
Lie SA, Loy ST, Lee CC, Kim SJ, Soh CR. Performance of the Oxylog® 1000 portable ventilator in a hyperbaric environment. Diving Hyperb Med 2018;48(2):102-106.
Anand VK, Alemar G, Griswold JA Jr. Intracranial complications of mucormycosis: an experimental model and clinical review. Laryngoscope 1992;102(6):656-62.
Anand S, Krishnan N, Bajpai M. Utility and safety of hyperbaric oxygen therapy as a rescue treatment in complicated cases of hypospadias: A systematic review and meta-analysis. J Pediatr Urol 2022;18(1):39–46.
4 studies, 176 patients (101 in the HBO group) evaluating HBOT given in the perioperative period to patients who had undergone multiple failed hypospadias operations (inclusion criteria, p.40; two studies gave 20 pre-operative plus 10 adjuvant sessions, p.42); studies at moderate risk of bias, heterogeneous. Both pooled outcomes favoured HBOT and both were statistically significant: graft failure RR 0.19 (95% CI 0.05–0.73, p=0…
Anand J, Pawlas N, Schetz D, Kot J. Management of acute intoxication with carbon monoxide – Polish Medical Society, Section of Clinical Toxicology position statement. Int J Occup Med Environ Health 2025;38(5):457–473.
A national position statement of the Polish Medical Society, Section of Clinical Toxicology, on the management of acute CO poisoning — triage, normobaric oxygen, indications for HBOT, and long-term neurological follow-up. Note co-author J Kot (ECHM Secretary-General / National Center for Hyperbaric Medicine, Gdańsk).
Andel H, Felfernig M, Andel D, Blaicher W, Schramm W. Hyperbaric oxygen therapy in osteomyelitis. Anaesthesia 1998;53(Suppl 2):68–69.
Reducing barometric pressure to 375 mmHg, which reduces ambient oxygen partial pressure from In infected bone, hypoxia was found with a mean of 2.7 kPa against 5.9 kPa in normal tissue, and In a rabbit model of Staphylococcus aureus osteomyelitis, eradication of bone infection by HBO alone
Anderson DC, Bottini AG, Jagiella WM, Westphal B, Ford S, Rockswold GL, Loewenson RB. A pilot study of hyperbaric oxygen in the treatment of human stroke. Stroke 1991;22(9):1137-42.
Andrade SM, Santos IC. Hyperbaric oxygen therapy for wound care. Rev Gaucha Enferm 2016;37(2):e59257.
Andren J, Bennett MH. An observational trial to establish the effect of hyperbaric oxygen treatment on pelvic late radiation tissue injury due to radiotherapy. Diving Hyperb Med 2020;50(3):250-255 (PMID 32957127; DOI 10.28920/dhm50.3.250-255).
Anguiano-Hernandez YM, Contreras-Mendez L, Hernandez-Cueto MA, Alvarado-Yaah JE, Munoz-Medina JE, Santillan-Verde MA, Barbosa-Cabrera RE, Delgado-Quintana CA, Trejo-Rosas S, Santacruz-Tinoco CE, Gonzalez-Ibarra J, Gonzalez-Bonilla CR. Modification of HIF-1alpha, NF-kappaB, IGFBP-3, VEGF and adiponectin in diabetic foot ulcers treated with hyperbaric oxygen. Undersea Hyperb Med 2019;46(1):35-44.
Annane D, Chevret S, Jars-Guincestre MC, Chillet P, Elkharrat D, Gajdos P, Raphael JC. Prognostic factors in unintentional mild carbon monoxide poisoning. Intensive Care Med 2001;27(11):1776–1781.
Observational cohort of unintentional mild CO poisoning assessing early predictors of persistent neurological sequelae at 1 month. Apathy and headache were the main moderate sequelae. Loss of consciousness (and a second clinical predictor) were jointly associated with persistent neurological sequelae on multivariate analysis — i.e. clinical risk-stratification markers in mild CO exposure. ⚠️ Full read 21 Oct 2026 (all 6 pages)…
Annane D, Depondt J, Aubert P, Villart M, Géhanno P, Gajdos P, Chevret S (ORN96 study group). Hyperbaric Oxygen Therapy for Radionecrosis of the Jaw: A Randomized, Placebo-Controlled, Double-Blind Trial From the ORN96 Study Group. J Clin Oncol 2004;22(24):4893–4900.
The trial was stopped early at the second interim analysis (triangular test) for potentially 1-year recovery: 6/31 (19%) with HBO vs 12/37 (32%) with placebo — RR 0.60 (95% CI 0.25–1.41; Time to treatment failure HR 1.33 (95% CI 0.68–2.60; P=0.41); time to pain relief HR 1.00 (95% CI
Annane D, Chadda K, Gajdos P, Jars-Guincestre MC, Chevret S, Raphael JC. Hyperbaric oxygen therapy for acute domestic carbon monoxide poisoning: two randomized controlled trials. Intensive Care Med 2011;37(3):486–492.
Trial A: no difference in 1-month complete recovery with vs without HBO — 58% vs 61%; OR 0.90 Trial B: two HBO sessions were worse than one — 47% vs 68%; OR 0.42 (95% CI 0.23–0.79).
Hyperbaric Oxygen Therapy for Children with Autistic Spectrum Disorders. US Autism & Asperger's Association 2007:1-10.
Public Comments and Responses for HBO and DFU CPG. unknown 2012:1-1.
Index of Hyperbaric Unit Specific Competencies. unknown 2013:1-42.
Catastrophic Hyperbaric Chamber Fire Report dated March 27 2026. unknown 2026.
Antunes BN, Müller DCM, Milech V, Caye P, Degregori EB, Vargas D, et al. Behavior and changes in rectal temperature in dogs and cats undergoing hyperbaric oxygen therapy: clinical data review. Undersea Hyperb Med 2024;51(4):361-367.
Anzalone CL, Cockerill CC, Cofer SA. Hyperbaric oxygen therapy for wound breakdown after oronasal fistula and cleft palate repair: four cases. Undersea Hyperb Med 2017;44(4):315–319.
Australia and New Zealand Hyperbaric Medicine Group Accepted Indications for Hyperbaric Oxygen Therapy (revised and approved December 2006). Diving Hyperb Med 2007;37(1):35.
Apolo-Arenas MD, Guerrero-Nogales L, Díaz-Muñoz CL, Caro-Puértolas B, Parraca JA, Caña-Pino A. Use of the Hyperbaric Chamber Versus Conventional Treatment for the Prevention of Amputation in Chronic Diabetic Foot and the Influence on Fitting and Rehabilitation: A Systematic Review. Int J Vasc Med 2024;2024:8450783.
Across the included studies, HBOT + standard care was favourable versus standard care alone for Frames HBOT as usable for both primary and secondary prevention of the vascular complication, and
Aprilli RR, Parra RS, de Oliveira HF, Aprilli F, da Rocha JJ, Féres O. The effect of hyperbaric oxygenation on the distal intestine of rats subjected to ionizing radiation. Undersea Hyperb Med 2011;38(6):503–507.
Arieli R. Saving the pilot's brain: prevention of punctate lesions in the white matter. Undersea Hyperb Med 2019;46(1):91-92.
Arieli R. Effect of an air break on the occurrence of seizures in hyperbaric oxygen therapy may be predicted by the power equation for hyperoxia at rest. Diving Hyperb Med 2020;50(1):75-76.
Arnold JF, Marmolejo V. Visualization of angiogenesis and vasculogenesis in a late tissue radiation injury of the chest wall treated with adjuvant hyperbaric oxygen therapy using fluorescence angiography. Undersea Hyperb Med 2019;46(1):69-73.
Artru F, Chacornac R, Deleuze R. Hyperbaric oxygenation for severe head injuries. Preliminary results of a controlled study. Eur Neurol 1976;14(4):310-8.
Asadamongkol B, Zhang JH. The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging. Med Gas Res 2014;4(1):7.
Ashamalla HL, Ames JW, Uri A, Winkler P. Hyperbaric oxygen in the management of osteoradionecrosis. Med Pediatr Oncol 1996;27(1):48–53.
Ashton C, Banham N, Needham M. Acute spontaneous spinal cord infarction: Utilisation of hyperbaric oxygen treatment, cerebrospinal fluid drainage and pentoxifylline. Diving Hyperb Med 2020;50(4):325-331.
Aslan Y, Aktas S, Vural P, Baki AM, Inci E. Serum HSP70 levels in sudden sensorineural hearing loss and their modulation after hyperbaric oxygen therapy: a prospective controlled study. Ear Nose Throat J 2026 (online ahead of print. DOI 10.1177/01455613261471930).
Asserson DB, Becker DB, Alleman TL, Kruchevsky D. Hyperbaric Oxygen as a Treatment Modality for Radiation-Induced Breast Calcinosis. Undersea Hyperb Med 2026;53(3):467-470.
Astasio-Picado Á, Jurado-Palomo J, Pozo-Aranda B, Cobos-Moreno P. Comparative Evidence on Negative Pressure Therapy and Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers: A Systematic Review of Independent Effectiveness and Clinical Applicability. Medicina (Kaunas) 2026;62(1):109.
Both NPWT and HBOT are effective adjuncts in DFU management. No standardized head-to-head RCTs — the review cannot establish relative superiority or the optimal ⚠️ Full read 21 Oct 2026 (all 17 PDF pages, Tables A1–A3): corrections.
Ata N, Karaca E. Investigation of a cluster of decompression sickness cases following a high-altitude chamber flight. Diving and Hyperbaric Medicine 2021;51(1):82-85.
Ata SO, Akay C, Mumcu E, Ata N. Influence of atmospheric pressure changes on dentin bond strength of conventional, bulk-fill and single-shade resin composites. Diving Hyperb Med 2022;52(3):175-182.
Athanasiou K, Sotiropoulos G, Kalentzos VN. Arterial Gas Embolism after breath-hold diving. An interesting case report in Greece. Undersea Hyperb Med 2025;52(3):233-237.
Influence of hyperbaric oxygenation on oxidative stress parameters and antioxidant enzymes in patients with diabetes mellitus type 2 [conference abstract]. Atherosclerosis 2017;263:e276.
Attar S, Esmond WG, Cowley RA. Hyperbaric oxygenation in vascular collapse. J Thorac Cardiovasc Surg 1962;44:759-70.
Attar S, Esmond WG, Blair E, Cowley RA. Experimental aspects of the use of hyperbaric oxygen in hemorrhagic shock. Am Surg 1964;30:243-6.
Attar SM, Cowley RA. Re-evaluation of hyperbaric oxygenation in hemorrhagic shock. Surg Forum 1965;16:17-9.
Attar S, Scanlan E, Cowley RA. Further evaluation of hyperbaric oxygen in hemorrhagic shock. In: Brown IW, Cox BG, eds. Proceedings of the Third International Conference on Hyperbaric Medicine. Washington DC: National Academy of Sciences–National Research Council 1966:417–424.
Au SCL, Chong SSY. Prognostic factors for acute central retinal artery occlusion treated with hyperbaric oxygen: The Hong Kong study report number five. World Journal of Methodology 2025;15(2):96777.
Au-Yeung KL, Selvaraj C, Amin T, et al. Effect of enriched oxygen inhalation on lower limb skin temperatures in diabetic and healthy humans: a pilot study. Diving Hyperb Med 2022;52(1):2-6.
Aufgang Y, Devaney B, Chan J, Millar I, Tsouras T. Quantifying discrepancy between indicated and actual oxygen flow rates delivered by Comweld Ezi-flow low and standard flowmeters under hyperbaric conditions: a technical report. Diving Hyperb Med 2026;56(2):154-160.
Avcı AU, Abaylı SY. The Experience of Hyperbaric Oxygen Therapy in Earthquake-Related Crush Injuries: Could Be Beneficial Even with Delay in Initiation. Undersea Hyperb Med 2025;52(3):261-270.
Ay H, Yüksel R, Şimşek K, Topal T, Yeşilyurt Ö, Öter Ş, Korkmaz A, Özler M, Uysal B, Yaman H, Bedir O, Bilgiç H. A new utilization area for hyperbaric oxygen? Improving quality of stored blood. Turk J Med Sci 2015;45(1):105-11.
Aydin F. Hyperbaric oxygen treatment in children: experience in 329 patients. Diving and Hyperbaric Medicine Journal 2023;53(3):203-209 (DOI 10.28920/dhm53.3.203-209).
Aydin G, Zaman T. Hyperbaric Oxygen Treatment in the Management of Post-surgical Pyoderma Gangrenosum Following Reduction Mammoplasty: A Case Report. Undersea Hyperb Med 2026;53(3):505-510.
Azevedo LA, Parra RS, Da Rocha JJ, Ramalho LN, Ramalho FS, Féres O. Hyperbaric oxygen on the healing of ischemic colonic anastomosis — an experimental study in rats. Undersea Hyperb Med 2010;37(6):405–411.
Azmi YA, Alkaff FF, Soetanto KM, Wirjopranoto S, Postma MJ, Purba AKR. The impact of sodium-glucose cotransporter-2 inhibitors on the incidence, therapy, and outcomes of Fournier gangrene: insights from a systematic review of case reports. Syst Rev 2025;14(1):25.
Azzopardi CP, Matity L, Muscat S. Anton's syndrome as a presentation of decompression illness. Diving Hyperb Med 2017;47(1):59-61.
Azzopardi CP, Caruana J, Matity L, Muscat S, Meintjes WAJ. Increasing prevalence of vestibulo-cochlear decompression illness in Malta: an analysis of hyperbaric treatment data from 1987-2017. Diving Hyperb Med 2019;49(3):161-166.
Azzopardi CP, Magri K, Borg A, Schembri J, Sammut J. Echocardiography – techniques and pitfalls whilst diagnosing persistent (patent) foramen ovale as a risk factor in divers with a history of decompression sickness. Diving and Hyperbaric Medicine 2021;51(1):98-102.
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Babel S, Bosco G, Camporesi E. Hyperbaric Oxygen Treatment for Enhancing Athletic Recovery: A Systematic Review and Meta-Analysis. Undersea Hyperb Med 2026;53(2):305-318.
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Babul S, Rhodes EC, Taunton JE, Lepawsky M. Effects of intermittent exposure to hyperbaric oxygen for the treatment of an acute soft tissue injury. Clin J Sport Med 2003;13(3):138-47.
Baechli H, Schmutz J, Mayr JM. Hyperbaric oxygen therapy (HBO) for the treatment of an epidural abscess in the posterior fossa in an 8-month-old infant. Pediatr Neurosurg 2008;44(3):239-42.
Bagli BS, Çevik SG, Çevik MT. Effect of hyperbaric oxygen treatment in central retinal artery occlusion. Undersea Hyperb Med 2018;45(4):421-425.
Bağlı BS, Durgut O. Hyperbaric oxygen therapy as adjuvant therapy in necrotizing fasciitis of the face: case report. Undersea Hyperb Med 2018;45(6):695-699 (PMID 31158939).
Bagli BS, Aygun H. Hyperbaric oxygen therapy decreases QTc dispersion that increased in CO poisoning. Undersea Hyperb Med 2018;45(6):673-677.
Bagli BS. Clinical efficacy of hyperbaric oxygen therapy on idiopathic sudden sensorineural hearing loss. Undersea Hyperb Med 2020;47(1):51-57.
Bahramnezhad F, Montaseri M, Jackson AC. Adjunctive hyperbaric oxygen therapy for poststernotomy deep sternal wound infection, mediastinitis, and sternal osteomyelitis after cardiac surgery: a scoping review. J Cardiothorac Surg 2026:in press.
Bai C, Li T, Chen Y, Xu T, Wang X, Yu J, et al. Protective effects of hyperbaric oxygen preconditioning against LPS-induced acute lung injury in rats. Undersea Hyperb Med 2018;45(3):323-333.
Bai Z, Wang H, Sun H, Cui L. Effect of hyperbaric oxygen therapy on the patients with venous leg ulcer: A systematic review and meta-analysis. Asian J Surg 2023;46(10):4131–4137.
HBOT + surgery: smaller ulcer area (WMD −2.64, 95% CI −3.86 to −1.42), shorter ulcer healing HBOT + non-surgery: higher ulcer percent-area reduction (PAR) (WMD 20.82, 95% CI 5.86 to 35.79). Concludes adjunctive HBOT improves VLU healing metrics.
Baines CR, Cooper PD, O'Rourke GA, Miller C. Evaluation of the Abbot FreeStyle Optium Neo H blood glucose meter in the hyperbaric oxygen environment. Diving Hyperb Med 2020;50(2):144-151.
Baines C, Vicendese D, Cooper PD, McGuiness W, Miller C. Comparison of venous, capillary and interstitial blood glucose data measured during hyperbaric oxygen treatment from patients with diabetes mellitus. Diving Hyperb Med 2021;51(3):240-247.
Baitule S, Patel AH, Murthy N, Sankar S, Kyrou I, Ali A, Randeva HS, Robbins T. A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on Glycaemia in People with Diabetes Mellitus. Medicina (Kaunas) 2021;57(10):1134.
Bakdalieh A, Siddiqui D, Chen DG, Yu M. Hyperbaric Oxygen Therapy Versus Intravenous Thrombolysis in the Treatment of Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. J Clin Med 2026;15(7):2628.
HBOT pool, within-arm pre-post change: MD −0.57 logMAR (95% CI −0.72 to −0.42), 6 studies, n=351. IVT pool, within-arm pre-post change: MD −0.53 logMAR (95% CI −0.92 to −0.13), 7 studies, n=130 — a Clinically meaningful improvement (≥0.3 logMAR): 45.8% of 546 HBOT patients, 42.0% of 150 IVT patients —
Bakhtiani P, Mansuri O, Yadav A, Osuoha C, Knight P, Baynosa R, McLafferty R, Jakoby M. Impact of hyperbaric oxygen on diabetic ulcers is unaffected by glycemic control. Undersea Hyperb Med 2015;42(3):183–190.
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Banham ND. Oxygen toxicity seizures: 20 years' experience from a single hyperbaric unit. Diving Hyperb Med 2011;41(4):202-10.
Banham ND. Livedoid vasculopathy successfully treated with hyperbaric oxygen. Diving Hyperb Med 2013;43(1):35-6.
Banham ND, Saw J, Hankey GJ, Ghia D. Cerebral arterial gas embolism proven by computed tomography following transthoracic echocardiography using bubble contrast. Diving Hyperb Med 2020;50(3):300-302.
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Median treatments to resolution: 1 (IQR 1–1) FH01 vs 2 (IQR 1–2) TT6m (P=0.01) — fewer with the Complete resolution after the first treatment: 17/20 (85%) FH01 vs 8/21 (38%) TT6m (P=0.003). Final outcomes comparable: 19/20 (FH01) vs 20/21 (TT6m) asymptomatic at completion (P=0.97); all
Banham N, da Silva E, Lippmann J. Cerebral arterial gas embolism (CAGE) during open water scuba certification training whilst practising a controlled emergency swimming ascent. Diving Hyperb Med 2023;53(4):345-350.
Bao XC, Chen H, Fang YQ, Wang N, Wang FF. Changes in acid-base status in oxygen toxicity at 230 kPa oxygen as a function of exposure time. Undersea Hyperb Med 2021;48(3):239-245.
Bapteste L, Kamar Z, Mazaud A, Balança B. Air embolism during lumbar surgery in the prone position. Diving Hyperb Med 2021;51(3):303-305.
Baptista LA, Guincho J, Donato M, Araújo P, Amaro CE, Escada PA. Hyperbaric oxygen therapy as salvage treatment for post-traumatic sudden sensorineural hearing loss: a case report. Diving Hyperb Med 2025;55(4):423-426 (DOI 10.28920/dhm55.4.423-426).
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Reoperations: 10% (HBOT) vs 45% (non-HBOT), P=0.03. Recurrence (of those who did/didn't get HBO after first surgery): 14% vs 58%, P<0.01. Good outcome (Glasgow Outcome Score 5): 80% (HBOT) vs 45% (non-HBOT), P=0.04. HBOT well tolerated
Bärtsch P, Merki B, Hofstetter D, Maggiorini M, Kayser B, Oelz O. Treatment of acute mountain sickness by simulated descent: a randomised controlled trial. BMJ 1993;306(6885):1098-101.
Başci O, Çimşit M, Zeren S, Saglican Y, Akgün U, Kocaoglu B, et al. Effect of adjuvant hyperbaric oxygen on healing of cartilage lesions treated with microfracture: an experimental study in rats. Undersea Hyperb Med 2018;45(4):411-419.
Bass BH. The treatment of varicose leg ulcers by hyperbaric oxygen. Postgrad Med J 1970;46(537):407-408.
Bayoumy AB, de Ru JA. The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review. Eur Arch Otorhinolaryngol 2019;276(7):1859–1880.
Beale P, Kitchen L, Graf WR, Fenton ME. Abdominal decompression illness following repetitive diving: a case report and review of the literature. Undersea Hyperb Med 2019;46(2):211-215.
Beevor H, Frawley G. Iatrogenic cerebral gas embolism: analysis of the presentation, management and outcomes of patients referred to The Alfred Hospital Hyperbaric Unit. Diving Hyperb Med 2016;46(1):15–21.
Time to first HBOT was the ONLY independent predictor of good neurological outcome (OR 0.94 per hour, Mean time from recognition to HBOT was 15 h — the authors' central problem: treatment was impeded by Mortality 4/45 (8.9%); good outcome (GOS-E 7–8) in 27, moderate disability in 13.
Beilharz AG, Banham N, Gawthrope I. The incidence of cardiac arrest requiring defibrillation and defibrillation protocols in Australasian hyperbaric units. Diving Hyperb Med 2025;55(4):338-342 (DOI 10.28920/dhm55.4.338-342).
Bell MDD. The use of hyperbaric oxygen in the management of severe anaemia in a Jehovah's Witness. Anaesthesia 2000;55(3):293.
A letter to the Editor. It is not a research paper. It enrols nobody, measures nothing and reports no outcome. Its content is an argument in four parts about a case report published the previous year. It is filed here because it is the only published dissent attached to that case, and because a page that presented the case report alone would misrepresent the record.
Bell J, Thombs PA, Davison WJ, Weaver LK. Decompression tables for inside chamber attendants working at altitude. Undersea Hyperb Med 2014;41(6):505-513.
Bell J, Weaver LK, Deru K. Performance of the Hospira Plum A+ (HB) hyperbaric infusion pump. Undersea Hyperb Med 2014;41(3):235-43.
Bell J, Weaver LK, Deru K. Performance of three large-volume infusion pumps with the monoplace hyperbaric chamber. Undersea Hyperb Med 2016;43(1):9-19.
BenAri O, Efrati S, Sano M, Bendlin BB, Lin H, Liu X, Sela I, Almog G, Livny A, Sandler I, Ben-Haim S, Sagi R, LeRoith D, Schnaider Beeri M, Ravona-Springer R. A double-blind placebo-controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design. Alzheimers Dement (N Y) 2020;6(1):e12008.
Benedetti S, Lamorgese A, Piersantelli M, Pagliarani S, Benvenuti F, Canestrari F. Oxidative stress and antioxidant status in patients undergoing prolonged exposure to hyperbaric oxygen. Clin Biochem 2004;37(4):312-317.
Benites Condezo AF, Araujo RZ, Koga DH, Curi MM, Cardoso CL. Hyperbaric oxygen therapy for the placement of dental implants in irradiated patients: systematic review and meta-analysis. Br J Oral Maxillofac Surg 2021;59(6):625–632.
No evidence that the risk of implant failure differed between irradiated patients who received HBOT Implant-failure risk did not depend on anatomical site. ⚠️ Full read 21 Oct 2026 (all 8 pages, Tables 3–4): the "meta-analysis" is one estimate from one retrospective series. The three included studies (Curi 2018, August 1998, Cotic) are all retrospective case series. Cotic gave no group-level survival. August had no failures in…
Benix L, Sukumaran MT, Lakshmanan V, Sankaran R, Kumar V. The impact of adjunct hyperbaric oxygen therapy on healing diabetic foot ulcers: a retrospective case-control study at a tertiary care center. Cureus 2025;17(12):e99432.
Bennett M, Mitchell S, Dominguez A. Adjunctive treatment of decompression illness with a non-steroidal anti-inflammatory drug (Tenoxicam) reduces compression requirement. Undersea Hyperb Med 2003;30(3):195-205.
Primary recovery outcome — no significant difference. Health status score >1 at discharge was Number of recompressions — significantly fewer with tenoxicam. Median treatments to discharge Subjects requiring more than two treatments: 53 (61%) placebo versus 35 (40%) tenoxicam, a 21%
Bennett M, Heard R. Hyperbaric oxygen therapy for multiple sclerosis. Cochrane Database Syst Rev 2004;2004(1):CD003057.
9 trials, 504 participants (ten reports). Two trials broadly positive, seven showed no treatment Conclusion: "no consistent evidence to confirm a beneficial effect… we do not believe routine use is COI (disclosed): lead author is a hyperbaric-facility medical director (does not routinely treat MS);
Bennett M, Best TM, Babul S, Taunton J, Lepawsky M. Hyperbaric oxygen therapy for delayed onset muscle soreness and closed soft tissue injury. Cochrane Database Syst Rev 2005;2005(4):CD004713.
Bennett MH, Kertesz T, Yeung P. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss and tinnitus: a systematic review of randomized controlled trials. J Laryngol Otol 2005;119(10):791–798.
6 RCTs, 304 subjects. Significantly increased chance of a 25% PTA hearing-threshold improvement — RR 1.39 ⚠️ Full read 21 Oct 2026 (all 8 pages): the headline numbers did not change in the 2012 Cochrane update. Both versions report RR 1.39 (1.05–1.84), NNT 5 (3–20) for ≥25% improvement and RR 1.53 (0.85–2.78) for ≥50%. In 2012 both still rest on two trials with 114 patients (evidence/bennett-2012-cochrane-ssnhl). Between 2005…
Bennett MH, Jepson N, Lehm J. Hyperbaric oxygen therapy for acute coronary syndrome: a systematic review of randomised trials. Diving Hyperb Med 2006;36(4):201-207.
Bennett MH, Trytko BE, Jonker B. A systematic review of the use of hyperbaric oxygen therapy in the treatment of acute traumatic brain injury. unknown 2006;36(1):39-46.
Bennett MH, Wasiak J, French C, Kranke P, Schnabel A. Hyperbaric oxygen therapy for acute ischemic stroke. Stroke 2006;37(7):1953–1954 (Cochrane Corner, section editor Graeme J. Hankey; epub 1 Jun 2006. Summarises Cochrane CD004954.pub2 (2005), PMID 16034959).
Bennett M, Newton H. Hyperbaric oxygen therapy and cerebral palsy--where to now? Undersea Hyperb Med 2007;34(2):69-74.
Bennett MH. The Evidence Basis of Diving and Hyperbaric Medicine: A Synthesis of the High Level Clinical Evidence with Meta-analysis. Saarbrücken: VDM Verlag Dr. Müller 2009:675 pp (PDF).
Bennett M, Perczuk A. Critical appraisal: HBOT did not improve exercise performance immediately following hyperbaric oxygen exposure. Diving Hyperb Med 2010;40(2):93.
Bennett M, Mitchell S, Neuman T, Piantadosi CA, Feldmeier J, Hampson NB, et al. Hyperbaric oxygen therapy and neurological disease. Undersea Hyperb Med 2010;37(5):371-3; author reply 373-4.
Bennett MH, Wasiak J, Schnabel A, Kranke P, French C. Hyperbaric oxygen therapy for acute ischemic stroke. Stroke 2010;41(2):e185–e186.
Bennett M. Hyperbaric oxygen therapy improved pain and range of motion for patients with Ficat stage II idiopathic femoral head necrosis. Diving Hyperb Med 2011;41(3):158.
Bennett M. Hyperbaric oxygen therapy improved both pain scores and range of motion in patients with early idiopathic femoral head necrosis (Ficat stage II) [critical appraisal]. Diving Hyperb Med 2011;41(2):105.
Bennett M. Critical appraisal: Hyperbaric oxygen therapy did not improve arm volume or functional scores in post-radiation lymphoedema. Diving Hyperb Med 2012;42(1):45.
Bennett MH, Lehm JP, Mitchell SJ, Wasiak J. Recompression and adjunctive therapy for decompression illness. Cochrane Database Syst Rev 2012;5:CD005277.
Recompression is the universally accepted standard treatment of DCI — but there is NO randomised Two RCTs (268 patients) addressed adjuncts: adding the NSAID tenoxicam did not improve recovery ⚠️ Full read 21 Oct 2026 (2012 Cochrane PDF, 30 pages; the 2008 DHM version checked): the figures above match the abstract. What the record left out bears on both adjunct results.
Bennett MH, Stanford RE, Turner R. Hyperbaric oxygen therapy for promoting fracture healing and treating fracture non-union. Cochrane Database Syst Rev 2012;11(11):CD004712.
No randomised controlled trials met the inclusion criteria — an empty review. Three RCTs were Conclusion: the review "failed to locate any relevant clinical evidence to support or refute" HBOT
Bennett MH, Kertesz T, Perleth M, Yeung P, Lehm JP. Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus. Cochrane Database Syst Rev 2012;10:CD004739.
No significant effect on the chance of a 50% improvement in pure-tone average (RR 1.53, 95% CI Significant effect on the chance of a 25% improvement in pure-tone average (RR 1.39, 95% CI Absolute audiometric gain 15.6 dB greater with HBOT (95% CI 1.5–29.8; P=0.03).
Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Cochrane Database Syst Rev 2012;(12):CD004609.
Bennett M. Critical appraisal: The addition of hyperbaric oxygenation to specialised wound care for chronic diabetic foot ulcers improved healing and quality of life. Diving Hyperb Med 2012;42(2):104.
Bennett M. Critical appraisal: Postoperative hyperbaric oxygen reduced neurological deficit, brain oedema and abnormal brain density on CT imaging following resection of meningiomas with associated brain oedema. Diving Hyperb Med 2012;42(4):238.
Bennett MH, Mitchell SJ, Young D, King D. The use of deep tables in the treatment of decompression illness: the Hyperbaric Technicians and Nurses Association 2011 Workshop. Diving Hyperb Med 2012;42(3):171–180.
Bennett M. HBO Evidence website. Diving Hyperb Med 2012;42(2):105.
Bennett M. Critical appraisal: Hyperbaric oxygen therapy no better than sham in improving post-concussion symptoms following mild traumatic brain injury. Diving Hyperb Med 2013;43(3):173.
Bennett MH. Randomized controlled trials in diving and hyperbaric medicine. Undersea Hyperb Med 2013;40(5):419-38.
Bennett MH, Weibel S, Wasiak J, Schnabel A, French C, Kranke P. Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev 2014;(11):CD004954.
Bennett MH. Hyperbaric medicine and the placebo effect. Diving Hyperb Med 2014;44(4):235-40.
Bennett MH, French C, Schnabel A, Wasiak J, Kranke P, Weibel S. Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Cochrane Database Syst Rev 2015;2015(12):CD005219.
Cochrane systematic review/meta-analysis of normobaric (NBOT) and hyperbaric (HBOT) oxygen for migraine and cluster headache (update of the 2008 review). 11 trials, 209 participants; trial quality poor-to-moderate.
Bennett M. Critical appraisal: A single hyperbaric oxygen exposure preoperatively may modulate inflammatory markers and clinical complications following pancreatodudenectomy. Diving Hyperb Med 2015;45(4):258.
Bennett MH, Feldmeier J, Hampson NB, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 2016;Issue 4:CD005005 (searches to Dec 2015; re-published Issue 11, 2018 — edited, no change to conclusions).
Osteoradionecrosis — mucosal coverage: RR 1.30 (95% CI 1.1–1.6, P = 0.003), NNTB 5 (246 Wound breakdown after operative treatment for ORN: significantly more likely without HBOT — Radiation proctitis (improvement/cure): RR 1.72 (95% CI 1.0–2.9, P = 0.04), NNTB 5 (single
Bennett M. Critical appraisal: Hyperbaric oxygen therapy may improve mobility, reduce complications and return circulation in post-amputation patients having rehabilitation for prosthesis fitting. Diving Hyperb Med 2017;47(4):265.
Bennett MH, Feldmeier J, Smee R, Milross C. Hyperbaric oxygenation for tumour sensitisation to radiotherapy. Cochrane Database Syst Rev 2018;(4):CD005007.
19 trials, 2286 participants (1103 HBOT, 1153 control). HBOT during radiotherapy improved local tumour control, mortality and local tumour recurrence in head-and-neck cancer (mortality reduced at 1 and 5 years; less local recurrence at 1 and 5 years). Benefits may only occur with unusual radiotherapy fractionation schemes; HBOT was associated with severe radiation tissue injury (and oxygen-toxicity seizures). Results demand ca…
Bennett MH. Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder. Diving Hyperb Med 2018;48(2):115.
Bennett MH, Hui CF, See HG, Au-Yeung KL, Tan C, Watson S. The myopic shift associated with hyperbaric oxygen administration is reduced when using a mask delivery system compared to a hood - a randomised controlled trial. Diving Hyperb Med 2019;49(4):245-252.
Bennett M. Annual update on the Database of Randomised Controlled Trials in Diving and Hyperbaric Medicine. Diving Hyperb Med 2020;50(3):307.
Bennett MH. REPRINTED FROM THE 2023 HYPERBARIC INDICATIONS MANUAL 15TH EDITION: Randomized Controlled Trials in Hyperbaric Medicine. Undersea Hyperb Med 2026;53(3):543-568.
Bennett MH, Mitchell SJ. Emerging indications for hyperbaric oxygen. Curr Opin Anaesthesiol 2019;32(6):792-798.
Benson J, Adkinson C, Collier R. Hyperbaric oxygen therapy of iatrogenic cerebral arterial gas embolism. Undersea Hyperb Med 2003;30(2):117–126.
Bent JP, April MM, Ward RF, Packard AM. Role of otoscan-assisted laser myringotomy in hyperbaric oxygen therapy. Undersea Hyperb Med 2000;27(3):159-161.
Benzidi Y, Duburcq T, Mathieu D, Parmentier-Decrucq E. Evaluation of pressure in water-filled endotracheal tube cuffs in intubated patients undergoing hyperbaric oxygen treatment. Diving Hyperb Med 2020;50(3):230-237.
Berdal-Sanner K, Andvik SKK, Müller B, Riisnes IO, Holsen DS. Kalsifylaksi ved leversykdom og akutt nyresvikt [Calciphylaxis in liver disease and acute kidney failure]. Tidsskr Nor Laegeforen 2026;146(11).
Bergel'son MN, Rybalov AG. [Physicochemical mechanism of hemolysis under conditions of increased barometric pressure]. Probl Gematol Pereliv Krovi 1972;17(11):11-6 (Russian).
Berger MR. Jehovah's Witnesses and the problem with blood. Orthop Nurs 1982;1(4):17–21.
Bergeron Gravel S. HBOT for radiation cystitis: a retrospective study of long term efficacy. Slide presentation, Radiation Oncology, CHU de Québec (74 slides; no date or venue printed) 2018 (undated; the slides cite UpToDate (September 2018), so the talk is 2018 or later).
Berkutskaia TS, Bykov EG, Leonov AN. [Structural-metabolic characteristics of the myocardium in acute hemorrhage and hyperbaric oxygenation]. Arkh Patol 1975;37(10):36-41 (Russian with English abstract).
Berland N, Blumenberg A. Comment on the effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning. Clin Toxicol (Phila) 2026:online ahead of print.
Bernardo ATB. Global Competency of Hyperbaric Nurses: An Integrative Literature Review. International Journal of Special Education 2026;41(11s):330-349.
Bernbeck B, Christaras A, Krauth K, Lentrodt S, Strelow H, Schaper J, Janssen G, Mödder U, Göbel U. Bone marrow oedema and aseptic osteonecrosis in children and adolescents with acute lymphoblastic leukaemia or non-Hodgkin-lymphoma treated with hyperbaric-oxygen-therapy (HBO): an approach to cure? -- BME/AON and hyperbaric oxygen therapy as a treatment modality. Klin Padiatr 2004;216(6):370–378.
Between 11/1988 and 01/2001, 291 patients with acute lymphoblastic leukaemia or non-Hodgkin lymphoma (264 ALL, 27 NHL) were treated at the Clinic for Paediatric Oncology, Haematology and Immunology, University of Düsseldorf. 27 (9.3%) were diagnosed with bone marrow oedema (BME) and/or aseptic osteonecrosis (AON) on MRI, and it is these 27 who form the study. 19 of 27 received HBO; the remaining 8
Berntsson H, Thien A, Hind D, Stewart L, Mahzabin M, Tung WS, et al. Interventions for Managing Late Gastrointestinal Symptoms Following Pelvic Radiotherapy: a Systematic Review and Meta-analysis. Clin Oncol (R Coll Radiol) 2024;36(5):318–334.
RCTs (1990–2023) of interventions for late GI symptoms after pelvic radiotherapy. HBO showed conflicting results; sucralfate + argon plasma coagulation INCREASED ENDOSCOPIC MARKERS OF MODERATE-TO-SEVERE BLEEDING compared with APC alone (one trial, 119 participants, risk ratio 2.26, 95% CI 1.12 to 4.55) — a HARM, not a benefit. ⚠️ REVERSED AND CORRECTED 2 Sep 2026: this page previously read "increased endoscopic markers of impr…
Berry GH, Dixon B, Ward AJ. The Leeds results for radiotherapy in HBO for carcinoma of the head and neck. Clin Radiol 1979;30(6):591–592.
Significant gain in local tumour control (P<0.001) and survival (P<0.05) with HBO radiotherapy vs No increase in early or late tissue reactions or morbidity between groups.
Bert P. La Pression Barométrique: recherches de physiologie expérimentale. Paris 1878:1190 pp (PDF; scan with OCR text layer).
Bessereau J, Genotelle N, Chabbaut C, Huon A, Tabah A, Aboab J, Chevret S, Annane D. Long-term outcome of iatrogenic gas embolism. Intensive Care Med 2010;36(7):1180–1187.
Crude mortality 14/119 (12%) at ICU discharge, rising to 25/119 (21%) at 1 year. Neurological sequels in 45/105 ICU survivors (42.9%) at discharge (vegetative state, focal motor Independent predictors of 1-year mortality: cardiac arrest at the accident and at ICU admission, and
Bessereau J, Tabah A, Genotelle N, Français A, Coulange M, Annane D. Middle-ear barotrauma after hyperbaric oxygen therapy. Undersea Hyperb Med 2010;37(4):203-208.
Bevers RF, Bakker DJ, Kurth KH. Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. Lancet 1995;346(8978):803-805 (PMID 7674746. DOI 10.1016/s0140-6736(95)91620-2).
British Hyperbaric Association Technical Working Party. Guide to Fire Safety Standards for Hyperbaric Treatment Centres. British Hyperbaric Association 1996:1-24.
British Hyperbaric Association. Fire Safety Guidelines for Multiplace Hyperbaric Treatment Facilities. British Hyperbaric Association 2025.
Bhatt D, Sanchez E, Angus T, Li K, Cosar M. Self-Trephination Resulting in Exposed Brain Matter and Cerebral Abscess in a Schizophrenic Patient With Delusions. Cureus 2025;17(1):e77003.
Biadacz-Sadurska A, Krefta A, Tłustochowicz W. Effective treatment of audiovestibular involvement in Cogan's syndrome with biologics and hyperbaric oxygen therapy. Eur J Case Rep Intern Med 2026;13:007109.
Bidstrup D, Jansen EC, Hyldegaard O. Quantitative Romberg's test in acute carbon monoxide poisoning treated by hyperbaric oxygen. Undersea Hyperb Med 2017;44(6):559-567.
Bidstrup D, Ravn F, Smidt-Nielsen IG, Wahl AM, Jansen EC, Hyldegaard O. Non-invasive monitoring of carboxyhemoglobin during hyperbaric oxygen therapy. Undersea Hyperb Med 2021;48(1):33-42.
Biggs AT, Littlejohn LF, Dainer HMHM. Department of Defense positions on alternative uses of hyperbaric oxygen therapy. Undersea Hyperb Med 2022;49(1):57-63.
Bilic I, Petri NM, Bezic J, Alfirevic D, Modun D, Capkun V, Bota B. Effects of hyperbaric oxygen therapy on experimental burn wound healing in rats: a randomized controlled study. Undersea Hyperb Med 2005;32(1):1–9.
Bilic I, Petri NM, Krstulja M, Vuckovic M, Salamunic I, Kraljevic KS, Capkun V, Lusic I. Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats. Neurol Res 2012;34(10):931-6.
Bingham G, Koch B, Lee G, Millar I. Ventilator performance under hyperbaric conditions: a study of the Servo 900C ventilator. Diving Hyperb Med 2007;37(4):199-203.
Bingham G, Millar I, Koch S, Paul E, Varma D, Pilcher D. Changes in oxygenation in mechanically ventilated critically ill patients following hyperbaric treatment. Diving Hyperb Med 2011;41(2):59-63.
Binkley M, Kelly M, Hardy K. Cerebral arterial gas embolism in a patient with hypoplastic left heart syndrome treated with emergent hyperbaric oxygen: case report. Undersea Hyperb Med 2020;47(3):431-434.
Bion V, Jape D, Niesen R, Angliss M, Bruscino-Raiola F, Mitra B, Devaney B. Validation of necrotising infection clinical composite endpoint in a retrospective cohort of patients with necrotising soft tissue infections. Diving Hyperb Med 2024;54(3):155-161 (PMID 39288918. DOI 10.28920/dhm54.3.155-161).
Bird N. CT finding of VGE in the portal veins and IVC in a diver with abdominal pain: a case report. Undersea Hyperb Med 2007;34(6):393-397.
Bishop AJ, Mudge E. A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. Int Wound J 2012;9(6):665-676.
Bitterman H, Reissman P, Bitterman N, Melamed Y, Cohen L. Oxygen therapy in hemorrhagic shock. Circ Shock 1991;33(3):183-91.
Bitterman H, Brod V, Levi H, Bravojibotovsky Y, Bitterman N. Hyperbaric oxygen induces redistribution of blood flow in hemorrhagic shock [abstract]. Undersea Hyperb Med 1996;23(Suppl):45–46 (UHMS ASM, Anchorage, 1996).
Bitterman H, Brod V, Weisz G, Kushnir D, Bitterman N. Effects of oxygen on regional hemodynamics in hemorrhagic shock. Am J Physiol 1996;271(1 Pt 2):H203-11.
Bitterman H, Rubenstein EJ, Brod V. Effects of oxygen on heart performance in hemorrhagic shock [abstract 99]. Undersea Hyperb Med 1999;26(Suppl) (UHMS Annual Meeting, 26–29 June 1999).
Bitterman H, Weber G, Goldberg M, Rubinshtein R, Brod V. Endothelium dependent mechanism of oxygen induced redistribution of blood flow in hemorrhagic shock and sepsis [abstract 102]. Undersea Hyperb Med 2005;32(4):271 (Abstracts from the 38th UHMS Annual Scientific Meeting).
Bjerregård A, Jansen E. Monitoring carbon dioxide in mechanically ventilated patients during hyperbaric treatment. Diving Hyperb Med 2012;42(3):134-6.
Blair E, Henning G, Esmond WG, Attar S, Cowley RA, Michaelis M. The effect of hyperbaric oxygenation (ohp) on three forms of shock--traumatic, hemorrhagic, and septic. J Trauma 1964;4:652-63.
Blake DF, Naidoo P, Brown LH, Young DA, Lippmann J. Partial Retraction: A comparison of the tissue oxygenation achieved using different oxygen delivery devices and flow rates. Diving and hyperbaric medicine 2016;46(1):55.
Blake DF, Young DA, Brown LH. Retraction of three papers investigating transcutaneous oxygen tensions in healthy volunteers. Diving Hyperb Med 2016;46(1):57.
Blake DF, Crowe M, Mitchell SJ, Aitken P, Pollock NW. Vibration and bubbles: a systematic review of the effects of helicopter retrieval on injured divers. Diving Hyperb Med 2018;48(4):235-240.
Blake DF, Young DA, Brown LH. Transcutaneous oximetry: variability in normal values for the upper and lower limb. Diving Hyperb Med 2018;48(1):2-9.
Blake DF, Crowe M, Lindsay D, Turk R, Mitchell SJ, Pollock NW. Divers treated in Townsville, Australia: worse symptoms lead to poorer outcomes. Diving and Hyperbaric Medicine 2024;54(4):308-319.
Blake DF, Crowe M, Lindsay D, Turk R, Mitchell SJ, Pollock NW. Oxygen treatment and retrieval pathways of divers with diving-related conditions in Townsville, Australia: a 15-year retrospective review. Diving Hyperb Med 2025;55(2):79-90.
Blanc P, Boussuges A, Henriette K, Sainty JM, Deleflie M. Iatrogenic cerebral air embolism: importance of an early hyperbaric oxygenation. Intensive Care Med 2002;28(5):559–563.
Patients treated with HBO <6 h had a better outcome than those treated later. Among those treated Beyond 6 h, the delay was shorter in patients who recovered than in those with sequelae/death Venous air embolism treated <6 h did better; the time-to-HBO was shorter for venous than arterial
Blanshard J, Toma A, Bryson P, Williamson P. Middle ear barotrauma in patients undergoing hyperbaric oxygen therapy. Clin Otolaryngol Allied Sci 1996;21(5):400-3.
Blatteau JE, Pontier JM. Effect of in-water recompression with oxygen to 6 msw versus normobaric oxygen breathing on bubble formation in divers. Eur J Appl Physiol 2009;106(5):691-5.
Blatteau JE, Gempp E, Constantin P, Louge P. Risk factors and clinical outcome in military divers with neurological decompression sickness: influence of time to recompression. Diving Hyperb Med 2011;41(3):129-134.
15 of 59 divers (25.4%) had incomplete resolution at one month, all involving spinal cord lesions. Time to recompression did not predict outcome on univariate analysis. With a ROC-derived cut-off of On multivariate analysis the association reached significance but was clinically negligible —
Blatteau JE, Morin J, Roffi R, Druelle A, Sbardella F, Castagna O. Clinical problem solving: Mental confusion and hypoxaemia after scuba diving. Diving and Hyperbaric Medicine 2020;50(2):181-184.
Blatteau JE, Lambrechts K, Ruffez J. Factors influencing the severity of long-term sequelae in fishermen-divers with neurological decompression sickness. Diving and Hyperbaric Medicine 2020;50(1):9-16.
Blatteau JE, Mirasoglu B, Germonpre P, Kot J, Marroni A, Welslau W. ECHM-EUBS Position statement on the use of 'mild hyperbaric therapies' in humans. Diving Hyperb Med 2023;53(2):161-163.
Blatteau JE, Gempp E. Fit for diving after musculoskeletal decompression sickness: how to detect and manage bone lesions? Undersea Hyperb Med 2025;52(1):9-14.
Blatteau JE, Roffi R, Valero B. Blurred vision after diving, what's your diagnosis? Diving Hyperb Med 2025;55(4):434-435.
Bleakley CM, McDonough SM, MacAuley DC. Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review. Aust J Physiother 2008;54:7-20.
Bliss C, Huang E, Savaser D. Safety of a continuous glucose monitoring device during hyperbaric exposure. Undersea Hyperb Med 2020;47(1):13-19.
Blogg SL, Møllerløkken A, Gennser M. Observed decompression sickness and venous bubbles following 18-msw dive profiles using RN Table 11. Undersea and Hyperbaric Medicine 2017;44(3):211-219.
Blogg SL, Tillmans F, Lindholm P. The risk of decompression illness in breath-hold divers: a systematic review. Diving and Hyperbaric Medicine 2023;53(1):31-41.
Bocanegra MJR, Castro RQ, Martínez LP, Lagunes BA, Pagola PG, Leyva SH, et al. Hyperbaric Oxygen Treatment Decreases Cd36 Gene Expression Through HIF-1α/PPAR-γ and Reverses Non-Alcoholic Fatty Liver Disease in Rats. Undersea Hyperb Med 2026;53(2):215-226.
Bodilsen J, Dalager-Pedersen M, Kjærgaard N, van de Beek D, Brouwer MC, Nielsen H. Positive predictive value of ICD-10 diagnosis codes for brain abscess in the Danish National Patient Registry. Clin Epidemiol 2018;10:1503-1508.
Boerema I, Meyne NG, Brummelkamp WK, Bouma S, Mensch MH, Kamermans F, Stern Hanf M, van Aalderen W. Life Without Blood (A study of the influence of high atmospheric pressure and hypothermia on dilution of the blood). J Cardiovasc Surg — year, volume and pages NOT ESTABLISHED; see 'Provenance' below UNRESOLVED — the reprint says 1959; the paper is widely cited as 1960;UNRESOLVED:UNRESOLVED.
At normal atmospheric pressure — three pigs weighing about 12 Kg. When the haemoglobin fell At three atmospheres absolute on oxygen. "The same experiment was repeated in a high pressure Summary as printed: haemoglobin lowered in young pigs to 0.4 per cent, the blood exchanged for
Boerema I, Meyne NG, Brummelkamp WH, Bouma S, Mensch MH, Kamermans F, Stern Hanf M, van Aalderen W. [Life without blood]. Ned Tijdschr Geneeskd 1960;104:949–954 (published 7 May 1960; in Dutch. The eighth author's initial is absent from PubMed; 'W' is from Dr Weir's list and is unverified).
Boerema I, Brummelkamp WH, Meijne NG, editors. Clinical Application of Hyperbaric Oxygen: Proceedings of the First International Congress, Amsterdam, September 1963. Amsterdam: Elsevier 1964:438 pp (PDF; scan with OCR text layer); 147 illustrations, 65 tables.
Boet S, Cheng-Boivin O, Martin L, Hurskainen T, Etherington C. Evidence for simulation-based education in hyperbaric medicine: A systematic review. Diving Hyperb Med 2019;49(3):209-215.
Boet S, Martin L, Cheng-Boivin O, Etherington N, Louge P, Pignel R, Pellegrini M, Magnan MA, Bennett M. Can preventive hyperbaric oxygen therapy optimise surgical outcome? A systematic review of randomised controlled trials. Eur J Anaesthesiol 2020;37(8):636-648.
Boet S, Etherington C, Djaiani G, Tricco AC, Sikora L, Katznelson R. Efficacy and safety of hyperbaric oxygen treatment in SARS-COV-2 (COVID-19) pneumonia: a systematic review. Diving Hyperb Med 2021;51(3):271-281.
Boet S, Burns JK, Jenisset E, Papp M, Bourbonnais S, Pignel R. A Delphi study to identify relevant scenarios as the first step toward an international hyperbaric medicine simulation curriculum. Diving Hyperb Med 2022;52(1):44-48.
Boet S, Etherington C, Ghanmi N, Ioudovski P, Tricco AC, Sikora L, et al. Efficacy and safety of hyperbaric oxygen treatment to treat COVID-19 pneumonia: a living systematic review update. Diving Hyperb Med 2022;52(2):126-135.
Bojić L, Kovačević H, Andrić D, Romanović D, Petri NM. Hyperbaric oxygen dose of choice in the treatment of glaucoma. Arh Hig Rada Toksikol 1993;44(3):239–247.
Visual acuity and IOP: no statistically significant difference between treated and control groups, Visual-field values increased after HBO in all subgroups, dose-dependently — the increase was Authors recommend a 20-session course for initial treatment (with re-treatment when fields decline).
Bokeriia LA, Krutik IG, Khapiĭ KhKh, Gadzhiev AA. [ECG, EEG and hemodynamic characteristics in artificial circulation with hemodilution under hyperbaric oxygenation]. Anesteziol Reanimatol 1979;(5):23-8 (Russian).
Bonner LB, Sadler C, Lindholm P, Scholtens DM, Dulai PS; HBOT-UC Consortium. Hyperbaric oxygen therapy for ulcerative colitis patients hospitalized for moderate to severe flares (HBOT-UC): study protocol for a multi-center, randomized, double-blind, sham-controlled trial. Trials 2025;26(1):220.
No efficacy data yet — protocol only; the trial to watch that would move UC from investigational Senior author Dulai also led the positive 2018 phase-2A UC RCT already on file
Bonnington S, Banham N, Foley K, Gawthrope I. Oxygen toxicity seizures during United States Navy Treatment Table 6: An acceptable risk in monoplace chambers? Diving Hyperb Med 2021;51(2):167-172.
Booher AG, McGonagle KE, Peacock JL, Silverman EM, Hannigan PM, Bornt LC, Bihrle W, Buckey JC, Moses RA. Factors Associated With Hematuria Resolution and Hematuria Admissions After Hyperbaric Oxygen Therapy for Chronic Radiation Cystitis. Urol Pract 2026;13(6):686-694.
Borab Z, Mirmanesh MD, Gantz M, Cusano A, Pu LLQ. Systematic review of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis. J Plast Reconstr Aesthet Surg 2017;70(4):529–538.
8 articles (1 observational cohort, 5 case series, 2 case reports) — no controlled trials. They describe improvement in symptoms and wounds with HBO for radiation-induced skin necrosis. Pooled complete wound healing 79.6% (78/98) — from only six of the eight studies, 98 of the 720 patients, with no control arm and no formal meta-analysis. ⚠️ Added 31 Aug 2026: the review's own pooled headline figure was absent from this page,…
Borer RC Jr, Rozenek R, Russo AC, Strauss MB. Delayed onset of muscle soreness, neutrophil inflammatory response and hyperbaric oxygen therapy. Undersea Hyperb Med 1999;26(Suppl):12.
Bornside GH. Bactericidal effect of hyperbaric oxygen determined by direct exposure. Proceedings of the Society for Experimental Biology and Medicine 1969;130(4):1165-1167.
Borromeo CN, Ryan JL, Marchetto PA, Peterson R, Bove AA. Hyperbaric oxygen therapy for acute ankle sprains. Am J Sports Med 1997;25(5):619-25.
Bosco G, Casarotto A, Nasole E, Camporesi E, Salvia R, Giovinazzo F, Zanini S, Malleo G, Di Tano A, Rubini A, Zanon V, Mangar D, Bassi C. Preconditioning with hyperbaric oxygen in pancreaticoduodenectomy: a randomized double-blind pilot study. Anticancer Res 2014;34(6):2899-906.
Bosco G, Garetto G, Rubini A, Paoli A, Dalvi P, Mangar D, Camporesi EM. Safety of transport and hyperbaric oxygen treatment in critically-ill patients from Padua hospitals into a centrally-located, stand-alone hyperbaric facility. Diving Hyperb Med 2016;46(3):155-159.
Bosco G, Vezzani G, Enten G, Manelli D, Rao N, Camporesi EM. Femoral condylar necrosis: treatment with hyperbaric oxygen therapy. Arthroplast Today 2018;4(4):510-515.
Bosco G, Rizzato A, Vezzani G, Zanon V, Camporesi E. Therapeutic Mechanisms of Action for Hyperbaric Oxygen on Femoral Head Necrosis. Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. IntechOpen 2018 (Chapter 2).
Mechanistic account for HBO in femoral head necrosis (FHN/AVN): increased oxygen tension in
Bose JG, Kumar S, Anand S, Mohanty C. The role of hyperbaric oxygen treatment in a case of pyomyositis. Diving Hyperb Med 2026;56(2):191-194.
Botha DM, Coopoo Y, Botha MK, Collins R, Lynch E, Niekerk RLV. The effect of hyperbaric oxygen and blood platelet injection therapy on the healing of hamstring injuries in rugby players: A Case series report. African Journal for Physical, Health Education, Recreation and Dance 2015;(Suppl 1):29-39.
Bothma PA, Brodbeck A, Bapat U. Malfunction of the Siaretron 1000 Iper™ hyperbaric ventilator. Diving Hyperb Med 2009;39(1):45-7.
Bothma PA, Brodbeck AE, Smith BA. Cerebral venous air embolism treated with hyperbaric oxygen: a case report. Diving Hyperb Med 2012;42(2):101-103.
Bothma PA, Heij RE. Despite animal studies, HBOT is the treatment of choice for cerebral gas embolism [letter]. Diving Hyperb Med 2013;43(4):249.
Bothma P. Pneumothorax in the hyperbaric chamber: easier and earlier diagnosis with ultrasound. Undersea Hyperb Med 2015;42(6):619.
Bouachour G, Cronier P, Gouello JP, Toulemonde JL, Talha A, Alquier P. Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial. J Trauma 1996 Aug;41(2):333–9.
Complete healing: 17/18 (HBOT) vs 10/18 (placebo), P < 0.01. Repeat surgery (skin flap/graft, vascular surgery, or amputation): 1 (HBOT) vs 6 (placebo), Effect concentrated by risk: in patients > 40 years with grade III soft-tissue injury,
Bourke A, Hui B. Critical appraisal: Weak evidence that HBOT is of benefit in the treatment of patients with Herpes zoster. Diving Hyperb Med 2013;43(3):174.
Bourke A. Weak evidence for benefit of hyperbaric oxygen in patients more than six months after stroke. Diving Hyperb Med 2014;44(2):104.
Boussi-Gross R, Golan H, Fishlev G, Bechor Y, Volkov O, Bergan J, Friedman M, Hoofien D, Shlamkovitch N, Ben-Jacob E, Efrati S. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury - randomized prospective trial. PLoS One 2013;8(11):e79995.
Boussi-Gross R, Golan H, Volkov O, Bechor Y, Hoofien D, Beeri MS, Ben-Jacob E, Efrati S. Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy. Neuropsychology 2015;29(4):610-621.
Bove AA, Clark JM, Simon AJ, Lambertsen CJ. Successful therapy of cerebral air embolism with hyperbaric oxygen at 2.8 ATA. Undersea Biomed Res 1982;9(1):75–80.
Bove AA, ed. Bove and Davis' Diving Medicine. 4th ed. Philadelphia: Saunders (Elsevier) 2004:xviii + 589 pp (PDF 615 pp) (Zotero HSCG8UFV dates the item 2005; the imprint page gives copyright 2004. The printed-to-PDF offset varies by chapter (from PDF − 13 in ch 1 to PDF + 7 in the appendices and index) because blank versos are missing from the PDF; see the locator note in the body. Locators on this page are PDF pages unless marked printed p.).
Bove AA. Cardiovascular aspects of hyperbaric oxygen therapy. In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 25 2008:573-586.
Boykin JV Jr. Re: Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns [letter]. Undersea Hyperb Med 2013;40(2):212.
Boyko M, Carberry R. Reviewer Comment on Elfil et al. "Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta-Analysis". Can J Neurol Sci 2025:1.
A commentary/peer-review note (not primary evidence) critically appraising the Elfil 2025 CRAO meta-analysis that this wiki cites as a positive synthesis. It accepts the physiological rationale (inner-retinal oxygen supply rises from ~50% to ~97% under hyperbaric oxygenation) but flags several limitations of the pooled evidence.
Bozkurt I, Yalcin N, Uluyardimci E, Akgul EA. Combination of hyperbaric oxygen and core decompression therapies improve outcomes in the treatment of hip osteonecrosis. Hip Int 2022;32(6):759–765 (epub 12 Apr 2021).
Bradic J, Petkovic A, Simonovic N, Radovanovic M, Jeremic J, Zivkovic V, et al. Preconditioning with hyperbaric oxygen and calcium and potassium channel modulators in the rat heart. Undersea Hyperb Med 2019;46(4):483-494.
Bradley KR, Krassow JL, Richards MF, Beckstrand DP, Wolf EG. Chronic decompression illness cognitive dysfunction improved with hyperbaric oxygen: a case report. Undersea Hyperb Med 2020;47(1):131-137.
Brady LW, Plenk HP, Hanley JA, Glassburn JR, Kramer S, Parker RG. Hyperbaric oxygen therapy for carcinoma of the cervix--stages IIB, IIIA, IIIB and IVA: results of a randomized study by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981;7(8):991–998.
No significant difference in survival between the air and HBO arms. More deaths from complications / intercurrent disease in the HBO arm: 5/19 (HBO) vs 2/29 (air) — a (Added 31 Aug 2026.) 5/19 is an AS-TREATED denominator. Ten of the 29 patients randomised to oxygen
Brady NJ, Patel PS, Moayedi S, Sward D. A novel source of carbon monoxide for suicide attempt. Undersea Hyperb Med 2022;49(3):329-331.
Brampton W, Sayer MDJ. Decompression sickness after a highly conservative dive in a diver with known persistent foramen ovale: Case report. Diving and Hyperbaric Medicine 2021;51(1):111-115.
Branco BH, Fukuda DH, Andreato LV, Santos JF, Esteves JV, Franchini E. The Effects of Hyperbaric Oxygen Therapy on Post-Training Recovery in Jiu-Jitsu Athletes. PLoS One 2016;11(3):e0150517.
Brauzzi M, Andreozzi F, De Fina L, Tanasi P, Falini S. Acute coronary syndrome and decompression illness: a challenge for the diving physician. Diving Hyperb Med 2013;43(4):229-31.
Brenna CT, Khan S, Djaiani G, Buckey JC, Katznelson R. The role of routine pulmonary imaging before hyperbaric oxygen treatment. Diving Hyperb Med 2022;52(3):197-207.
Brenna CTA, Salvatori M, Khan S, Djaiani G, Schiavo S, Katznelson R. The role of routine cardiac investigations before hyperbaric oxygen treatment. Diving and Hyperbaric Medicine Journal 2024;54(2):120-126 (DOI 10.28920/dhm54.2.120-126).
Brenna CT, Khan S, MacDougall M, Tarshis J, Katznelson R, Bahrey L. Hyperbaric oxygen therapy to promote wound healing in severe pancytopenia: a case report. J Wound Care 2025;34(11):944-950.
Brenner I, Shephard RJ, Shek PN. Immune function in hyperbaric environments, diving, and decompression. Undersea Hyperb Med 1999;26(1):27–39.
Brewster E, Collins B, Funnell GR, Smith EB. The effect of high pressure on the hemolysis of red blood cells. Undersea Biomed Res 1976;3(2):151–155.
Briceño-Souza E, Méndez-Domínguez N, Cárdenas-Dajdaj R, Chin W, Huchim-Lara O. Dysbaric osteonecrosis associated with decompression sickness in a fishing diver. Undersea and Hyperbaric Medicine 2019;46(2):217-220.
Brito T, Pithan N, Martins G, Jessen B, Assumpção C, Porto T, Filho O, Siqueira-Filho A. Case reports: hyperbaric oxygen therapy for the treatment of cerebral air embolism. Undersea Hyperb Med 2011;38(3):207–212.
Britten JS, Myers RAM. Effects of hyperbaric treatment on carbon monoxide elimination in humans. Undersea Biomed Res 1985;12(4):431–438.
Brod VI, Krausz MM, Hirsh M, Adir Y, Bitterman H. Hemodynamic effects of combined treatment with oxygen and hypertonic saline in hemorrhagic shock. Crit Care Med 2006;34(11):2784-91.
Brölmann FE, Ubbink DT, Nelson EA, Munte K, van der Horst CM, Vermeulen H. Evidence-based decisions for local and systemic wound care. Br J Surg 2012;99(9):1172-83.
Bronshteyn V, Hendriksen SM, Lee SJ, Logue C. Surviving cardiac arrest after carbon monoxide poisoning treated with hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(1):37-40 (PMID 38615351).
Broome J, Colvin AP, Welham JA, Watt S, Gough-Allen R, Alcock D, Lonsdale P, James P, Munro S. Health & Safety for Therapeutic Hyperbaric Facilities: A Code of Practice. Norwich: British Hyperbaric Association 2000:41 pp (Zotero 4AD9QGR7; read from the scanned PDF (OCR text layer), 24 Oct 2026).
A goal-setting code written by the BHA Health & Safety working party with the HSE as consultee (PDF pp 3–4, 8). It covers the safety of staff and others around a therapeutic chamber; it excludes clinical treatment decisions except where they affect safety (PDF p 8). It applies to facilities giving recompression or HBOT to patients, not to diving-contractor or compressed-air-work chambers.
Brouwer MC, Coutinho JM, van de Beek D. Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis. Neurology 2014;82(9):806-13.
Brouwer MC, van de Beek D. Epidemiology, diagnosis, and treatment of brain abscesses. Curr Opin Infect Dis 2017;30(1):129-134.
Brouwer RJ, Engberts AC, Borger van der Burg BLS, van Dongen TTCF, van Hulst RA, Hoencamp R. Meta-analysis on the effect of hyperbaric oxygen as adjunctive therapy in the outcome of anastomotic healing of experimental colorectal resections in rats. Diving Hyperb Med 2018;48(3):173-185.
Brouwer RJ, Lalieu RC, Hoencamp R, van Hulst RA, Ubbink DT. A systematic review and meta-analysis of hyperbaric oxygen therapy for diabetic foot ulcers with arterial insufficiency. J Vasc Surg 2020;71(2):682–692.
11 studies, 729 patients (7 RCTs, 2 controlled clinical trials, 2 retrospective cohorts); 4 used for quantitative synthesis. DFU with arterial insufficiency (PAOD). Major amputations significantly fewer with HBO: 10.7% vs 26.0%; risk difference 15% (95% CI 6–25%); P=0.002; NNT 7 (95% CI 4–20). No significant difference for minor amputations. ⚠️ Full read 21 Oct 2026 (pages 682–692.e1; Tables I–III, Figs 1–4):
Brouwer RJ, van Reijen NS, Dijkgraaf MG, Hoencamp R, Koelemay MJW, van Hulst RA, Ubbink DT. Economic analysis of hyperbaric oxygen therapy for the treatment of ischaemic diabetic foot ulcers. Diving Hyperb Med 2024;54(4):265–274.
Cost (ITT): mean difference €3,791 in favour of higher HBOT cost, but the BCA 95% CI was very QALYs: 0.54 (HBOT+SC) vs 0.56 (SC); difference −0.02, not significant. No benefit for Wagner stage II; cost-per-limb-saved estimates were highly uncertain (very wide CIs).
Brown DR, Davis NL, Lepawsky M, Cunningham J, Kortbeek J. A multicenter review of the treatment of major truncal necrotizing infections with and without hyperbaric oxygen therapy. Am J Surg 1994;167(5):485–489.
Mortality 9/30 (30%) with HBO vs 10/24 (42%) without — NOT statistically significant. The study failed to show that HBO reduced mortality or the number of debridements. Selection bias acknowledged: the HBO group had more clostridial infections and was younger (i.e.
Browne K, Wood D, Clezy K, Lehm J, Walsh WR. Reduction of bacterial load with the addition of ultraviolet-C disinfection inside the hyperbaric chamber. Diving Hyperb Med 2020;50(4):332-337.
Brubakk AO, Neuman TS, eds. Bennett and Elliott's Physiology and Medicine of Diving. 5th ed. Edinburgh: Saunders (Elsevier Science) 2003:x + 779 pp (PDF 808 pp) (Zotero XVNLQ4ST dates the item 2007 (reprint date); the imprint page gives fifth edition 2003. Book page = PDF page − 16.).
Brummelkamp WH, Boerema I, Hoogendyk L. Treatment of clostridial infections with hyperbaric oxygen drenching. A report on 26 cases. Lancet 1963;1(7275):235-8.
An uncontrolled consecutive series of 26 patients with clostridial infection (Clostridium welchii) treated in the hyperbaric chamber at the University Surgical Clinic, Wilhelmina Gasthuis, Amsterdam. The paper states that treatment of gas-gangrene and other anaerobic infections began in Amsterdam in November, 1960, as an offshoot of work on high atmospheric pressure in cardiac surgery that had bee
Brunner A, Lindenmann J, Pistracher K, Micko A, Pichler A, Enzinger C, Smolle-Jüttner F, Wolfsberger S, Kurschel-Lackner S. Hyperbaric oxygen therapy for brain abscesses: A useful adjuvant treatment for a faster recovery. Neurosurgical Review 2025;48:583 (article number 583; the journal does not print a page range or an issue number for this article).
Radiological, 6 months — no residual abscess in 20 patients (80%) with HBOT vs 14 patients (46.7%) Radiological, 3 months — no residual abscess in 6 patients (24%) with HBOT vs 3 patients (10%) Radiological, 12 months — 20 patients (80%) vs 17 patients (56%), p = 0.477 (the difference had
Buckley NA, Juurlink DN, Isbister G, Bennett MH, Lavonas EJ. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev 2011;4:CD002041.
Six RCTs (1361 participants). Pooled random-effects OR for neurological deficits 0.78 (95% CI Two trials found benefit at 1 month; four did not. Design/analysis flaws in all trials: the ⚠️ Full read 21 Oct 2026 (Cochrane PDF, 31 pages; the 2005 Toxicol Rev precursor checked): additions.
Budal OH, Risberg J, Troland K, Moen G, Nordahl SH, Vaagboe G, et al. Pneumocephalus, a rare complication of diving. Undersea Hyperb Med 2011;38(1):73-9.
Buettner MF, Wolkenhauer D. Hyperbaric oxygen therapy in the treatment of open fractures and crush injuries. Emerg Med Clin North Am 2007;25(1):177–188.
A narrative review written by a hyperbaric physician and a hyperbaric technologist at a wound and hyperbaric clinic in Iowa, for the Emergency Medicine Clinics of North America. It is a teaching article: its stated purpose is that emergency physicians should familiarise themselves with hyperbaric oxygen because of their role in the early management of these injuries. It states no research question
Bulsara VM, Bulsara MK, Lewis E (Australia). Protocol for prospective randomised assessor-blinded pilot study comparing hyperbaric oxygen therapy with PENtoxifylline+TOcopherol± CLOdronate for the management of early osteoradionecrosis of the mandible. BMJ Open 2019;9(3):e026662.
None — protocol only. Outcomes (ORN resolution, pain, quality of life) will appear in the results
Bulutlar E, Yilmaz A, Uluutku Bulutlar GB, Aslan Y, Bozdağ HN, Küçükodaci Z. Effect of hyperbaric oxygen treatment on ischaemia-reperfusion injury in rats detorsioned after experimental ovarian torsion. Diving Hyperb Med 2024;54(1):16-22 (DOI 10.28920/dhm54.1.16-22).
Bunn HF. Oxygen Delivery in the Treatment of Anemia. N Engl J Med 2022;387(25):2362-2365.
Burman F, Sheffield R, Posey K. Decision process to assess medical equipment for hyperbaric use. Undersea Hyperb Med 2009;36(2):137-144.
Burman F. Quality Assurance for a Hyperbaric Treatment Centre. unknown 2012:1-13.
Burman F. Low-pressure fabric hyperbaric chambers. S Afr Med J 2019;109(4):12574.
Burman F. Electrical safety in hyperbaric facility. 2025:11-13 (conference/《chapter》 material; no journal stated on the source).
Burnett W, Clark RG, Duthie HL, Smith AN. The treatment of shock by oxygen under pressure. Scott Med J 1959;4:535-8.
Busko M. Hyperbaric oxygen for diabetic foot ulcer: useless or useful? Medscape Medical News 2015 (13 July 2015; www.medscape.com/viewarticle/847842).
Buss HF, Ferreira FT, Giles TG, Giles TG. Systematic review of penile glans necrosis. J Sex Med 2025;22(11):1978-1991.
Butler FK, Hagan C, Murphy-Lavoie H. Hyperbaric oxygen therapy and the eye. Undersea Hyperb Med 2008;35(5):333-87.
Butler GJ, Al-Waili N, Passano DV, Ramos J, Chavarri J, Beale J, et al. Altitude mountain sickness among tourist populations: a review and pathophysiology supporting management with hyperbaric oxygen. J Med Eng Technol 2011;35(3-4):197-207.
Butler FK, Hagan C, Van Hoesen K, Murphy-Lavoie H. Management of central retinal artery occlusion following successful hyperbaric oxygen therapy: case report. Undersea Hyperb Med 2018;45(1):101-107.
Butler FK, Moon RE. Emergency hyperbaric oxygen therapy: A service in need of resuscitation - an open letter. Undersea Hyperb Med 2020;47(4):649-652.
Buxton JT, Stallworth JM, Bradham GB. Hematocrit changes under hyperbaric oxygen. Am Surg 1964;30:18-22.
Bűyűk B, Öztopuz Ö. Hyperbaric oxygen mitigates KIM-1 and inflammatory cytokine levels in kidney transplantation. Undersea Hyperb Med 2023;50(3):289-300.
Byrne BT, Lu JJ, Valento M, Bryant SM. Variability in hyperbaric oxygen treatment for acute carbon monoxide poisoning. Undersea Hyperb Med 2012;39(2):627–638.
Byrne B, Sherwin R, Courage C, Baylor A, Dolcourt B, Brudzewski JR, Mosteller J, Wilson RF. Hyperbaric oxygen therapy for systemic gas embolism after hydrogen peroxide ingestion. J Emerg Med 2014;46(2):171-175.
Byun YJ, Patel J, Nguyen SA, Lambert PR. Hyperbaric oxygen therapy in malignant otitis externa: A systematic review of the literature. World J Otorhinolaryngol Head Neck Surg 2021;7(4):296-302.
Cade IS, McEwen JB. Megavoltage radiotherapy in hyperbaric oxygen: a controlled trial. Cancer 1967;20(5):817–821.
No benefit at either site, and a harm signal in bladder: bronchus carcinoma showed "little if any (The UNSW appraisal cats/Cade records "no evidence of improved survival with the addition of HBO to
Cade IS, McEwen JB, Dische S, Saunders MI, et al. (MRC Working Party). Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the bladder. Br J Radiol 1978;51(611):876–878.
No benefit was shown with the use of hyperbaric oxygen (survival/local control) vs air.
Cakmak T, Metin S, Yaman H, Demirbas S, Yildiz S, Turker T, Akin A. The effect of hyperbaric oxygen therapy on ischemia-modified albumin levels in people with diabetes with foot ulcers. Undersea Hyperb Med 2014;41(4):277–281.
Cakmak T, Battal B, Kara K, Metin S, et al. A case of tension pneumothorax during hyperbaric oxygen therapy in an earthquake survivor with crush injury complicated by ARDS (adult respiratory distress syndrome). Undersea Hyperb Med 2015;42(1):9-13.
Camporesi EM, Vezzani G, Bosco G, Mangar D, Bernasek TL. Hyperbaric Oxygen Therapy in Femoral Head Necrosis. J Arthroplasty 2010;25(6 Suppl):118–123.
Significant pain improvement with HBO after 20 treatments; range of motion improved significantly ⚠️ Read against the Results (full read 21 Oct 2026, pages 2–3): Pain (Fig. 1, page 2, read from the image): VAS about 5.9 → 5.1 → 2.3 → 1.4 with HBO versus about
Camporesi EM, Bosco G. Hyperbaric oxygen pretreatment and preconditioning. Undersea Hyperb Med 2014;41(3):259-63.
Camporesi E, Vezzani G, Zanon V, Manelli D, Enten G, Quartesan S, Bosco G. Review on hyperbaric oxygen treatment in femoral head necrosis. Undersea Hyperb Med 2017;44(6):497-508.
Canarslan-Demir K, Ozgok-Kangal K, Saatci-Yasar A, Akif Erdol M, Koc B. Analysis of the cardiovascular effects of hyperbaric oxygen therapy in diabetic patients. Undersea Hyperb Med 2023;50(4):425-431 (DOI 10.22462/01.01.2023.6).
Canarslan Demir K, Turgut B, Ozgok Kangal K, Zaman T, Şimşek K. Hyperbaric oxygen treatment in delayed post-hypoxic encephalopathy following inhalation of liquefied petroleum gas: a case report. Diving Hyperb Med 2023;53(4):351-355 (DOI 10.28920/dhm53.4.351-355).
Canarslan Demir K, Turgut B, Sariyerli Dursun GB, Konyalioğlu FS, Zaman T. The role of hyperbaric oxygen treatment in the management of spondylodiscitis. Diving and Hyperbaric Medicine Journal 2024;54(3):162-167 (DOI 10.28920/dhm54.3.162-167).
Canarslan-Demir K, Ozgok-Kangal K, Artan E, Turgut B. Does Covid-19 Cause Avascular Necrosis? Undersea Hyperb Med 2025;52(3):361-368.
Canarslan Demir K, Avci AU, Yüsra Abayli S, Konyalioglu FS, Turgut B. Longitudinal study of changes in pulmonary function among inside attendants of hyperbaric oxygen therapy. Diving Hyperb Med 2025;55(1):11-17 (DOI 10.28920/dhm55.1.11-17).
Canarslan Demir K, Avci AU, Ozgok Kangal MK, Ceylan B, Abayli SY, Ozler I, Yilmaz KB. Hyperbaric oxygen therapy for managing cancer treatment complications: a safety evaluation. Medicina (Kaunas) 2025;61(3):385.
Canarslan-Demir K, Yel AK, Aydın G, Zaman T. Healing fragile bones: a case report on hyperbaric oxygen therapy in pycnodysostosis. Diving Hyperb Med 2025;55(2):191-194 (PMID 40544148. DOI 10.28920/dhm55.2.191-194).
Canoğlu UC, Yorulmaz IS, Gamsızkan M, İskender A, Alpay M, Sungur MA, Sheikhvatan M. Effects of Piracetam and Hyperbaric Oxygen on Histopathological and Circulating Biochemical Responses Following Sciatic Nerve Crush Injury in Rats. Medicina (Kaunas) 2026;62(10):1904.
Cao H, Ju K, Zhong L, Meng T. Efficacy of hyperbaric oxygen treatment for depression in the convalescent stage following cerebral hemorrhage. Exp Ther Med 2013;5(6):1609-1612.
Cao D, Zheng J, Xian LF, Tang GM, Sun XJ, Xu WG, et al. Role of iron in lung injury-induced by hyperoxia. Undersea Hyperb Med 2014;41(1):27-31.
Cao HY, Yu TH, Han CH, Liu WW, Zhang PX, Tang P. Roflumilast, a phosphodiesterase-4 inhibitor, improves hyperoxia-induced lung injury via anti-inflammation. Undersea Hyperb Med 2020;47(2):189-196.
Cao Y, Tang P, Tan H, Ma W, Chai H, Lin B, Zhu Y, Xiao W, Wen T, Zhang J, Li Y, Liu S. Application of hyperbaric oxygen therapy in femoral head necrosis: a systematic review and meta-analysis. EFORT Open Rev 2025;10(7):466–474.
Pre-post (within HBO): significant improvement — VAS pain MD −2.94 (P<0.0001), SF-12 PCS MD +17.28, Between-group (HBO vs non-HBO): NOT significant — SF-12 PCS MD −0.39 (P=0.92), SF-12 MCS +0.76 ⚠️ Full read 21 Oct 2026 — what the "between-group" null rests on (Results, pages 469–471; Figs 3B, 4B, 7):
Capelli-Schellpfeffer M, Gerber GS. THE USE OF HYPERBARIC OXYGEN IN UROLOGY. J Urol 1999;162(3 Pt 1):647–654.
HBO is a treatment alternative for ischaemic processes unresponsive to conventional therapy; particularly useful for intractable haemorrhagic cystitis after pelvic radiation. Patient-selection factors and absolute contraindications (active viral disease, untreated pneumothorax, concurrent doxorubicin/cisplatin) discussed. Further investigation warranted for necrotising fasciitis (Fournier's gangrene), post-traumatic ischaemic…
Cardenas Ureña KG, Ramírez Nava JC, Márquez Celedonio FG, Salas Nolasco OI, Villegas Domínguez JE, Crespo-Cortés CN. Clinical efficacy of adjuvant therapy with hyperbaric oxygen in diabetic nephropathy. Undersea Hyperb Med 2020;47(3):415-422.
Cardinal J, Slade A, McFarland M, Keihani S, Hotaling JN, Myers JB (University of Utah). Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis. Curr Urol Rep 2018;19(6):38.
13 studies, 602 patients who received HBO for hemorrhagic radiation cystitis (HRC); 84% had partial or complete resolution. Only 1 randomised study (2012); recent series confirmed safety/efficacy and identified predictors of success vs failure. Earlier HBO initiation and lower-grade haematuria tend to predict better response (risk factors for success/failure identified). ⚠️ Full read 21 Oct 2026 (pages 2–7):
Carl UM, Hartmann KA. Hyperbaric oxygen treatment for symptomatic breast edema after radiation therapy. Undersea Hyperb Med 1998;25(4):233–234.
Carlisle R, Lanphier EH, Rahn H. Hyperbaric oxygen and persistence of vision in retinal ischemia. Journal of Applied Physiology 1964;19(5):914-918.
Carlson S, Jones J, Brown M, Hess C. Prevention of hyperbaric-associated middle ear barotrauma. Ann Emerg Med 1992;21(12):1468–1471.
No reduction in middle-ear barotrauma with the decongestant — approximately the same proportion in No subject developed gross haemorrhage or tympanic-membrane rupture (Teed 5).
Carmona C, Alorda B, Gracia L, Perez-Vidal C, Salinas A. A ZigBee-based wireless system for monitoring vital signs in hyperbaric chambers: Technical report. Undersea Hyperb Med 2017;44(3):243-256.
Carneiro SN, Guerreiro DV, Cunha AM, Camacho ÓF, Aguiar IC. Hyperbaric oxygen therapy in sudden sensorineural hearing loss following spinal anesthesia: case reports. Undersea Hyperb Med 2016;43(2):153–159.
Carney AY. Hyperbaric oxygen therapy - an introduction. Critical Care Nursing Quarterly 2013;36(3):274-279.
Carolla RL, Mengel CE, Husney RM. Effect of in vivo hyperoxia on erythrocyte fatty acid composition. Aerosp Med 1968;39(12):1290-3.
Carolla RL, Brubaker LH, Mengel CE. Age of red blood cells destroyed by in vivo hyperoxia. Aerosp Med 1974;45(11):1273-5.
Carson S, McDonagh M, Russman B, Helfand M. Hyperbaric oxygen therapy for stroke: a systematic review of the evidence. Clin Rehabil 2005;19(8):819-833.
Carter MJ, Eckert KA, Fife CE, Gelly HB. Systematic Review of Comparative Studies Evaluating Hyperbaric Oxygen Therapy on Skin Flap and Graft Surgical Indications. Plast Reconstr Surg Glob Open 2026;14(5):e7750.
Four RCTs → significant overall effect on flap/graft survival within 4 weeks (log-OR 1.045, SE 0.31, Evidence levels very-low to moderate; 11 strong + 13 conditional recommendations, including a ⚠️ Full read 21 Oct 2026 (all 12 pages): the pooled figures hold. A citing letter needs five further points.
Cartwright PE, Perkins TG, Santhanam P, Weaver LK, Deru K, Orrison WW. Quantitative analysis tool for clinical functional MRI in mild traumatic brain injury. Undersea Hyperb Med 2019;46(3):245-249.
Cartwright PE, Perkins TG, Wilson SH, Weaver LK, Orrison WW. Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls. Undersea Hyperb Med 2019;46(3):291-297.
Casillas S, Galindo A, Camarillo-Reyes LA, Varon J, Surani SR. Effectiveness of Hyperbaric Oxygenation Versus Normobaric Oxygenation Therapy in Carbon Monoxide Poisoning: A Systematic Review. Cureus 2019;11(10):e5916.
Concludes HBO is effective in moderate-to-high-risk CO poisoning and should be the therapy of choice Acknowledges the literature is heterogeneous and conflicting — trials differ in severity thresholds, ⚠️ Full read 21 Oct 2026 (pages 1–9; Table 1):
Caspersen C, Stensrud T, Storebø M, Thorsen E. Exhaled nitric oxide and lung function after moderate normobaric hyperoxic exposure. Undersea Hyperb Med 2013;40(1):7-13.
Catalogna M, Sasson E, Hadanny A, Parag Y, Zilberman-Itskovich S, Efrati S. Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: a randomized, sham-controlled trial. Neuroimage Clin 2022;36:103218.
Catalogna M, Hadanny A, Parag Y, Adler M, Elkarif V, Efrati S. Functional MRI evaluation of hyperbaric oxygen therapy effect on hand motor recovery in a chronic post-stroke patient: a case report and physiological discussion. Front Neurol 2023;14:1233841.
Catty J, Seguin O, Juillie JL, Mathieu D, Parmentier-Decrucq E. Acoustic emission, an innovative diagnosis tool for therapeutic hyperbaric chambers: or how to requalify safely using pneumatic pressure test. Diving Hyperb Med 2024;54(3):204-211.
Cavaliere M, De Luca P, Scarpa A, et al. Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late? Medicina (Kaunas) 2022;58(10):1421.
HBOT + OS and HBOT-alone groups both improved auditory function (p<0.05). Timing-dependent: HBOT was the best choice when started ≤7 days from onset; HBOT + OS was best Audiogram-shape dependent: downsloping and flat SSNHL improved most with HBOT + OS; upsloping did
Çekin E, Cincik H, Ulubil SA, Gungor A. Effectiveness of hyperbaric oxygen therapy in management of sudden hearing loss. J Laryngol Otol 2009;123(6):609-12.
Celebi AR, Kilavuzoglu AE, Altiparmak UE, Cosar CB, Ozkiris A. Hyperbaric oxygen for the treatment of the rare combination of central retinal vein occlusion and cilioretinal artery occlusion. Diving Hyperb Med 2016;46(1):50–53.
Celebi ARC. Hyperbaric Oxygen Therapy for Central Retinal Artery Occlusion: Patient Selection and Perspectives. Clin Ophthalmol 2021;15:3443–3457.
Ceponis PJ, Weaver LK, Churchill S. Facial nerve paralysis in a diver: a case report. Undersea Hyperb Med 2017;44(2):161-165.
Ceponis PJ, Fox W, Tailor TD, Hurwitz LM, Amrhein TJ, Moon RE. Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report. Undersea Hyperb Med 2017;44(1):73-77.
Cervaens Costa Maia M, Camacho OF, Pinto Marques AF, Barata de Silva Coelho PM. Hyperbaric oxygen therapy treatment for the recovery of muscle injury induced in rats. Diving Hyperb Med 2013;43(4):222-5.
Cervaens M, Lumini-Oliveira J, Ascensão A, Magalhães J, Camacho O, Barata P. The influence of hyperbaric environment on the skeletal muscle mitochondrial energetic of rats after induced muscle contusion. Undersea Hyperb Med 2018;45(6):653-662.
Çevik MÖ, Bağli BS, Çevik SG. Hyperbaric oxygen treatment results in a group of Turkish central retinal artery occlusion patients with a combined presence of thrombophilic mutations. Undersea Hyperb Med 2020;47(1):65-73.
Çevik SG, Ozbek M, Simsek M, Taşkın G, Orak MS, Artunay O. Time-Dependent Efficacy of Hyperbaric Oxygen Therapy in Central Retinal Artery Occlusion. Undersea Hyperb Med 2026;53(3):471-480.
Chambers AC, Leaper DJ. Role of oxygen in wound healing: a review of evidence. J Wound Care 2011;20(4):160-164.
Chan YS, Chen AC, Yuan LJ, Lin SS, Yang CY, Lee MS, et al. Effects of hyperbaric oxygen and platelet derived growth factor on medial collateral ligament fibroblasts. Undersea Hyperb Med 2007;34(3):181-90.
Chan CY, Nadler J, Yeo SYB, Sim XLS, Gurberg J. Sudden hearing loss in enlarged vestibular aqueduct syndrome: a systematic review of treatment and outcomes. J Laryngol Otol 2026;140(8):826–830 (first published online 2 June 2026; issue number from PubMed (not printed on the held PDF)).
The first systematic review of treatment for sudden hearing loss in enlarged vestibular aqueduct syndrome (EVAS), which the authors call an "EVAS crisis" (p.826). It collects case reports and case series and sums episode-level outcomes into three treatment groups: no treatment, systemic steroids, and salvage HBOT given to steroid partial or non-responders. Scope note (appraiser judgement). EVA is
Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L. Clinical practice guideline: sudden hearing loss (update). Otolaryngol Head Neck Surg 2019;161(1 Suppl):S1-S45.
Chandrinou A, Korompeli A, Grammatopoulou E, Gaitanou K, Tsoumakas K, Fildissis G. Avascular necrosis of the femoral head: Evaluation of hyperbaric oxygen therapy and quality of life. Undersea Hyperb Med 2020;47(4):561-569.
Chang CH, Conley JJ, Herbert C Jr (New York). RADIOTHERAPY OF ADVANCED CARCINOMA OF THE OROPHARYNGEAL REGION UNDER HYPERBARIC OXYGENATION: AN INTERIM REPORT. Am J Roentgenol Radium Ther Nucl Med 1973;117(3):509–516.
An interim analysis reporting increased tumour regression / local response in the HBO-radiotherapy
Chang WC, Tsou HK, Kao TH, Yang MY, Shen CC. Successful treatment of extended epidural abscess and long segment osteomyelitis: a case report and review of the literature. Surg Neurol 2008;69(2):117-20; discussion 120.
Chang DC, Lee JT, Lo CP, Fan YM, Huang KL, Kang BH, Hsieh HL, Chen SY. Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning. Undersea Hyperb Med 2010;37(1):23–33.
Chang Y, Han Q, Bao X, Wang M, Jin Y, Zhang S, et al. Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury. Undersea Hyperb Med 2023;50(2):155-165.
Chang GH, Wong CH, Lee AT, Cheng YC, Liu WC. Stellate ganglion block combined with hyperbaric oxygen therapy for sudden sensorineural hearing loss: a retrospective three-arm study. Life (Basel) 2026;16(8):1349.
Charaghvandi DA, Teguh DN, van Hulst RA. Hyperbaric oxygen therapy in patients suffering from wounds in calciphylaxis: a narrative review. Undersea Hyperb Med 2020;47(1):111–122.
Chateau-Degat ML, Belley R. Hyperbaric oxygen therapy decreases blood pressure in patients with chronic wounds. Undersea Hyperb Med 2012;39(5):881–889.
Khandelwal S, Chaudhary P, Poddar DD, Saxena N, Singh RA, Biswal UC. Comparative Study of Different Treatment Options of Grade III and IV Diabetic Foot Ulcers to Reduce the Incidence of Amputations. Clin Pract 2013;3(1):e9.
Complete healing: 40% (antiseptic) vs 60% (HBO) vs 80% (rhPDGF) — difference across groups Mean healing time similar (6.75 / 6.83 / 7.6 weeks; ANOVA P = 0.6534, NS). Confounder: the PDGF arm had larger mean baseline ulcers (9.90 vs 14.91 vs 19.26 cm²; P=0.059),
Chaushu H, Ungar OJ, Abu Eta R, Handzel O, Muhanna N, Oron Y. Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss: A systematic review and meta‐analysis. Clin Otolaryngol 2023;48(3):395–402.
Pooled spontaneous recovery ≈ 60.28% (95% CI 38.88–79.94%), heterogeneity I²=86.0%. Conclusion: spontaneous recovery of ISSNHL is high (close to 60%) and should not be overlooked — ⚠️ Full read 21 Oct 2026 (all 8 pages, Tables 2–4): the 60% rests on 180 ears from five studies, with incompatible definitions of "recovery". 942 records were screened, 13 full texts reviewed, 7 studies synthesised qualitatively and 5 pooled (180 ea…
Chegini Z, Didehdar M, Khoshbayan A, Rajaeih S, Salehi M, Shariati A. Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series. Mycoses 2020;63(12):1264-1282.
Chen CE, Shih ST, Fu TH, Wang JW, Wang CJ. Hyperbaric Oxygen Therapy in the Treatment of Chronic Refractory Osteomyelitis: A Preliminary Report. Chang Gung Med J 2003;26(2):114–21.
The wounds healed in 11 patients, a 79% success rate. No recurrence at an average follow-up of 15 Average number of HBO treatments: 33.6 (range, 30 to 60). Surgical procedures during HBO averaged 1.6 (range, 0 to 3), on top of the 5.4 performed before it.
Chen SY, Huang E, Wang V, Fan YM, Ho CF, Yip PK. Improvement of clinical outcome and cerebral perfusion in a patient of atherosclerotic cerebral infarction after repetitive hyperbaric oxygen treatment--a case report and literature review. Undersea Hyperb Med 2011;38(5):375-9.
Chen TL, Xu B, Liu JC, Li SG, Li DY, Gong GC, Wu ZF, Lin SL, Zhou YJ. Effects of hyperbaric oxygen on aggressive periodontitis and subgingival anaerobes in Chinese patients. J Indian Soc Periodontol 2012;16(4):492-7.
Chen H, Zheng J, Cai Z, Peng Z, Li R, Xu W, et al. Pravastatin protects hyperbaric hyperoxia-induced lung injury via inhibiting inflammation in mice. Undersea Hyperb Med 2015;42(1):49-56.
Chen CY, Wu RW, Hsu MC, Hsieh CJ, Chou MC. Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs 2017;44(6):536–545.
Complete ulcer closure: 25% (5/20) HBOT vs 5.5% (1/18) control (P=.001). Amputation rate: 5% HBOT vs 11% control (χ²=15.204, P=.010). Statistically significant improvements in inflammation index, wound blood flow, and HRQoL (SF-36)
Chen X, Cheng X, Ma W, Chen C. Effects of hyperbaric oxygen therapy on open tibial fractures in rabbits after transient seawater immersion. Undersea Hyperb Med 2017;44(3):235-242.
Chen CY, Chou WY, Ko JY, Lee MS, Wu RW. Early Recovery of Exercise-Related Muscular Injury by HBOT. Biomed Res Int 2019;2019:6289380.
Chen C, Hu H, Chen RY. Varied effects exerted on sudden sensorineural hearing loss through HBO2 therapeutic pressure. Undersea Hyperb Med 2021;48(4):417-423.
Chen P, Vilorio NC, Dhatariya K, Jeffcoate W, Lobmann R, McIntosh C, Piaggesi A, Steinberg J, Vas P, Viswanathan V, Wu S, Game F (IWGDF Editorial Board). Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev 2024;40(3):e3644 (published online 2023-05-25).
The current IWGDF evidence-based guideline (GRADE method: PICO questions, systematic review, summary-of- judgement tables) on wound-healing interventions for diabetes-related foot ulcers — 29 recommendations. It is the update of the 2019 IWGDF guideline and thus supersedes the 2016 systematic review (evidence/game-2016-iwgdf) as the standing IWGDF position.
Chen P, Vilorio NC, Dhatariya K, Jeffcoate W, Lobmann R, McIntosh C, Piaggesi A, Steinberg J, Vas P, Viswanathan V, Wu S, Game F (IWGDF). Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review. Diabetes Metab Res Rev 2024;40(3):e3786.
RCT-only methodology (re-evaluating older studies against modern reporting/RoB standards); the graded For HBO, the paired guideline conditionally recommends adjunctive HBO in ischaemic/neuro-ischaemic DFU ⚠️ Full read 21 Oct 2026 (all 44 PDF pages; HBO section 3.3.1, pages 13–14): the HBO findings this record had left to the guideline page.
(Retracted Publication). Chen XC, Chen HR, Lu SJ, et al. Retracted. PDF on file (marked RETRACTED). RETRACTED: Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis. Int Wound J 2024.
Chen JL, Zhi HX, Pan JY, Chen ZH, Huang JL, Yao J. Hyperbaric oxygen therapy in the treatment of severe gastric laceration with active bleeding: A case report. World J Gastrointest Endosc 2025;17(1):100904.
Chen KY, Chan HC, Chan CM. Can hyperbaric oxygen therapy revolutionise the management of central retinal artery occlusion? A systematic review and meta-analysis of its efficacy and safety. Br J Ophthalmol 2026:bjo-2025-328496 (online first 8 Oct 2026).
Chen P, Chiu JC, Lei KF, Chen SC, Chan YS. Histologic and physiologic effects of PRP and HBO on muscle healing after contusion injury in an animal model. Injury 2026;57(10):113547.
Cheung B, Oreopoulos G, Evans AW, Katznelson R. Hyperbaric oxygen therapy in the treatment of ischemia-reperfusion injury following dialysis access-steal syndrome: case report. Undersea Hyperb Med 2017;44(5):421-424.
Chevasutho P, Premmaneesakul H, Sujiratana A. Descriptive study of decompression illness in a hyperbaric medicine centre in Bangkok, Thailand from 2015 to 2021. Diving and Hyperbaric Medicine 2022;52(4):277-280.
Chi T-H, Chiang MC, Chen RF, Yuan CH. Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss? J R Army Med Corps 2018 (accepted 31 Oct 2017).
Day 8, before any HBOT (Table 2): partial recovery 19/30 in group A vs 12/30 in group B (p = 0.087) — the HBOT Day 13, after the whole HBOT course (Table 3): no difference (complete 2 vs 4, partial 15 vs 14; p = 0.701). Day 180 (Table 4): complete 3 vs 8, partial 11 vs 16, slight 13 vs 4, none 3 vs 2 (χ² across four categories
Chiabo J, Kauert A, Casolla B, Contenti J, Nahon-Esteve S, Baillif S, Arnaud M. Efficacy and safety of hyperbaric oxygen therapy monitored by fluorescein angiography in patients with retinal artery occlusion. Br J Ophthalmol 2024;108(7):956–962.
Retinal revascularisation on FA: 48.4% by day 14, 87.1% by day 21. Mean BCVA 1.51 → 1.10 logMAR at 1 month; 15/31 (48.4%) achieved the ≥0.3 logMAR endpoint. Safety: 6/31 (19.4%) minor barotrauma, none requiring discontinuation. Better response in
Chiles KA, Staff I, Johnson-Arbor K, Champagne A, McLaughlin T, Graydon RJ. A Double-Blind, Randomized Trial on the Efficacy and Safety of Hyperbaric Oxygenation Therapy in the Preservation of Erectile Function after Radical Prostatectomy. J Urol 2018;199(3):805-811.
Chin KF, Xie YS, Abidia A, Laden G, Greenman J, Monson JRT, Grout P, McCollum PT. The relationship of hyperbaric oxygen therapy and vascular endothelial growth factor in diabetic patients with leg ulcers: a double-blind randomised controlled trial. Undersea Hyperb Med 2001;28(Suppl):63, abstract Q112, UHMS Annual Scientific Meeting, 14-16 June 2001, San Antonio, Texas.
No baseline VEGF difference between arms (376.5 ± 184.6 vs 424.7 ± 317.8 pg/ml; P=0.08). Printed P value does not fit the figures [derived]. A two-sample t test on 376.5 ± 184.6 vs 424.7 ± 317.8 pg/mL with 8 per arm gives t = −0.37, P = 0.72, not the printed 0.08; the conclusion (no baseline difference) stands. The abstract also gives the storage temperature as "-800C" (−80 °C). Re-read 30 Oct 2026 from the page image Dr Weir…
Chin W, Huchim O, Wegrzyn GH, Sprau SE, Salas S, Markovitz GH. CO and CO2 analysis in the diving gas of the fishermen of the Yucatan Peninsula. Undersea Hyperb Med 2015;42(4):297-305.
Chin W, Jacoby L, Simon O, Talati N, Wegrzyn G, Jacoby R, Proano J, Sprau SE, Markovitz GH, Hsu R, Joo E. Hyperbaric programs in the United States: Locations and capabilities of treating decompression sickness, arterial gas embolisms, and acute carbon monoxide poisoning: survey results. Undersea Hyperb Med 2016;43(1):29–43.
Chin W, Joo E, Ninokawa S, Popa DA, Covington DB. Efficacy of the U.S. Navy Treatment Tables in treating DCS in 103 recreational scuba divers. Undersea Hyperb Med 2017;44(5):399-405.
Chingan Martino V, Pusel M, Bouamama D, Gibert D, Cheret A. Hyperbaric Oxygen Therapy for Diabetic Lower-Limb Wounds in the Caribbean: A Retrospective Cohort Study. International Wound Journal 2026;23(9):e71040.
A retrospective review of every diabetic adult who received at least one hyperbaric session for a lower-limb wound at the only hyperbaric facility in Guadeloupe, between January 2020 and June 2023. Of 257 patients treated in that period, 71 met the inclusion criteria. Protocol was 2.5 ATA on 100% oxygen, a median of 36 sessions (IQR 20.0–51.5) at a mean of 4.5 sessions per week. There is no contro
Chmelař D, Jor O, Tlapák J, Hájek M. Synergistic application of antibiotics and hyperbaric oxygen therapy. Med Gas Res 2026;16(2):176-177.
Cho I, Lee H-M, Choi S-W, Kong S-K, Lee I-W, Goh E-K, Oh S-J. Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial. Audiology & Neurotology 2018;23(4):199–207.
Study (HBOT) group had significantly better thresholds at 500 Hz (p<0.05) at 1 month and 1 kHz (p<0.05) Average PTA and PTA at 2, 4, 8 kHz: no significant difference. WDS improvement significantly higher with HBOT at 3 months (ITT 66.4% vs 56.7%, p=0.029;
Choi S, Kim HH, Oh SB, Jung YS. Repetitive hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity after acute carbon monoxide poisoning. Undersea Hyperb Med 2021;48(4).
Choi KK, Kim Y, Yon DK, Kang WS. Adjunctive hyperbaric oxygen therapy for severe traumatic limb injuries: a systematic review and meta-analysis. Medicina (Kaunas) 2026;62(8):1589.
Chong KT, Hampson NB, Bostwick DG, Vessella RL, Corman JM. Hyperbaric oxygen does not accelerate latent in vivo prostate cancer: implications for the treatment of radiation-induced haemorrhagic cystitis. BJU Int 2004;94(9):1275-1278.
Chong KT, Hampson NB, Corman JM. Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis. Urology 2005;65(4):649-653.
Chong SJ, Tan TW. Cerebral arterial gas embolism in a diver using closed circuit rebreather diving apparatus. Diving Hyperb Med 2008;38(1):46-7.
Chong SJ, Liang W, Kim SJ, Kang WL. Future synergism in diving accident management: The Singapore model. Diving Hyperb Med 2010;40(1):41-3.
Chong SJ, Tan MK, Liang W, Kim SJ, Soh CR. Maintenance of negative-pressure wound therapy while undergoing hyperbaric oxygen therapy. Diving Hyperb Med 2011;41(3):147–150.
No difference in pain scores between HBOT-with-NPWT and HBOT-without. NPWT continued to extract exudate during HBOT (5–12 mL aspirated). 5/6 patients had better dressing appearance when NPWT was maintained during HBOT (P=0.006), i.e.
Chong SJ, Kan EM, Song C, Soh CR, Lu J. Characterization of early thermal burns and the effects of hyperbaric oxygen treatment: a pilot study. Diving Hyperb Med 2013;43(3):157–161.
WBC and IL-1β, IL-4, IL-6, IL-10, IFN-γ were significantly elevated 24 h post-burn, but no significant HBOT had no significant effect on burn depth (LDI/histology). Recruitment much slower than planned → far fewer patients than intended (underpowered).
Chu H, Zhang X, Zhao H, Meng X, Wang D, Wang Y. Hyperbaric oxygen therapy for hypoglycaemic encephalopathy due to insulinoma: a case report. Diving Hyperb Med 2025;55(4):430-433.
Chu HT, Zhao H, Wang SS, Meng X, Wang D, Zhu XB, Wang Y, Yang XW. Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis. Immun Ageing 2026.
Chua ME, Kim JJK, Ming JM, De Jesus MJ, See MC 4th, Bagli DJ, Rickard M, Koyle MA, Lorenzo AJ. The utilization of hyperbaric oxygenation therapy in hypospadias repair: a systematic review and meta-analysis. Int Urol Nephrol 2022;54(2):273-285.
Overall, from 576 cases (301 HBO against 275 control):
Chuck AW, Hailey D, Jacobs P, Perry DC. Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. Int J Technol Assess Health Care 2008;24(2):178–183.
HBO was cost-saving AND more effective (dominant): 12-year cost CND$40,695 with HBOT vs CND$49,786 Budget impact of treating prevalent Canadian DFU cases estimated at CND$14.4–19.7 million/year over
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The first clinical paper of the hyperbaric-radiotherapy era, and, through it, the first clinical paper of modern hyperbaric medicine. Its opening sentence describes it as "A PRELIMINARY investigation" into irradiating carcinomata in patients breathing oxygen at a pressure of three atmospheres absolute (30 lb. per square inch gauge pressure). The idea came from Gray et al. (1953), whose work on pla
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Reports a "significant and consistently positive body of evidence" that HBO prevents dermal States the vast majority of clinical reports show reduced mortality, length of stay, number of surgeries
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Mean SOMA-LENT improvement nearly double with HBOT (5.00 vs 2.61, p=0.0019); group mean lower Responders by clinical assessment: 88.9% vs 62.5% (p=0.0009). Absolute risk reduction 32%, NNT 3 after initial allocation (as printed); ITT analysis stronger (p=0.0006).
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Clarke R. Nathanial Henshaw: Not history's pioneering hyperbaric practitioner. Undersea Hyperb Med 2024;51(2):107-113.
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All four patients healed their amputation stumps and were fit with prostheses. At most-recent follow-up, all were ambulating and using their prostheses — hip disarticulation averted.
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Cooper PD, Smart DR. Identifying and acting on inappropriate metadata: a critique of the Grattan Institute Report on questionable care in Australian hospitals. Diving Hyperb Med 2017;47(1):44-54.
Cooper PD, Smart DR. Identifying and acting on potentially inappropriate care? Inadequacy of current hospital coding for this task. Diving Hyperb Med 2017;47(2):88-96.
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42 studies, 2785 patients (28 retrospective, 5 RCTs); median 34.5 sessions at 2.45 atm. Pelvic district largest cohort; high response rates (67–100%) for haemorrhagic cystitis. Breast and head-and-neck: RCTs failed to show consistent benefit (QoL/toxicity improved only in retrospective reports).
LeDez KM (editor); Standards of Practice and Patient Safety Committee: LeDez K (Chair), Evans W, Wherrett C, Doherty P, Boisvert J, Bateman B, Linden R, Harrison D, Katznelson R. Other contributors: Burman F, LeGros T, Murphy PS, Gericke D. Guidelines to the Practice of Clinical Hyperbaric Medicine and Provision of Hyperbaric Oxygen Treatment. Canadian Undersea and Hyperbaric Medical Association, First Edition 2015:1-73.
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BETWEEN the two treatments: no significant difference at four of the five frequencies tested (0.25, 0.5, WITHIN each arm, thresholds improved from baseline — significantly at all five frequencies after HBO Severity subgroup — the one between-group subgroup result, and it favours the steroid: patients with
D'hoore L, Germonpré P, Rinia B, Caeyers L, Stevens N, Balestra C. Effect of normobaric and hyperbaric hyperoxia treatment on symptoms and cognitive capacities in Long COVID patients: a randomised placebo-controlled, prospective, double-blind trial. Diving Hyperb Med 2025;55(2):104-113 (PMID 40544138. DOI 10.28920/dhm55.2.104-113).
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Eight studies (level III and above) on adjunctive HBO for complicated acute wounds, flaps and grafts. HBO increases tissue oxygenation and aids difficult-wound healing; the literature supports chronic-wound use more strongly than acute-wound / flap / graft use. ⚠️ Full read 21 Oct 2026 (pages 209e–214e; Tables 2–3): What the 8 studies are: Perrins 1967 (48 split-skin grafts, graft take 91.7% vs 62.7%); Hart 1974 (16
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Dedichen H, Race D, Schenk WG. Hemodilution and concomitant hyperbaric oxygenation. Effects on cardiovascular function. J Thorac Cardiovasc Surg 1967;53(3):341-8.
Degener S, Pohle A, Strelow H, Mathers MJ, Zumbé J, Roth S, Brandt AS. Long-term experience of hyperbaric oxygen therapy for refractory radio- or chemotherapy-induced haemorrhagic cystitis. BMC Urol 2015;15:38.
Degregori EB, Caye P, Soares ABU, Schiefler OHM, Antunes BN, Reinstein RS, et al. Impact of hyperbaric oxygen therapy on tolerability, clinical signs, lactatemia and glycemia in patients with pyometra. Undersea Hyperb Med 2025;52(3):293-304.
Dejonckheere CS, Käsmann L, Schmeel LC, Walter S, Anzböck T, Dreyer S, Sarria GR, Gkika E, Layer JP. Hyperbaric oxygen therapy for chronic radiotherapy-related adverse effects: A clinically focused review. CA Cancer J Clin 2026;76(1):e70058.
Covers the shared hypoxia/fibrosis pathophysiology and HBOT's role across ORN, radiation cystitis, Notes the ECHM (European Committee for Hyperbaric Medicine) consensus recommends HBO use for these
Dellis AE, Skolarikos A, Vavasis P, Spyropoulos E, Kalentzos VN. Spontaneous hydrocele resolution after hyperbaric oxygen treatment: a clinical case report. Undersea Hyperb Med 2010;37(4):199-201.
Demchenko IT, Piantadosi CA. Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures. Undersea Hyperb Med 2006;33(3):169-74.
Demchenko IT, Welty-Wolf KE, Allen BW, Piantadosi CA. Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. Am J Physiol Lung Cell Mol Physiol 2007;293(1):L229-L238.
Demir M, Kara O, Yıldız A, Guven D. Efficacy of hyperbaric oxygen therapy in a young woman with idiopathic branch retinal artery occlusion. Diving Hyperb Med 2013;43(3):164–165.
Demir M, Sahin M, Korkmaz A. Atrial fibrillation associated with carbon monoxide poisoning. Undersea Hyperb Med 2019;46:203-206.
Demir AE, Ilbasmis S, Toklu AS. A COVID-19 infection incidentally detected during hyperbaric oxygen treatment and preventive measures for COVID-19 transmission in a multiplace hyperbaric chamber. Diving Hyperb Med 2022;52(1):58-62.
Demir L, Avci M. Effect of hyperbaric exposure on pulmonary functions in hyperbaric chamber inside attendants. Undersea Hyperb Med 2022;49(3):161-169.
Demir L, Öztürk M. Use of hyperbaric oxygen therapy in severe earthquake injuries. Ulus Travma Acil Cerrahi Derg 2024;30(3):185-191 (DOI 10.14744/tjtes.2024.60979 — journal, volume, issue and page range read off the publisher PDF on 2026-08-06; the Zotero record had no journal and gave the first page as 184).
Demir L. Does hyperbaric chamber attendance pose an asthma risk? Case report. Undersea Hyperb Med 2024;51(4):387-391 (DOI 10.22462/727).
Demircan T, Ergözen S, Yıldırım B, Ünsal Hİ, Bilir A. Hyperbaric Oxygen Therapy in Cancer: Friend, Foe, or Context-Dependent Modulator? Biology (Basel) 2026;15(17):1512.
DeMis J, Keuski BM, Due A. Hyperbaric treatment deviations for U.S. Navy divers: Spinal DCS. Undersea Hyperb Med 2023;50(4):383-390 (DOI 10.22462/613).
Denham DW, Denham MA. EEG-based brain biomarker supports hyperbaric oxygen therapy for acute concussions. Undersea Hyperb Med 2025;52(2):81-92.
Dennis TJ, Mohr NM, Bailey OE. The role of hyperbaric oxygen therapy in septic shock: is it time for human studies? Undersea Hyperb Med 2022;49(1):43-55.
Denton AS, Andreyev HJN, Forbes A, Maher EJ. Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer 2002;87(2):134–143.
63 studies (6 RCTs) of non-surgical late-radiation-proctitis interventions; RCTs covered anti-inflammatory combinations, rectal steroids, sucralfate, SCFA enemas and thermal therapy — not directly comparable, so no standard management could be recommended. HBO is reviewed as one non-surgical option (angiogenic mechanism; a results table of the then-available HBO series) but was not among the RCTs and yields no pooled comparati…
Dequanter D, Jacobs D, Shahla M, Paulus P, Aubert C, Lothaire P. The effect of hyperbaric oxygen therapy on treatment of wound complications after oral, pharyngeal and laryngeal salvage surgery. Undersea Hyperb Med 2013;40(5):381-385.
Dereli D, Çakiroğlu S, Köse AA, Tokar B. Hyperbaric oxygen treatment in bilateral orchiopexy and post-circumcision haematoma in a thrombocytopenic patient with Noonan syndrome. Diving Hyperb Med 2024;54(2):133-136 (DOI 10.28920/dhm54.2.133-136).
Deru K, Weaver LK, Koumandakis G, Churchill S. Deru Chamber Cultures UHM 2021. Undersea Hyperb Med 2021.
Desai S, Shinde S, Desai R, Mane M, Shinde A. Evidence-Based Management and Functional Outcomes of Femoral Head Avascular Necrosis: A Systematic Review. Cureus 2026;18(8):e114825.
de Smet GHJ, Kroese LF, Menon AG, Jeekel J, van Pelt AWJ, Kleinrensink GJ, Lange JF. Oxygen therapies and their effects on wound healing. Wound Repair Regen 2017;25(4):591–608.
65 studies: 17 local oxygen therapy (of which 7 tested an oxygen dressing), 29 HBOT, 16 perioperative inspired oxygen, 1 testing both TWO2 and HBOT and 2 testing other oxygen therapies. 18 of the 29 HBOT studies (62%) reported ≥1 significant positive wound-healing outcome; the abstract rounds this to 63%. The 77% figure in the abstract belongs to the local oxygen group, not to HBOT, and only "a minority" of the supplemental-in…
Desola J. Hydroxycobalamin, hyperbaric oxygen and cyanide poisoning. Undersea Hyperb Med 2011;38(4):217-20.
Devaney B. Equipoise: an important ethical consideration when contemplating participation in a randomised controlled trial of hyperbaric oxygen treatment in necrotising soft tissue infections. Diving Hyperb Med 2024;54(1):57-60.
Devaney B, Wackett JPC, Ma N, Nguyen A, Yogaraj V, Hedetoft M, Hyldegaard O, Burrell A, Mitra B. Core outcome set for research in necrotising soft tissue infection patients: an international, multidisciplinary, modified Delphi consensus study. Diving Hyperb Med 2025;55(2):91-103.
Devaney B, Mathew J, Ferris S, Roberts L, Covelli C, Orosz J, et al. Novel use of hyperbaric oxygen treatment for treatment-resistant disseminated Saksenaea and Fusarium in a patient on extracorporeal membrane oxygenation (ECMO): a case report. Diving Hyperb Med 2025;55(4):309-314 (DOI 10.28920/dhm55.4.309-314).
De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA. The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis. Biomolecules 2021;11(8):1210.
✅ What the review actually reports, quoting its own abstract: HBOT-induced oxidative stress ⛔ HIF-1α and NF-κB were INHIBITED, not activated. The paper states it plainly: ⛔ "Hormetic" and "Nrf2" were this library's words, not the paper's. The word hormetic appears
Dubai Health Authority. Hyperbaric Oxygen Therapy (HBOT) Service Standards 2016. unknown 2016:1-30.
Dhanda J, Hall TJH, Wilkins A. Patterns of treatment of osteoradionecrosis with hyperbaric oxygen therapy in the United Kingdom [meeting abstract]. Br J Oral Maxillofac Surg 2008;46(Suppl 1):e44.
Di Censo F, Di Censo M, Colasante G, Bordin M, Al Oum M. Bilateral non-arteritic ischemic optic neuropathy treated with HBO2 therapy: a case report of angiographic and electrodiagnostic findings. Undersea Hyperb Med 2016;43(2):167–173.
Di Vincenzo H, Kauert A, Martiano D, Chiabo J, Di Vincenzo D, Sozonoff I, Baillif S, Martel A. Efficacy and safety of a standardized hyperbaric oxygen therapy protocol for retinal artery occlusion. Undersea Hyperb Med 2022;49(4):495-505.
Diacono E, Magri K. Recurrent dysbarism presenting with amnesia and hypoaesthesia in a professional breath-hold diver. Diving and Hyperbaric Medicine 2022;52(3):213-216.
Dilip M, Bielawski A, Owen E. Hyperbaric oxygen therapy for cerebral air gas embolism following orthotopic heart transplant: case report. Undersea Hyperb Med 2018;45(6):685-688.
Dillard LK, Mishra P, Der C, Elrakhawy M, Jagasia A, Chadha S. Interventions for sudden sensorineural hearing loss: a systematic review and quality assessment of clinical practice guidelines. Int J Audiol 2026;65(6):639-651 (published online 25 Oct 2025).
Ding JB, Chen JR, Xu HZ, Qin ZY. Effect of Hyperbaric Oxygen on the Growth of Intracranial Glioma in Rats. Chin Med J (Engl) 2015;128(23):3197–3203.
Ding W, Zhu Q, Zhao H, Wei G, Huang G, Shi J, et al. Pre-Activation of Mitophagy Protects Against Hyperbaric Oxygen-Induced Central Nervous System Oxygen Toxicity. Int J Mol Sci 2026;27(11).
Ding C, Wu J, Zhang G, Feng X, Zhu J. Development and validation of a machine learning-based predictive model for prognosis in cerebral hemorrhage patients after hyperbaric oxygen therapy. Medical Gas Research 2027;17(1):15–21.
Diop S, Mounier R, Gaillard M, Gouëzel C, Genty T. Hyperbaric Oxygenation for Cerebral Acute Gas Emboli After Cardiac Surgery: A Single-Center 10-Year Retrospective Study. A A Pract 2026;20(6):e02239.
Diop S, Mounier R. Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting. Med Gas Res 2026;16(1):53-58.
Dische S, Hewitt HB. Carcinoma of cervix with severe anaemia: treatment by radiotherapy without blood transfusion using hyperbaric oxygen. Br J Radiol 1972;45(539):848–850.
Dische S. The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the bladder. Br J Radiol 1973;46(541):13–17.
No benefit was found from hyperbaric oxygen in the bladder-carcinoma series. (Some apparent differences were confounded by case selection; results did not reach a significant
Dische S. The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the uterine cervix. Br J Radiol 1974;47:99–107.
An early survival advantage of ~20% in favour of oxygen at 1 year was seen, but this was lost by 3 Local failure rate lower with oxygen in the early years, but not statistically significant. Significant late morbidity in small/large intestine (incl. rectum) in a few cases; no difference in
Dische S, Anderson PJ, Sealy R, Watson ER. Carcinoma of the cervix--anaemia, radiotherapy and hyperbaric oxygen. Br J Radiol 1983;56(664):251-5.
Dische S, Saunders MI, Sealy R, Werner ID, Verma N, Foy C, Bentzen SM. Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial. Radiother Oncol 1999;53(2):93–98.
No advantage in tumour control was shown with hyperbaric oxygen. Evidence for an increase in late morbidity with hyperbaric oxygen.
Dituri J, Sadler R, Siddiqi F, Sadler C, Javeed N, Annis H, Whelan H. Echocardiographic evaluation of intracardiac venous gas emboli following in-water recompression. Undersea Hyperb Med 2016;43(2):103-12.
Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med 1992;38(3):112–114.
Faster control of infection with HBO: positive cultures fell from 19→3 in the study group vs Fewer major amputations: 2 (study) vs 7 (control), P<0.05. Average hospital stay was not significantly affected (40.6 vs 47 days).
Doenyas-Barak K, Kutz I, Lang E, Levi G, Efrati S. Memory surfacing among veterans with PTSD receiving hyperbaric oxygen therapy. Undersea Hyperb Med 2023;50(4):395-401.
Doguchi H, Saio M, Kuniyoshi S, Matsuzaki A, Yoshimi N. The enhancing effects of hyperbaric oxygen on mouse skin carcinogenesis. J Toxicol Pathol 2014;27(1):67-72.
Doi Y, Onji Y. Oxygen deficit in hemorrhagic shock under hyperbaric oxygen. In: Wada J, Iwa T, eds. Proceedings of the Fourth International Congress on Hyperbaric Medicine. Baltimore: Williams & Wilkins 1970:181–184.
Dokmak A, Sweigart B, Orekondy NS, Jangi S, Weinstock JV, Hamdeh S, et al. Efficacy and safety of hyperbaric oxygen therapy in fistulizing Crohn's disease: a systematic review and meta-analysis. J Clin Gastroenterol 2024;58(2):120-130.
Domachevsky L, Adir Y, Grupper M, Keynan Y, Bentur Y. Hyperbaric oxygen in the treatment of carbon monoxide poisoning. Clin Toxicol (Phila) 2005;43(3):181-188.
Domachevsky L, Keynan Y, Shupak A, Adir Y. Hyperbaric oxygen in the treatment of sudden deafness. Eur Arch Otorhinolaryngol 2007;264:951-953.
Donati A, Damiani E, Zuccari S, Domizi R, Scorcella C, Girardis M, Giulietti A, Vignini A, Adrario E, Romano R, Mazzanti L, Pelaia P, Singer M. Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study. BMC Anesthesiol 2017;17(1):49.
Donega S, Fishbein KW, Dominelli P, Herman AB, de Cabo R, Gorospe M, Ferrucci L. Oxygenaging: A Physiological Framework for Geroscience. Aging Cell 2026:e70664.
Doolette DJ, Goble SJ, Pirone CJ. Health outcome of hyperbaric-chamber inside attendants following compressed-air exposure and oxygen decompression. SPUMS J 2004;34(2):63-67.
Doolette DJ, Mitchell SJ. In-water recompression. Diving Hyperb Med 2018;48(2):84-95.
Dova S, Psillas G, Tsaligopoulos M, et al. The effectiveness of hyperbaric oxygen therapy on the final outcome of patients with sudden sensorineural hearing loss. Am J Otolaryngol 2022;43(5):103564.
No significant difference: hearing-improvement rate 64% (SS+HBOT) vs 56% (SS) — P=0.369. No significant difference within any disease-severity subgroup. A descending-type audiogram was an unfavourable prognostic factor (significantly lower gain,
Draghi L, Ross FL. Managing Complex Wounds After Treatment Failure: Patterns Identified in an Advanced Wound Healing Center. Adv Skin Wound Care 2026;39(9):457-461.
Drenjancevic I, Kibel A, Kibel D, Seric V, Cosic A. Blood pressure, acid-base and blood gas status and indicators of oxidative stress in healthy male rats exposed to acute hyperbaric oxygenation. Undersea Hyperb Med 2013;40(4):319-28.
Drenjancevic I, Kibel A. Restoring vascular function with hyperbaric oxygen treatment: recovery mechanisms. J Vasc Res 2014;51(1):1-13.
Drewry A, Gorman DF. Lidocaine as an adjunct to hyperbaric therapy in decompression illness: a case report. Undersea Biomed Res 1992;19(3):187–190.
Drewry A, Gorman D. A preliminary report on a prospective randomized, double-blind, controlled study of oxygen and oxygen-helium in the treatment of air-diving decompression illness. SPUMS J 1992;22(3):139-42.
Du X, Zhang X, Liu J, Wang Z. Effects of Oxygen Therapy on Patients with a Chronic Wound: A Systematic Review and Meta-analysis. Adv Skin Wound Care 2024;37(5):1–9.
Short-term wound healing: RR 1.54 (95% CI 1.20–1.99) favouring oxygen therapy. Amputation rate: RR 0.53 — lower with oxygen therapy. Also: greater percentage reduction in ulcer size, shorter healing time, and higher post-study
Dubois C, Hentzen C, Schnitzler A, Daubresse L, Morin J. Evidence-based guidelines for long-term care in spinal cord-related decompression illness. Diving Hyperb Med 2026;56(2):161-169.
Ducassé JL, Celsis P, Marc-Vergnes JP. Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation? Undersea Hyperb Med 1995;22(1):9–15.
After the initial 2 h, the HBO group had significant improvement in clinical and biological Carboxyhaemoglobin normalised in both groups after the shared 10 h NBO — but at 3 weeks the NBO group Authors conclude HBO reduces time to initial recovery and the number of delayed functional
Dulai PS, Gleeson MW, Taylor D, Holubar SD, Buckey JC, Siegel CA. Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharmacol Ther 2014;39(11):1266-1275.
Dulai PS, Buckey JC Jr, Raffals LE, Swoger JM, Claus PL, O'Toole K, Ptak JA, Gleeson MW, Widjaja CE, Chang JT, Adler JM, Patel N, Skinner LA, Haren SP, Goldby-Reffner K, Thompson KD, Siegel CA. Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial. Am J Gastroenterol 2018;113(10):1516–1523.
Clinical remission at days 5 and 10: 50% (HBOT) vs 0% (sham), p=0.04. Less progression to second-line therapy during admission: 10% vs 63%, p=0.04. Fewer in-hospital colectomies: 0% vs 38%, p=0.07 (trend). No serious adverse events.
Dulai PS, Raffals LE, Hudesman D, Chiorean M, Cross R, Ahmed T, Winter M, Chang S, Fudman D, Sadler C, Chiu EL, Ross FL, Toups G, Murad MH, Sethuraman K, Holm JR, Guilliod R, Levine B, Buckey JC Jr, Siegel CA. A phase 2B randomised trial of hyperbaric oxygen therapy for ulcerative colitis patients hospitalised for moderate to severe flares. Aliment Pharmacol Ther 2020;52(6):955-963.
Dulberger A, Slade JB, Thornton JA, McNeary-Garvin A, Kelly JA, Edmonds L. The effects of hyperbaric oxygen on MRI findings in rheumatoid arthritis: A pilot study. Undersea Hyperb Med 2023;50(1):39-43.
Dunworth SA, Natoli MJ, Cooter M, Cherry AD, Peacher DF, Potter JF, et al. Hypercapnia in diving: a review of CO₂ retention in submersed exercise at depth. Undersea Hyperb Med 2017;44(3):191-209.
Duong-Quy S, Hoc TV, Nguyen-Duy T, Tang-Thi-Thao T, Nguyen-Van T, Huynh-Anh T, Mai-Xuan T, Tran-Quang P, Nguyen-Ba V, Nguyen-Trong B, Nguyen-Ngoc-Phuong T, Doan-Ngoc H, Vu-Van G, Nguyen-Viet N, Soyez F, Martin F, Penzel T, Kushida C, Craig T. Hyperbaric Oxygen Therapy and Its Physio-Mechanical Effects on Sleep Breathing Disorder: A Systematic Review. Pulm Ther 2026;12(1):39-55 (epub 28 Nov 2025; volume 12(1) is the 2026 issue).
du Toit DF, Pretorius CF, Esterhuizen N, du Toit LB. Gasgangreen: 'n bespreking van 3 gevalle en literatuuroorsig. S Afr Med J 1985;68(10):760-2 (Authors, title, journal, year, volume and page range are ALL printed in the article itself — the English summary block on printed page 760 ends 'S Afr Med J 1985; 68: 760-762', and the running heads read '760 SAMJ VOLUME 68 9 NOVEMBER 1985', 'SAMT DEEL 68 9 NOVEMBER 1985 761' and '762 SAMJ VOLUME 68 9 NOVEMBER 1985' The ISSUE number 10 is the only field NOT printed in the scan; it comes from PubMed. There is NO DOI — SAMJ of 1985 predates DOI assignment and none is findable.).
Duzgun AP, Satır HZ, Ozozan O, Saylam B, Kulah B, Coskun F. Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers. J Foot Ankle Surg 2008;47(6):515–519.
Major (proximal-to-MTPJ) amputation: 0% (HBOT) vs 34% (ST), P<0.05. Far less need for operating-room management: ~16% (HBOT) vs 100% (ST) required OR intervention to HBOT-group ulcers were more likely to heal; where amputation was still needed it was more distal
European Baromedical Association for Nurses, Operators and Technicians (EBAss). Education of nurses, operators and technicians in hyperbaric facilities in Europe: EBAss/ECHM Resources manual. EBAss / European Committee for Hyperbaric Medicine 2008:1-18.
European Committee for Hyperbaric Medicine. ECHM position on Hyperbaric Oxygen Therapy (HBOT) in multiplace hyperbaric chambers during coronavirus disease (COVID-19) outbreak. European Committee for Hyperbaric Medicine 2020:1-3.
European Committee for Hyperbaric Medicine. ECHM Consensus Conference 2026, Geneva, 14 September 2026 — draft recommendation sheets and preliminary indications table. European Committee for Hyperbaric Medicine (unpublished draft) 2026 (Supplied by Dr Weir (Downloads/Unsorted/Documents/HBO/ECHM). The sheets describe themselves as 'notes reproduced from slides'; their compiler is not named. Three companion session summaries were written for SAUHMA colleagues by Dr Eddelene Bouwer.).
Eckert KA, Fife CE, Carter MJ. Systematic Review of Hyperbaric Oxygen for Late Radiation Tissue Injury (Bowel, Bladder). Undersea Hyperb Med 2025;52(3):313–325.
3 RCTs, 273 subjects — two double-blind (rectal symptoms), one open (cystitis). One low risk of bias, two Moderate certainty, weak recommendation for HBO for rectal complications or cystitis — decision is Beneficial effect on rectal and bladder LRTI confirmed at moderate certainty despite heterogeneity.
Eckmann DM. Intravital microscopy methods in microvascular blood flow and tissue oxygenation. Undersea Hyperb Med 2011;38(6):479-82.
ECRI Institute. Infusion Pumps to Consider for Use with Hyperbaric Chambers. Health Devices 2016:1-6.
Edinguele WFOP, Barberon B, Poussard J, Thomas E, Reynier JC, Coulange M. Middle-ear barotrauma after hyperbaric oxygen therapy: a five-year retrospective analysis on 2,610 patients. Undersea Hyperb Med 2020;47(2):217-228.
The Editors. HBO2 and Cerebral Palsy in Children: Letters to the Editor (editorial introduction). Undersea Hyperb Med 2007;34(1):1.
Edmonds C. Case report. Flying after diving. Diving Hyperb Med 2006;36(3):148-149.
Edmonds C, Bennett M, Lippmann J, Mitchell SJ. Diving and Subaquatic Medicine. 5th ed. Boca Raton (FL): CRC Press, Taylor & Francis Group 2016:xxi + 816 pp (PDF 837 pp).
Edsell ME, Bailey M, Joe K, Millar I. Hyperbaric oxygen therapy in the treatment of skin ulcers due to calcific uraemic arteriolopathy: experience from an Australian hyperbaric unit. Diving Hyperb Med 2008;38(3):139–144 (PubMed gives issue 2; the PDF masthead reads Volume 38 No. 3 September 2008).
Edvinsson B, Thilén U, Nielsen NE, Christersson C, Dellborg M, Eriksson P, Hlebowicz J. Does persistent (patent) foramen ovale closure reduce the risk of recurrent decompression sickness in scuba divers? Diving and Hyperbaric Medicine 2021;51(1):63-67.
Edwards AE, Hart GM. Hyperbaric oxygenation and the cognitive functioning of the aged. J Am Geriatr Soc 1974;22(8):376-379.
Efrati S, Gall N, Bergan J, Fishlev G, Bass A, Berman S, Abu-Hamad R, Feigenzon M, Weissgarten L. Hyperbaric oxygen, oxidative stress, NO bioavailability and ulcer oxygenation in diabetic patients. Undersea Hyperb Med 2009;36(1):1–12.
34% (17/50) had an insufficient TcPO₂ rise during HBO; in them TAOS and NO fell and MDA rose — NAC attenuated these changes (raised TAOS/NO, lowered MDA) and improved oxygenation; in the In the 66% with a sufficient TcPO₂ rise, TAOS rose and MDA fell regardless of NAC; cure rate 82%
Efrati S, Fishlev G, Bechor Y, Volkov O, Bergan J, Kliakhandler K, Kamiager I, Gal N, Friedman M, Ben-Jacob E, Golan H. Hyperbaric oxygen induces late neuroplasticity in post stroke patients — randomized, prospective trial. PLoS One 2013;8(1):e53716.
Efrati S, Ben-Jacob E. How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy--an editorial perspective. Undersea Hyperb Med 2014;41(2):71-6.
Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, Fishlev G, Ablin JN, Bergan J, Volkov O, Friedman M, Ben-Jacob E, Buskila D. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial. PLoS One 2015;10(5):e0127012.
Eftedal OS, Lydersen S, Helde G, White L, Brubakk AO, Stovner LJ. A randomized, double blind study of the prophylactic effect of hyperbaric oxygen therapy on migraine. Cephalalgia 2004;24(8):639-44.
Efuni SN, Shimkevich LL, Tepliakov VG, Derevianko TP. [Changes in the internal organs after hemodilution under hyperbaric oxygenation]. Biull Eksp Biol Med 1982;93(3):110-3 (Russian with English abstract).
Eggert JV, Worth ER, Van Gils CC. Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner grade 3 or 4 diabetic foot ulcers. Undersea Hyperb Med 2016;43(1):1-8 (PMID 27000008).
Eggleton P, Bishop AJ, Smerdon GR. Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Manag Res 2015;2:81-93.
Egkher E, et al. Hyperbaric oxygenation in gas gangrene [abstracted in J Trauma]. Aktuelle Traumatologie [abstract in The Journal of Trauma] 1976;6:289-295.
Eid HS, El Sayed W. The effect of hyperbaric oxygen therapy on improving bony stability in LeFort I maxillary advancement. Undersea Hyperb Med 2011;38(2):117-26.
Ekici M, Mazlum EC, Laçin MB, Akçin ME, Günay AE, Ozan F. The effect of hyperbaric oxygen therapy on lesion size in early-stage femoral head avascular necrosis. Diving Hyperb Med 2025;55(3):226-230 (DOI 10.28920/dhm55.3.226-230).
El Hadji S, Teguh DN, Ridderikhof ML. Hyperbaric oxygen therapy for late radiation tissue toxicity injury after head and neck cancer: a systematic review of the literature. Radiat Oncol 2025;20(1):149.
HBOT presented across the included studies as a reliable and safe treatment for LRTTI in HNC; beneficial Includes the Annane ORN trial (RR 0.60; 95% CI 0.25–1.41; p=0.23 — not significant), illustrating the ⚠️ Full read 21 Oct 2026 — the randomised ORN evidence in the review is null (pages 4–5): Annane recovery
Elder MJ, Rawstron JA, Davis M. Hyperbaric oxygen in the treatment of acute retinal artery occlusion. Diving Hyperb Med 2017;47(4):233-238.
A retrospective clinical audit, not a trial. Between early 2003 and December 2012, every patient presenting to Christchurch Hospital with acute retinal artery occlusion (ARAO) was referred for consideration of hyperbaric oxygen; 31 consecutive patients' records were reviewed. The study was discussed formally with the New Zealand Ministry of Health and designated an audit. Follow-up ranged from one
Elfil M, Sabet H, Abbas A, Bayoumi A, Ghaith HS, et al. Efficacy and Safety of Hyperbaric Oxygen Therapy for Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. Can J Neurol Sci 2025 (online ahead of print):1-10.
HBOT was associated with improved best-corrected visual acuity (BCVA): MD −0.63 (95% CI −1.14 to Lower rates of neovascular glaucoma (7.9% vs 15.8%) and stroke (4.3% vs 16.6%) in the HBOT
Elkhanfari Z, Ait Hmadouche S, Babour S, Radi A, Abilkassem R. Hyperbaric oxygen therapy as an adjunctive treatment for pediatric Fournier's gangrene. Cureus 2026;18(10):e117815.
Elkhatib WY, Teixeira MT, Welch BT, LeTourneau WM, Diedrich DA, Toups G. Myocardial Ischemia-Associated Arterial Embolism Management from Pulmonary Cryotherapy. Undersea Hyperb Med 2025;52(3):349-356.
Elliott DP, Paton BC. Effect of 100 percent oxygen at 1 and 3 atmospheres on dogs subjected to hemorrhagic hypotension. Surgery 1965;57:401-8.
Elliott EJ, Smart DR. The assessment and management of inner ear barotrauma in divers and recommendations for returning to diving. Diving Hyperb Med 2014;44(4):208-22.
Elliott E, Manger S, Mercer J, Stevens J. A feasibility study of combined hyperbaric oxygen treatment and a lifestyle medicine program for multimorbid conditions. Diving Hyperb Med 2026;56(3):245-256.
El-Rabbany M, Duchnay M, Raziee HR, Zych M, Tenenbaum H, Shah PS, Azarpazhooh A. Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy. Cochrane Database Syst Rev 2019;(11):CD011559.
HBO + antibiotics vs antibiotics alone after dental extraction: fewer ORN with HBO — RR 0.18 (Marx 1985: 2/37 vs 11/37 at 6 months). Very low certainty. HBO + antibiotics vs antibiotics alone before dental implant placement: no benefit — RR 3.00 (0/13 vs event in HBO arm; wide CI, 1-year). Very low certainty. Overall: evidence uncertain due to suboptimal reporting and inadequate sample sizes; more well-designed RCTs needed. Ma…
Elraiyah T, Tsapas A, Prutsky G, Domecq JP, Hasan R, Firwana B, Nabhan M, Prokop L, Hingorani A, Claus PL, Steinkraus LW, Murad MH. A systematic review and meta-analysis of adjunctive therapies in diabetic foot ulcers. J Vasc Surg 2016;63(2 Suppl):46S–58S.
Adding HBOT to conventional therapy (wound care + offloading) was associated with increased healing — Peto odds ratio 14.25 (wide 95% CI; large effect) — and with a reduced amputation rate versus conventional therapy. Overall: low- to moderate-quality evidence supports HBOT as an adjunct to enhance DFU healing and potentially prevent amputation (arterial pump/pharmacologic agents less supported).
Elsharnoby AM, El-Barbary AH, Eldeeb AE, Hassan HA. Resistant Chronic Venous Leg Ulcers: Effect of Adjuvant Systemic Hyperbaric Oxygen Therapy Versus Venous Intervention Alone. Int J Low Extrem Wounds 2022;24(2):444–451.
Area reduction: no significant difference at 3 months; significant difference favouring HBO at 6 Complete closure at 12 months: 83.3% (HBO) vs 53.8% (venous intervention alone), P=0.02 (at 3 Mean time to complete closure significantly shorter with HBO (P=0.001); positive correlation
Eltorai I. Hyperbaric oxygen in the management of pressure sores in patients with injuries to the spinal cord. J Dermatol Surg Oncol 1981;7(9):737-740.
Emerson TS, Keiler J. Pattern shift visual evoked potential screening for HBO2 in mild-to-moderate carbon monoxide poisoning. Undersea Hyperb Med 1998;25(1):27–32.
Emmerton W, Banham ND, Gawthrope IC. Survey comparing the treatment of central retinal artery occlusion with hyperbaric oxygen in Australia and New Zealand with the recommended guidelines as outlined by the Undersea and Hyperbaric Medical Society. Diving and Hyperbaric Medicine Journal 2024;54(2):97-104 (DOI 10.28920/dhm54.2.97-104).
Ennis WJ, Huang ET, Gordon H. Impact of Hyperbaric Oxygen on More Advanced Wagner Grades 3 and 4 Diabetic Foot Ulcers: Matching Therapy to Specific Wound Conditions. Adv Wound Care (New Rochelle) 2018;7 (Mary Ann Liebert).
Population-level mITT healing across all 2,651,878 wounds of every aetiology was 74.2% (74.16% in Table 1); for wounds classified as diabetic it was 70.9% (328,158/462,888; 70.89% mITT); the Wagner 3–4 subgroup healed only 56.04%. ⚠️ Corrected 31 Aug 2026: this bullet previously read "Population-level DFU healing 74.2%". The paper's 74.2% is the population-level mITT healing rate for ALL wounds of every aetiology — "During the…
Ercan E, Demir AE, Sabaner E, Toklu AS. Incidence of decompression sickness in hypobaric hypoxia training. Undersea and Hyperbaric Medicine 2020;47(2):203-210.
Erdmann D, Roth AC, Hussmann J, Lyons SF, Mody NJ, Kucan JO, Russell RC. Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice. Undersea Hyperb Med 1995;22(4):395–399.
Eroğlu HA, Büyük B, Öztopuz Ö, Makav M, Aydeğer C. Effects of hyperbaric oxygen treatment on liver and kidney tissue in chronic arsenic toxicity. Undersea Hyperb Med 2022;49(4):467-477.
Ersanli D, Akin T, Yildiz S, Akin A, Bilge AH, Uzun G. The effect of hyperbaric oxygen on intraocular pressure. Undersea Hyperb Med 2006;33(1):1-4.
Ersoz F, Arikan S, Sari S, Korpinar S, Ozcan O, Poyraz B, Purisa S, Toklu AS. Effect of hyperbaric oxygen treatment on pilonidal disease surgery. Undersea Hyperb Med 2016;43(7):821-825.
Wound healing time significantly shorter with HBO: 50 ± 11 days (Group 2) vs 83 ± 18 days (Group 1),
Eryigit B, Ziylan F, Yaz F, Thomeer HGXM (UMC Utrecht). The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review. Eur Arch Otorhinolaryngol 2018;275(12):2893–2904.
Systematic review (studies 2002–2018; English/Dutch/German). Whole ISSHL group: no significant difference between HBO (+steroid) and control. Severe/profound (≥81 dB): significant benefit of HBO + systemic steroid (treatment effect p=0.005; higher mean
Escobar SJ, Slade JB Jr, Hunt TK, Cianci P. Adjuvant hyperbaric oxygen therapy (HBO2) for treatment of necrotizing fasciitis reduces mortality and amputation rate. Undersea Hyperb Med 2005;32(6):437-443 (PMID 16509286).
Eskes A, Vermeulen H, Lucas C, Ubbink DT. Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds. Cochrane Database Syst Rev 2013;(12):CD008059.
Cochrane systematic review of RCTs of HBOT for acute surgical and traumatic wounds. 4 trials, 229 participants — clinically heterogeneous, so no meta-analysis was possible.
Esmond WG, Attar S, Cowley RA. Hyperbaric oxygenation in experimental hemorrhagic shock: experimental chamber design and operation. Trans Am Soc Artif Intern Organs 1962;8:384-93.
Esposito M, Worthington HV. Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants. Cochrane Database Syst Rev 2013;(9):CD003603 (PMID 24085641. DOI 10.1002/14651858.CD003603.pub3).
Esterhai JL Jr, Pisarello J, Brighton CT, Heppenstall RB, Gellman H, Goldstein G. Adjunctive Hyperbaric Oxygen Therapy in the Treatment of Chronic Refractory Osteomyelitis. The Journal of Trauma 1987;27(7):763–768.
The primary result is null and the authors state it twice, in the abstract and in the discussion: Whole series: 24 patients healed (86%); four failed to respond. By arm: "Three of the four failures had been treated with at least 20 days of adjunctive hyperbaric
Estrada EJ, Decima JL, Bortman G, Roberti J, Romero EB, Samaja G, Saavedra AR, Martínez G, Gutiérrez S. Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial. Cell Transplant 2019;28(12):1632-1640.
European Underwater and Baromedical Society. EUBS 2026 Abstract Book: 50th Annual Scientific Meeting of EUBS, Geneva, Switzerland, 14–18 September 2026. European Underwater and Baromedical Society 2026:126 pp (PDF supplied by Dr Weir (Downloads/Unsorted/Documents/HBO/ECHM/EUBS2026-Abstract-Book-full.pdf)).
Evanger K, Vaagbø G, Thorsen E, Haugen OH. Posterior segment changes of the eye during hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(6):589-96.
Evanger K, Vaagbø G, Haugen OH. Short-term effects on ocular variables immediately after hyperbaric oxygen exposures. Undersea Hyperb Med 2018;45(4):395-402.
Evanger K, Vaagbø G, Haugen OH, Müller B. Myopic Shift in Patients During Hyperbaric Oxygen Treatment: A Systematic Review. Undersea Hyperb Med 2026;53(3):481-494.
Faglia E, Favales F, Aldeghi A, et al. Adjunctive Systemic Hyperbaric Oxygen Therapy in Treatment of Severe Prevalently Ischemic Diabetic Foot Ulcer: A randomized study. Diabetes Care 1996;19(12):1338–1343.
Major amputation: 8.6% (3/35) HBOT vs 33.3% (11/33) control (P=0.016); RR 0.26 (95% CI 0.08–0.84). TcPO₂ (foot dorsum) rose significantly more with HBOT: +14.0 ± 11.8 vs +5.0 ± 5.4 mmHg (P=0.0002). Multivariate analysis confirmed s-HBOT protective (OR 0.084, P=0.033); low ankle-brachial index and
Faglia E, Clerici G, Caminiti M, Vincenzo C, Cetta F. Heel ulcer and blood flow: the importance of the angiosome concept. Int J Low Extrem Wounds 2013;12(3):226-230.
Fahmy S, Wadee AN, Battesha HHM, Shafeek MM, Hegazy AAA, Ahmed YF. Hyperbaric Oxygen Therapy Combined with Polarized Light Therapy on Neuropathic Foot Ulcer: A Randomized Controlled Study. Am J Phys Med Rehabil 2026.
Fakkert RA, Karlas N, Schober P, Weber NC, Preckel B, van Hulst RA, Weenink RP (Amsterdam UMC). Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies. Critical Care 2023;27(1):282.
Group-level (10 studies, 263 patients): patients with favourable outcome were treated 2.4 h earlier IPD (8 studies, 126 patients): a significant relationship between time-to-HBOT and probability of Magnitude: probability of favourable outcome falls from ≈65% when HBOT is started immediately to
Fakkert RA, van Beers L, Weber NC, Preckel B, van Hulst RA, Weenink RP (Amsterdam UMC). Functional outcome and quality of life after iatrogenic cerebral air embolism treated with hyperbaric oxygen: a prospective cohort study. Diving Hyperb Med 2025;55(4):330–337.
Only about a third achieved good functional recovery. At 6 months, full recovery (GOS 5) in Mortality 23% (5/22) at 6 months. Quality of life: 9/17 survivors (53%) reported a decline in QoL versus their pre-incident status
Fan DF, Liu K, Xu WG, Zhang RJ, Liu Y, Kang ZM, Sun XJ, Li RP. Hyperbaric oxygen preconditioning reduces the incidence of decompression sickness in rats via nitric oxide. Undersea Hyperb Med 2010;37(3):173–180 (PDF author list also includes Tao HY and Zhang JL).
Fan DF, Hu HJ, Sun XJ, Meng XE, Zhang Y, Pan SY. Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production. Undersea Hyperb Med 2016;43(1):45-8.
Fan D, Lv Y, Hu H, Pan S. Severe pulmonary edema following hyperbaric oxygen therapy for acute carbon monoxide poisoning: a case report and clinical experience. Undersea Hyperb Med 2017;44(3).
Fang T, Xue Z, Yang L, et al. Cerebral Air Embolism After Percutaneous Kyphoplasty: A Case Report and Systematic Review of Mechanisms and Management. World Neurosurg 2025;199:124074.
HBOT is described as a cornerstone of CAE management. Among the analysed cases, all 3 patients who Mechanism: HBO raises ambient pressure → accelerates nitrogen resorption / bubble reduction and improves Limitations acknowledged: chamber accessibility and time-to-treatment, and HBOT risks (barotrauma,
Fattori B, Berrettini S, Casani A, Nacci A, De Vito A, De Iaco G (Pisa, Italy). Sudden hypoacusis treated with hyperbaric oxygen therapy: a controlled study. Ear Nose Throat J 2001.
HOT group had a significantly greater mean PTA improvement than the vasodilator group — relative gain Improvement was independent of age and sex. Among HOT patients, 17/30 (56.7%) had a good recovery and 8/30 (26.7%) a significant recovery.
Faunø Thrane J, Ovesen T. Scarce evidence of efficacy of hyperbaric oxygen therapy in necrotizing soft tissue infection: a systematic review. Infect Dis (Lond) 2019;51(7):485–492.
The included studies were few, heterogeneous and at high risk of bias; the review found a lack of Individual-study relative risks were reported but not pooled, given the quality and heterogeneity. ⚠️ Full read 21 Oct 2026 (pages 485–491; Tables 1–4, Fig. 1):
US Food and Drug Administration. Hyperbaric Oxygen Therapy: Don’t Be Misled. FDA Consumer Health Information 2013:1-2.
Fedorko L, Bowen JM, Jones W, Oreopoulos G, Goeree R, Hopkins RB, et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39(3):392–9.
Met criteria for major amputation: 11/49 (HBOT) vs 13/54 (sham); OR 0.91 (0.37–2.28), p=0.85. Healed: 20% (HBOT) vs 22% (sham); OR 0.90 (0.35–2.31), p=0.82. All wound-healing indices: no significant between-group difference.
Feitosa MR, Féres Filho O, Tamaki CM, Perazzoli C, Bernardes MV, Parra RS, et al. Adjunctive hyperbaric oxygen therapy promotes successful healing in patients with refractory Crohn's disease. Acta Cir Bras 2016;31(Suppl 1):19-23.
Feldman J, Renda N, Markovitz GH, Chin W, Sprau SE. Treatment of carbon monoxide poisoning with hyperbaric oxygen and therapeutic hypothermia. Undersea Hyperb Med 2013;40(1):71–79.
Feldman-Idov Y, Melamed Y, Ore L. Improvement of ischemic non-healing wounds following hyperoxygenation: the experience at Rambam-Elisha Hyperbaric Center in Israel, 1998-2007. Isr Med Assoc J 2011;13(9):524-529 (PMID 21991710).
Feldmeier JJ, Lange JD, Cox SD, Chou LJ, Ciaravino V. Hyperbaric oxygen as prophylaxis or treatment for radiation myelitis. Undersea Hyperb Med 1993;20(3):249–255.
Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen as an adjunctive treatment for delayed radiation injury of the chest wall: a retrospective review of twenty-three cases. Undersea Hyperb Med 1995;22(4):383-393 (PMID 8574126).
Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen an adjunctive treatment for delayed radiation injuries of the abdomen and pelvis. Undersea Hyperb Med 1996;23(4):205–213.
Feldmeier JJ, Davolt DA, Court WS, Onoda JM, Alecu R. Histologic morphometry confirms a prophylactic effect for hyperbaric oxygen in the prevention of delayed radiation enteropathy. Undersea Hyperb Med 1998;25(2):93–97.
Feldmeier JJ, Heimbach RD, Davolt DA, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen as a treatment for delayed radiation complications: a single physician group's experience [meeting abstract]. Int J Radiat Oncol Biol Phys 1998;42(1 Suppl).
Feldmeier JJ, Heimbach RD, Davolt DA, McDonough MJ, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen in the treatment of delayed radiation injuries of the extremities. Undersea Hyperb Med 2000;27(1):15-19.
Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med 2003;30(1):1-18.
Feldmeier JJ. Hyperbaric oxygen for delayed radiation injuries. Undersea Hyperb Med 2004;31(1):133–145.
Feldmeier JJ, Hopf HW, Warriner RA 3rd, Fife CE, Gesell LB, Bennett M. UHMS position statement: topical oxygen for chronic wounds. Undersea Hyperb Med 2005;32(3):157-168.
Feldmeier JJ. Hyperbaric oxygen therapy and delayed radiation injuries (soft tissue and bony necrosis): 2012 update. Undersea Hyperb Med 2012;39(6):1121–1139.
Feldmeier J. Dental extractions, radiation necrosis and hyperbaric oxygen: an editorial perspective. Undersea Hyperb Med 2013;40(3):219–220.
Feldmeier JJ, Kirby JP, Buckey JC, Denham DW, Evangelista JS, Gelly HB, et al. Physiologic and biochemical rationale for treating COVID-19 patients with hyperbaric oxygen. Undersea Hyperb Med 2021;48(1):1-12.
Feldmeier JJ, Kirby JP, Gelly HB, Robins M, Peters J, Gruhn P, Pal S. Controlled CMS data demonstrates a cost and clinical advantage for hyperbaric oxygen for radiation cystitis. Undersea Hyperb Med 2024;51(2):145-157.
Feldmeier JJ, Hampson NB. A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: an evidence based approach. Undersea Hyperb Med 2002;29(1):4–30.
74 publications reporting HBO in the treatment or prevention of delayed radiation injury, appraised with three established evidence-evaluation systems; all but 7 reported a positive result. Delayed radiation injury (soft-tissue and bony radionecrosis) is one of the (then thirteen) UHMS-approved HBO indications; the authors recommend HBO for delayed radiation injuries of soft tissue and bone at most sites, noting the benefit is…
Feng JJ, Li YH. Effects of hyperbaric oxygen therapy on depression and anxiety in the patients with incomplete spinal cord injury (a STROBE-compliant article). Medicine (Baltimore) 2017;96(29):e7334 (DOI:10.1097/MD.0000000000007334. First Affiliated Hospital of Zhengzhou University).
Feng T, Zhang Q, Wei J, Wang X, Geng Y. Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Exp Ther Med 2022;23(3):242.
HBO arm: significantly better recovery of tinnitus, aural fullness and vertigo (P<0.05) and Efficacy influenced by age, onset time, hearing threshold, tinnitus, plasma viscosity, CRP.
Ferguson BJ, Mitchell TG, Moon R, Camporesi EM, Farmer J. Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Rev Infect Dis 1988;10(3):551-9.
Fernandes FL, Lavor M, de Carvalho GM, Guimarães AC. Hyperbaric oxygen in the treatment of perichondritis of the pinna. Diving Hyperb Med 2013;43(3):166-7.
Fernández Canedo I, Padilla España L, Millán Cayetano JF, Repiso Jiménez JB, Pérez Delgado M, de Troya Martín M. Hyperbaric oxygen therapy: an alternative treatment for radiation-induced cutaneous ulcers. Australasian Journal of Dermatology 2018;59(3):e203-e207.
Ferreira APP, Vide SS, Fernandes TDF, Coelho PMBS, Camacho OF. Hyperbaric oxygen therapy as an adjuvant to source control in necrotizing soft tissue infections. Undersea Hyperb Med 2017;44(6):535-542.
Ferreira Júnior LH, dos Reis DC, Batista JD, Filice LS, Dechichi P, Rocha FS. Hyberbaric oxygen and bone reconstruction. Minerva Stomatol 2020;69(2):119–125.
Fiesseler FW, Silverman ME, Riggs RL, Szucs PA. Indication for hyperbaric oxygen treatment as a predictor of tympanostomy tube placement. Undersea Hyperb Med 2006;33(4):231-235.
Fife CE, Buyukcakir C, Otto GH, Sheffield PJ, Warriner RA, Love TL, Mader J. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1,144 patients. Wound Repair Regen 2002;10(4):198-207.
A retrospective, multicentre, prognostic-factor analysis. Six hyperbaric facilities contributed charts. - 1,144 records of diabetic patients: 1,006 reviewed by one physician from five Texas hyperbaric facilities, plus 79 from Travis Air Force Base, California, and 59 from Memorial Hermann Hospital, Texas, reviewed by a different examiner [derived: 1006 + 79 + 59]. - These were all diabetic patient
Fife CE, Smart DR, Sheffield PJ, Hopf HW, Hawkins G, Clarke D. Transcutaneous oximetry in clinical practice: consensus statements from an expert panel based on evidence. Undersea Hyperb Med 2009;36(1):43-53.
Fife CE, Eckert KA, Carter MJ. An Update on the Appropriate Role for Hyperbaric Oxygen: Indications and Evidence. Plast Reconstr Surg 2016;138(3 Suppl):107S–116S.
HBOT uniquely ameliorates tissue hypoxia, dampens pathologic inflammation, and mitigates ischaemia–reperfusion Numerous small RCTs are supportive, but sham/blinding and chamber logistics constrain trial design — hence the
Fife CE, Gelly H, Walker D, Eckert KA. Rapid analysis of hyperbaric oxygen therapy registry data for reimbursement purposes: Technical communication. Undersea Hyperb Med 2016;43(6):633-639.
Fife CE, Eckert KA. The Hyperbaric Oxygen Therapy Registry: Driving quality and demonstrating compliance. Undersea Hyperb Med 2018;45(1):1-8.
Figueroa XA, Wright JK. Clinical results in brain injury trials using HBO2 therapy: Another perspective. Undersea Hyperb Med 2015;42(4):333-51.
Fijen VA, Westerweel PE, van Ooij PJAM, van Hulst RA. Tympanic membrane bleeding complications during hyperbaric oxygen treatment in patients with or without antiplatelet and anticoagulant drug treatment. Diving Hyperb Med 2016;46(1):22-25.
Filipo R, Attanasio G, Viccaro M, Russo FY, Mancini P, Rocco M, Pietropaoli P, Covelli E. Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss. Acta Otolaryngol 2012;132(5):475–481.
Severe (PTA 70–90 dB) and profound (>90 dB) ISSNHL; one arm 10 days HBO + IV steroid, the other IT steroid + Overall success rate superior with IT steroid + HBO, but not statistically significant. IT steroid's excellent ⚠️ Full read 21 Oct 2026 (all 7 pages): allocation and protocol.
Findley LJ, Redstone PM. Blood transfusion in adult Jehovah's Witnesses. A case study of one congregation. Arch Intern Med 1982;142(3):606-7.
Fischer BH, Marks M, Reich T. Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. N Engl J Med 1983;308(4):181-6.
Fischer B, Jain KK, Braun E, Lehrl S. Effect of hyperbaric oxygenation on disorders of the blood. Handbook of Hyperbaric Oxygen Therapy. Berlin: Springer 1988:176–183.
Fischer HG, Koch A, Kähler W, Pohl M, Pau HW, Zehlicke T. The measurement of Eustachian tube function in a hyperbaric chamber using an ear canal microphone. Diving Hyperb Med 2016;46(1):33-37.
Fischer GA, Hangan D, Li JG, Saxe B, Christiansen C, Paticoff K, et al. Case report of auricular avulsion injury, repair, and adjunctive treatment. Undersea Hyperb Med 2026;53(1):105-109.
Fitzpatrick DT, Franck BA, Mason KT, Shannon SG. Risk factors for symptomatic otic and sinus barotrauma in a multiplace hyperbaric chamber. Undersea Hyperb Med 1999;26(4):243-247.
Flegg JA, McElwain DLS, Byrne HM, Turner IW. A three species model to simulate application of hyperbaric oxygen therapy to chronic wounds. PLoS Comput Biol 2009;5(7):e1000451.
Flegg JA, Byrne HM, McElwain DLS. Mathematical model of hyperbaric oxygen therapy applied to chronic diabetic wounds. Bull Math Biol 2010;72(7):1867-1891.
Fletcher GH, Lindberg RD, Caderao JB, Wharton JT (MD Anderson Hospital). Hyperbaric oxygen as a radiotherapeutic adjuvant in advanced cancer of the uterine cervix. Preliminary results of a randomized trial. Cancer 1977;39:617-623 (preliminary results of a randomized trial; advanced carcinoma of the uterine cervix).
Absolute NED (no-evidence-of-disease) survival — no statistically significant difference between air ⚠️ Corrected 23 Oct 2026: this bullet previously read "An increase in complications was seen", which, beside an HPO-vs-air trial, reads as an HPO harm. The paper says the opposite about HPO: "It does not seem that the HPO has had an effect on the major complications. However, there was an increase in the incidence of complicati…
Fliefel R, Tröltzsch M, Kühnisch J, Ehrenfeld M, Otto S. Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. Int J Oral Maxillofac Surg 2015;44(5):568-585.
Fock A, Millar I. Two unusual presentations of probable decompression sickness after deep mixed-gas recreational diving. Diving Hyperb Med 2008;38(1):40-2.
Foley K, Banham N, Bonnington S, Gawthrope I. Oxygen toxicity seizure mimics. Diving Hyperb Med 2021;51(2):161-166.
Foley A, Confino J, Halvorson R, Petrie K, Torres A, Feeley B. Return To Sport Following ACL Reconstruction. Curr Rev Musculoskelet Med 2025;18(12):599-610.
Forner L. Does hyperbaric oxygen have the potential to improve quality of life in irradiated patients? What is the evidence? An editorial perspective. Undersea Hyperb Med 2013;40(6):475–477.
Forner L, Lee A, Jansen EC. Survey of referral patterns and attitudes toward hyperbaric oxygen treatment among Danish oncologists, ear, nose and throat surgeons and oral and maxillofacial surgeons. Diving Hyperb Med 2014;44(3):163-6.
Forner L, Berkowicz A, Dickmeiss E, Hyldegaard O, Jansen EC, Fischer-Nielsen A. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen. Diving Hyperb Med 2019;49(3):175-185.
Forner LE, Dieleman FJ, Shaw RJ, Kanatas A, Butterworth CJ, et al. Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1. Radiother Oncol 2022;166:137–144.
Healing at 1 year: 70% (21/30) with HBO + surgery vs 51% (18/35) with surgery alone — HBO was The difference did NOT reach statistical significance — the combined study was underpowered
Foster JH. Hyperbaric oxygen therapy: contraindications and complications. J Oral Maxillofac Surg 1992;50(10):1081-1086.
Foster PP, Butler BD. Decompression to altitude: assumptions, experimental evidence, and future directions. Journal of Applied Physiology 2009;106(2):678-690.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA. Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;120(1):22–28.
7 studies, 246 patients (6 prospective, 1 retrospective; only 2 controlled). HBO may have utility for radiation-induced xerostomia refractory to other therapies and may produce long-term improvement in subjective xerostomia; objective/quality-of-life data more limited. ⚠️ Full read 21 Oct 2026 (pages 23–27): The "refractory xerostomia" conclusion was not tested. 5 of 7 populations were having HBOT for ORN or
Fraga Carvalho C, Lopes VC, Agareno G, Spessoto AC, Facio FN, Fava Spessoto LC. Hyperbaric Oxygen Therapy for Patients With Viral or Radiation-Induced Hemorrhagic Cystitis. Cureus 2025;17(3):e80755 (DOI 10.7759/cureus.80755).
Francis J. Undiagnosed pneumothorax: An editorial perspective. Undersea Hyperb Med 2015;42(1):5.
Francis A, Baynosa RC. Hyperbaric Oxygen Therapy for the Compromised Graft or Flap. Advances in Wound Care 2017;6(1):23–32.
Francis A, Baynosa R. Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms. Diving Hyperb Med 2017;47(2):110-117.
Franco R, Shaw CA, Paterson A. Neuroprotection under pressure: rethinking hyperbaric oxygen therapy. Exploration of Neuroprotective Therapy 2026;6:1004157.
Frank HA, Fine J. Traumatic shock. v. a study of the effect of oxygen on hemorrhagic shock. J Clin Invest 1943;22(2):305-14.
Franzblau SA; Hirning LC; King S. Book reviews [including Clinical application of hyperbaric oxygen: proceedings of the First International Congress, Amsterdam, September 1963, ed. Boerema I, Brummelkamp WH, Meijne NG]. JAMA 1964.
Frawley G. Reply. Diving Hyperb Med 2016;46(2):120.
Frawley L, Devaney B, Tsouras T, Frawley G. Performance of the BBraun perfusor space syringe driver under hyperbaric conditions. Diving Hyperb Med 2017;47(1):38-43.
Fredette V. Effect of hyperbaric oxygen upon anaerobic streptococci. Can J Microbiol 1967;13(4):423-425.
Fredman R, Wiser I, Friedman T, Heller L, Karni T. Skin-sparing mastectomy flap ischemia salvage using urgent hyperbaric chamber oxygen therapy: a case report. Undersea Hyperb Med 2014;41(2):145-147.
Freiberger JJ, Padilla-Burgos R (Duke University). Update on the Duke randomised controlled trial of hyperbaric oxygen for osteonecrosis of the jaw in patients who have taken bisphosphonates. Undersea Hyperb Med 2007;34(4):241 — UHMS ASM abstract.
As of Feb 2007: IRB approval Aug 2006; 32 subjects interviewed, 7 enrolled, 2 treated, 1 withdrawn — Reasons for declining/ineligibility include "previous radiation treatment" — i.e. radiation ORN
Freiberger JJ, Padilla-Burgos R, McGraw T, Suliman HB, Kraft KH, Stolp BW, Moon RE, Piantadosi CA (Duke University). What Is the Role of Hyperbaric Oxygen in the Management of Bisphosphonate-Related Osteonecrosis of the Jaw: A Randomized Controlled Trial of Hyperbaric Oxygen as an Adjunct to Surgery and Antibiotics. J Oral Maxillofac Surg 2012;70(7):1573–1583.
46 patients (25 HBO, 21 standard; mean age 66, 57% women). Primary endpoint (change in oral lesion size and number): no significant difference between groups. But 17/25 HBO-treated (68%) improved, with better/faster healing on some secondary and longer-term measures.
Freilich DB, Seelenfreund MH. Hyperbaric oxygen, retinal detachment, and sickle cell anemia. Arch Ophthalmol 1973;90(2):90-3.
Friedman HI, Fitzmaurice M, Lefaivre JF, Vecchiolla T, Clarke D. An evidence-based appraisal of the use of hyperbaric oxygen on flaps and grafts. Plast Reconstr Surg 2006;117(7 Suppl):175S-190S.
Friedman AJ, Shander A, Martin SR, Calabrese RK, Ashton ME, Lew I, Seid MH, Goodnough LT. Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment. Obstet Gynecol Surv 2015;70(5):342-53.
Fritz GW, Gunsolley JC, Abubaker O, Laskin DM. Efficacy of Pre- and Postirradiation Hyperbaric Oxygen Therapy in the Prevention of Postextraction Osteoradionecrosis: A Systematic Review. J Oral Maxillofac Surg 2010;68(11):2653–2660.
From 696 citations, 14 acceptable publications (1 RCT, 8 cohort-controlled, 5 observational) were analysed. Most had small samples, lacked clear inclusion/exclusion criteria, and under-reported the radiation-to-extraction interval. Conclusion: insufficient information to show HBO reduces the incidence of ORN in irradiated patients requiring tooth extraction — the prophylactic benefit is not established by the available evidenc…
Fu B, Li M, Liu Q, Zhou S, Zhu H, Wan L, Qian Y. Effects of hyperbaric oxygen therapy on EEG and sEMG signals after low-load exercise. PeerJ 2026;14:e21554.
Fujita M, Todani M, Ajimi Y, Yatabe T, Yokobori S, Araki M, Chihara N, Nagayama M, Sakamoto T, Tsuruta R; Japan Resuscitation Council (JRC) Neuroresuscitation Task Force. Evaluating the Efficacy of Hyperbaric Oxygen Therapy for Acute Carbon Monoxide Poisoning: A Systematic Review and Meta‐Analysis. Acute Med Surg 2026;13(1):e70114.
No significant benefit of HBO on mortality or neurological outcomes. The ≥2.5 ATA subgroup showed no advantage over control either. Moderate-to-substantial heterogeneity; GRADE certainty low to very low.
Fukami Y, Kobayashi S, Sekoguchi E, Kurumiya Y. Randomized controlled trial of hyperbaric oxygen therapy in adhesive postoperative small bowel obstruction. Langenbecks Arch Surg 2018;403(5):555-559.
No significant differences in time to oral intake, length of stay, need for long intestinal-tube Overall success of medical treatment 72.5% (no-HBO) vs 78.8% (HBO), p=0.594 — no benefit.
Gabb G, Robin ED. Hyperbaric oxygen: a therapy in search of diseases. Chest 1987;92(6):1074-1082.
Gäde AHF, Schiegnitz E, Eckert AW, Sagheb K, Al-Nawas B, Kupka JR. The influence of hypoxia on tissue regeneration in oral and maxillofacial surgery – a systematic review. Clin Oral Investig 2026;30:125.
9/5,790 studies; among the interventions studied, HBO consistently improved bone healing in
Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho O. The role of hyperbaric oxygen therapy in the treatment of radiation lesions. Clin Transl Oncol 2022;24(12):2466-2474 (PMID 35976581; DOI 10.1007/s12094-022-02892-x).
Gaitanou K, Fildissis G, Vavasis P, Kalentzos V, Baltopoulos G. Management of sudden hearing loss with hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(5):363–370.
Gall RA, Rahimi RR. Arterial Gas Embolism in Breath-Hold Diver. Undersea Hyperb Med 2024;51(1):93-95.
Gallego-Vilar D, García-Fadrique G, Povo-Martín IJ, Miralles-Aguado J, Garau-Perelló C, Sanchis-Verdú L, Gimeno-Argente V, Bosquet-Sanz M, Rodrigo-Aliaga M, Claramonte-Ramón FJ, Gallego-Gómez J. Hyperbaric oxygen treatment in urology. Arch Esp Urol 2011;64(6):507-516.
Narrative review of urological HBO: strongest application intractable haemorrhagic radiation cystitis, plus Fournier's gangrene and ischaemic/wound-healing uses; typical course 4–44 sessions (mean ~19). Evidence level low — most underlying reports are case series; no comparative estimates. ⚠️ Full read 21 Oct 2026 (all 10 pages, Spanish with English summary): the AMSTAR-2 table and the counts hold: 56 papers (1 RCT, 7 reviews,…
Gallego-Vilar D, García-Fadrique G, Povo-Martin I, Salvador-Marin M, Gallego-Gomez J. Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. Urol Int 2013;90(4):411-416.
Gamba JL, Woodruff WW, Djang WT, Yeates AE. Craniofacial mucormycosis: assessment with CT. Radiology 1986;160(1):207-12.
Gambrell J, Bhatt NA, Kitchen L. A case of a critically injured diver with multiorgan failure and severe pulmonary overinflation syndrome in a resource-limited setting. Undersea Hyperb Med 2020;47(4):555-560.
Game FL, Apelqvist J, Attinger C, Hartemann A, Hinchliffe RJ, Löndahl M, Price PE, Jeffcoate WJ (IWGDF working group). Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review. Diabetes Metab Res Rev 2016;32(Suppl 1):154–168.
Heterogeneity prevented any pooled analysis. The overall conclusion is conservative: with the possible exception of negative-pressure wound Controlled studies remain few and mostly of poor methodological quality.
Gamze Sümen S, Yakupoğlu S, Gümüş T, Benzonana N. Hyperbaric oxygen treatment for toxic epidermal necrolysis: A case report. Diving Hyperb Med 2021;51(2):216-219.
Gao GK, Wu D, Yang Y, Yu T, Xue J, Wang X, et al. Cerebral magnetic resonance imaging of compressed air divers in diving accidents. Undersea Hyperb Med 2009;36(1):33-41.
Gao G, Xie L, Wu D, Sun Q, Yang Y, Guan J, et al. The relevance of magnetic resonance imaging in spinal cord decompression sickness: a survey of seven cases. Undersea Hyperb Med 2014;41(2):105-9.
Gao-Yu C, Cong-Yina D, Li-Jun Z, Fei L, Hua F. Effects of hyperbaric oxygen preconditioning on energy metabolism and glutamate level in the peri-infarct area following permanent MCAO. Undersea Hyperb Med 2011;38(2):91-9.
García E, Mitchell SJ. Bubbles in the skin microcirculation underlying cutis marmorata in decompression sickness: Preliminary observations. Diving and Hyperbaric Medicine 2020;50(2):173-177.
Garcia-Bustos V, Cabañero-Navalón MD. Ten-year Spanish cohort of diving-related injuries in a non-hyperbaric tertiary hospital on the Spanish Mediterranean coast. Undersea and Hyperbaric Medicine 2021;48(4):382-390.
Garcia-Covarrubias L, McSwain NE Jr, Van Meter K, Bell RM. Adjuvant Hyperbaric Oxygen Therapy in the Management of Crush Injury and Traumatic Ischemia: An Evidence-Based Approach. Am Surg 2005 Feb;71(2):144–151.
Method: MEDLINE/OVID/Cochrane search, 1966–Dec 2003; clinical papers with ≥5 patients; scored by a Yield: 9 documents, ~150 patients. Most were retrospective, uncontrolled case series lacking Result: 8 of 9 studies showed a beneficial effect of HBO, with only one major complication.
García Estévez DA. Hyperbaric oxygen therapy as a therapeutic option for post-COVID syndrome fatigue. Neurologia (Engl Ed) 2026:502029, in press.
Garetto G, Bosco G. Bebe Vio: On top of the world. Undersea Hyperb Med 2017;44(1):79-80.
Gariel C, Delwarde B, Beroud S, Soldner R, Floccard B, Rimmelé T. Is decompression illness possible during hyperbaric therapy? A case report. Undersea Hyperb Med 2017;44(3):283-285.
Garrabou G, et al.; Cardellach F. Mitochondrial Injury in Human Acute Carbon Monoxide Poisoning: The Effect of Oxygen Treatment. J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev 2011;29(1):32–51.
Gasier HG, Fothergill DM. Oxidative stress, antioxidant defenses and nitric oxide production following hyperoxic exposures. Undersea Hyperb Med 2013;40(2):125-34.
Gavaza T, Matei N. Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application. Medical Gas Research 2027;17(1):306–313.
A narrative review of hyperbaric oxygen used around the time of surgery. The authors define the window explicitly (p. 306): preoperative = within 72 hours before surgery; postoperative = initiated within 2 weeks after surgery; and they report finding no reports of intraoperative HBOT at all. The authors are candid about the design (p. 311): the evidence base "is constrained by the narrative design
Gawthrope IC. Ultrasound in diving and hyperbaric medicine. Diving Hyperb Med 2012;42(1):36-9.
Gawthrope IC, Playford DA, King B, Brown K, Wilson C, McKeown B. The cardiac effects of hyperbaric oxygen at 243 kPa using inchamber echocardiography. Diving Hyperb Med 2014;44(3):141-5.
Gemeinsamer Bundesausschuss. Beschluss über eine Änderung der Richtlinie Methoden vertragsärztliche Versorgung bzw. Krankenhausbehandlung: Hyperbare Sauerstofftherapie bei diabetischem Fußsyndrom. Vom 21. September 2017. Berlin: G-BA (BAnz AT 10.01.2018 B3 and B4) 2017:2 + 2 pp; Tragende Gründe 11 pp (decisions 21 Sep and 19 Oct 2017; in force 11 Jan 2018; supersedes the 2008 hospital-sector decision (exclusion except Wagner ≥ III); URL https://www.g-ba.de/bewertungsverfahren/methodenbewertung/69/).
Geçkil N. Treatment approaches in cases of mandibular osteoradionecrosis: A systematic meta-analysis. J Stomatol Oral Maxillofac Surg 2025;126(3S):102316.
Success by modality: HBO + surgery 69% (95% CI 0.47–0.85) vs HBO alone 38% (0.20–0.61) vs No significant difference between HBO alone and surgery alone (z=0.139, p=0.889). Combination significantly better than either monotherapy (HBO vs HBO+surgery p=0.015; surgery vs
Geldof NI, van Hulst RA, Ridderikhof ML, Teguh DN. Hyperbaric oxygen treatment for late radiation-induced tissue toxicity in treated gynaecological cancer patients: a systematic review. Radiat Oncol 2022;17(1):164.
Radiation cystitis: 3 of 4 studies reported decreased complaints with HBOT. Radiation proctitis: improvement reported. Wound complications: all studies reported improvement — the subgroup that benefits most.
Gelfand MS, Stephens DS, Howell EI, Alford RH, Kaiser AB. Brain abscess: association with pulmonary arteriovenous fistula and hereditary hemorrhagic telangiectasia: report of three cases. Am J Med 1988;85(5):718-20.
Gelly HB, Fife CE, Walker D, Eckert KA. Trends in Medicare Costs of Hyperbaric Oxygen Therapy, 2013 through 2022. Undersea Hyperb Med 2024;51(2):137-144.
Gelmann D, Jasani G, Moayedi S, Sward D. Inner ear decompression sickness in a hyperbaric chamber inside tender: a case report. Undersea Hyperb Med 2021;48(4):443-448.
Gelsomino M, Tsouras T, Millar I, Fock A. A pleural vacuum relief device for pleural drain unit use in the hyperbaric environment. Diving Hyperb Med 2017;47(3):191-197.
Gempp E, Blatteau JE, Simon O, Stephant E. Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. Diving Hyperb Med 2009;39(4):200-4.
Gempp E, Blatteau JE. Risk factors and treatment outcome in scuba divers with spinal cord decompression sickness. J Crit Care 2010;25(2):236-242.
21 of 63 (33%) had incomplete resolution at one month, including 8 (12%) with severe disability Time to treatment did not predict outcome. Univariate P = .15: of those treated at ≤3 h, Choice of table did not predict outcome. At 2.8 ATA, 40 [derived: 30 + 10] patients gave
Gempp E, Louge P, De Maistre S, Emile L, Blatteau JE. Neuron-specific enolase and S100B protein levels in recreational scuba divers with neurological decompression sickness. Diving Hyperb Med 2014;44(1):26-9.
Georgiev K, Dimitrov D, Cekov M, Todorova H, Terzi V. Hyperbaric oxygenation in septal dermoplasty. Medical Review 2026;62(5):51-54.
Geramipanah F, Sadighpour L, Assadollahi R. The effect of environmental pressure and resin cements on the push-out bond strength of a quartz fiber post to teeth root canals. Undersea Hyperb Med 2016;43(2):143-50.
Germonpré P. Hyperbaric oxygen therapy in the treatment of burns - frostbite. NATO STO Educational Notes STO-EN-HFM-245, paper 9 2014:9-1–9-16.
Gesell LB, Warnick RE, Breneman JC, Vogt CJ, Lindsell CJ. A randomized, controlled trial of hyperbaric oxygen therapy for brain radionecrosis. Undersea Hyperb Med 2005;32(4):235–236 — UHMS Annual Scientific Meeting abstracts.
A single-centre randomized controlled trial testing HBOT for PET-confirmed brain radionecrosis in patients with stable or worsening disease on a steroid dose that cannot be tapered. - Design: randomised to standardised steroid management alone vs steroid management + HBOT; steroids standardised over 3 months, titrated to oedema volume and Karnofsky score. HBOT arm = 60 treatments over 3 months on
Gesell LB, Trott A. De novo cataract development following a standard course of hyperbaric oxygen therapy. Undersea Hyperb Med 2007;34(6):389-92.
Ghanizadeh A. Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials. Med Gas Res 2012;2:13.
Ghannam M, Beran A, Ghazaleh D, Ferderer T, Berry B, Banna MA, Mohl L, Streib C, Thacker T, Matos I. Cerebral Air Embolism after Esophagogastroduodenoscopy: Insight on Pathophysiology, Epidemiology, Prevention and Treatment. J Stroke Cerebrovasc Dis 2019;28(12):104403.
Documents endoscopy as a specific iatrogenic route for CAE; presentation is stroke-like (focal deficit, HBOT features among treatment options for significant CAE, alongside supportive care and positioning; Case-report-based literature — establishes an uncommon procedural cause, not efficacy.
Giardiello F, De Medeiros Quirino L, Brigante R, Chumak M. Hyperbaric oxygen therapy for enhanced postoperative recovery in hair transplantation. Cureus 2025;17(12):e99635 (DOI 10.7759/cureus.99635).
Gibbens A, Bennett M. Critical appraisal: Hyperbaric oxygen therapy reduces muscle tenderness and raises pain threshold in patients suffering from fibromyalgia (Yildiz S, Kiralp MZ, Akin A, Keskin I, Ay H, Dursun H, Cimsit M). Diving Hyperb Med 2007;37(4):225.
Gibbs CR, Commons KH. Grommets in HBOT patients: GA vs LA, unanswered questions. Diving Hyperb Med 2015;45(2):136.
Gifford GD. Toxicity of hyperbaric oxygen to bacteria in relation to the cell cycle and catalase synthesis. J Gen Microbiol 1968;52:375-379.
A microbiology paper in which oxygen at 10 atmospheres for 18 hours is used to synchronise growth of B. subtilis and E. coli, and the resistance of B. subtilis to a second exposure is mapped across the cell cycle. Resistance was maximal just after division and coincided approximately with peak catalase activity, supporting peroxide handling as the resistance mechanism.
Gill AL, Bell CN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM 2004;97(7):385-395.
Glad RM, Bouhoutsos DC, Douglass FM. Effect of hyperbaric oxygen therapy and changing surgical concepts of gas gangrene: four case reports. Am J Surg 1965;109:230-232.
Glover M, Smerdon GR, Andreyev HJ, Benton BE, Bothma P, Firth O, Gothard L, et al. Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial. Lancet Oncol 2016;17(2):224–233.
84 randomised (55 HBO, 29 sham). No significant difference in IBDQ bowel-component change (median No significant difference in IBDQ rectal-bleeding change among those bleeding at baseline Adverse events typical of HBO (refractive eye changes, ear pain); serious AEs not treatment-related.
Goh EZ, Beech N, Johnson NR, Batstone M. The dental management of patients irradiated for head and neck cancer. Br Dent J 2023;234(11):800–804.
Covers the full dental picture in irradiated H&N cancer patients: mucositis, xerostomia, radiation caries, On HBO specifically: notes previous systematic reviews found weak to no evidence, and cites the combined
Gois E, Daniel RA, Parra RS, Almeida AL, Rocha JJ, Garcia SB, et al. Hyperbaric oxygen therapy reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis. Undersea Hyperb Med 2012;39(3):693-8.
Golan H, Makogon B, Volkov O, Smolyakov Y, Hadanny A, Efrati S. Imaging-based predictors for hyperbaric oxygen therapy outcome in post-stroke patients. Report 1. Med Hypotheses 2020;136:109510.
Goldman RJ. Hyperbaric Oxygen Therapy for Wound Healing and Limb Salvage: A Systematic Review. PM&R 2009;1(5):471–489.
Diabetic foot ulcers complicated by surgical infection: HBOT reduces amputation — OR 0.242 (95% CI Moderate evidence that HBOT helps refractory lower-extremity osteomyelitis (extent of effect Moderate level: HBOT promotes healing of arterial ulcers, calciphylactic & refractory vasculitic
Goldstein LJ, Gallagher KA, Bauer SM, Bauer RJ, Baireddy V, Liu ZJ, et al. Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide. Stem Cells 2006;24(10):2309-18.
Gómez-Ramírez S, Bisbe E, Shander A, Spahn DR, Muñoz M. Management of Perioperative Iron Deficiency Anemia. Acta Haematol 2019;142(1):21-29.
Gonchar DI. [Hyperbaric oxygenation and hemosorption in the intensive therapy of posttransfusion hemolysis]. Anesteziol Reanimatol 1985;(4):32–34 (Russian).
Gong XB, Feng RH, Dong HM, Liu WH, Gu YN, Jiang XY, Lou YH, Xu J, Dou QL. Efficacy and Prognosis of Hyperbaric Oxygen as Adjuvant Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-Analysis Study. Front Pediatr 2022;10:707136.
Gong J, Sun X, Fu H, Zhang Y, Gao T. Comparative efficacy and safety of non-pharmacological nursing interventions for diabetic foot ulcers: a systematic review and network meta-analysis. BMC Nurs 2025;24(1):1445.
Gong S, Liao B, Zhao L, Liu J, Wu N, Wang P. Dual Effects and Clinical Application Prospects of Hyperbaric Oxygen Therapy in Glioblastoma: A Mini Review. Neurosurgical Subspecialties 2026:45-51.
Gong S, Tang M, He J, Wu X, Shi M, Yang M, Shi L, Huang L, Li L, Zhou D, Zhao Y. Efficacy of hyperbaric oxygen therapy for post-stroke depression: association with inflammatory biomarker reduction in a sham-controlled randomized trial. J Stroke Cerebrovasc Dis 2026;35(8):108685.
González-Flores JE, González-Espinosa A, Sandoval-Polito A, Rahumathulla T, Fukumoto-Inukai KA, Martínez-Wagner R, Vazquez-Hernandez AJ, Hussein-Ayoub BS, Husseiny Y. Hyperbaric Oxygen Therapy for Ischemic Complications After Immediate Breast Reconstruction: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg 2026;50(13):5142-5155.
González Flores JE, Vázquez Hernández DB, Gonzalez Espinosa A, Sandoval Polito A, Navalón Calzada A, Romero Cázares EO. Hyperbaric Oxygen Therapy in Modern Surgical Practice: Mechanistic Basis and Clinical Applications Across Specialties. Cureus 2026;18(1):e102116.
González Flores JE, et al. Hyperbaric oxygen therapy in surgical wound healing and tissue salvage: a structured narrative review. Cureus 2026.
Goodrich E, Goodrich RP, Reese CA. Sensorineural hearing loss after spine surgery treated with hyperbaric oxygen therapy: two case reports. Undersea Hyperb Med 2018;45(2):217-224.
Gordon H, Minozzi S, Kopylov U, Verstockt B, Chaparro M, Buskens C, et al. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment. J Crohns Colitis 2024;18(10):1531-1555.
Gorenstein SA, Castellano ML, Slone ES, Gillette B, Liu H, Alsamarraie C, et al. Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls. Undersea Hyperb Med 2020;47(3):405-413.
Gorji R, Camporesi EM. Hyperbaric oxygen therapy in the treatment of carbon dioxide gas embolism. Undersea Hyperb Med 2004;31(3):285–289.
Gorman DF, Leitch IA. The role of HBO in treatment of thermal burn injuries. South Pacific Underwater Medicine Society Journal (SPUMS J) 1988;18(4):121-123.
Gossett WA, Rockswold GL, Rockswold SB, Adkinson CD, Bergman TA, Quickel RR. The safe treatment, monitoring and management of severe traumatic brain injury patients in a monoplace chamber. Undersea Hyperb Med 2010;37(1):35-48.
Gothard L, Haviland J, Bryson P, Laden G, Glover M, Harrison S, Woods M, Cook G, Peckitt C, Pearson A, Somaiah N, Stanton A, Mortimer P, Yarnold J (Royal Marsden). Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiother Oncol 2010;97(1):101–107.
No significant between-group difference in reduction of affected-arm volume at 12 months (standardised Secondary endpoints (lymphoscintigraphy, dielectric constant, etc.) were similar between groups. ⚠️ Full read 21 Oct 2026 (pages 101–106):
Gottlieb SF, Neubauer RA. HBO2 and Cerebral Palsy in Children: Letter to the Editor. Undersea Hyperb Med 2007;34(1):1-3.
Gottlieb SF. TBI study questioned: Dr. Gottlieb. Undersea Hyperb Med 2017;44(1):81-82.
Gottlieb SF. TBI study questioned: Dr. Gottlieb's response to Dr. Weaver. Undersea Hyperb Med 2017;44(1):85.
Gottrup F, Dissemond J, Baines C, Frykberg R, Jensen PØ, Kot J, Kröger K, Longobardi P. Use of oxygen therapies in wound healing, with special focus on topical and hyperbaric oxygen treatment. J Wound Care 2017;26(Sup5):S1-S43.
Götze G, Bloching M, Hainz M, Knipping S. Invasive Aspergillose der Schädelbasis mit Orbitaspitzensyndrom [Invasive aspergillosis of the skull base with orbit infiltration]. HNO 2007;55(7):560-3.
Gouin E, Caillard A, Veses C, Luciani M, Lecomte C, Dugrenot E, Guerrero F, Blatteau JÉ. Technical diving accidents in France: a 15-year retrospective study reporting a high prevalence of musculoskeletal decompression sickness. Diving Hyperb Med 2026;56(2):125-136.
e3–4. Graffeo C, Dishong W. Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy. Am J Emerg Med 2013;31(4):756.
Managed with ventilation, vasopressors, haemodialysis and 30 adjunctive HBO treatments (2.0 ATA, 90 Sustained improvement in all haemodynamic parameters, RBC volume, and renal/respiratory function;
Graffeo CS, Petitt MJ, Neubauer LE, Steckler GD, Knapp BJ. Reversal of a Globus Pallidus Injury in a Severe Carbon Monoxide Poisoned Patient. Undersea Hyperb Med 2025;52(4):565-569.
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Greensmith JE. Hyperbaric oxygen reverses organ dysfunction in severe anemia. Anesthesiology 2000;93(4):1149–1152.
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Gröger M, Radermacher P, Speit G, Muth CM. Genotoxicity of hyperbaric oxygen and its prevention: what hyperbaric physicians should know. Diving Hyperb Med 2008;38(4):200-5.
Grolman RE, Wilkerson DK, Taylor J, Allinson P, Zatina MA. Transcutaneous oxygen measurements predict a beneficial response to hyperbaric oxygen therapy in patients with nonhealing wounds and critical limb ischemia. Am Surg 2001;67(11):1072-1079 (discussion 1080. PMID 11730224).
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Grover I, Neuman T. Hyperbaric oxygen therapy. In: Encyclopedia of Respiratory Medicine 2006:292ff (editors and year not printed on the supplied pages; latest reference cited 2005; year as for the first edition).
Guan ZB, Zhou YY, Cen Y, Feng HD, Liu WW, Yi HJ, et al. Necrostatin-1 prolongs latency to convulsion in mice exposed to high oxygen partial pressure. Diving Hyperb Med 2021;51(2):134-139.
Guenzani S, Mereu D, Messersmith M, Olivari D, Arena M, Spanò A. Inner-ear decompression sickness in nine trimix recreational divers. Diving Hyperb Med 2016;46(2):111-6.
Guillard E, Nancy B, Floch H, Henckes A, Cochard G, Arvieux J, et al. Intracerebral hemorrhage related to systemic gas embolism during hysteroscopy. Undersea Hyperb Med 2010;37(2):89-93.
Guillén-Pino F, Morera-Fumero A, Henry-Benítez M, Alonso-Lasheras E, Abreu-González P, Medina-Arana V. Descriptive study of diving injuries in the Canary Islands from 2008 to 2017. Diving and Hyperbaric Medicine 2019;49(3):204-208.
Guilliod RR, Pompeo MQ. Discussion: An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg 2016;138(3 Suppl):117S-118S.
Gul F, Boran OF, Arslantas R. Microcirculation and Hyperbaric Oxygen Treatment. In: Drenjančević I, editor. Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. London: IntechOpen 2018:47–62.
A critical-care physiology chapter by three Turkish anaesthetists. About 14 of its 16 pages cover microcirculatory anatomy, Fick diffusion, Starling forces (Table 1 gives the textbook values: net filtration +13.3 mmHg at the arterial end, −6.7 mmHg at the venous end, +0.3 mmHg mean), local and endothelial regulation (NO, prostacyclin, gap junctions), bedside monitoring (sidestream/incident dark-fi
Gunes AE, Aktas S. A review of hyperbaric oxygen therapy for avascular necrosis. Acta Medica Mediterranea 2017;33(1):29-34.
Gunes AE, Aktas S. Effect of hyperbaric oxygen therapy on complete blood count. Undersea Hyperb Med 2017;44(4):357-364.
Gunes AE, Cimsit M. Can amputation be prevented in diabetic foot? Interdisciplinary approach to diabetic foot: a case report. Undersea Hyperb Med 2017;44(2):157-160.
Gunes AE, Gozeneli O, Akal AA, Guldur ME, Savik E. Reduction of side effects of hyperbaric oxygen therapy with thymoquinone treatment in rats. Undersea Hyperb Med 2017;44(4):337-343.
Guo D, Pan S, Wang M, Guo Y. Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: two case reports. Undersea Hyperb Med 2020;47(2):181-187.
Guo D, Li D, Xue R, Lv Y, Pan S. Case report of CT-guided lung biopsy complicated by air embolism. Undersea Hyperb Med 2023;50(3):273-281.
Gao Y, Yin L, Xiang T, Ni T, Shi J. Reduce Flap Necrosis After Autologous Breast Reconstruction: A Systematic Review. J Craniofac Surg 2025;36(6):e598–e605.
Gupta P, Sahni T, Jadhav GK, Manocha S, Aggarwal S, Verma S. A retrospective study of outcomes in subjects of head and neck cancer treated with hyperbaric oxygen therapy for radiation induced osteoradionecrosis of mandible at a tertiary care centre: an Indian experience. Indian J Otolaryngol Head Neck Surg 2013;65(Suppl 1):S140-S143 (PMID 24427631. DOI 10.1007/s12070-013-0640-z).
Gupta M, Somasundaram I. Hyperbaric Oxygen Therapy: Principles and Applications. Springer Nature Singapore (book) 2023:153.
Gur I, Gur I, Jerdev T, Nov Y. Hyperbaric Oxygen Therapy for Acute Acoustic Trauma: Blast versus Noise-Induced Hearing Loss. Isr Med Assoc J (IMAJ) 2026;28(6):369-375.
Gur I, Gur I, Gitzman M, Attal L, Matsliah Y, Zaher E, Duvdevan-Strier N, Nov Y. Comparative effectiveness of varying hyperbaric oxygen protocols in the treatment of acute central retinal artery occlusion. Eye (Lond) 2026;40(6):821–826.
Gur I, Safrai A, Nov Y. The effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning. Clin Toxicol (Phila) 2026;64(10):888-896.
Gur I, Ofir D, Moravia A, Orenstein S, Kalla C. Knowledge Gaps in Our Understanding of Hyperbaric Oxygen Therapy in Post-traumatic Stress Disorder: Current Evidence, Proposed Solutions, and Preliminary Results. Isr Med Assoc J (IMAJ) 2026;28(6):376-382 (PMID 42345229).
Guthrie SD. Preconditioning is one of the 4 P's: An editorial perspective. Undersea Hyperb Med 2015;42(2):103-6.
Gutierrez G, Brotherton J. Management of severe anemia secondary to menorrhagia in a Jehovah's Witness: a case report and treatment algorithm. Am J Obstet Gynecol 2011;205(2):e5–8.
Haas RM, Hannam JA, Sames C, Schmidt R, Tyson A, Francombe M, et al. Decompression illness in divers treated in Auckland, New Zealand, 1996-2012. Diving Hyperb Med 2014;44(1):20-5.
Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY) 2020;12(22):22445-22456.
Hachmo Y, Hadanny A, Mendelovic S, Hillman P, Shapira E, Landau G, Gattegno H, Zrachya A, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial. Aging (Albany NY) 2021;13(22):24500-24510.
Hadanny A, Tal S, Fishlev G, Bechor Y, Efrati S. Delayed blood-brain barrier disruption after shallow-water diving demonstrated by magnetic resonance imaging. Diving Hyperb Med 2015;45(2):116-20.
Hadanny A, Golan H, Fishlev G, Bechor Y, Volkov O, Suzin G, et al. Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci 2015;33(4):471-86.
Hadanny A, Meir O, Bechor Y, Fishlev G, Bergan J, Efrati S. The safety of hyperbaric oxygen treatment--retrospective analysis in 2,334 patients. Undersea Hyperb Med 2016;43(2):113-22.
Hadanny A, Meir O, Bechor Y, Fishlev G, Bergan J, Efrati S. Seizures during hyperbaric oxygen therapy: retrospective analysis of 62,614 treatment sessions. Undersea Hyperb Med 2016;43(1):21-8.
Hadanny A, Maliar A, Fishlev G, Bechor Y, Bergan J, Friedman M, Avni I, Efrati S. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol 2017;11:115–125 (eCollection; published 29 Dec 2016).
BCVA significantly improved after HBOT: 2.14±0.50 → 1.61±0.78 logMAR (P<0.0001). The cherry-red spot (CRS), not elapsed time, marks irreversibility: meaningful visual improvement in ⚠️ Corrected 31 Aug 2026: the two parenthetical flags above are new. The percentages and P values
Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open 2018;8(9):e023387.
Hadanny A, Daniel-Kotovsky M, Suzin G, Boussi-Gross R, Catalogna M, Dagan K, Hachmo Y, Abu Hamed R, Sasson E, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Tal S, Zemel Y, Bechor Y, Efrati S. Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial. Aging (Albany NY) 2020;12(13):13740-13761.
Hadanny A, Rittblat M, Bitterman M, May-Raz I, Suzin G, Boussi-Gross R, Zemel Y, Bechor Y, Catalogna M, Efrati S. Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis. Restor Neurol Neurosci 2020;38(1):93-107.
Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S. Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial. Sports Med Open 2022;8(1):22.
Hadanny A, Catalogna M, Yaniv S, Stolar O, Rothstein L, Shabi A, Suzin G, Sasson E, Lang E, Finci S, Polak N, Fishlev G, Harpaz RT, Adler M, Goldman RE, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. Sci Rep 2022;12(1):15233.
Hájek M, Chmelar D, Tlapák J, Novomeský F, Rybárová V, Klugar M. Hyperbaric oxygen treatment in recurrent development of complex regional pain syndrome: A case report. Diving Hyperb Med 2021;51(1):107-110.
Hájek M, Chmelař D, Poláčková A, Hodrová M, Dokulil M, Tlapák J, Jor O. Hyperbaric oxygen therapy: a novel treatment option in complex regional pain syndrome and other chronic pain conditions. Med Gas Res 2026;16(4):543-544.
✅ A serviceable short account of CRPS — its pathophysiology, the diagnostic problem, and current treatment — from authors with real hyperbaric experience. As orientation to the condition, it reads well. ⚠️ The hyperbaric argument is mechanistic and asserted. CRPS is characterised by regional pain disproportionate to the injury, and the case made is that hyperbaric oxygen addresses the inflammatory
Hajjar R, Bews KA, Alaoui AA, Khan S, Gleason L, Sanchez E, Reynolds IS, Kane SV, Perry WR, Mathis KL, McKenna NP. Hyperbaric oxygen therapy in the management of refractory perianal Crohn's disease. J Clin Med 2025;14(19):6843.
Halwani C, Turki S, Gharsallah H. Les surdités brusques : efficacité de l'oxygénothérapie hyperbare combinée au traitement corticoïde systémique [Sudden deafness: the effectiveness of hyperbaric oxygen therapy combined to systemic corticosteroid treatment]. Tunis Med 2021;99(3):358–362.
Hamarat MB, Arslan A. The effect of hyperbaric oxygen therapy on bladder symptoms of female patients with overactive bladder. Undersea Hyperb Med 2022;49(3):383-390.
Hammad AF, Erkaya M, Hull TL, Floruta C, Spivak AR, Kanters A, et al. Impact of hyperbaric oxygen therapy on complex perineal fistula healing. Colorectal Dis 2026;28(3):e70398.
Hammarlund C, Sundberg T (Helsingborg, Sweden). Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. Plast Reconstr Surg 1994;93(4):829–833.
Mean wound-area decrease (oxygen group): 6% (wk 2), 22% (wk 4), 35.7% (wk 6) vs air group: 2.8%, The response was gradual over the 6 weeks of chamber treatment (dose-dependent pattern).
Hampson NB, Simonson SG, Kramer CC, Piantadosi CA. Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med 1996;23(4):215-219.
Hampson NB (ed.). Hyperbaric oxygen therapy: 1999 committee report. Undersea and Hyperbaric Medical Society, Kensington, MD 1999:35–36.
Hampson NB, Little CE. Hyperbaric treatment of patients with carbon monoxide poisoning in the United States. Undersea Hyperb Med 2005;32(1):21–26.
Hampson NB, Dunford RG, Ross DE, Wreford-Brown CE. A prospective, randomized clinical trial comparing two hyperbaric treatment protocols for carbon monoxide poisoning. Undersea Hyperb Med 2006;33(1):27–32.
Abnormal neurocognitive screen immediately post-treatment: 4/18 (22%) at 2.4 ATA vs 2/12 (17%) at Delayed abnormality: 1 patient in each group (P=0.75). Mean COHb 24.8 ± 8.8%; mean delay to HBO Conclusion: it is feasible to randomise CO patients to different protocols; detecting a true
Hampson NB, Stock AL. Storm-related carbon monoxide poisoning: lessons learned from recent epidemics. Undersea Hyperb Med 2006;33(4):257-63.
Hampson NB. Carboxyhemoglobin elevation due to hemolytic anemia. J Emerg Med 2007;33(1):17-9.
Hampson NB, Weaver LK. Carbon monoxide poisoning: a new incidence for an old disease. Undersea Hyperb Med 2007;34(3):163-8.
Hampson N, Corman J. Rate of delivery of hyperbaric oxygen treatments does not affect response in soft tissue radionecrosis. Undersea Hyperb Med 2007;34(5):329-334.
Hampson NB, Holm JR, Wreford-Brown CE, Feldmeier J. Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury. Cancer 2012;118(15):3860-8 (The PDF on file is the ONLINE-FIRST version. It carries no volume, issue or page numbers — its own footer reads 'Cancer Month 00, 2011' and its abstract ends 'Cancer 2011;000:000-000' Volume 118, issue 15, pages 3860-8 and the journal year 2012 were LOOKED UP in PubMed (PMID 22139864), not read from this PDF.).
Hampson NB, Dunn SL, =UHMCS/CDC CO Poisoning Surveillance Group. Symptoms of carbon monoxide poisoning do not correlate with the initial carboxyhemoglobin level. Undersea Hyperb Med 2012;39(2):657-665.
Hampson NB, Dunn SL, Yip FY, Clower JH, Weaver LK. The UHMS/CDC carbon monoxide poisoning surveillance program: three-year data. Undersea Hyperb Med 2012;39(2):667-85.
Hampson NB, Bell J, Clower JH, Dunn SL, Weaver LK. Partnering with a medical specialty society to perform online public health surveillance. Undersea Hyperb Med 2012;39(2):647-55.
Hampson NB. Oxygen toxic seizures during hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(6):605-606.
Hampson NB, Courtney TG, Holm JR. Ambulatory measurement of ambient carbon monoxide levels. Undersea Hyperb Med 2015;42(3):273-8.
Hampson NB, Holm JR. Suicidal carbon monoxide poisoning has decreased with controls on automobile emissions. Undersea Hyperb Med 2015;42(2):159-64.
Hampson NB, Moon RE, Weaver LK. Another perspective on ACEP policy on critical issues in carbon monoxide poisoning: Invited commentary. Undersea Hyperb Med 2017;44(2):89-92.
Hampson NB, Holm JR, Courtney TG. Garage carbon monoxide levels from sources commonly used in intentional poisoning. Undersea Hyperb Med 2017;44(1):11-15.
Hampson NB. Cost effectiveness of residential carbon monoxide alarms. Undersea Hyperb Med 2017;44(5):393-397.
Hampson NB. Carboxyhemoglobin: a primer for clinicians. Undersea Hyperb Med 2018;45(2):165-171.
Hampson NB. Racial and ethnic trends in unintentional carbon monoxide poisoning deaths. Undersea Hyperb Med 2019;46(4):495-501.
Hampson NB, Moon RE. Arterial gas embolism breathing compressed air in 1.2 metres of water. Diving Hyperb Med 2020;50(3):292-294.
Hampson NB. Carbon monoxide poisoning while scuba diving: a rare event? Undersea Hyperb Med 2020;47(3):487-490.
Hampson NB. Preventing carbon monoxide poisoning in the Hudson River Tunnel in 1921: recounting history. Undersea Hyperb Med 2021;48(1):89-96.
Hampson NB, Holm JR. Comparison of four low-level carbon monoxide alarms suitable for home use or when traveling. Undersea Hyperb Med 2022;49(3):307-313.
Hampson NB. Mass Carbon Monoxide Poisoning on a Train in Italy, March 1944. History Reconstructed. Undersea Hyperb Med 2024;51(3):247-251.
Hampson NB, Holm JR; with reply by Inman AL, Sorrell LP, Lagina AT. Delayed treatment of decompression sickness: letter and response. Undersea Hyperb Med 2021;48(2):207-208.
Hampson NB, Ocak T. Comparison of normobaric vs. hyperbaric oxygen in the relief of carbon monoxide headache pain. Undersea Hyperb Med 2017;44(4):331-336.
Han CH, Zhang PX, Liu Y, Zheng J, Liu K, Wei D, et al. Changes in angiotensin II and angiotensin-converting enzyme of different tissues after prolonged hyperoxia exposure. Undersea Hyperb Med 2017;44(1):39-44.
Han S, Lee Y, Lim H, Cho YS, Noh H, Shin HJ, et al. Compartment syndrome in the forearm related to carbon monoxide intoxication: case report. Undersea Hyperb Med 2018;45(6):689-693.
Han J, Kim SK, Park JE, Jeong J. Hyperbaric Oxygen Treatment Enhances Definitive Endoderm Differentiation and Hepatic Maturation of Human-Induced Pluripotent Stem Cells in Association with mTORC2-Dependent AKT Phosphorylation. International Journal of Stem Cells 2026:published online 17 September 2026.
A laboratory application rather than a clinical one: whether hyperbaric exposure during the definitive endoderm step improves the efficiency of making hepatocyte-like cells from human induced pluripotent stem cells. It is filed here because the exposure is a clinical-range hyperbaric protocol and the mechanism it identifies bears on how hyperbaric oxygen acts on cells generally. Protocol: pressuri
Han SY, Seo HW, Lee SH, Chung JH. Semicircular canal dysfunction in profound sudden sensorineural hearing loss and its prognostic value: implications for the proper indication of hyperbaric oxygen therapy. Sci Rep 2026;16(1).
Hangai S, Yoshimi A, Hosoi A, Matsusaka K, Ichikawa M, Fukayama M, Kurokawa M. An indeterminate result of QuantiFERON-TB Gold In-Tube for miliary tuberculosis due to a high level of IFN-γ production. Int J Hematol 2014;99(4):523-6.
Hansen MB, Jansen T, Sifakis MB, Hyldegaard O, Jansen EC. Chamber personnel's use of Nitrox 50 during hyperbaric oxygen treatment: a quality study--research report. Undersea Hyperb Med 2013;40(5):395-402.
Hansen MB, Treschow F, Skielboe M, Hyldegaard O, Jansen EC, Nielsen JB. Monitoring cardiac output during hyperbaric oxygen treatment of haemodynamically unstable patients. Diving Hyperb Med 2013;43(1):3-8.
Hansen MB, Simonsen U, Garred P, Hyldegaard O. Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation—the protocol of the prospective cohort BIONEC study. BMJ Open 2015;5(5):e006995.
Hansen K, Hansen ES, Tolbod LP, Kristensen MC, Ringgaard S, Brubakk AO, et al. A CT-, PET- and MR-imaging-compatible hyperbaric pressure chamber for baromedical research. Diving Hyperb Med 2015;45(4):247-54.
Harch PG. Department of Defense trials for hyperbaric oxygen and TBI: issues of study design and questionable conclusions. Undersea Hyperb Med 2013;40(5):469-70.
Harch PG, Andrews SR, Rowe CJ, Lischka JR, Townsend MH, Yu Q, Mercante DE. Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial. Med Gas Res 2020;10(1):8-20.
Harch PG. Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in mild traumatic brain injury persistent postconcussion syndrome. Front Neurol 2022;13:815056.
Harlan NP, Davies LH, Weaver LK, Cloward TV, Churchill S, Deru K, et al. Spontaneous cerebral gas embolism and pulmonary arteriovenous malformation: a case report. Undersea Hyperb Med 2015;42(5):425-8.
Harlan N, Weaver LK, Deru K. Inaccurate pulse CO-oximetry of carboxyhemoglobin due to digital clubbing: case report. Undersea Hyperb Med 2016;43(1):59-61.
Harlan NP, Ptak JA, Rees JR, Cowan DR, Fellows AM, Moses RA, Kertis JA, Hannigan PM, Juggan SA, Peacock J, Bennett M, Buckey JC. International Multicenter Registry for Hyperbaric Oxygen Therapy: results through June 2021. Undersea Hyperb Med 2022;49(1):275-287.
Established 2011 (International Report Registered Identifier DERR1-10.2196/18857) to capture outcomes and complications for both UHMS-approved and selected unapproved indications — the "unapproved" arm being the unusual and valuable part. A REDCap template was distributed to participating centres for prospective, de-identified collection. | | | |---|---| | Contributing centres | 22 | | Patients |
Haroon AT, Patel M, Al-Mehdi AB. Lung metastatic load limitation with hyperbaric oxygen. Undersea Hyperb Med 2007;34(2):83-90.
Harper R, McGregor N. Severe blood loss anemia and the Jehovah's Witness patient: the hyperbaric challenge [abstract C24]. Undersea Hyperb Med 2010;37(5) (Abstracts from the 2010 UHMS ASM).
Harrington SA, Moses RA. Role of hyperbaric oxygen therapy in radiation cystitis. Curr Urol Rep 2026;27(1):40.
Harris R. Tales from the South Pacific – diving medicine in Vanuatu. Diving Hyperb Med 2006;36(1):22-23.
Harris RJ, Frawley G, Devaney BC, Fock A, Jones AB. A 10-year estimate of the incidence of decompression illness in a discrete group of recreational cave divers in Australia. Diving Hyperb Med 2015;45(3):147-53.
Harrison BC, Robinson D, Davison BJ, Foley B, Seda E, Byrnes WC. Treatment of exercise-induced muscle injury via hyperbaric oxygen therapy. Med Sci Sports Exerc 2001;33(1):36-42.
Harrison DW, Brasher PM, Eng JJ, Harris D, Hoens AM, Khazei A, Yao JK, Abu-Laban RB. Hyperbaric Oxygen Post Established Stroke. Cureus 2024;16(6):e63395.
Hart GB. Exceptional blood loss anemia. Treatment with hyperbaric oxygen. JAMA 1974;228(8):1028-9.
Uncontrolled series of three patients with acute blood-loss anaemia who refused blood transfusion on religious grounds and were transferred to the Long Beach Naval Hospital in hypovolaemic shock for hyperbaric therapy. Reported by a single naval hyperbaric physician; this is the paper Wright 2002 cites as the origin of the practice.
Hart GB, O'Reilly RR, Broussard ND, Yanda RL. Treatment of burns with hyperbaric oxygen. Surg Gynecol Obstet 1974;139(5):693–696.
The landmark early clinical burns series reporting HBO given during the first day of burn care. Only a brief third-party digest is held.
Hart GB, Lamb RC, Strauss MB. Gas gangrene. J Trauma 1983;23(11):991–1000.
A collective review of gas gangrene combined with the authors' own HBO-treated case series. The central thesis: optimal care is the triad surgery + antibiotics + hyperbaric oxygen.
Hart GB, Strauss MB, Riker J. Vital capacity of quadriplegic patients treated with hyperbaric oxygen. The Journal of the American Paraplegia Society 1984;7(1):8-9.
Hart GB, Strauss MB, Lennon PA. Hyperbaric oxygen (HBO) in the treatment of acute blood loss anemia [abstract 94]. Undersea Biomed Res 1985;12(1 Suppl):56–57 (Program and abstracts, Undersea Medical Society Annual Scientific Meeting, Long Beach, 11–14 June 1985).
Hart GB, Lennon PA, Strauss MB. Hyperbaric oxygen in exceptional acute blood-loss anemia. J Hyperbaric Med 1987;2(4):205–210 (J Hyperbaric Med (1986–1992) is not indexed in PubMed; checked by citation lookup 29 Oct 2026).
Hart GB, Strauss MB, Roessler P. HBO and erythropoietin in exceptional blood loss anemia [abstract]. Undersea Biomed Res 1992;19(Suppl) (UHMS Annual Scientific Meeting, 23–27 June 1992; title in the programme only).
Hart GB. HBO and exceptional blood loss anemia. In: Kindwall EP, Whelan HT, eds. Hyperbaric Medicine Practice. 2nd ed. Flagstaff, AZ: Best Publishing 1999:741–751 (UHMS 15th ch 13 cites the revised 2nd ed (2002), same pages).
Hart GB, Strauss MB. Gender differences in human skeletal muscle and subcutaneous tissue gases under ambient and hyperbaric oxygen conditions. Undersea Hyperb Med 2007;34(3):147-61.
Hart GB, Strauss MB. Effects of cigarette smoking on tissue gas exchange during hyperbaric exposures. Undersea Hyperb Med 2010;37(2):73-87.
Hart B. Osteomyelitis (Refractory) with literature review supplement. Undersea Hyperb Med 2013;39(3):753-775.
Hart BB, Wilson SH, Churchill S, Deru K, Weaver LK, Minnakanti M, et al. Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med 2019;46(3):313-327.
Hart BB, Weaver LK, Wilson SH, Lindblad AS, Churchill S, Deru K. Executive summary: Secondary analyses of DoD-sponsored studies examining hyperbaric oxygen for persistent post-concussive symptoms after mild traumatic brain injury. Undersea Hyperb Med 2019;46(3):221-226.
Hart BB, Weaver LK, Gupta A, Wilson SH, Vijayarangan A, Deru K, et al. Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies. Undersea Hyperb Med 2019;46(3):353-383.
Hart BB. Verbatim reprint of the UHMS Hyperbaric Oxygen Therapy Indications Manual, Chapter 12 (Refractory Osteomyelitis). Hyperbaric oxygen for refractory osteomyelitis. Undersea Hyperb Med 2021 Third Quarter;48(3):297–321.
Definition: refractory osteomyelitis = chronic osteomyelitis that persists or recurs after Mechanism: the low oxygen tensions typical of infected bone are restored to normal by HBO₂ Central/high-risk sites deserve special consideration — sternal (often fatal; recurrence 3–8% even
Hartge FJ, Bennett TL. Low forced expiratory flow rates and forceful exhalation as a cause for arterial gas embolism during submarine escape training: a case report. Undersea Hyperb Med 2015;42(5):429-36.
Haute Autorité de santé, Service évaluation des actes professionnels (Biga J, project lead). Oxygénothérapie hyperbare. Classement CCAM 19.01.05. Rapport d'évaluation. Saint-Denis La Plaine: HAS 2007:106 pp (validated by the HAS College January 2007; copy held on HUG Geneva site; original at has-sante.fr).
Hassan Z, Mullins RF, Friedman BC, Shaver JR, Brandigi C, Alam B, Mian MAH. Treating necrotizing fasciitis with or without hyperbaric oxygen therapy. Undersea Hyperb Med 2010;37(2):115-123.
Hatibie MJ, Islam AA, Hatta M, Moenadjat Y, Susilo RH, Rendy L. Hyperbaric oxygen therapy for second-degree burn healing: an experimental study in rabbits. Adv Skin Wound Care 2019;32(3):1–4.
Hatling D, Høgset A, Guttormsen AB, Müller B. Iatrogenic cerebral gas embolism–A systematic review of case reports. Acta Anaesthesiol Scand 2019;63(2):154–160.
A broad range of procedures cause ICGE — central venous catheter insertion/removal, haemodialysis Hyperbaric oxygen was the predominant specific treatment where a treatment was stated: of the 264 Latest reported outcome by treatment (GOS, Table 4) — uncontrolled:
Hauken MA, Gjestad R, Sekse RJT, Müller B, Velure GK. Sexual health following hyperbaric oxygen treatment in pelvic cancer survivors with radiation injuries: a longitudinal observational study. J Sex Med 2026;23(7):qdag189 (DOI 10.1093/jsxmed/qdag189).
Haux GFK; Lohmeyer P, translator; Workman WT, contributor. History of Hyperbaric Chambers. Flagstaff (AZ): Best Publishing 2000:176 pp (PDF; two scans held).
Hawkins GC, Bennett MH, van der Hulst AE. The outcome of chronic wounds following hyperbaric oxygen therapy: a prospective cohort study — the first year interim report. Diving Hyperb Med 2006;36(2):94–98.
Hayashi K, Takahashi T, Ikegawa M, Horie M, Oyaizu T, Enomoto M, Shibata S, Yagishita K, Ueno T. The facilitatory effects of hyperbaric oxygen treatment on membrane bone wound healing in a rat calvarial defect model. Undersea Hyperb Med 2016;43(2):135–142.
He Z, Sun X, Chen J, Zhang M. Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis. J Wound Care 2026;35(2):193–200.
Flap survival: OR 8.57 (95% CI 5.54–13.26). Skin-flap O₂ saturation MD +19.94; post-op skin temperature MD +0.71; time to swelling resolution
He X, Li T, Huang W, Liu G, Yang T, Zhang X, Li X, Feng Q. Comparative efficacy and safety of non-pharmacological interventions for erectile dysfunction: a systematic review and network meta-analysis. Sex Med Rev 2026;14:1-10.
Heck T, Lohana D, Mallela D, Mandil O, Sun L, Saxena P, Decker AM, Wang HL (University of Michigan). Hyperbaric oxygen therapy as an adjunct treatment of periodontitis, MRONJ, and ONJ: a systematic literature review. Clin Oral Investig 2024;28(1):77.
ORN prophylaxis: HBO superior to antibiotics in preventing ORN in patients with a history of high Established ORN (surgical excision): HBO does not yield significant benefit, but does not worsen Periodontitis (adjunct to SRP): mixed results; study variability precludes conclusions.
Hedetoft M, Hyldegaard O. Postural stability in patients with decompression sickness evaluated by means of Quantitative Romberg testing. Undersea Hyperb Med 2015;42(5):389-98.
Hedetoft M, Polzik P, Olsen NV, Hyldegaard O. Neuronal nitric oxide inhibition attenuates the protective effect of HBO2 during cyanide poisoning. Undersea Hyperb Med 2018;45(3):335-350.
Hedetoft M, Olsen NV, Smidt-Nielsen IG, et al. Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment. Diving Hyperb Med 2020;50(1):17-23.
Hedetoft M, Bennett MH, Hyldegaard O. Adjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: A systematic review and meta-analysis. Diving Hyperb Med 2021;51(1):34–43.
Mortality: pooled OR 0.44 (95% CI 0.33–0.58) in favour of HBOT — 4,770 deaths among 48,744 patients Major amputation: pooled OR 0.60 (95% CI 0.28–1.28) — favours HBOT in point estimate but not The authors judge the clinical evidence sparse and of generally low quality; HBOT for NSTI remains
Hehenberger K, Brismar K, Lind F, Kratz G. Dose-dependent hyperbaric oxygen stimulation of human fibroblast proliferation. Wound Repair Regen 1997;5(2):147-150.
Heiden C. HBOT for malignant otitis externa. Diving Hyperb Med 2010;40(4):182.
Helfrich ET, Saraiva CM, Chimiak JM, Nochetto M. A review of 149 Divers Alert Network emergency call records involving diving minors. Diving Hyperb Med 2023;53(1):7-15.
Helms A, Evans AW, Chu J, Sahgal A, Ostrowski R, Sosiak T, Wolf G, Gillett J, Whelan H. Hyperbaric oxygen for neurologic indications: action plan for multicenter trials in stroke, traumatic brain injury, radiation encephalopathy and status migrainosus. Undersea Hyperb Med 2011;38(5):309-319.
Hemsinli D, Altun G, Kaplan ST, Yildirim F, Cebi G. Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit. Diving Hyperb Med 2018;48(1):31-35.
Hendaus MA. Subdural empyema in children. Glob J Health Sci 2013;5(6):54-9.
Hendier L, Soule H, Abbas M, Pittet D, Pignel R, Boet S. Evaluation of bacterial survival on inert surfaces in a hyperbaric environment. Diving Hyperb Med 2025;55(3):231-235 (PMID 40986918. DOI 10.28920/dhm55.3.231-235).
Heng MCY, Pilgrim JP, Beck FWJ. A simplified hyperbaric oxygen technique for leg ulcers. Archives of Dermatology 1984;120(5):640-645.
Henk JM, Kunkler PB, Smith CW (South Wales Radiotherapy and Oncology Service, Velindre Hospital, Cardiff). Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet 1977;2(8029):101–103.
294 patients admitted between October 1964 and March 1972 — 143 allocated to hyperbaric No difference in survival. Actuarial survival curves were the same in both groups. Local tumour control was significantly better with HBO — recurrence-free rates by the actuarial
Henk JM. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers? Int J Radiat Oncol Biol Phys 1986;12(8):1339–1341.
Survival and local-control rates were significantly higher in the HBO group — one of the positive ⚠️ Corrected 23 Oct 2026 on full read: this bullet said HBO was associated with greater morbidity. In this trial it was not — "No difference in normal tissue effects were detected" (Abstract, p.1339) and "There was no significant increase in morbidity in the HBO group" (p.1340). The greater morbidity, especially laryngeal perichon…
Herbstein K, Murchland JB. Retinal vascular changes after treatment with hyperbaric oxygen. Med J Aust 1984;140(12):728-729.
Hernyta C, Mustika A, Harnanik T. The effect of hyperbaric oxygen therapy on lipid profile, blood glucose, HbA1c levels and wound healing in diabetic foot ulcer patients. Adolesc Saude 2026;21(6s):2165–2180.
Hexdall E, Brave R, Kraft K, Siewers J. Diving deep into hyperbaric oxygen therapy. Nursing 2016;46(10):28-36.
Heyboer M 3rd, Wojcik SM, McCabe JB, Faruqi MS, Kassem JN, Morgan M, Schopfer G. Hyperbaric oxygen and dental extractions in irradiated patients: short- and long-term outcomes. Undersea Hyperb Med 2013;40(3):283–288.
Heyboer M 3rd, Wojcik SM, Grant WD, Faruqi MS, Morgan M, Hahn SS. Professional attitudes in regard to hyperbaric oxygen therapy for dental extractions in irradiated patients: a comparison of two specialties. Undersea Hyperb Med 2013;40(3):275–282.
Heyboer M 3rd, Milovanova TN, Wojcik S, Grant W, Chin M, Hardy KR, Lambert DS, Logue C, Thom SR. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen — changes with oxygen dosage. Stem Cell Res 2014;12(3):638–645.
Heyboer M 3rd, Wojcik SM, Grant WD, Chambers P, Jennings S, Adcock P. Middle ear barotrauma in hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(5):393-397.
Heyboer M, Jennings S, Grant WD, Ojevwe C, Byrne J, Wojcik SM. Seizure incidence by treatment pressure in patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med 2014;41(5):379-85.
Heyboer Rd M, Wojcik SM, Smith G, Santiago W. Effect of hyperbaric oxygen therapy on blood pressure in patients undergoing treatment. Undersea Hyperb Med 2017;44(2):93-99.
Heyboer M, Sharma D, Santiago W, McCulloch N. Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified. Adv Wound Care (New Rochelle) 2017;6(6):210-224.
Heyboer M, Byrne J, Pons P, Wolner E, Seargent S, Wojcik SM. Use of in-chamber transcutaneous oxygen measurement to determine optimal treatment pressure in patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med 2018;45(4):389-394.
Heyboer M 3rd, Wojcik SM, Swaby J, Boes T. Blood glucose levels in diabetic patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med 2019;46(4):437-445.
Hibbs HW, Harasym MP, Bansal D, Stewart J. Effects of a single hyperbaric oxygen exposure on haematocrit, prothrombin time, serum calcium, and platelet count. Diving Hyperb Med 2007;37(3):143-145.
Hillard JR. Severe claustrophobia in a patient requiring hyperbaric oxygen treatment. Psychosomatics 1990;31(1):107-8.
Hingorani A, LaMuraglia GM, Henke P, Meissner MH, Loretz L, Zinszer KM, Driver VR, Frykberg R, Carman TL, Marston W, Mills JL, Murad MH. The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. J Vasc Surg 2016;63(2 Suppl):3S-21S.
Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med Hypotheses 2001;57(6):764-769.
Hirai M, Kitajima T, Park SC, Takagi T, Honda I, Ohe Y, Inoue D, Fukui M, Marumo S. Bronchial Chondronecrosis After Proton Beam Therapy Successfully Treated With Hyperbaric Oxygen Therapy. Respirol Case Rep 2026;14:e70705.
Hisamoto K, Okubo N, Fujita M, Fukushima H, Okizuka Y, Yamanaka T, Matsui T, Morihara T, Hojo T, Fukuoka Y, Takahashi K. Mild hyperbaric hyperoxia improves aerobic capacity and suppresses cardiopulmonary stress during the maximal cycle-ergometer test. PLoS One 2025;20(5):e0323885.
Ho YW, Chung PY, Hou SK, Chang ML, Kang YN. Should We Use Hyperbaric Oxygen for Carbon Monoxide Poisoning Management? A Network Meta-Analysis of Randomized Controlled Trials. Healthcare (Basel) 2022;10(7):1311.
HBO had no better outcomes than NBO overall. Two-session HBO was worse than one-session for general fatigue (RR 1.29, 95% CI 1.03–1.62),
Hochedez P, Thomas L, Mehdaoui H. Hyperbaric oxygen therapy after Bothrops lanceolatus snake bites in Martinique: a brief report. Undersea Hyperb Med 2010;37(6):399-403.
Hoencamp E, van Dongen TTCF, van Ooij PJAM, Wingelaar TT, Vervelde ML, Koch DAA, van Hulst RA, Hoencamp R. Systematic review on the effects of medication under hyperbaric conditions: consequences for the diver. Diving Hyperb Med 2019;49(2):127–136.
Hofmeyr R, Tölken G, De Decker R. Acute high-altitude illness. S Afr Med J 2017;107(7):556-561.
Hoggan BL, Cameron AL. Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries. Support Care Cancer 2014;22(6):1715–1726.
Protocol-driven SR of comparative studies of HBO vs observation/conventional/sham for non-neurological soft-tissue radiation injury. Benefit shown for radiation proctitis and for irradiated head/neck soft-tissue wounds; radiation cystitis showed little difference between groups. Safety and effectiveness assessed together; overall an encouraging but site-dependent signal on a limited comparative evidence base.
Holbach KH, Wassmann H, Kolberg T. Verbesserte Reversibilität des traumatischen Mittelhirnsyndroms bei Anwendung der hyperbaren Oxygenierung [Improved reversibility of the traumatic midbrain syndrome using hyperbaric oxygen]. Acta Neurochir (Wien) 1974;30(3-4):247-56.
Holck P, Hunter RW. NIHSS applied to cerebral neurological dive injuries as a tool for dive injury severity stratification. Undersea Hyperb Med 2006;33(4):271-80.
Holland NJ, Bernstein JM. Bell's palsy. BMJ Clin Evid 2014;2014:1204.
Holt J, Weaver LK. Carbon monoxide poisoning mimicking arterial gas embolism in a commercial diver. Undersea Hyperb Med 2012;39(2):687-90.
Holy R, Navara M, Dosel P, Fundova P, Prazenica P, Hahn A. Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss (ISSNHL) in association with combined treatment. Undersea Hyperb Med 2011;38(2):137–142.
Holy R, Prazenica P, Stolarikova E, Dosel P, Fundova P, Kovar D, Astl J. Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment. Undersea Hyperb Med 2016;43(3):201–205.
Hong WT, Kim J, Kim SW. Minimizing tissue damage due to filler injection with systemic hyperbaric oxygen therapy. Arch Craniofac Surg 2019;20(4):246-250.
Hornbeak K, Duchnick J, Medak A, Lindholm P, Tanaka HL. Point-of-care ultrasound in a multiplace hyperbaric chamber. Undersea Hyperb Med 2021;48(3):221-226.
Houlihan RT. Rheomelanin accumulation in the blood and lungs and hemolysis in rats poisoned by hyperbaric oxygen. J Am Osteopath Assoc 1970;69(10):1040.
Howard MA, Asmis R, Evans KK, Mustoe TA. Oxygen and wound care: a review of current therapeutic modalities and future direction. Wound Repair Regen 2013;21(4):503-11.
Howard AE, Buzzacott P, Gawthrope IC, Banham ND. Effect of antiplatelet and/or anticoagulation medication on the risk of tympanic barotrauma in hyperbaric oxygen treatment patients, and development of a predictive model. Diving Hyperb Med 2020;50(4):338-342.
Hsia HC, Eriksson E, Gurtner GC, Veves A, Hamdy O, Margolis DJ, Armstrong DG, Lavery LA, Grice EA, Schultz G, Conte MS, Kirsner RS, Attinger CE, Steinberg JS, Evans KK, Weir D, Kim PJ, Orgill DP, Liechty KW, Rubin JP. Management of diabetic wounds: expert panel consensus statement. Adv Wound Care (New Rochelle) 2025;15(7):487-519.
Hsieh YH, Liang CM, Tai MC, Chen YJ. Benefit of hyperbaric oxygen therapy treatment in direct traumatic optic neuropathy: case report. Undersea Hyperb Med 2018;45(4):463-471.
Hsieh CH, Wen YW, Liao CT, Lee SR. Hyperbaric oxygen treatment after surgery and radiation for oral cancers does not increase the likelihood of a second primary development, nor reduce disease specific or overall survival. Undersea Hyperb Med 2025;52(3):271-278.
Hsiung CW, Liu YC, Chen TH, Chang WT, Chang CP, Huang CC, Liao PC. Cardiac extracellular vesicle proteomics identifies mitochondrial and contractile dysfunction in carbon monoxide poisoning and their reversal by hyperbaric oxygen therapy. Mol Med 2026;32(1):in press.
Hsu S-L, Wang C-J, Lee MS-S, Chan Y-S, Huang C-C, Yang KD. Cocktail therapy for femoral head necrosis of the hip. Arch Orthop Trauma Surg 2010;130(1):23–29.
Group A (cocktail) 74% improved / 16% unchanged / 10% worse; Group B (ESWT alone) 79.2% / 10.4% / 10.4% — p=0.717 across the three categories. ⚠️ Corrected 31 Aug 2026: this bullet previously read "Overall 74% improved, 16% unchanged (remainder worse)". Those are GROUP A's figures alone, not the overall result; presenting the cocktail arm's numbers as overall hid that the comparator arm did slightly better in every category. T…
Htay AM, Wilson E. Lateral ST-elevation myocardial infarction from systemic air embolism after CT guided lung biopsy. Diving Hyperb Med 2024;54(3):233-236 (DOI 10.28920/dhm54.3.233-236).
Hu H, Sun Q. A discussion about sensorineural hearing loss: Hu H, Sun Q. Undersea Hyperb Med 2020;47(1):175.
Hu Y, Chen H, Xiong J, Sun W. [The efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (J Clin Otorhinolaryngol Head Neck Surg, China) 2020 Jun;34(6):521–523,527.
"Effective" response (≥15 dB gain): A 78.9%, B 81.5%, C 61.9%; C vs A and C vs B both significant Mean threshold gain: A 27.2±17.5, B 26.9±16.7, C 17.6±18.5 dB HL → pooled +9.5 dB (95% CI 2.5–16.4) Two HBO schedules equivalent → scheduling can follow chamber capacity / patient convenience.
Hu HJ, Zhang W, Fan DF. Letter: HBO2 combined with steroid therapy for sudden sensorineural hearing loss within two weeks. Undersea Hyperb Med 2021;48(1):103-104.
Hu Y, Ye Y, Ji X, Wu J. The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss. Med Gas Res 2024;14(4):180-185.
Hu Z, Guo W, Wu H. A study on the effect of acute hyperbaric oxygen intervention on aerobic endurance. J Physiol Anthropol 2025;44(1):22.
Hu X, Meng H, Liang J, An H, Zhou J, Gao Y, You C, Zhang Z, Gong X, Liu Y. Comparison of the efficacy of 12 interventions in the treatment of diabetic foot ulcers: a network meta-analysis. PeerJ 2025;13:e19809.
99 RCTs, 7,356 patients, 12 adjunctive interventions against standard of care or placebo — EGF, Wound healing rate — HBOT SIGNIFICANT (95 RCTs, 6,807 patients). Ten of the twelve interventions Amputation — HBOT SIGNIFICANT, and one of only two that were (30 RCTs, 2,526 patients, eight
Hu W, Xi Y, Xu C, Luo R. Cognitive Enhancement in PSCI: a Retrospective Study on rTMS and HBO therapy. Journal of Clinical Medicine Research 2025;6(3):514-517.
Hua C, Bosc R, Sbidian E, De Prost N, Hughes C, Jabre P, Chosidow O, Le Cleach L. Interventions for necrotizing soft tissue infections in adults. Cochrane Database Syst Rev 2018;5(5):CD011680.
Huang JL, Zhang YL, Xiao X, Zhang JH, Lian QL, Liu Y, et al. Bidirectional influences of acetazolamide on central nervous system oxygen toxicity of rats. Undersea Hyperb Med 2010;37(5):271-80.
Huang G, Xu W. Edaravone may be an efficacious adjunctive therapeutic agent for decompression sickness: an editorial perspective. Undersea Hyperb Med 2013;40(3):215-7.
Huang E. Adjunctive hyperbaric oxygen therapy for diabetic foot ulcers: an editorial perspective. Undersea Hyperb Med 2015;42(3):177–181.
Huang ET (chair), Mansouri J, Murad MH, Joseph WS, Strauss MB, Tettelbach W, Worth ER; UHMS CPG Oversight Committee. A clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers. Undersea Hyperb Med 2015;42(3):205–247.
Huang CC, Ho CH, Chen YC, Lin HJ, Hsu CC, Wang JJ, Su SB, Guo HR. Hyperbaric oxygen therapy is associated with lower short- and long-term mortality in patients with carbon monoxide poisoning. Chest 2017;152(5):943-953.
Huang ET. Hyperbaric medicine today: an historically noble discipline challenged by loss of critical access and overutilization -- an introduction to invited commentary. Undersea Hyperb Med 2017;44(1):1-3.
Huang E, Shah J, Pestell D, Kot J, Mathieu D, Smart D, Longobardi P, Sahni T, Rech FV, Löndahl M, Kawashima M, Weir G. An open letter to the American Diabetes Association board of directors: special commentary. Undersea Hyperb Med 2017;44(5):373-376.
Huang E, Heyboer M 3rd, Savaser DJ. Hyperbaric oxygen therapy for the management of chronic wounds: patient selection and perspectives. Chronic Wound Care Manag Res 2019;6:27-37.
Huang ET, Savaser DJ, Heyboer M 3rd. Arterial insufficiencies: hyperbaric oxygen therapy for selected problem wounds. Undersea Hyperb Med 2020;47(3):491–530.
Huang C, Zhong Y, Yue C, He B, Li Y, Li J. The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis. World J Emerg Surg 2023;18(1):23.
Mortality significantly lower with HBOT: RR 0.52 (95% CI 0.40–0.68; P<0.05). Multi-organ dysfunction (MODS) lower: RR 0.21 (95% CI 0.16–0.26). Amputation: no significant difference (RR 0.84, 95% CI 0.62–1.13); more debridements performed in
Patel A, Batura D. Hyperbaric oxygen therapy and Fournier’s gangrene: a systematic review and meta-analysis. Med Gas Res 2026;16(4):508–513.
HBOT associated with significantly lower mortality vs controls. Hospital length of stay and number of surgical debridements: inconsistent, not significantly different. ⚠️ Full read 21 Oct 2026 (all 6 pages of the proof PDF): the numbers, and a design flaw that bears on them.
Huang GS, Chiang SW, Chen CC, Peng YJ, Hsu YJ, Huang KL, Chou YC, Lin MH, Liu YC, Wang CY. Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2 Quantification Study. Cartilage 2026:online ahead of print, 1-12.
Huang C, Lin L, Tang T. Hyperbaric Oxygen Therapy Is Associated with Lower Mortality in Patients with Fournier’s Gangrene: A Meta-Analysis. Medicina (Kaunas) 2026;62(6):1199.
Mortality: 9.55% (HBOT) vs 27.45% (control); RR 0.33 (95% CI 0.23–0.48, p<0.001). A large, significant
Hubbard M, Davis FM, Malcolm K, Mitchell SJ. Decompression illness and other injuries in a recreational dive charter operation. Diving Hyperb Med 2018;48(4):218-223.
Huchim-Lara O, Chin W, Salas S, Rivera-Canul N, Cordero-Romero S, Tec J, Joo E, Mendez-Dominguez N. Decompression sickness among diving fishermen in Mexico: observational retrospective analysis of DCS in three sea cucumber fishing seasons. Undersea and Hyperbaric Medicine 2017;44(2):149-156.
Huchim-Lara O, Hernández-Flores A, Villanueva-Poot R, Garcia E. The cost of decompression illness: the case of lobster and sea cucumber fishery in Yucatan, Mexico. Undersea Hyperb Med 2018;45:531-539.
Hughes SM, Hodgson J, Richards MF. Diving medical officers as hospitalists: a case of arterial gas embolism following a routine GI procedure. Undersea Hyperb Med 2020;47(4):621-624.
Hughes SM, Hodgson J, Richards MF. Response: Impact of anesthetic drugs on venous filtration of intravascular gas. Undersea Hyperb Med 2021;48(2):206.
Hughes HJJ, McPhail S, Wilson N, Osborne M. Cardiac arrest in diving: The key to success. Undersea Hyperb Med 2023;50(1):57-64.
Hui B, Bennett M. Critical appraisal: Pre-conditioning with hyperbaric oxygen treatment (HBOT) may induce cerebral and cardiac protection in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Diving Hyperb Med 2014;44(1):50.
Huijun H, Qiang S, Dazhi G, Yu Z, Yan L, Shuyi P, et al. Sex differences may affect the severity of poisoning and prognosis after carbon monoxide poisoning: a retrospective study. Undersea Hyperb Med 2016;43(3):207-15.
Hulshof MCCM, Stark NM, van der Kleij A, Sminia P, Smeding HMM, Gonzalez Gonzalez D. Hyperbaric oxygen therapy for cognitive disorders after irradiation of the brain. Strahlenther Onkol 2002;178(4):192–198.
All eligible patients completed HBO and testing (feasible). 1 of 7 patients had a meaningful improvement in neuropsychological functioning. At 3 months the HBO group showed a small but NOT significant benefit vs the untreated group.
Hurlburt S, Orwig D. Registered Nurses in Hyperbaric Medicine: Increasing Patient Compliance with Hyperbaric Oxygen Therapy. Undersea Hyperb Med 2026;53(1):59-64.
Hussain H, Fadel A, Garcia E, Hernandez RJ, Saadoon ZF, Naseer L, Casmartino E, Hamad M, Schnepp T, Sarfraz R, Angly S, Jayakumar AR. Clostridial myonecrosis: a comprehensive review of toxin pathophysiology and management strategies. Microorganisms 2024;12(7):1464.
Hussain SA, Rehman R, Amin F, Abid A, Saleem N. Hyperbaric oxygen therapy as an adjunct to standard medical and surgical care for diabetic foot ulcers: an updated systematic review and meta-analysis of randomized controlled trials. Diabetes 2026;75(Suppl 1):1462-P (ADA Scientific Sessions abstract).
19 RCTs, 1269 participants (635 HBOT, 634 control). Ulcer healing RR 1.97 (95% CI 1.48–2.62), Major amputation RR 0.48 (0.24–0.97), 7 RCTs, 467 participants, I² 36.5%; no significant ⚠️⚠️ Publication-bias signal: funnel-plot asymmetry AND Egger's test p < 0.001.
Hutchison JH, Kerr MM, Inall JA, Shanks RA. Controlled trials of hyperbaric oxygen and tracheal intubation in asphyxia neonatorum. Lancet 1966;1(7444):935-9.
Hwang K. Hyperbaric Oxygen Therapy to Avoid Blindness From Filler Injection. J Craniofac Surg 2016;27(8):2154–2155.
A brief technical-strategy note: reviews that of 98 filler/fat-injection blindness cases only 2 recovered vision, notes only 2 prior HBOT-in-ophthalmic-artery-occlusion cases (neither improved), and relays one favourable case (central retinal vein + cilioretinal artery occlusion) treated with HBOT (2-hour sessions at 253 kPa daily for 14 days) whose visual acuity returned from 20/200 to 20/20 — at
Hwang L, Song M, Lee Y, Shin TM. Methods for preventing middle ear barotrauma in computer-controlled pressurization of monoplace hyperbaric chambers. Undersea Hyperb Med 2019;46(2):107-116.
Hyldegaard O, Jensen T. Effect of heliox, oxygen and air breathing on helium bubbles after heliox diving. Undersea Hyperb Med 2007;34(2):107-22.
Hyldegaard O, Nekludov M, Arnell P, Nedrebø T, Karlsson Y, Madsen MB, Skrede S, … Norrby-Teglund A, Hedetoft M. Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort. Infect Dis Ther 2025;14:1715–1738.
All-cause mortality — HBO₂ vs non-HBO₂: 30-day 22/325 (7%) vs 34/80 (43%); 90-day 36/325 (11%) In exploratory analysis, HBO₂ was associated with lower 30-day all-cause mortality — unadjusted and Critical caveat (authors' own): HBO₂-treated patients were LESS acutely ill (lower SAPS-2/SOFA)
Iaconetta G, Ranalli C, Antonino JR, Siglioccolo A, Narciso N, Scrofani R, Amoroso E, Cascella M, De Simone M. Hyperbaric oxygen therapy in traumatic and non-traumatic spinal cord injuries: insights from nearly five decades of evidence with single-center experience. Brain Sci 2026;16(2):165.
Iakovlev VN, Leonov AN. [Mechanisms of oxygen supply to the brain in hyperbaric oxygen therapy of acute blood loss]. Patol Fiziol Eksp Ter 1983;(5):19-22 (Russian).
Iakovlev VN, Leonov AN. [Bioenergetic processes in the cerebral cortex and diensephalon during hyperbaric oxygenation therapy of acute blood loss]. Biull Eksp Biol Med 1983;95(5):48-50 (Russian with English abstract).
Iakovlev VN, Leonov AN. [Enzyme activity and content of glycerophosphate shuttle metabolites in the cortex and medulla oblongata during hyperbaric oxygenation therapy of acute hemorrhage]. Biull Eksp Biol Med 1985;100(11):551-3 (Russian with English abstract).
Iakovlev VN, Leonov AN. [Ammonia detoxication reactions in the brain during the hyperbaric oxygen therapy of acute blood loss]. Patol Fiziol Eksp Ter 1986;(2):32-5 (Russian).
Iakovlev EV, Iakovlev VV. Facial baroparesis: a critical differential diagnosis for scuba diving accidents--case report. Undersea Hyperb Med 2014;41(5):407-9.
Icme F, Kozaci N, Ay MO, Avci A, Gumusay U, Yilmaz M, Satar S (Turkey). The relationship between blood lactate, carboxy-hemoglobin and clinical status in CO poisoning. Eur Rev Med Pharmacol Sci 2014;18(3):393–397.
Lactate and COHb were significantly higher in patients with GCS < 15 than GCS = 15 (p < 0.01) — both track clinical severity in acute CO poisoning. Treatments recorded (NBOT/HBOT) but the study is a severity-biomarker analysis, not an efficacy comparison.
Idris OA, Ahmedfiqi YO, Shebrain A, Al-Assil T, Pacione SC, Haj D, Motan AD, Momani F, Bzizi H, Jahromi BS, Lewis RM, Ver Steeg K 2nd. Hyperbaric Oxygen Therapy for Complications in Nipple-Sparing Mastectomy with Breast Reconstruction: A Systematic Review. J Clin Med 2024;13(12):3535.
Igwe MC, Alum EU, Ogbuabor AO, Oboma YI, Bede-Ojimadu O, Idehen CI. Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers in Sub-Saharan Africa: A Critical Review of Clinical Evidence, Health-System Feasibility and Public Health Implications. Int Wound J 2026;23(9):e71027.
Ilancheran A, Millar I, Tsouras T. Successful hyperbaric oxygen treatment of a patient with a HeartMate III left ventricular assist device. Diving Hyperb Med 2023;53(2):147-150.
Imai K, Mori T, Izumoto H, Takabatake N, Kunieda T, Watanabe M. Hyperbaric oxygen combined with intravenous edaravone for treatment of acute embolic stroke: a pilot clinical trial. Neurol Med Chir (Tokyo) 2006;46(8):373-8; discussion 378.
Inal A, Hallak M, Baktir MA, Ekebaş G, Atasever A. Investigation Of The Effects Of Hyperbaric Oxygen Therapy On Hepatotoxicity Induced By Leflunomide in Rats. Undersea Hyperb Med 2024;51(4):353-359.
[Anonymous abstracts section]. Hyperbaric oxygen for burns [abstract digest of Hart GB, O'Reilly RR, Broussard N, Yanda RL. Treatment of burns with hyperbaric oxygen. Surg Gynecol Obstet 1974;139:692]. Injury 1975.
[Anonymous]. Hyperbaric oxygen in acute blood loss. Injury 1975;6(4):362.
Inman AL, Sorrell LP, Lagina AT. Decompression sickness responsive to delayed treatment with hyperbaric oxygen: a case report of two divers. Undersea Hyperb Med 2020;47(4):551-554.
Irgens A, Vaagbø G, Aanderud L. Quality of life — the effect of hyperbaric oxygen treatment on radiation injury. Undersea Hyperb Med 2013;40(6):479-485.
Isakov IuV, Uteshev NS, Kusova NN, Pravdenkova SV, Rasshchepkina NA. [Effect of hyperbaric oxygenation on patient hemodynamics and respiration in blood loss as a consequence of gastroduodenal hemorrhages]. Vestn Khir Im I I Grek 1981;127(11):111–114 (Russian; English abstract).
Ishii Y, Deie M, Adachi N, Yasunaga Y, Sharman P, Miyanaga Y, Ochi M. Hyperbaric oxygen as an adjuvant for athletes. Sports Medicine 2005;35(9):739-746.
Ivanov M, Brkic P, Vajic UJ, Mihailovic-Stanojevic N, Milacic D, Jovovic D, Karanovic D, Djelic M, Jeremic R, Miloradovic Z. Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury. Undersea Hyperb Med 2020;47(1):21-30.
Iwashita Y, Yoshioka N, Murakami K, Mukoyama K, Sato R, Kodani N, Makiishi T. Cervical epidural abscess secondary to a post-traumatic hematoma, successfully treated with adjunctive hyperbaric oxygen therapy: a case report. J Clin Med 2025;14(20):7346.
Izhytska NV, Sobczyk KA, Ogrodnik KW, Mazurkiewicz M, Malentowicz D, Szafraniec NJ. Effects of hyperbaric oxygen therapy in the treatment of selected diseases of the nervous system. Wiad Lek 2026;79(8):1982-1988.
A short review covering mechanism, Alzheimer's disease, Parkinson's disease and stroke, concluding that HBOT is a "promising supportive approach" needing randomised trials. The method is one sentence (page 1982).
Izquierdo-Alventosa R, Inglés M, Cortés-Amador S, Gimeno-Mallench L, Sempere-Rubio N, Chirivella J, Serra-Añó P. Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Ther Adv Musculoskelet Dis 2020;12:1759720X20930493.
Jacobson YG, Defalco AJ, Mundth ED, Keller MA. Hyperbaric oxygen in the therapy of experimental hemorrhagic shock. Surg Forum 1965;16:15-7.
Jacobson YG, Keller M, Mundth ED, Defalco AJ, McClenethan JE. Hemorrhagic shock. Influence of hyperbaric oxygen on metabolic parameters. Calif Med 1966;105(2):93-6.
Jacobson YG, Keller ML, Mundth ED, et al. Hyperbaric oxygen therapy in experimental hemorrhagic shock. In: Brown IW, Cox BG, eds. Proceedings of the Third International Conference on Hyperbaric Medicine. Washington DC: NAS–NRC 1966:425–431.
Jacoby H, Camporesi EM, Ross SB, Sucandy I, Bosco G, Syblis C, Crespo K, Rosemurgy A. Outcomes after pancreaticoduodenectomy with or without preoperative hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(1):7-15 (DOI 10.22462/648).
Jacomini C, Junqueira AE, Almeida AL, Parra RS, Rocha JJ, Féres O. Anal canal mucinous adenocarcinoma with invasion of gluteus and perineum treated with surgery and hyperbaric oxygen therapy. Undersea Hyperb Med 2012;39(6):1115-8.
Jaeger NJ, Brosious JP, Gustavson RB, McFarlin CA, Gearhart W, Zamboni WA, Baynosa RC. Pneumomediastinum following hyperbaric oxygen therapy for carbon monoxide poisoning: case report. Undersea Hyperb Med 2013;40(6):521–523.
Jain KK, editor. Textbook of Hyperbaric Medicine. 5th rev. and updated ed. Cambridge (MA): Hogrefe & Huber 2009:xvii + 576 pp (PDF 593 pp).
Jain KK. HBO therapy in the management of radionecrosis (Textbook of Hyperbaric Medicine, chapter 17). Springer International Publishing 2017;(ch 17):207-219.
Jain KK. HBO therapy in wound healing, plastic surgery, and dermatology. Chapter 16 in: Textbook of hyperbaric medicine. Textbook of Hyperbaric Medicine (Springer) 2017:183-205.
Jain KK, editor. Textbook of Hyperbaric Medicine. 6th ed. Cham: Springer International Publishing 2017:xxv + 640 pp (PDF 660 pp).
Jalabi MW, Abidia A, Kuhan G, Laden G, Verma D, McCollum PT. The safety and effect of hyperbaric oxygen therapy in patients with diabetic retinopathy — a double-blind randomised controlled trial. Undersea Hyperb Med 2001;28(Suppl):abstract P99 (UHMS Annual Scientific Meeting, San Antonio).
A significant myopic shift developed with oxygen vs controls at 3 months (P=0.019 right eye, No significant change in ocular blood flow or tonometry in either group. No new vessel formation on retinal photography/angiography, and no regression or worsening of
Jali MI, Moodley Y, Kader S, Cheddie S. Outcomes of haemorrhagic radiation proctitis at a South African tertiary hospital. S Afr J Surg 2023;61(1):17-20.
James J, Lehm J, Bennett M. Clinical indicators in hyperbaric medicine. Diving Hyperb Med 2012;42(1):49.
Jang DH, Khatri UG, Shortal BP, Kelly M, Hardy K, Lambert DS, et al. Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 2018;6(1):4.
Janisch T, Siekmann U, Kopp R. Cerebral air embolism after pleural streptokinase instillation. Diving Hyperb Med 2013;43(4):237-8.
Jansen D, Dickstein DR, Erazo K, Stacom E, Lee DC, Wainwright SK. Hyperbaric oxygen for COVID-19 patients with severe hypoxia prior to vaccine availability. Undersea Hyperb Med 2022;49(3):295-305.
Jay GD, McKindley DS. Alterations in pharmacokinetics of carboxyhemoglobin produced by oxygen under pressure. Undersea Hyperb Med 1997;24(3):165–173.
COHb half-life: 26.3 ± 3.7 min on HBO vs 71.3 ± 9.9 min on NBO (P<0.05) — HBO roughly halved Elevated O₂ partial pressure shifted COHb elimination from zero-order to first-order kinetics Authors: HBO provides a pharmacokinetic advantage over non-rebreather-mask O₂ for clearing mild
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Mean absolute hearing gain +10.3 dB (95% CI 6.5–14.1; I²=0%) favouring HBOT. Odds of hearing recovery (≥10 dB PTA gain) OR 4.3 (95% CI 1.6–11.7; I²=0%) favouring HBOT. Benefit was seen with HBOT as part of a combination regimen (with steroids).
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100% normobaric oxygen is the immediate treatment for all symptomatic CO exposure; management is by On HBOT, the guideline is deliberately cautious: the evidence of benefit is regarded as ⚠️ Full read 21 Oct 2026 (all 35 PDF pages): the "Key points" above understate the HBOT recommendations and leave out three of them.
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A multi-society S2k clinical practice guideline on the management of diving accidents — decompression illness (DCI): decompression sickness and arterial gas embolism. Covers pre-hospital 100% oxygen, fluids, and recompression / hyperbaric oxygen therapy.
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Complete healing with intact skin at 3 years: 13/17 = 76% (Group A / HBO) vs 10/21 = 48% (Group B / Amputation (below knee): 2/17 (12%) HBO vs 7/21 (33%) conventional — also untested. ⚠️ Corrected The only between-group outcome this paper tests is mean healing time, and it is NULL: 15 ± 7 months
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Wound area: 59% reduction (HT) vs a 26% increase (CT). Complete healing in 3 (HT) vs 0 (CT); wound-score improvement in 10 (HT) vs 5 (CT); surgical Amputation: 1 (HT) vs 5 (CT). A positive correlation was found between TcPO₂ and markers of
Kavram G, Yasa B, Bor M, Bilgin L, Ince EZ, Mirasoglu B, et al. Hyperbaric oxygen treatment of neonates: a case series. Diving Hyperb Med 2025;55(3):284-288 (DOI 10.28920/dhm55.3.284-288).
Kawashima M, Yamaguchi T, Tamura H, Kawashima M. Treatment of Osteomyelitis by Hyperbaric Oxygen Therapy. 2020:67–80.
A textbook chapter, and it must be cited as one. It is a narrative account of the rationale, the protocol and the older clinical literature for hyperbaric oxygen in osteomyelitis, written by the orthopaedic team at Kawashima Orthopaedic Hospital, Nakatsu, Japan. It has no methods section, no search strategy, no inclusion criteria and no synthesis. Embedded in it are the authors' own uncontrolled i
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Kelly M, Gelly H, Shapshak D; Undersea and Hyperbaric Medical Society. UHMS Position Statement: Office-based hyperbaric oxygen facility credentialing guidelines. Version 3, 26 March 2021.
Kelly M, Gelly H, O'Neill O, Shapshak D. UHMS Position Statement: Physician's Duties in Hyperbaric Medicine - 99183. Undersea Hyperb Med 2024;51(2):v–viii.
Physician oversight of HBO₂ delivery is central to safety and quality; the statement articulates the International-society governance guidance (authority tier), aligned with the SAUHMA policy that a
Kelly M, Jones ET, Shapshak D. Rapid Progression of Cutaneous Large B-Cell Lymphoma During Hyperbaric Oxygen Therapy: A Case Report. Undersea Hyperb Med 2025;52(3):357-360.
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Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR. Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea Hyperb Med 2013;40(2):115-23.
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Keogh AJ. Clostridial brain abscess and hyperbaric oxygen. Postgrad Med J 1973;49(567):64–66.
A single case report — described by the author as the first case of "gas gangrene" of the brain treated with hyperbaric oxygen — with a short narrative review of the previously published cases. It is not a series, not a cohort, and contains no comparison group. This is the one paper in the wiki's intracranial-abscess set whose author argues AGAINST hyperbaric oxygen. The summary states: "It is sug
Keohane C, Westby D, Nolan FC, Twyford M, Tawfick W, Walsh SR. Hyperbaric Oxygen as an Adjunct in the Treatment of Venous Ulcers: A Systematic Review. Vasc Endovascular Surg 2023;57(6):607–616.
Systematic review (PRISMA; RoB-2 / ROBINS-I) of HBOT for venous leg ulcer (VLU) — does HBOT increase complete VLU healing or reduce VLU area vs controls. Six studies, with significant heterogeneity (no standard control, outcome reporting, or follow-up duration).
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Kessler L, Bilbault P, Ortéga F, et al. Hyperbaric Oxygenation Accelerates the Healing Rate of Nonischemic Chronic Diabetic Foot Ulcers. Diabetes Care 2003;26(8):2378–2382.
Ulcer-area reduction at day 15 (end of HBO): 41.8% ± 25.5 (HBO) vs 21.7% ± 16.9 (control) — P=0.037 Benefit not sustained at day 30 (48.1% vs 41.7%, NS) — a time-dependent effect. Peri-ulcer TcPO₂ rose markedly during HBO (21.9 → 454.2 mmHg, P<0.001); complete healing in 2 (HBO) vs
Khairy S, Ginzarly M, Wang Z, Qureshi U, Zaitoun R, Efrati S. Anatomical and metabolic brain imaging correlation of neurological improvements following hyperbaric oxygen therapy—post-stroke recovery: a case report. J Med Case Rep 2025;19(1):493.
Khallouli A, Khelifi K, Saidane R, Choura R, Maalej A, Ben Sassi R. Hyperbaric oxygen treatment of central retinal vein occlusion with cilioretinal artery occlusion secondary to hormonal treatment: Case report and review. Diving Hyperb Med 2020;50(4):431-436.
Khan H, Islam MS, Kaur M, Burns JK, Etherington C, Dion P-M, Alsayadi S, Boet S. Efficacy of searching in biomedical databases beyond MEDLINE in identifying randomised controlled trials on hyperbaric oxygen treatment. Diving Hyperb Med 2024;54(1):2-8 (DOI 10.28920/dhm54.1.2-8).
Khan S, Brenna CTA, Pendergrast J, Malinowski AK, Salvatori M, Katznelson R, Tarshis J. Hyperbaric Oxygen Therapy during Pregnancy for Critical Anemia Secondary to Sickle Cell Disease with Post-Transfusion Hyperhemolysis: A Case Report. Hematol Rep 2024;16(3):552–558.
Baseline. Pre-pregnancy haemoglobin on hydroxyurea ranged from 90 to 100 g/L; the printed The transfusion reaction. Pre-exchange Hb was 93 g/L with HbS 73.4%; post-exchange Hb was 96 g/L HBOT prescription. 100% oxygen in a monoplace chamber at 2.8 ATA, reduced to 2.0 ATA for the
Khandelwal S, Wall J, Kaide C, Katz G. Case report: successful use of hyperbaric oxygen therapy for a complete scalp degloving injury. Undersea Hyperb Med 2008;35(6):441-5.
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Kienitz LT, McCoy AM, Robbins MA. Hyperbaric oxygen therapy does not improve recovery of deep pain perception in dogs after hemilaminectomy for intervertebral disk disease. Am J Vet Res 2026;87(8):ajvr.26.01.0009.
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Fasciotomy timing dominates outcome: mean RFT 25.1 h (good outcome) vs 47.1 h (poor), p<0.05; HBOT associated with better outcomes: good-outcome rate higher with HBOT (p=0.006); on logistic
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A registry-based observational study with a concurrent control group — the design most of this indication's literature lacks. Adults presenting within 24 hours of CRAO symptom onset between October 2016 and February 2019. Thirty-four consecutive patients were identified; 19 were included. Fourteen were excluded for presenting more than 24 hours after onset and one for failing to attend follow-up f
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Despite the same modal dose, about one-third of patients showed exceptionally high "high-dose
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Primary endpoints (RAND-36 physical functioning & role-physical at 13 weeks): NO significant difference Harms: favourable — 43 AEs in 49% of HBOT vs 38 AEs in 44% of placebo (mostly cough, chest Conclusion: 10 HBOT sessions did not show more short-term benefit than placebo for long COVID.
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Mortality 12/53 (22.6%). HBO decreased systemic toxicity and prevented further extension of infection, improving overall
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Kot J. Medical equipment for multiplace hyperbaric chambers. Part I: Devices for monitoring and cardiac support. Eur J Underwater Hyperb Med 2005;6(4):115-120.
Kot J. Medical equipment for multiplace hyperbaric chambers. Part II: Ventilators. Eur J Underwater Hyperb Med 2006;7(1):9-12.
Kot J. Medical equipment for multiplace hyperbaric chambers. Part III: Infusion pumps and syringes. Eur J Underwater Hyperb Med 2006;7(2):29-31.
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Kot J. Medical devices and procedures in the hyperbaric chamber. Diving Hyperb Med 2014;44(4):223-227.
Kot J. Staffing and training issues in critical care hyperbaric medicine. Diving Hyperb Med 2015;45(1):47-50.
Kot J, Siondalski P, Lenkiewicz E. The Hyperbaric Protective Tube: A housing for a left ventricular assist device (LVAD) in a multiplace hyperbaric chamber. Diving Hyperb Med 2019;49(2):137-140.
Kot J, Lenkiewicz E, Lizak E, Góralczyk P, Chreptowicz U. Spinal cord decompression sickness in an inside attendant after a standard hyperbaric oxygen treatment session. Diving Hyperb Med 2021;51(1):103-106.
Kot J, Desola J, Lind F, Mueller P, Jansen E, Burman F, et al. A European code of good practice for hyperbaric oxygen therapy - Review 2022. Diving Hyperb Med 2023;53(4 Suppl):1-17.
Kot J; with reply by Wilmshurst PT, Edge C. PFO and DCS of hyperbaric personnel [letter]; Reply — PFO and DCS of hyperbaric personnel. Diving Hyperb Med 2025;55(1):65-66.
Krajčovičová Z, Meluš V, Zigo R, Matišáková I, Večeřa J, Kašlíková K. Efficacy of hyperbaric oxygen therapy as a supplementary therapy of sudden sensorineural hearing loss in the Slovak Republic. Undersea Hyperb Med 2018;45(3):363–370.
⚠️ Cohort overlap (21 Oct 2026): the same group's 2019 pressure-comparison paper (evidence/ssnhl-2019-hbo2-pressure-comparison-2-0-vs-2-5-ata) uses the same hospital and ethics code (26210120019) and a window, July 2015 to June 2018, that contains this study's. These 68 patients are very probably among its 115. Do not count the two as independent. ⚠️ Full read 21 Oct 2026 (all 8 pages): the paper states randomisation. "Patient…
Krajcovicova Z, Melus V, Zigo R, Matisaková I, Vecera J, Kralova E. Response: A discussion about sensorineural hearing loss. Undersea Hyperb Med 2020;47(1):175-176.
Krajčovičová Z, Zigo R, Meluš V, Králová E. Efficacy of hyperbaric oxygen salvage therapy for sudden sensorineural hearing loss after ineffective primary treatment in the Slovak Republic. Undersea Hyperb Med 2025;52(2):109-115.
Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 2015;Issue 6:CD004123 (searches to 17 Feb 2015; re-published Issue 3, 2020 — edited, no change to conclusions).
DFU healing at 6 weeks: pooled 5 trials (205 pts) — RR 2.35 (95% CI 1.19–4.62; P = 0.01) Major amputation (DFU): pooled 5 trials (312 pts) — RR 0.36 (95% CI 0.11–1.18), not Venous ulcers: 1 trial (16 pts) — significant ulcer-area reduction at 6 weeks only
Kratochvílovà B, Profant O, Astl J, Holý R. Our experience in the treatment of idiopathic sensorineural hearing loss (ISNHL): Effect of combination therapy with HBO₂ and vasodilator infusion therapy. Undersea Hyperb Med 2016;43(7):771-780.
Krimus L, Hasan Rizvi S, Marinov A, Clarke H, Katznelson R. Hyperbaric oxygen therapy for treatment of COVID-19-related parosmia: a case report. Undersea Hyperb Med 2023;50(4):433-435 (DOI 10.22462/01.01.2023.25).
Kronlund P, Lind F, Olsson D. Hyperbaric critical care patient data management system. Diving Hyperb Med 2012;42(2):85-7.
Krzystanek M, Romanczyk M, Surma S, Kozmin-Burzynska A. Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review. Pharmaceuticals (Basel) 2021;14(6):595.
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Kumar A, Shukla U, Prabhakar T, Srivastava D. Hyperbaric oxygen therapy as an adjuvant to standard therapy in the treatment of diabetic foot ulcers. J Anaesthesiol Clin Pharmacol 2020;36(2):213–218.
Complete healing without any surgical intervention: 78% (group H) vs 0% (group S), P=0.001. Amputation: 2 patients (group H) needed distal amputation vs 3 (group S) proximal amputation — ⚠️ Full read 21 Oct 2026 (all 6 pages, Table 2): the amputation bullet above undercounts the control arm.
Kumar S, Chaudhry H, Mohanty C, Bhutani S, Risham M, Lanjekar K. Hyperbaric oxygen treatment (HBOT) in a case of traumatic chondronecrosis of the cricoid cartilage. Diving and Hyperbaric Medicine Journal 2024;54(3):249-251 (DOI 10.28920/dhm54.3.249-251).
Kumar S, Kansal V, Chaudhry HBS, Bhutani S, Mohanty CS. Evaluation of the efficacy of modified low-dose HBO₂ therapy. Undersea Hyperb Med 2025;52(4):507-513.
Kuo TC, Chao WC, Yang CH, Tsai MS, Tsai YT, Lee YC. Intratympanic steroid injection versus hyperbaric oxygen therapy in refractory sudden sensorineural hearing loss: a meta-analysis. Eur Arch Otorhinolaryngol 2022;279(1):83–90.
No significant difference in mean post-treatment hearing gain between ITS and HBO salvage. Word discrimination and hearing gain across 250–8000 Hz were comparable between the two. ⚠️ Full read 21 Oct 2026 (all 8 pages): the numbers behind "no difference". The review has 4 studies and 314 subjects: 3 observational studies and 1 RCT (Cvorovic 2013, evidence/cvorovic-2013-ssnhl-salvage-rct). Pooled mean hearing gain favoured intr…
Kurschel S, Mohia A, Weigl V, Eder HG. Hyperbaric oxygen therapy for the treatment of brain abscess in children. Childs Nerv Syst 2006;22:38–42 (the article header prints volume 22, pages 38–42; no issue number is printed on the paper).
All five children improved clinically, with continuous regression of the inflammatory pathology on At 6 months all five were in good clinical condition without neurological sequelae, except one child No recurrence at a mean follow-up of 21 months (range 7–72 months).
Kusuba Y, Taki K, Ohta A. Questionnaire results of hyperbaric oxygen therapy for acute carbon monoxide poisoning in Japan. Undersea Hyperb Med 2012;39(2):639–645.
Kutlay M, Colak A, Demircan N, Akin ON, Kibici K, Dündar K, Yildirim S. Effect of hyperbaric oxygen therapy on fetal spinal grafts: an experimental study. Undersea Hyperb Med 2000;27(4):205–213.
Kutlay M, Çolak A, Yıldız Ş, Demircan N, Akın ON. Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscesses. Neurosurgery 2005;57(6):1140–1146 (the PDF prints DOI 10.1227/01.NEU.0000186012.95462.E5 on the title page although the PubMed record carries no DOI).
All 13 patients achieved infection control and healing. Mortality 0%. Recurrence after completion of Two abscesses recollected within the first 2 weeks and were re-aspirated on days 6 and 9 — an early Outcome at end of follow-up: 12 patients in good condition — 9 (69.2%) without sequelae, 3 (23%) with
Kutlay M, Colak A, Simsek H, Yildiz S, Topuz K, Kaya S, et al. Antibiotic and hyperbaric oxygen therapy in the management of post-operative discitis. Undersea Hyperb Med 2008;35(6):427-40.
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Kwee E, Borgdorff M, Schepers T, Halm JA, Winters HAH, Weenink RP, Ridderikhof ML, Giannakópoulos GF (Amsterdam UMC). Adjunctive hyperbaric oxygen therapy in the management of severe lower limb soft tissue injuries: a systematic review. Eur J Trauma Emerg Surg 2024;50(3):1093–1100.
7 studies, 229 patients — 2 RCTs, 1 retrospective cohort, 3 case series, 1 case report. The placebo-controlled RCT favoured HBO; the non-placebo RCT found early HBO reduced tissue necrosis and ⚠️ Full read 21 Oct 2026 (pages 1094–1099; Tables 1–4, Figs 1–2):
Labmayr V, Huetter K, Ornig M, Lanz P, Puchwein P, Holweg P. Functional recovery after open talar neck fracture with foot dislocation: A case report. Trauma Case Rep 2026;65:101419.
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Lakkis T, Elshoura AMA, Soria Behr GA, Eduardo Mauricio MC, Sil-Zavaleta S, Cai LY, Rai M. Central Retinal Artery Occlusion in Acute Care: Current Practices and Emerging Therapies. Cureus 2025;17(9):e92786.
Positions HBOT and targeted thrombolysis as promising emerging therapies within a multidisciplinary
Lalieu RC, Brouwer RJ, Ubbink DT, Hoencamp R, Bol Raap R, van Hulst RA. Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review. Wound Repair Regen 2020;28(2):266–275.
7 studies (2 RCTs) restricted to non-ischaemic diabetic foot ulcers. No significant difference in complete wound healing (5 studies), major amputation (2 no difference; 1 large retrospective study found 2% more major amputations with HBO, uncorrected for baseline), or minor amputation (2 studies). Conclusion: current evidence suggests HBO does not accelerate wound healing (or reduce amputation) in non-ischaemic diabetic ulcers…
Lalieu RC, Bol Raap RD, Dubois EFL, van Hulst RA. Sudden death after oxygen toxicity seizure during hyperbaric oxygen treatment: Case report. Diving Hyperb Med 2020;50(2):185-188.
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Lalieu RC, Akkerman I, van Hulst RA. Hyperbaric Oxygen Therapy for Venous Leg Ulcers: A 6 Year Retrospective Study of Results of a Single Center. Front Med (Lausanne) 2021;8:671678.
37/59 (63%) achieved complete or near-complete wound healing. Wound size decreased by ~94% (median decrease 7.5 cm²; IQR 16.2). Patients mostly reported
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Lansdorp NC, van Hulst RA. Double-blind trials in hyperbaric medicine: a narrative review on past experiences and considerations in designing sham hyperbaric treatment. Clin Trials 2018;15(5):462-476.
Three sham strategies across 42 trials: (1) lower pressure, 21% O₂; (2) same pressure, reduced O₂; (3) same pressure, 21% O₂ (Results). Strategy 1 is judged closest to an inert placebo and still allows adequate blinding, at a practical cost (Conclusion). Authors declare no conflicts.
Lansdorp CA, Buskens CJ, Gecse KB, D'Haens GR, Van Hulst RA. Wound healing of metastatic perineal Crohn's disease using hyperbaric oxygen therapy: a case series. United European Gastroenterol J 2020;8(7):820-827.
Lansdorp CA, Buskens CJ, Gecse KB, D'Haens GRAM, van Hulst RA. Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study. BJS Open 2021;5(3):zrab042.
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Baseline WB-CN did not differ between fire and non-fire CO patients (p=0.42). HBO did not significantly change WB-CN (before-vs-after difference similar between groups, p=0.7);
Lawson-Smith P, Jansen EC, Hilsted L, Johnsen AH, Hyldegaard O. Effect of acute and delayed hyperbaric oxygen therapy on cyanide whole blood levels during acute cyanide intoxication. Undersea Hyperb Med 2011;38(1):17-26.
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HBO within 6 h → significantly fewer poor 6-month neurocognitive outcomes than 6–24 h (p=0.027), and Dose-response: poor outcomes rose as the treatment interval lengthened (p=0.008); the early advantage
Lee JS, Cha YS. Application of a new hyperbaric oxygen therapy protocol in patients with arterial and venous gas embolism due to hydrogen peroxide poisoning. Undersea Hyperb Med 2021;48(2):187-193.
Lee CH, Choi JG, Lee JS, Lee Y, Kim H, Kim YS, Cha YS. Seizure during hyperbaric oxygen therapy: experience at a single academic hospital in Korea. Undersea Hyperb Med 2021;48(1).
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Lee JY, Hyun MH, Yang G, Lee S. Efficacy and safety of hyperbaric oxygen therapy for radiation-induced dermatitis in patients with breast cancer: a randomized pilot study. Support Care Cancer 2025;33(5):399.
25/30 completed. Grade ≥2 RID 73.3% in both arms — no difference (p=0.700). No statistically significant differences in any primary or secondary endpoint; non-significant trends toward Authors: no significant reduction in RID; larger trials with optimized HBOT protocols needed.
Lee JH, Lee HY, Sun KH, Heo T, Lee SM. Risk Factors for Middle Ear Barotrauma in Patients with Carbon Monoxide Poisoning Undergoing Monoplace Hyperbaric Oxygen Therapy: A Retrospective Cohort Study. J Clin Med 2025;14(9):2984.
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LeGros TL, Murphy-Lavoie H. Reprinted from the 2023 Hyperbaric Indications Manual 15th Edition: Sudden Sensorineural Hearing Loss. Undersea Hyperb Med 2024;51(4):425-448.
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Leitch DR, Greenbaum LJ Jr, Hallenbeck JM. Cerebral arterial air embolism: I. Is there benefit in beginning HBO treatment at 6 bar? Undersea Biomed Res 1984;11(3):221–235.
Leite MS, Damaceno-Rodrigues NR, Simone MR, Santos AB, Bueno HM, Battlehner CN, et al. Structural alterations in adult rat carotid bodies exposed to hyperbaric oxygenation. Undersea Hyperb Med 2010;37(6):419-32.
Leite CBG, Meirelles D, Morimoto LR, Ormond Filho AG, Cavalheiro CM, Leite MS, D'Elia CO, Demange MK. Effect of Hyperbaric Oxygen Therapy on Early MRI-Based Graft Healing Following ACL Reconstruction With Hamstring Autografts. Orthop J Sports Med 2026;14(2):23259671251413600.
Lentrodt S, Lentrodt J, Kübler N, Mödder U. Hyperbaric oxygen for adjuvant therapy for chronically recurrent mandibular osteomyelitis in childhood and adolescence. J Oral Maxillofac Surg 2007;65(2):186–191.
All 3 patients have been free of any symptoms from 20 to 74 months (mean, 41 months) and "therefore Case 1 — an 11-year-old girl, chronic osteomyelitis on MRI, treated with penicillin G, Case 2 — a 13-year-old boy, the most instructive of the three. He had had the unerupted left
Leonov AN, Barsukov VA. [Changes in tissue respiration, and liver sulfhydryl group and free radical concentration in animals in general anemia and under hyperbaric oxygenation]. Biull Eksp Biol Med 1969;68(12):40-2 (Russian).
Leonov AN, Barsukov VA. [Changes in animal cerebral tissue respiration, sulfhydryl group and free radical concentration during anemia formation and hyperbaric oxygenation]. Patol Fiziol Eksp Ter 1970;14(1):40-3 (Russian).
Leonov AN, Iakovlev VN. [Nitrogen metabolism in the central nervous system in acute anemization and oxygen barotherapy]. Patol Fiziol Eksp Ter 1971;15(2):42-5 (Russian).
Leonov AN, Akulenko ME. [High-energy phosphate compounds in the central nervous system in acute blood loss and in hyperbaric oxygen therapy]. Patol Fiziol Eksp Ter 1973;17(5):50-4 (Russian).
Leonov AN, Iakovlev VN. [Role of cerebral nitrogen metabolism in the mechanisms of the therapeutic action of oxygen under elevated pressure in hemorrhagic shock]. Biull Eksp Biol Med 1977;83(4):418-20 (Russian with English abstract).
Lepawsky M, Growe GH, Salvian AJ, Holland DR. Erythropoietin unimpaired by hyperbaric oxygen in exceptional blood loss anemia [abstract]. Undersea Biomed Res 1991;18(Suppl) (Program and abstracts, UHMS Annual Scientific Meeting, San Diego, 19–23 June 1991).
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No trials met the inclusion criteria — there are no randomised/pseudo-randomised trials of The review therefore could neither support nor refute HBOT for NF; good-quality trials are needed. ⚠️ Full read 21 Oct 2026 (PDF pages 1–11): points the record above had missed.
Levin D, Norman D, Zinman C, Rubinstein L, Sabo E, Misselevich I, Reis D, Boss JH. Treatment of experimental avascular necrosis of the femoral head with hyperbaric oxygen in rats: histological evaluation of the femoral heads during the early phase of the reparative process. Exp Mol Pathol 1999;67(2):99-108.
Levin EG, Ritter A, Bachar G, Mizrachi A, Shoffel-Havakuk H, Kurman N, Popovtzer A, Hamzany Y. Management of laryngeal chondroradionecrosis: a single-center experience. Head Neck 2025;47(1):300-308.
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26 enrolled, 7 withdrew. Spontaneous resolution of gross haematuria (before HBOT): 3/19 (15.8%). Resolution after HBOT: 14/16 (87.5%).
Lewis I, Smart D, Brown B, Baines C. Performance of the Baxter Infusor LV10 under hyperbaric conditions. Diving Hyperb Med 2015;45(1):37-41.
Leys AM, Hans GH, Saldien V, Wildemeersch D. Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes – A Systematic Review. J Pain Res 2026;19:597243 (PMID 41913797 DOI 10.2147/JPR.S597243).
Li KC, Bao XC, Fang YQ, Ma J, Meng M, Chen HT, et al. Different activation of ERK1/2 and p38 with hyperbaric oxygen in dorsal root ganglion. Undersea Hyperb Med 2011;38(2):149-53.
Li Y, Dong H, Chen M, Liu J, Yang L, Chen S, Xiong L. Preconditioning with repeated hyperbaric oxygen induces myocardial and cerebral protection in patients undergoing coronary artery bypass graft surgery: a prospective, randomized, controlled clinical trial. J Cardiothorac Vasc Anesth 2011;25(6):908-16.
Li CQ, Gerson S, Snyder B. Case report: hyperbaric oxygen and MRI findings in radiation-induced optic neuropathy. Undersea Hyperb Med 2014;41(1):59–63.
Li W, Ye Z, Wang W, Wang K, Li L, Zhao D. Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis: A systematic review and meta-analysis. Orthopade 2017;46(5):440–446 (article in English).
Clinical effect strongly favoured HBO: OR 4.95 (95% CI 3.24–7.55, P<0.00001). Held in subgroups: Asian OR 4.77 (3.06–7.44); non-Asian OR 7.07 (1.77–28.27).
Li X, Li J, Yang X, Sun Z, Zhang J, Zhao W, Dong S, Li C, Ye Y, Chen J, Li Y, Xiang Y, Mao J, Li G, Guo H, Zhang W, Guo H, Zhang Y, Zhang M, Zhang W, Xu Z, Zhao B, Wei J, Zhao G, Ma R, Shen X, Ge C, Zheng C, Li S, Wang Y. Hyperbaric-Oxygen Therapy Improves Survival and Functional Outcome of Acute Severe Intracerebral Hemorrhage. Arch Med Res 2017;48(7):638-652.
Li N, Meng X-E, Guo D-Z, Fan D-F, Pan S-Y. Wound healing process and related laboratory indexes in patients with type 2 diabetes mellitus after hyperbaric oxygen intervention. Biomed Res (India) 2017;28(20):9005–9010.
Wound area: significantly smaller in the HBO arm than control at weeks 2–5 of treatment (P<0.05). Markers at 30 days: HBO arm had lower CRP, IL-6, TNF-α, MDA and higher SOD-1, VEGF, Ang-2 than ⚠️ Full read 21 Oct 2026 (pages 2–4):
Li Y, Zhang H, Hao YF, Liang Y, Wei LG, Xu TS, et al. Evaluation of hyperbaric oxygen effects on slow coronary flow patients using gated myocardial perfusion imaging tomography. Undersea Hyperb Med 2018;45(4):403-409.
Li Y, Hao YF, Wang T, Zhang JF, Liang Y, Xiao WL, et al. Hyperbaric oxygen may improve vascular endothelial function in patients undergoing coronary stent implantation. Undersea Hyperb Med 2019;46(2):145-152.
Li H, Bai X, Pan S. Repetitive 1.6 ATA hyperbaric oxygen therapy for bilateral ARCO Stage II steroid-associated osteonecrosis of the femoral head. Undersea Hyperb Med 2020;47(4):625-633.
Li Y, Xu X, Bao J, Wang W. Effects of hyperbaric oxygen pretreatment on brain antioxidant capacity in rats with decompression sickness. Undersea Hyperb Med 2021;48(3):287-295.
Li CX, Sun JL, Gong ZC, Liu H, Ding MC, Zhao HR. An umbrella review exploring the effect of radiotherapy for head and neck cancer patients on the frequency of jaws osteoradionecrosis. Cancer Radiother 2023;27(5):434-446.
Li X, Lu L, Min Y, Fu X, Guo K, Yang W, Li H, Xu H, Guo H, Huang Z. Efficacy and safety of hyperbaric oxygen therapy in acute ischaemic stroke: a systematic review and meta-analysis. BMC Neurol 2024;24(1):55.
Li Y, Sun R, Lai C, Liu K, Yang H, Peng Z, Xu D, Huang F, Tang K, Peng Y, Liu X. Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn's disease. J Transl Med 2024;22(1):518.
Li B, Li H, Chen H, Sui Y, Zeng J, Lin X, et al. Utilizing Hyperbaric Oxygen Therapy to Improve Cognitive Function in Patients With Alzheimer's Disease by Activating Autophagy-Related Signaling Pathways. Physiol Res 2025;74(1):141-147.
Liang XX, Hao YG, Duan XM, Han XL, Cai XX. Hyperbaric oxygen therapy for post-stroke depression: a systematic review and meta-analysis. Clin Neurol Neurosurg 2020;195:105910.
Liberty M, Ginting AR, Darlan DM, Liberty P, Gohtama S. Efficacy and safety of hyperbaric oxygen therapy for women with fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. Reumatologia 2026;64(3):181-191.
Lifson N, Salloum G, Kurochkin P, Bivona M, Yin HY, Alpert S. Treatment outcomes on neovascularization after CRAO treated with hyperbaric oxygen. Undersea Hyperb Med 2021;48(4):425-430.
Lim ML, Kim SJ, Tan MK, Lim KH, See HG. Provision of emergency hyperbaric oxygen treatment for a patient during the COVID-19 pandemic. Diving Hyperb Med 2021;51(1):78-81.
Limberg AK, Giurleo LM, Ruiz V, Anup A, Buckey JC, Faro FD, Van Citters DW, Hixon KR. In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy. J Orthop Res 2026;44(4):e70204.
Lin TF, Chen SB, Niu KC. The vascular effects of hyperbaric oxygen therapy in treatment of early diabetic foot. Undersea Hyperb Med 2001;28(Suppl):abstract Q120.
After 30 sessions, the HBO group showed significantly improved TcPO₂ (57.7 vs 35.8 mmHg, control), Table 1 in full (mean ± SD; control vs HBO): TcPO₂ 39.4 vs 35.9 at baseline, 40.8 vs 49.3 after 15 Recalculated between-group comparisons after 30 sessions [derived] (unpaired t test from mean ± SD, 17 HBO vs 12 control): TcPO₂ p = 0.010, laser-Doppler p < 0.001, HbA1c p = 0.026. The asterisks (p < 0.01) may refer to the within-g…
Lin HY, Ku CH, Liu DW, Chao HL, Lin CS, Jen YM. Hyperbaric oxygen therapy for late radiation-associated tissue necroses: is it safe in patients with locoregionally recurrent and then successfully salvaged head-and-neck cancers? Int J Radiat Oncol Biol Phys 2009;74(4):1077-1082.
Hermann RM, Carl UM. Hyperbaric oxygen therapy for late radiation-associated tissue necroses: is it safe in patients with locoregionally recurrent and then successfully salvaged head-and-neck cancers? (Int J Radiat Oncol Biol Phys 2009;74:1077-1082). Int J Radiat Oncol Biol Phys 2010;76(5):1600 (Letter to the Editor; author reply on the same page).
Lin CH, Su WH, Chen YC, Feng PH, Shen WC, Ong JR, Wu MY, Wong CS. Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: a systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore) 2018;97(39):e12456 (PMID 30278526. DOI 10.1097/MD.0000000000012456).
Lin LJ, Alfonso AR, Ross FL, Chiu ES, Fleisher KE. Management of stage 0 medication-related osteonecrosis of the jaw with hyperbaric oxygen therapy: a case report and review of the literature. Undersea Hyperb Med 2020;47(2):241-251.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 2023;8(8):CD005005.
Cochrane systematic review / meta-analysis of RCTs of HBOT vs no HBOT for treating or preventing late radiation tissue injury (LRTI). Eighteen studies, 1071 participants (publications 1985–2022) — four new studies added, with new evidence for radiation proctitis, radiation cystitis, and prevention & treatment of osteoradionecrosis (ORN). GRADE used for certainty.
Lin CY, Chang CH, Chang CJ, Ko JY, Wu SY, Kuo PH. Salvage therapy for refractory sudden sensorineural hearing loss (RSSNHL): a systematic review and network meta-analysis. Int J Audiol 2025;64(1):1-10 (epub 22 Jan 2024).
Lin N, Yu E, Lussier A, Gouin E, Lindholm P. Use of in-water recompression for decompression illness after deep freediving: a case series. Diving Hyperb Med 2025;55(4):376-383.
Lin X, Wang L, Wu M, Chen Q, Li B, Niu S, Zhu L. Effectiveness of hyperbaric oxygenation therapy in post-stroke dysphagia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials. Eur J Med Res 2026;31:1374 (open access, CC BY-NC-ND 4.0; received 2 Jan 2026, accepted 8 Jul 2026).
A PROSPERO-registered (CRD420251059307) systematic review restricted to RCTs in which the experimental arm received the control arm's dysphagia rehabilitation plus HBOT, so that the arms differed only by HBOT (p.3). Trials combining HBOT with more than one experimental intervention were excluded (p.3). Nine databases including three Chinese ones were searched to 1 May 2026 with no language restric
Lin YX, Li D, Huang Z, Huang N, Shi SM, Xu F, Wu SZ, Chen L, Huang C. A randomized controlled trial of mild hyperbaric oxygen therapy on cognitive performance and sleep quality in healthy young adults at high altitude: Exploratory functional near-infrared spectroscopy study. Travel Med Infect Dis 2026;73:103008.
Lind F. A pro/con review comparing the use of mono- and multiplace hyperbaric chambers for critical care. Diving Hyperb Med 2015;45(1):56-60.
Lindblom U, Tosterud C. Pulmonary barotrauma with cerebral arterial gas embolism from a depth of 0.75−1.2 metres of fresh water or less: A case report. Diving Hyperb Med 2021;51(2):224-226.
Lindenmann J, Matzi V, Neuboeck N, Ratzenhofer-Komenda B, Maier A, Smolle-Juettner FM. Severe hydrogen sulphide poisoning treated with 4-dimethylaminophenol and hyperbaric oxygen. Diving Hyperb Med 2010;40(4):213-7.
Lindenmann J, Fink-Neuboeck N, Schilcher G, Smolle-Juettner FM. Severe methaemoglobinaemia treated with adjunctive hyperbaric oxygenation. Diving Hyperb Med 2015;45(2):132-4.
Lindenmann J, Smolle C, Kamolz LP, Smolle-Juettner FM, Graier WF. Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair. Int J Mol Sci 2021;22(21):11754.
Lindfors OH, Räisänen-Sokolowski AK, Hirvonen TP, Sinkkonen ST. Inner ear barotrauma and inner ear decompression sickness: a systematic review on differential diagnostics. Diving and Hyperbaric Medicine 2021;51(4):328-337.
Lindfors OH, Lundell RV, Arola OJ, Hirvonen TP, Sinkkonen ST, Räisänen-Sokolowski AK. Inner ear decompression sickness in Finland: a retrospective 20-year multicenter study. Undersea and Hyperbaric Medicine 2021;48(4):399-408.
Linman JW, Pierre RV. Studies on the erythropoietic effects of hyperbaric hyperoxia. Ann N Y Acad Sci 1968;149(1):25-33.
Liow MH, Ho BH, Kim SJ, Soh CR, Tang KC. MRI findings in cervical spinal cord type II neurological decompression sickness: a case report. Undersea Hyperb Med 2014;41(6):599-603.
Lippmann J, Fock A, Arulanandam S. Cerebral arterial gas embolism with delayed treatment and a fatal outcome in a 14-year-old diver. Diving Hyperb Med 2011;41(1):31-34.
Lippmann J, Millar I. Severe carbon monoxide poisonings in scuba divers: Asia-Pacific cases and causation. Undersea Hyperb Med 2022;49(3):341-353.
Mathew B, Laden G. Carbon monoxide poisoning: lest we forget. Diving Hyperb Med 2023;53(3):292.
Lipski A, Koszela K, Pingot J, Słupiński M, Irzmański R, Woldańska-Okońska M. The Impact of Selected Physical Factors on Neurogenesis—What Do We Know? Cells 2026;15(21):1917.
A narrative review from rehabilitation and physical-medicine departments in Łódź and Warsaw covering exercise, magnetic stimulation, electrical stimulation (tDCS and others), ultrasound, intermittent hypoxia, HBOT, whole-body cryotherapy, light therapy and massage (§2.1–2.9, Tables 1–2). It states that it "uses the wording originally used in the source articles" (abstract) and that the most releva
Lipsky BA, Berendt AR. Hyperbaric oxygen therapy for diabetic foot wounds: has hope hurdled hype? Diabetes Care 2010;33(5):1143-1145.
Liu W, Zhang J, Ma C, Liu Y, Li R, Sun X, et al. Dual effects of hyperbaric oxygen on proliferation and cytotoxic T lymphocyte activity of rat splenic lymphocytes. Undersea Hyperb Med 2009;36(3):155-60.
Liu WW, Liu K, Mao D, Xu WG, Tao HY. Claustrophobia during routine hyperbaric oxygen treatment. Undersea Hyperb Med 2012;39(1):619-620.
Liu W, Wang D, Chen H, Liu K, Sun X, Tao H. Current status of decompression illness in China: analysis of studies from 2001-2011. Undersea Hyperb Med 2013;40(1):41-48.
Liu M, Wu X, Tong M. Effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection. Undersea Hyperb Med 2013;40(1):15-22.
Liu R, Li L, Yang M, Boden G, Yang G. Systematic Review of the Effectiveness of Hyperbaric Oxygenation Therapy in the Management of Chronic Diabetic Foot Ulcers. Mayo Clin Proc 2013;88(2):166–175.
13 controlled trials, 624 patients (7 randomised), 1966–2012. Adjunctive HBO vs no-HBO: healed ulcers RR 2.33 (95% CI 1.51–3.60); major amputation RR 0.29 (0.19–0.44); minor amputation not significantly affected (P=.30). Adverse events rare and reversible, not more frequent than without HBO (P=.37). Conclusion: HBO improved healing and reduced major-amputation risk in chronic DFU.
Liu WW, Liu K, Tao HY, Sun XJ. Detection of exhaled nitric oxide in hyperoxia exposure. Undersea Hyperb Med 2013;40(1):109-11.
Liu W, Liu K, Ma C, Yu J, Peng Z, Huang G, et al. Protective effect of hydrogen sulfide on hyperbaric hyperoxia-induced lung injury in a rat model. Undersea Hyperb Med 2014;41(6):573-8.
Liu WW, Xian LF, Tang GM, Cai ZY, Zheng J, Xu WG. A normobaric gas exposure animal chamber and its validation in hyperoxia exposure. Undersea Hyperb Med 2015;42(5):383-8.
Liu Y, Mao YF, Zheng J, Liu K, Han CH, Liu WW. Roles of transforming growth factor β in hyperoxia-induced lung injury. Undersea Hyperb Med 2016;43(3):225-31.
Liu Y, Zhang PX, Han CH, Wei D, Qiao T, Peng B, et al. Oridonin protects the lung against hyperoxia-induced injury in a mouse model. Undersea Hyperb Med 2017;44(1):33-38.
Liu Y. Adjuvant hyperbaric oxygen treatment of acute brain herniation after microsurgical clipping of a recurring cerebral aneurysm: a case report. Diving Hyperb Med 2021;51(4):373-375.
Liu Z, Wang X, Wu Z, Yin G, Chu H, Zhao P. HBOT has a better cognitive outcome than NBH for patients with mild traumatic brain injury: a randomized controlled clinical trial. Medicine (Baltimore) 2023;102(37):e35215.
Liu A, Hou X, Nie J, Wen Q, Pan Z. Decompression sickness followed by diabetic ketoacidosis and sepsis shock: an unusual case report. Undersea Hyperb Med 2024;51(1):41-46.
Liu X, Xu X, Lei Q, Jin X, Deng X, Xie H. Efficacy of hyperbaric oxygen therapy in treating sudden sensorineural hearing loss: an umbrella review. Front Neurol 2024;15:1453055.
Aggregates the existing SSNHL systematic reviews rather than primary trials; concludes HBO has a Mechanistic rationale: HBO raises cochlear oxygenation and promotes tissue repair.
Liu B, Wang J, Liu L, Lv M, Zhou D, Li M. Hyperbaric oxygen therapy for male infertility: a systematic review and meta-analysis on improving sperm quality and fertility outcomes. Med Gas Res 2025;15(4):529-534.
Liu K, Wang L, Liang L, Wei J. Complication of hyperbaric oxygen therapy. JACEP Open 2026;7(6):100529.
Liu Y, Yang C, Song Y, Sun Y, Wang H, Zhang Y, Tang H, Li Y. Survival rate and risk factors of implants in patients with head and neck neoplasms: a systematic review and meta-analysis. BMC Oral Health 2026;26:1266.
Irradiated bone: lower survival vs non-irradiated (18 studies, RR 0.95). HBO: significantly higher implant survival with HBO vs without (5 studies). Grafted bone also had lower survival (RR 0.92).
Liu D, Li T, Chu Q, Zhu J, Xia DD, Li X, Wang C, Xia Z. Oxygen physiology and mechanisms of oxygen toxicity: a narrative review. Med Gas Res 2026;16:473-482.
Liu J, Han T, Yan C, Ma Q, Yuan L, Ge S, Xu X, Liu X. Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition and functional independence post-stroke: a randomized controlled trial. J Neuroeng Rehabil 2026;23:192 (DOI 10.1186/s12984-026-01992-x).
Livingstone DM, Smith KA, Lange B. Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post-operative care. Diving Hyperb Med 2017;47(2):97-109.
Lo K, Katz D, Chan V, Miler I. Successful delayed treatment of acute glans penis ischaemia after adult circumcision: a case report. Diving Hyperb Med 2023;53(2):151-154.
Łodygowski O, Antoń B, Kozakiewicz M, Trybek G, Wach T. Medication-related osteonecrosis of the jaw: Current concepts in epidemiology, pathophysiology, diagnosis, and management. Wiad Lek 2026;79(8):1952-1959.
Löndahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients With Diabetes. Diabetes Care 2010;33(5):998–1003.
Complete healing of the index ulcer at 1 year: 52% (HBOT) vs 29% (placebo), p=0.03 (ITT). Per-protocol (>35 sessions completed): 61% vs 27%, p=0.009. Adverse-event frequency low.
Löndahl M, Fagher K, Katzman P. What is the role of hyperbaric oxygen in the management of diabetic foot disease? Curr Diab Rep 2011;11(4):285–293.
Historic HBO use rested on "weak scientific ground" (few, small studies), but the consistency of Two well-designed randomised double-blind placebo-controlled trials have since put HBO on firmer TcPO₂ (transcutaneous oxygen) shows promise for predicting who will benefit — the reconciling
Löndahl M. Hyperbaric oxygen therapy as adjunctive treatment for diabetic foot ulcers. Int J Low Extrem Wounds 2013;12(2):152-157.
Löndahl M, Boulton AJM. Hyperbaric oxygen therapy in diabetic foot ulceration: useless or useful? A battle. Diabetes Metab Res Rev 2020;36(Suppl 1):e3233.
Long B, Koyfman A. Emergency Medicine Evaluation and Management of Anemia. Emerg Med Clin North Am 2018;36(3):609-630.
Longobardi P, Hoxha K, Bennett MH. Is there a role for hyperbaric oxygen therapy in the treatment of refractory wounds of rare etiology? Diving Hyperb Med 2019;49(3):216–224.
Longobardi P, Hartwig V, Santarella L, Hoxha K, Campos J, Laurino M, Salvo P, Trivella MG, Coceani F, Rocco M, et al. Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment. Wound Repair Regen 2020;28(6):856–866.
Design: RCT, 81 patients with hard-to-heal venous leg ulcers (73 completed; 511 NIRS images), 3 arms — A = 30 HBO sessions twice daily over 3 weeks + conventional; B = 30 HBO once daily over 6 weeks + conventional; C = conventional therapy only. HBO adjunctive. Healing — read the comparisons, not the ordering. At the 6-week endpoint the paper's Results 3.3 report median ΔArea: A 25.14 (14.85–48.27), B 61.60 (44.31–95.26), C 52…
Longphre JM, Denoble PJ, Moon RE, Vann RD, Freiberger JJ. First aid normobaric oxygen for the treatment of recreational diving injuries. Undersea Hyperb Med 2007;34(1):43-9.
Lopes A, Costa RLR, Pinto GLS, Forghieri MCG, Larrè A, de Almeida TG, de Souza CB, Sartorelli V, Coelho FRG, Branco JR. Hyperbaric oxygen therapy as adjuvant for treating wound complications after extensive resection for vulvar malignancy. Undersea Hyperb Med 2018;45(1):27–32.
Lopes JRA, Dias MD, Correa JA, Batalha MAB, et al. Randomized controlled clinical trial evaluating the efficacy of hyperbaric oxygen therapy in facilitating the healing of chronic foot ulcers in diabetic patients: the study protocol. Trials 2020;21:816.
None — protocol only. Outcomes will appear in the eventual results publication.
Lopez AE, Rodriguez S, Flores I. Management of ischemic hemorrhagic cystitis with hyperbaric oxygen therapy. Undersea Hyperb Med 2001;28(1):35–36.
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Louge P, Gempp E, Hugon M. MRI features of spinal cord decompression sickness presenting as a Brown-Sequard syndrome. Diving Hyperb Med 2012;42(2):88-91.
Louge P, Pignel R, Serratrice J, Stirnemann J. Validation of sham treatment in hyperbaric medicine: a randomised trial. Diving Hyperb Med 2023;53(1):51–54.
60 volunteers compressed to 1.1, 1.3 or 1.5 atm abs; then 25 more with added blinding (faster compression with 1.1 atm abs was distinguishable; 1.3 and 1.5 atm abs were not different from each other. A compression to
Lu LQ, Strauss MB, Miller SS. The Gradient Perfusion Model Part 3: An extraordinary case of decompression sickness. Undersea and Hyperbaric Medicine 2018;45(3):307-311.
Lu L, Zhao L, Xie Y, Wang L, Ji Y, Luo X, Zhang C. Research hotspots and trends of hyperbaric oxygen therapy in stroke: bibliometrics and visual analysis. Med Gas Res 2026;16(3):380-388.
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Luhulla K, Martin Q, Bhoke A, Mahfudh S, Nkya A, Magohe A, et al. Case Report: Complete Coverage Of Chronic Sickle Cell Leg Ulcer Using Hyperbaric Oxygen Therapy Combined With Skin Grafting. Undersea Hyperb Med 2025;52(4):571-575.
Lun CY, Au Yeung KL, Lau YF, Yan WW, Tang KB. Treatment success in relation to timing of hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss. Diving Hyperb Med 2026;56(1):41-47.
Lundell RV, Arola O, Suvilehto J, Kuokkanen J, Valtonen M, Räisänen-Sokolowski AK. Decompression illness (DCI) in Finland 1999–2018: Special emphasis on technical diving. Diving and Hyperbaric Medicine 2019;49(4):259-265.
Luo X, Yu Y, Zhang S, Qi F. Effects of Hyperbaric Oxygen Therapy on Exercise-Induced Muscle Injury and Soreness: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil 2025;107(3):522-532.
Lv R, Zheng J, Ye Z, Sun X, Tao H, Liu K, et al. Advances in the therapy of hyperoxia-induced lung injury: findings from animal models. Undersea Hyperb Med 2014;41(3):183-202.
Lv Y, Zhang Y, Pan S. Brain stem and spinal cord demyelination due to acute carbon monoxide poisoning. Undersea Hyperb Med 2021;48(3):247-253.
Lyman R. Hyperbaric oxygen therapy in veterinary medicine--Challenges in safety, training and usage: An editorial perspective. Undersea Hyperb Med 2015;42(1):7-8.
Ma L, Li P, Shi Z, Hou T, Chen X, Du J. A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer. Ostomy Wound Manage 2013;59(3):18–24.
Design: prospective randomised controlled pilot, n=36 (18 HBO + standard care vs 18 standard care only), DFU Wagner ≤III, TcPO₂ >30 mmHg at dorsum (severe arteriopathy excluded); HBO 2.5 ATA, 90 min twice daily, 5 d/wk × 2 weeks (20 sessions). No sham (control = standard care only). Healing (surrogate): day-14 ulcer-area reduction 42.4% ± 20.0% (HBO) vs 18.1% ± 6.5% (control), P<0.05; no ulcer fully healed in either arm within…
Ma J, Fang YQ, Gu AM, Wang FF, Zhang S, Li KC. P38 activation is more important than ERK activation in lung injury induced by prolonged hyperbaric oxygen. Undersea Hyperb Med 2013;40(4):313-8.
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Macdonald HM. Hyperbaric oxygenation in the patient with malignancy: friend or foe? Diving Hyperb Med 2007;37(3):133-138.
MacFarlane C, Cronje FJ, Benn CA. Hyperbaric oxygen in trauma and surgical emergencies. J R Army Med Corps 2000;146(3):185–190.
Machado GF, Mokhtar J, Romão VT, Queiroz Ferreira MF, Perin JPS, Kreutz-Rodrigues L, Servidoni ACP, Miranda MM. Hyperbaric Oxygen Therapy for Ischemic Complications and Salvage Following Breast Reconstruction: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg 2026;50(15):6244-6256.
MacInnes L, Baines C, Bishop A, Ford K. Patient knowledge and experience of hyperbaric oxygen treatment. Diving Hyperb Med 2021;51(1):72-77.
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Mago V. Hyperbaric Medicine: Recent Advances and Clinical Scenarios. Singapore: Springer Nature Singapore 2025:preview pp 1–19 held.
Magri K, Bigeni S, Azzopardi CP, Camilleri L, Matity L, Muscat S, et al. Hyperbaric oxygen therapy awareness within a doctor population. Undersea Hyperb Med 2020;47(1):39-50.
Magri Gatt P, Diacono E, Matity L, Magri K. Atypical distally distributed cutis marmorata decompression sickness associated with unconventional use of thermal protection in a diver with persistent foramen ovale. Diving and Hyperbaric Medicine Journal 2023;53(3):285-289 (DOI 10.28920/dhm53.3.285-289).
Cronin WA, Khan K, Hall AA, Bodo M, Mahon RT. The effect of the perfluorocarbon emulsion Oxycyte in an ovine model of severe decompression illness. Undersea Hyperb Med 2021;48(1):25-31.
Maier S, Eckmann C. [Fournier's gangrene as special form of necrotizing fasciitis]. Chirurg 2020;91(4):307-312 (German. PMID 31965200. DOI 10.1007/s00104-019-01095-5).
Maken K, Bland DK. Hyperbaric oxygen for refractory hemorrhagic cystitis after stem cell transplantation: case report. Undersea Hyperb Med 2020;47(1):125-129.
Malazai AJ, Worku DG, McGee J, Van Meter K, Slakey DP. The history of hyperbaric oxygen therapy and kidney transplant surgery. Undersea Hyperb Med 2011;38(4):247-55.
Malda J, Dawson RA, Kairuz E, Topping G, Long R, Upton Z. In vitro models for evaluation of hyperbaric oxygen therapy in wound healing: a review. Diving Hyperb Med 2007;37(1):25–30.
Malerbi FK, Novais EA, Emmerson Badaró, Bonomo PP, Pereira AJ, Lottenberg CL, et al. Hyperbaric oxygen therapy for choroidal neovascularization: a pilot study. Undersea Hyperb Med 2015;42(2):125-31.
Mallam L, Watts D. Recompression of a diver with decompression illness found to be COVID-19 positive. Diving Hyperb Med 2022;52(3):223-224.
Mandour C, Gazzaz M, El Mostarchid B. Hyperbaric oxygen therapy in the treatment of brain abscess: about a case. Rom Neurosurg 2018;32(1):125-128.
Manheim M, Mogilevsky L, Geva A, Knoll O, Zehavi G, Gur I. Effects of hyperbaric oxygen therapy initiation latency on auditory outcomes following acute acoustic trauma. Diving Hyperb Med 2025;55(2):126-135 (PMID 40544140. DOI 10.28920/dhm55.2.126-135).
Manojlovic D, Stupin A, Mihaljevic Z, Matic A, Lenasi H, Drenjancevic I. Hyperbaric oxygenation affects acetylcholine-induced relaxation in female diabetic rats. Undersea Hyperb Med 2019;46(5):635-646.
Marchioni M, De Francesco P, Campi R, Carbonara U, Ferro M, Schips L, et al. Current management of radiation cystitis after pelvic radiotherapy: a systematic review. Minerva Urol Nephrol 2022;74(3):281–291.
Systematic review of radiation-cystitis treatments (HBO, formalin, aluminium, oral agents, laser, cystectomy). HBO complete-response ~52–87% across series — among the most effective non-invasive modalities. Radiation cystitis is under-reported; a stepwise approach with escalating aggressiveness is recommended, and ~10% ultimately need salvage cystectomy. ⚠️ Full read 21 Oct 2026 (all 11 pages): AMSTAR-2 stays critically low, b…
Marcinkowska AB, Mankowska ND, Kot J, Winklewski PJ. Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review. Neuropsychology Review 2022;32(1):99–126.
Controversial / mixed results on HBOT efficacy for cognitive disturbance across conditions (CO poisoning, Marked heterogeneity of conditions, protocols and neuropsychological instruments; authors call for
Mardanpour MM, Perumal AS, LeDez KM, Nicolau DV. Assessing the effectiveness of surfactants on the treatment of gas embolism in microfluidic networks mimicking microvasculature. J Colloid Interface Sci 2027;728:141730 (online 1 Oct 2026; volume dated 2027).
Margolis DJ, Gupta J, Hoffstad O, Papadopoulos M, Glick HA, Thom SR, Mitra N. Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation. Diabetes Care 2013;36(7):1961–1966.
Patients receiving HBO were less likely to heal (HR 0.68, 95% CI 0.63–0.73) and more likely to be After propensity-score and instrumental-variable analyses to address that selection, HBO neither
Mariani PJ, Cooney N. Air embolism's new scarlet letter. Undersea Hyperb Med 2009;36(6):407-8.
Marinides Z, Virgilio GVR. Recurrent facial nerve baroparesis in a military diver: a case report. Undersea Hyperb Med 2019;46(1):87-90.
Maritschnegg P, Sovinz P, Lackner H, Benesch M, Nebl A, Schwinger W, Walochnik J, Urban C. Granulomatous amebic encephalitis in a child with acute lymphoblastic leukemia successfully treated with multimodal antimicrobial therapy and hyperbaric oxygen. J Clin Microbiol 2011;49(1):446-8.
Marjot J, Mackenzie J, Jepson N, Reeves E, Bennett M. Investigation into the effect of hyperbaric hyperoxia on serum cardiac Troponin T levels as a biomarker of cardiac injury. Diving Hyperb Med 2023;53(3):281-284.
Marklund SL. Oxygen toxicity and protective systems. Clinical Toxicology 1985;23(4-6):289-298.
Markovitz GH. Two cases of Bacillus Calmette-Guérin cystitis treated with hyperbaric oxygen. Undersea Hyperb Med 2022;49(2):191-195.
Marmo M, Sacerdoti C, Di Minno RM, Guarino I, Villani R, Di lorio C. Anaphylactic shock during hyperbaric oxygen therapy. Undersea Hyperb Med 2012;39(1):613-6.
Marmo M, Villani R, Di Minno RM, Noschese G, Paganini M, Quartesan S, et al. Cave canem: HBO₂ therapy efficacy on Capnocytophaga canimorsus infections: a case series. Undersea Hyperb Med 2017;44(2):179-186.
Marois P, Vanasse M. HBO2 and cerebral palsy in children. Undersea Hyperb Med 2007;34(1):4-6; author reply 6.
Marshall GT, Thirlby RC, Bredfeldt JE, Hampson NB. Treatment of gastrointestinal radiation injury with hyperbaric oxygen. Undersea Hyperb Med 2007;34(1):35-42.
Martin R, Srivastava T, Lee J, Raj N, Koth KA, Whelan HT. Using hyperbaric oxygen for autism treatment: A review and discussion of literature. Undersea Hyperb Med 2015;42(4):353-9.
Martín Pérez SE, Iboleón Laynez E, Acevedo Rodríguez JA, Maggioni Torres MI, Pérez Betancort R, Díaz Rodríguez A, Cabezos Alonso D, García Camacho C, Martín Pérez IM. Effectiveness of Hyperbaric Oxygen Therapy for Musculoskeletal Pain Syndromes: A Systematic Review. Muscles 2025;4(4):63.
Martins-Mendes D, Costa R, Rodrigues I, Camacho Ó, Coelho PB, Paixão-Dias V, Luís C, Pereira AC, Fernandes R, Lima J, Soares R. Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers. Cells 2025;14(15):1196.
A small prospective comparison from Porto, Portugal, that tries to do three things at once: compare clinical outcomes of adjunctive HBOT against standard care alone in diabetic foot ulcers that had failed eight weeks of optimised care; track systemic inflammatory, angiogenic (VEGF, PlGF) and vasculogenic (SDF1-α) markers over three months; and count CD31-positive microvessels in debrided ulcer-bed
Marton J, Ciocan RA, Bâldea I, Gherman ML, Gheban D, Filip A, et al. Molecular Mechanisms, Dynamic Lesions, and Therapeutic Targets in Intestinal Ischemia-Reperfusion Injury: A Systematic Review. Int J Mol Sci 2026;27(4).
Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 1983;41(5):283-8.
A consecutive case series with pathology, from the Department of Oral and Maxillofacial Surgery, Wilford Hall USAF Medical Center, San Antonio, Texas. - 26 consecutive cases of osteoradionecrosis of the mandible. - Case-selection criterion, stated: an area greater than 1 cm of exposed bone in a field of irradiation that had failed to show any evidence of healing for at least six months. - Case his
Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg 1983;41(6):351-7.
A single-arm consecutive case series from the Department of Oral and Maxillofacial Surgery, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas — the same department as the pathophysiology paper. The author is identified as Lieutenant Colonel, USAF, DC; Assistant Chairman of the department and Director of Dental Research. - 58 patients referred to Wilford Hall with a diagnosis of "ref
Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc 1985;111(1):49–54.
74 patients (37 per arm) requiring tooth extraction in mandible irradiated to ≥6,000 rad. ORN incidence: 2/37 = 5.4% (HBO) vs 11/37 = 29.7% (penicillin — the paper itself prints 29.9%, in Table 1 and in the Discussion), P=0.005. (Reconciled 31 Aug 2026: this line read "29.9%" while this page's own CAT section uses 29.7%; 11/37 is 29.7%. Both figures are now shown so the two halves of the page agree.) Protocol (confirmed from f…
Marx RE, Ehler WJ, Tayapongsak P, Pierce LW. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg 1990;160(5):519-24.
A three-arm controlled laboratory experiment from the Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine / Jackson Memorial Medical Center, with the Hyperbaric Medicine Division, Clinical Investigative Directorate, Wilford Hall U.S.A.F. Medical Center. The stated purpose: to quantitate the angiogenesis induced in irradiated tissue by hyperbaric oxygen at 2.4 ATA for
Marx RE, Feldmeier JJ, Johnson RP. Hyperbaric oxygen is still needed in the management and prevention of mandibular necrosis: a response to Mr. Richard Clarke. Undersea Hyperb Med 2019;46(4):399-408.
Marzella L, Yin A, Darlington D, et al. Hemodynamic responses to hyperbaric oxygen administration in a rat model of hemorrhagic shock [abstract]. Circ Shock 1992;37:12.
Marzella L, Yin A, Darlington DN, Gann DS, Myers RAM. Organ blood flows and central hemodynamics in rats with hemorrhagic shock during hyperbaric oxygen exposure [abstract 145]. Undersea Biomed Res 1992;19(Suppl) (UHMS ASM 1992).
Mason JS, Buzzacott P, Gawthrope IC, Banham ND. A retrospective review of divers treated for inner ear decompression sickness at Fiona Stanley Hospital hyperbaric medicine unit 2014-2020. Diving Hyperb Med 2023;53(3):243-250 (DOI 10.28920/dhm53.3.243-250).
Mason JS, Wilmshurst P, Gawthrope IC, Banham ND. Severe neurological decompression sickness associated with right ventricular dilatation and a persistent foramen ovale. Diving and Hyperbaric Medicine 2025;55(1):59-64.
Massey PR, Sakran JV, Mills AM, Sarani B, Aufhauser DD Jr, Sims CA, Pascual JL, Kelz RR, Holena DN. Hyperbaric oxygen therapy in necrotizing soft tissue infections. Journal of Surgical Research 2012;177(1):146-151.
Masters T, Samson M, Tucci J, Lacey AM, Rogers C, Coward A, Punjab GV, Nygaard RM. The role of hyperbaric oxygen therapy for severe frostbite injury: insights from a retrospective cohort at a high volume burn center. Undersea Hyperb Med 2025;52(2):149-156.
Masterson JS, Fratkin LB, Osler TR, Trapp WG. Treatment of pneumatosis cystoides intestinalis with hyperbaric oxygen. Ann Surg 1978;187(3):245-247.
A report of two cases (⚠️ this record said "one patient" until 5 September 2026 — the local scan holds only pages 245 and 247, and the second case is on page 246; see "Page 246" below). The authors describe treating pneumatosis cystoides intestinalis — gas-filled cysts in the bowel wall — with hyperbaric oxygen, and discuss the pathophysiology, the aetiology, previous treatment reports, and why th
Mathew B, Laden G. Management of severe spinal cord injury following hyperbaric exposure. Diving Hyperb Med 2015;45(3):210.
Mathieu D, editor. Handbook on Hyperbaric Medicine. Dordrecht: Springer 2006:797 pp (PDF; 812 printed pages incl. index).
Mathieu D. Contraindications to hyperbaric oxygen therapy. In: Physiology and Medicine of Hyperbaric Oxygen Therapy. Elsevier/Saunders. Chapter 26 2008:587-598.
Mathieu D, Ratzenhofer-Komenda B, Kot J. Hyperbaric oxygen therapy for intensive care patients: position statement by the European Committee for Hyperbaric Medicine. Diving Hyperb Med 2015;45(1):42-6.
Mathieu D, Marroni A, Kot J. Tenth European Consensus Conference on Hyperbaric Medicine: preliminary report. Diving Hyperb Med 2016;46(2):122–123.
No Type 1A indications were identified — the authors note that much clinical research is still Table 1 is the same accepted / "not-indicated" list that appears, expanded with an agreement-level
Mathieu D, Marroni A, Kot J. Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med 2017;47(1):24–32.
The ECHM (European Committee for Hyperbaric Medicine) consensus on accepted/non-accepted HBOT indications, from the 10th European Consensus Conference (April 2016). Uses a modified GRADE system for evidence + DELPHI for consensus. The European counterpart to the UHMS Indications Manual. Authority tier — international society guidance (tier 4). Like UHMS, ECHM does not override SAUHMA 2023 (tier 2)
Mathieu D, Marroni A, Kot J. ECHM Consensus Conference and levels of evidence - Reply. Diving Hyperb Med 2017;47(2):134.
Matić P, Radak Đ, et al. Results of simultaneous application of hyperbaric oxygen and negative pressure wound therapy in diabetic foot ulcers treatment. Int J Diabetes Dev Ctries 2019;39.
60 patients (56.7% men, mean age 60.6y); ulcers ischaemic 45%, neuropathic 30%, combined 25%. Only 3 minor amputations (5%) over the study. Authors conclude simultaneous HBO+NPWT gives the best healing ⚠️ Full read 21 Oct 2026 (all 5 pages): the headline comparison does not use a valid test and gives no per-arm figures.
Matity L, Burman F, Kot J, Caruana J. Effectiveness of hyperbaric chamber ventilation. Diving and Hyperbaric Medicine Journal 2023;53(2):85-91 (DOI 10.28920/dhm53.2.85-91).
Mátity L, Burman F, Cronje F. Optimizing the hyperbaric chamber pressurization profile during standard hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(4):377-385 (DOI 10.22462/715).
Matsuda T. [Experimental study on hyperbaric oxygenation. 2. Effect of hyperbaric oxygenation on hemorrhagic shock]. Masui 1969;18(8):701-14 (Japanese).
Matveev DV, Kosheleva IV, Kuznetsov MR, Sorokina TV, Matveeva ED. Application of hyperbaric oxygen therapy in aesthetic surgery and cosmetology: current state of the issue, clinical outcomes, and prospects. Dela Press Book Series: Medical Sciences 2025;002:4 pp.
Maurer D. Hyperbare Oxygenation bei Wundheilungsstörungen: Therapeutisch nutzbare Effekte bei chronischen Wunden und klinische Datenlage. Wiesbaden: Springer Fachmedien (essentials) 2016:X + 44 pp.
Maurer D. Hyperbare Oxygenation in der Infektiologie: Wirkmechanismen bei Infektionen und klinische Datenlage. Wiesbaden: Springer Fachmedien (essentials) 2016:IX + 45 pp.
Mayevsky A. Hyperbaric Oxygenation: Mitochondrial Activity and Brain Physiological Functions. Cham: Springer Nature Switzerland 2023:xiii + 357 pp.
Mazokopakis EE, Kofteridis DP, Pateromihelaki AT, Vytiniotis SD, Karastergiou PG. Improvement of ulcerative pyoderma gangrenosum with hyperbaric oxygen therapy. Dermatol Ther 2011;24(1):134-136.
McCabe JB, McGinn Merritt W, Olsson D, Wright V, Camporesi EM. Emphysematous cystitis: rapid resolution of symptoms with hyperbaric treatment: a case report. Undersea Hyperb Med 2004;31(3):281-284.
McCool D, Butler C, Evans J, Aase C. A case report of cerebral arterial gas embolism (CAGE) associated with Takotsubo cardiomyopathy. Diving Hyperb Med 2019;49(3):229-232.
McCormick J, Houle T, Saltzman H, Whaley R, Roy R. Treatment of acute stroke with hyperbaric oxygen: time window for efficacy. Undersea Hyperb Med 2011;38(5):321-334.
McCrary BF, Weaver L, Marrs K, Miller RS, Dicks C, Deru K, et al. Hyperbaric oxygen (HBO2) for post-concussive syndrome/chronic TBI--product summary. Undersea Hyperb Med 2013;40(5):443-67.
McCray P, Johnson-Arbor K. Dermatologic medical ozone therapy complications treated with hyperbaric oxygen. Undersea Hyperb Med 2025;52(4):515-519.
McCurdy J, Siw KCK, Kandel R, Larrigan S, Rosenfeld G, Boet S. The Effectiveness and Safety of Hyperbaric Oxygen Therapy in Various Phenotypes of Inflammatory Bowel Disease: Systematic Review With Meta-analysis. Inflamm Bowel Dis 2022;28(4):611-621.
McDermott JJ, Dutka AJ, Evans DE, Flynn ET. Treatment of experimental cerebral air embolism with lidocaine and hyperbaric oxygen. Undersea Biomed Res 1990;17(6):525–534.
McEvoy MT, Shander A. Anemia, bleeding, and blood transfusion in the intensive care unit: causes, risks, costs, and new strategies. Am J Crit Care 2013;22(6 Suppl):eS1-13; quiz eS14.
McGeoch G. Two divers with acute vertigo and loss of balance. Diving Hyperb Med 2007;37(1):40-41.
McGeoch G, Davis FM. Analysis of a complex recreational scuba diving accident: French Pass, New Zealand, 2000. Diving Hyperb Med 2009;39(1):20-8.
McGlynn J, Heyboer M. Successful treatment of radiation-induced vaginal soft tissue radionecrosis with HBO2. Undersea Hyperb Med 2023;50(1):9-15.
McGrath BJ, Zimmerman JE, Williams JF, Parmet J. Carbon dioxide embolism treated with hyperbaric oxygen. Can J Anaesth 1989;36(5):586-589.
McGrath T, Hamilton R. Hyperbaric oxygen in the treatment of venomous snake bites. Undersea Hyperb Med 2010;37(6):393-4.
McHugh TP, Clarke D; Cronje FJ, editor. Hyperbaric Medicine: An Introduction. Pretoria: Eugene Marais HBO Therapy Center (unit manual; no imprint) 1996:85 pp (PDF).
McIlroy D, Banham N. Comparison of venous glucose to finger-prick glucose in patients with diabetes under hyperbaric hyperoxic conditions: a pilot study. Diving Hyperb Med 2013;43(4):226-8.
McLoughlin PL, Cope TM, Harrison JC. Hyperbaric oxygen therapy in the management of severe acute anaemia in a Jehovah's witness. Anaesthesia 1999;54(9):891–895.
HBO prescription, stated exactly: pulsed hyperbaric oxygen, 90 min at 2 ATA with a Within-patient haemodynamic change (Table 1). Adrenaline requirement fell from 6 to 3 Acid-base: base excess improved from −5.6 to −0.8 mmol.l⁻¹ during the first treatment, from a
MEDFAQs: Q&As on surface intervals when treating CO patients + COPD protocols. Undersea Hyperb Med 2017;44(2):189-190.
Medford MA, Gasier HG, Hexdall E, Moffat AD, Freiberger JJ, Moon RE. Research report: Charcoal type used for hookah smoking influences CO production. Undersea Hyperb Med 2015;42(4):375-80.
Meehan A, Searing E, Weaver LK, Lewandowski A. Baseline vestibular and auditory findings in a trial of post-concussive syndrome. Undersea Hyperb Med 2016;43(5):567-584.
Meehan A, Lewandowski A, Weaver LK, Hebert D, Deru K. Prospective study of anxiety, post-traumatic stress and depression on postural control, gait, otolith and visuospatial function in military service members with persistent post-concussive symptoms. Undersea Hyperb Med 2019;46(3):271-287.
Meehan A, Lewandowski A, Deru K, Hebert D, Weaver LK. Reference ranges and stability of auditory and vestibular measures in a comprehensive assessment battery for traumatic brain injury. Undersea Hyperb Med 2019;46(3):227-241.
Meehan A, Hebert D, Deru K, Weaver LK. Hidden hearing deficits in military service members with persistent post concussive symptoms. Undersea Hyperb Med 2019;46(3):251-260.
Meethale Thiruvoth F, Rajasulochana SR, Mathan Kumar S, Saravanan E, Sivanantham P, Kar SS. Hyperbaric oxygen therapy as an adjunct to the standard wound care for the treatment of diabetic foot ulcers in Indian patients: a cost utility analysis. Expert Rev Pharmacoecon Outcomes Res 2022;22(7):1087-1094.
Mehl C, Heblich F, Lenz R, Ludwig K, Kern M. The influence of a hyperbaric environment and increased oxygen partial pressure on the corrosion of dental alloys. Diving Hyperb Med 2011;41(3):151-5.
Meier EL, Hummelink S, Lansdorp N, Boonstra O, Ulrich DJO. Perioperative hyperbaric oxygen treatment and postoperative complications following secondary breast reconstruction after radiotherapy: a case-control study of 45 patients. Diving Hyperb Med 2021;51(3):288-294.
Meier EL, Mink van der Molen DR, Lansdorp CA, Batenburg MCT, van der Leij F, Verkooijen HM, Boonstra O, Hummelink S, Ulrich DJO. Hyperbaric oxygen therapy for local late radiation toxicity in breast cancer patients: A systematic review. The Breast 2023;67:46–54.
Pain significantly reduced in 4/5 studies measuring it. Breast/arm lymphoedema reduced in 4/7 studies; fibrosis in some; skin problems and Conclusion: HBOT might be useful for reducing LRT symptoms in breast-cancer patients, but the
Meijering JR, Risvanoglu N, Nederhoed JH, Hoencamp R, van Hulst RA, Ubbink DT (Amsterdam UMC). Shared decision-making when considering hyperbaric oxygen therapy: a systematic review. Diving Hyperb Med 2025;55(2):180–185.
A systematic review of shared decision-making in the context of HBOT — patient engagement, satisfaction and adherence when weighing a demanding multi-session therapy. A methods/decision-science synthesis, not a therapy efficacy review.
Meijering JR, Risvanoglu N, van Waard JD, Nederhoed JH, Hoencamp R, van Hulst RA, Ubbink DT. Decision regret and shared decision-making in patients undergoing hyperbaric oxygen therapy. Diving Hyperb Med 2026;56(1):52-58.
Melessen A, Wingelaar TT, van Ooij PJAM. Clinical utility of dipstick urinalysis in assessing fitness to dive in military divers, submariners, and hyperbaric personnel. Diving Hyperb Med 2024;54(2):105-109.
Meliante PG, D'Avino L, Barba G, Covelli E, Petrella C, Barbato C, Minni A. Salvage treatment strategies for refractory sudden sensorineural hearing loss—a comprehensive review and meta-analysis with practical recommendations. Front Neurol 2025;16:1627892.
HBO was effective as salvage, particularly at low frequencies. Combined ITS + HBO gave the best results in word recognition and pure-tone average, though not always ITS effective (methylprednisolone > dexamethasone); early initiation improved outcomes.
Melnyczenko AR. The availability of IV pumps and ventilators used in HBO. (PDF document. unknown 2020:1-4.
Memar MY, Yekani M, Alizadeh N, Bannazadeh Baghi H. Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomed Pharmacother 2019;109:440-447.
Memon A, Patel P. Carbon Monoxide Poisoning: Pathophysiology, Diagnosis, and Forensic Challenges in Fatal Exposures. Biopress Journal of Advanced Pharmacology 2026;2(7):6 pages (no continuous pagination in the held PDF).
Mendel V, Reichert B, Simanowski HJ, Scholz HC. Therapy with hyperbaric oxygen and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. Undersea Hyperb Med 1999;26(3):169-174.
Mendel V, Simanowski HJ, Scholz HC. Synergy of HBO2 and a local antibiotic carrier for experimental osteomyelitis due to Staphylococcus aureus in rats. Undersea Hyperb Med 2004;31(4):407–416.
Mendes AF Jr, da Mota Neto J, Heringer EM, de Simoni LF, Pires DD, Labronici PJ. Hyperbaric oxygen therapy as treatment for bilateral arm compartment syndrome after CrossFit: case report and literature review. Undersea Hyperb Med 2018;45(2):209-215.
Mendez N, Huchim-Lara O, Rivera-Canul N, Chin W, Tec J, Cordero-Romero S. Fatal cardiopulmonary decompression sickness in an untrained fisherman diver in Yucatán, Mexico: a clinical case report. Undersea and Hyperbaric Medicine 2017;44(3):279-281.
Mendoza JA, Hampson NB. Epidemiology of severe carbon monoxide poisoning in children. Undersea Hyperb Med 2006;33(6):439-46.
Meng F-C, Shen C-H, Chu C-M, Shih C-P, Lin H-C, Peng C-K, Chang SC, Huang K-L. Dried salted plum consumption ameliorates hyperbaric oxygen therapy-induced otalgia severity at the first chamber session: a prospective randomized controlled study. Undersea Hyperb Med 2017;44(6):551-557 (PMID 29281192; DOI 10.22462/11.12.2017.6).
MEB incidence (Teed grade 1–4): NOT reduced — 39.6% (21/53) with plum vs 37.8% (14/37) control, P = 1.000 (⚠️ corrected 23 Oct 2026: previously "overall ~39.6% (21/53)", which is the plum arm alone; the paper's word "overall" means Teed grade 1-4, not both arms); severe MEB (Teed 3–4) 18.9% Otalgia severity reduced: VAS ≥4 otalgia in ⚠️ TWO OUTCOMES WERE SPLICED INTO ONE COMPARISON — corrected 2 Sep 2026. The correct pair for…
Meng X, Sun Q, Guo Y. Excessive mechanism research about HBO2 on peripheral neuropathic pain. Undersea Hyperb Med 2018;45(3):377.
Meng X, Sun Q, Miao T, Liu Q, Ren H, Feng Y. Involvement of spinal cannabinoid receptor type 2 in the analgesia effect of hyperbaric oxygen treatment on paclitaxel-induced neuropathic pain. Undersea Hyperb Med 2022;49(1):65-75.
Meng W, Zhu W, Song Z, Pan Y, Xing X, Guo J, et al. Hyperbaric oxygen therapy improves oocyte yield and embryo quality in poor ovarian responders: a pre-post cohort study. Reprod Biol Endocrinol 2025;23(1):142.
Mengel CE, Kann HE, Smith WW, Horton BD. Effects of in vivo hyperoxia on erythrocytes. 1. hemolysis in mice exposed to hyperbaric oxygenation. Proc Soc Exp Biol Med 1964;116:259-61.
Mengel CE, Kann HE, Lewis AM, Horton B. Mechanisms of in vivo hemolysis induced by hyperoxia. Aerosp Med 1964;35:857-60.
Mengel CE, Kann HE, Heyman A, Metz E. Effects of in vivo hyperoxia on erythrocytes. ii. hemolysis in a human after exposure to oxygen under high pressure. Blood 1965;25:822-9.
Mengel CE, Kann HE. Effects of in vivo hyperoxia on erythrocytes. 3. In vivo peroxidation of erythrocyte lipid. J Clin Invest 1966;45(7):1150-8.
Mengel CE. The effects of hyperoxia on red cells as related to tocopherol deficiency. Ann N Y Acad Sci 1972;203:163-71.
Mensah-Kane P, Sumien N. The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases. GeroScience 2023;45:747-756.
Mermans JF, Tuinder S, von Meyenfeldt MF, van der Hulst RR. Hyperbaric oxygen treatment for skin flap necrosis after a mastectomy: a case study. Undersea Hyperb Med 2012;39(3):719–723.
Mesquita I, Araújo B, Soares-Guedes C, Teixeira C, Caridade-Silva R, Summavielle T, Pinto L, Domingos J, Godinho C, Teixeira FG. Advances in the management of depression in Parkinson's disease: a narrative review on vortioxetine, hyperbaric oxygen, and physical activity. Biomed Pharmacother 2026;204:119954.
Meybohm P, Froessler B, Goodnough LT, Klein AA, Muñoz M, Murphy MF, Richards T, Shander A, Spahn DR, Zacharowski K. 'Simplified International Recommendations for the Implementation of Patient Blood Management' (SIR4PBM). Perioper Med (Lond) 2017;6:5.
Meyerstein N, Mazor D, Tsach T, et al. Resistance of human red blood cells to hyperbaric oxygen under therapeutic conditions. J Hyperbaric Med 1989;4:1–5.
Mihailidis T, Davenport K. The Practical Management of Intractable Haematuria Within the National Health Service of the United Kingdom: A Literature Review. Cureus 2025;17(11):e96083.
Mihaljević Z, Labaj A, Jukić I, Stupin A, Kolobarić N, Drenjančević I, Kibel A. Hyperbaric oxygenation as a modulator of endothelial function: insights into redox and vasodilatory pathways. In: Drenjančević I, editor. 4th Regional Congress of Physiological Societies and 6th Congress of Croatian Physiological Society - Book of Abstracts. Osijek: Faculty of Medicine Osijek, University of Osijek 2026:18 (CROSBI ID 973040 (Croatian Scientific Bibliography); conference abstract).
Miike T, Sakamoto Y, Sakurai R, Ohta M, Goto A, Imahase H, et al. Effects of hyperbaric exposure on thrombus formation. Undersea Hyperb Med 2016;43(3):233-8.
Miike T, Sakamoto Y, Sakamoto Y, Matsuoka A, Shinada K, Nakayama K, et al. Influence of hyperbaric oxygen therapy on thrombus formation ability in humans. Undersea Hyperb Med 2020;47(4):591-595.
Mikolašević I, Cotić P, Matulić Čubranić S, Franolić M, Skočilić I, Salopek T, Golčić M, Košić A, Radošić L, Josipović B, Lisica K, Juras L, Francetić S, Bešvir A, Belančić A. Hyperbaric oxygen therapy for late radiation-induced duodenal toxicity after stereotactic body radiotherapy in a patient with cholangiocellular carcinoma: a unique case report. Curr Oncol 2026;33(8):459.
Millan SB, Hontz-Geisinger CA, Rooks BJ, Wahl AM, Covington DB. Prevention of middle ear barotrauma with oxymetazoline/fluticasone treatment. Undersea Hyperb Med 2021;48(2):149-152.
Millar IL, Mouldey PG. Compressed breathing air - the potential for evil from within. Diving Hyperb Med 2008;38(2):145-151.
Millar IL. Hyperbaric intensive care technology and equipment. Diving Hyperb Med 2015;45(1):50-6.
Millar IL, Lind FG, Jansson KÅ, Hájek M, Smart DR, Fernandes TD, et al. Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multi-centre randomised clinical trial. Diving Hyperb Med 2022;52(3):164–174.
Primary composite (necrosis/infection ≤14 d): 25/58 (43%) HBOT vs 34/59 (58%) — OR 0.55 (95% CI Tissue necrosis: 29% vs 53% — OR 0.35 (95% CI 0.16–0.78; P=0.01) (significant). Fewer late complications: 6/53 vs 18/52 — OR 0.22 (95% CI 0.08–0.64; P=0.007), including delayed
Miller S, Witucki P. Anemia case series [abstract]. Undersea Hyperb Med 2008;35(4) (Abstracts from the UHMS ASM 2008 (poster, 28 June 2008)).
Miller RS, Weaver LK, Bahraini N, Churchill S, Price RC, Skiba V, Caviness J, Mooney S, Hetzell B, Liu J, Deru K, Ricciardi R, Fracisco S, Close NC, Surrett GW, Bartos C, Ryan M, Brenner LA; HOPPS Trial Team. Effects of hyperbaric oxygen on symptoms and quality of life among service members with persistent postconcussion symptoms: a randomized clinical trial. JAMA Intern Med 2015;175(1):43-52.
Milstein DM, Helmers R, Hackmann S, Belterman CN, van Hulst RA, de Lange J. Sublingual microvascular perfusion is altered during normobaric and hyperbaric hyperoxia. Microvasc Res 2016;105:93-102.
Mimura K, Harada M, Sumiyoshi S, Toya G, Takagi M, Fujita E, et al. Long-term effects of carbon monoxide poisoning at Miike coal mine: A 33-year follow-up study. Undersea Hyperb Med 2023;50(2):111-143.
Mink van der Molen DR, Batenburg MCT, Maarse W, van den Bongard DHJG, Doeksen A, de Lange MY, van der Pol CC, Evers DJ, Lansdorp CA, van der Laan J, van de Ven PM, van der Leij F, Verkooijen HM. Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial. JAMA Oncol 2024;10(4):464–474.
Primary endpoint (pain) — NEGATIVE in ITT: moderate/severe pain at follow-up 50% (58/115) HBOT vs Fibrosis — POSITIVE in ITT: 33% vs 51%; OR 0.36 (95% CI 0.15–0.81), p=.02. No significant Completers (CACE): among the ~25% who actually completed HBOT, pain reduced (adjusted OR 0.34, 95%
Mirasoglu B, Egeren E, Karakaya H, Aktas S. Hyperbaric oxygen therapy for severe blast injury of lower extremity after terrorist attack: case report. Undersea Hyperb Med 2019;46(1):75-79.
Mirasoglu B, Kirmizi S, Aktas S. Sphenoid sinus mucocele as an unusual differential diagnosis in diving injuries. Diving and Hyperbaric Medicine 2020;50(2):168-172.
Mirasoglu B, Cetin H, Ozdemir Akgun S, Aktas S. Hyperbaric oxygen treatment for intrauterine limb ischaemia: a newborn in the chamber. Diving Hyperb Med 2021;51(2):220–223.
Mirow S, Wilson SH, Weaver LK, Churchill S, Deru K, Lindblad AS. Linear analysis of heart rate variability in post-concussive syndrome. Undersea Hyperb Med 2016;43(5):531-547.
Miszewska A, Sobczak O, Góralczyk P, Kot J. Temporal changes in diagnostic composition and treatment activity among mechanically ventilated ICU patients receiving hyperbaric oxygen therapy: an 11-year single-centre retrospective study. J Clin Med 2026;15(18):7089.
Miszewska A, Kot J. Staff-Reported Peri-Procedural Workflow Vulnerabilities and a Preliminary Checklist Prototype for Mechanically Ventilated Intensive Care Patients Undergoing Hyperbaric Oxygen Therapy: A Single-Centre Pilot Survey. J Clin Med 2026;15(14):5418.
Mitchell SJ. Treatment of decompression illness in the 21st century: a brief overview. Diving Hyperb Med 2007;37(2):73-75.
Mitchell SJ. Publication rates for Annual Scientific Meeting abstracts: a cause for concern? An editorial perspective. Undersea Hyperb Med 2013;40(5):373-5.
Mitchell SJ, Bennett MH. Unestablished indications for hyperbaric oxygen therapy. Diving Hyperb Med 2014;44(4):228-34.
Mitchell SJ, Doolette DJ. Pathophysiology of inner ear decompression sickness: potential role of the persistent foramen ovale. Diving Hyperb Med 2015;45(2):105-10.
Mitchell SJ, Bennett MH, Bryson P, Butler FK, Doolette DJ, Holm JR, Kot J, Lafère P. Consensus guideline: Pre-hospital management of decompression illness: expert review of key principles and controversies. Undersea Hyperb Med 2018;45(3):273-286.
Mitchell SJ, Bennett MH, Moon RE. Decompression sickness and arterial gas embolism. N Engl J Med 2022;386(13):1254-1264.
Mitchell SJ. Decompression illness: a comprehensive overview. Diving Hyperb Med 2024;54(1 Suppl):1-53.
Mitton C, Hailey D. Hyperbaric oxygen treatment in Alberta. Health Technology Assessment 8. Edmonton: Alberta Heritage Foundation for Medical Research 1998:45 pp (April 1998; URL https://www.ihe.ca/download/hyperbaric_oxygen_treatment_in_alberta.pdf).
Mladenov A, Diehl K, Muller O, von Heymann C, Kopp S, Peitsch WK. Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years. World J Emerg Surg 2022;17(1):43 (PMID 35932075. DOI 10.1186/s13017-022-00448-6).
Moayedi S, Gizaw A, Sweet S, Sethuraman K, Witting M. Pseudoephedrine prophylaxis does not prevent middle ear barotrauma in hyperbaric oxygen therapy. Undersea Hyperb Med 2025;52(2):101-107.
Moen I, Stuhr LEB. Hyperbaric oxygen therapy and cancer — a review. Target Oncol 2012;7(4):233-242.
Moffat AD, Weaver LK, Tettelbach WH. Compromised breast flap treated with leech therapy, hyperbaric oxygen, pentoxifylline and topical nitroglycerin: a case report. Undersea Hyperb Med 2015;42(3):281–284.
Moffat AD, Worth ER, Weaver LK. Glycosylated hemoglobin and hyperbaric oxygen coverage denials. Undersea Hyperb Med 2015;42(3):197-204.
Moghamis I, Alhammoud AA, Kokash O, Alhaneedi GA. The outcome of hyperbaric oxygen therapy versus core decompression in the non-traumatic avascular necrosis of the femoral head: retrospective cohort study. Ann Med Surg (Lond) 2021;62:450-454.
Moghib K, Dawoud ALA, Altalab G, Syed MS, Salomon I, Musse HAY, Doubie OAM, Elsekhary AI, Al-Dalaeen RA, Kandil GEH. Evaluating hyperbaric oxygen therapy as an adjunct to corticosteroids in sudden sensorineural hearing loss: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 2025;282(10):4949-4966.
Mohd Yazid B, Ayesyah A, Nurhanani AB, Mohd Rohaizat H. The Physiological, Biochemical and Quality of Life Changes in Chronic Diabetic Foot Ulcer after Hyperbaric Oxygen Therapy. Medicine & Health Medicine & Health (Universiti Kebangsaan Malaysia) 2017;12(2):210–219.
Complete ulcer healing at 6 months: 86.7% (26/30) HBOT vs 60% (18/30) control. Significant reduction in WCC and CRP across treatment in the HBOT group (p=0.046 and p=0.039). Significantly better mental and physical QoL (SF-36) in the HBOT group.
Molina-Vega J, Pferdehirt RE, Vardanian AJ. Hyperbaric Oxygen Therapy in Burn Care: A Systematic Review of Current Evidence. J Burn Care Res 2026;47(3):917–922.
Evidence inconsistent, no clear consensus on efficacy; protocols and outcome measures heterogeneous. ⚠️ Full read 21 Oct 2026 (all 6 pages, Table 1): two qualifiers. The "566 burn patients" include healthy volunteers. Niezgoda 1997 is counted among the RCTs, but it studied experimental burns inflicted on healthy volunteers. The review itself reports its 42% reduction in hyperaemia, 35% in wound size and 22% in exudate, "but no…
Molina-Vega J, Cascavita CT, Pferdehirt RE, Vardanian AJ. Current Use of Hyperbaric Oxygen Therapy in Plastic Surgery: A Systematic Review. Plast Reconstr Surg Glob Open 2026;14:e7989.
Monaca E, Strelow H, Jüttner T, Hoffmann T, Potempa T, Windolf J, et al. Assessment of hemostaseologic alterations induced by hyperbaric oxygen therapy using point-of-care analyzers. Undersea Hyperb Med 2014;41(1):17-26.
Monami M, Scatena A, Ragghianti B, Miranda C, Monge L, Silverii A, Uccioli L, Vermigli C; Panel of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome; SID and AMD. Effectiveness of most common adjuvant wound treatments (skin substitutes, negative pressure wound therapy, hyperbaric oxygen therapy, platelet-rich plasma/fibrin, and growth factors) for the management of hard-to-heal diabetic foot ulcers: a meta-analysis of randomized controlled trials for the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome. Acta Diabetol 2025;62(7):1081–1095 (epub 26 Dec 2024).
The evidence review behind the adjuvant-therapy question (PICO #28) of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome (SID and AMD). RCTs only, at least 12 weeks' follow-up, comparing an EMA-approved adjuvant with placebo or standard of care. 1,504 records screened, 51 trials included: 3 growth factors, 8 PRP/F, 27 skin substitutes, 5 NPWT, 8 HBOT (Results, page 1083). Primary
Monies-Chass I, Hashmonai M, Hoerer D, Kaufman T, Steiner E, Schramek A. Hyperbaric oxygen treatment as an adjuvant to reconstructive vascular surgery in trauma. Injury 1977;8(4):274-277.
Monis PL, Bhat V, Shetty S, Salins PC. Hyperbaric Oxygen Therapy in the Management of Zygomatic Bone Osteomyelitis. J Maxillofac Oral Surg 2020;20(3):414–417.
Facial swelling and pus discharge reduced with blood sugar control, before the HBO course is After 15 dives there was no more pus discharge from the left infraorbital fistula, though the After a total of 30 dives, repeat CT showed partial reconstitution of cortical bone with no
Monnot D, Michot T, Dugrenot E, Guerrero F, Lafère P. A survey of scuba diving-related injuries and outcomes among French recreational divers. Diving Hyperb Med 2019;49(2):96-106.
Monnot DPM, Boisvert J, Buteau D, Pollock NW. Retrospective review of enquiries to the Québec diving medicine call centre: 2004 through 2018. Diving and Hyperbaric Medicine 2021;51(2):152-160.
Montrief T, Long B, Koyfman A, Auerbach J. Fournier gangrene: a review for emergency clinicians. J Emerg Med 2019;57(4):488-500 (PMID 31472943. DOI 10.1016/j.jemermed.2019.06.023).
Moon RE, McGraw TA, Blakey G 3rd. Hyperbaric oxygen therapy for radiation necrosis of the jaw: comments on a randomized study. Undersea Hyperb Med 2005;32(3):145-147.
Moon RE. Adjunctive therapy for decompression illness: a review and update. Diving Hyperb Med 2009;39(2):81-7.
Moon RE. Hyperbaric oxygen treatment for air or gas embolism. Undersea Hyperb Med 2014;41(2):159–166.
Moon RE. Hyperbaric oxygen treatment for decompression sickness. Undersea Hyperb Med 2014;41(2):151-157.
Moon KC, Han SK, Lee YN, Jeong SH, Dhong ES, Kim WK. Effect of normobaric hyperoxic therapy on tissue oxygenation in diabetic feet: a pilot study. J Plast Reconstr Aesthet Surg 2014;67(11):1580-1586.
Moon RE. Iatrogenic cerebral gas embolism. Diving Hyperb Med 2016;46(2):119.
Moon H, Strauss MB, La SS, Miller SS. The validity of transcutaneous oxygen measurements in predicting healing of diabetic foot ulcers. Undersea Hyperb Med 2016;43(6):641-648.
Moon BI, Kim HR, Choi EJ, Kie JH, Seoh JY. Attenuation of collagen-induced arthritis by hyperbaric oxygen therapy through altering immune balance in favor of regulatory T cells. Undersea Hyperb Med 2017;44(4):321-330.
Moon RE. UHMS HBO₂ committee chair questions FDA on incorrect info. Undersea Hyperb Med 2017;44(6):611-612.
Moon RE, Mitchell S. Hyperbaric treatment for decompression sickness: current recommendations. Undersea Hyperb Med 2019;46(5):685-693.
Moon RE, Weaver LK. Hyperbaric oxygen as a treatment for COVID-19 infection? Undersea Hyperb Med 2020;47(2):177-179.
Moon RE, Mitchell SJ. Decompression Sickness: Current Recommendations. Undersea Hyperb Med 2025;52(1):55-64.
Moreira da Cruz DL, Oliveira-Pinto J, Mansilha A. The role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a systematic review with meta-analysis. Int Angiol 2021;41(1):63–73.
Major amputation: OR 0.53 (95% CI 0.32–0.90) favouring HBOT (I²=31%). Minor amputation: no difference (OR 0.89, I²=69%). Complete healing: OR 4.00 (95% CI 1.54–10.44) favouring HBOT (I²=70%).
Möring MM, Valkenburg AC, Schuur-van't Hof N, van Beekhuizen HJ, Lansdorp CA. Reduced symptoms of late radiation tissue injury of the vagina after treatment with hyperbaric oxygen therapy: A retrospective analysis of 19 patients. Gynecol Oncol 2025;197:27–33.
19 patients (median age 42), average 40 sessions (80 min of 100% O₂ at 2.5 ATA). 15/19 (79%) responders at end of treatment (median 3 symptoms improving). Most responsive symptoms: Improvement maintained at 3 months in 14/15 responders. No major adverse events.
Morishima R, Nakashima K, Suzuki S, Yamami N, Aoshima M. A diver with immersion pulmonary oedema and prolonged respiratory symptoms. Diving Hyperb Med 2018;48(4):259-261.
Morningstar M, Strauchman M. Hyperbaric oxygen therapy and mild hyperbaric oxygen therapy are not synonymous: a narrative review. Med Sci (Basel) 2026;14(3):360 (DOI 10.3390/medsci14030360).
Mozdzanowski C, Perdrizet GA. Peripheral neuropathy may increase the risk for asymptomatic otic barotrauma during hyperbaric oxygen therapy: research report. Undersea Hyperb Med 2014;41(4):267-272.
Mrázek R, Holek J, Szeligová L, Sevcík V, Buriánová L, Chaloupka V. [The influencing of posthemorrhagic hypotension and hemorrhagic shock using hyperbaric oxygenation and plasma substitute solutions (experiments on dogs)]. Bratisl Lek Listy 1970;53(1):48-60 (Czech).
Medicare Services Advisory Committee. Hyperbaric oxygen therapy. MSAC applications 1018–1020. Assessment report. Canberra: Commonwealth of Australia 2001:147 pp (report dated November 2000, first printed July 2001; ISSN 1443-7120 (print), 1443-7139 (online); prepared with the Centre for Clinical Effectiveness and the Health Economics Unit, Monash University (Villanueva E, Johnston R, Clavisi O, Burrows E, Bernath V, Rajendran M, Wasiak J, Fennessy P, Anderson J; Harris A, Yong K); recommendation accepted by the Minister 9 February 2001).
Mukherjee A, Raison M, Sahni T, Arya A, Lambert J, Marois P, et al. Intensive rehabilitation combined with HBO2 therapy in children with cerebral palsy: a controlled longitudinal study. Undersea Hyperb Med 2014;41(2):77-85.
Mulders L, Pruijt M, Van Oostrom J, Van Der Zanden E, Neefjes-Borst A, Koelink P, Wildenberg M, De Jonge W, Ridderikhof M, Van Hulst R, D'Haens G, Gecse K. Hyperbaric oxygen therapy alters bowel perfusion and improves outcomes in patients with treatment-refractory ulcerative colitis: a prospective pilot trial. J Crohns Colitis 2026;20(5):jjag065.
Müller PH, Beuster W, Hühn W, Knessl P, Joachim Roggenbach H, Warninghoff V, et al. Diving Accident Guidelines of the German Society for Diving and Hyperbaric Medicine: Summary version. Diving Hyperb Med 2008;38(4):212-7.
Mungan N, Mychaskiw G. Hyperbaric oxygen therapy: an under-appreciated treatment modality for eye disorders? Undersea Hyperb Med 2008;35(5):331-2.
Mungur A, Cochard G, Ozier Y, Lafère P. The effect of general anaesthesia and neuromuscular blockade on Eustachian tube compliance: a prospective study. Diving Hyperb Med 2016;46(3):166-169.
Munjewar C, Nabi I, Gautam S, Ahirwar N, Chaudhary P, Kumar R, Arora MP, Ramteke VK. Evaluation of the role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a prospective comparative study. Hellenic Journal of Surgery 2016;88(4):219-224.
Muñoz M, Gómez-Ramírez S, Besser M, Pavía J, Gomollón F, Liumbruno GM, Bhandari S, Cladellas M, Shander A, Auerbach M. Current misconceptions in diagnosis and management of iron deficiency. Blood Transfus 2017;15(5):422-437.
Murad MH, Haydour Q, Benkhadra K. ACP Journal Club. Review: in patients with chronic diabetic foot ulcers, hyperbaric oxygen reduces major amputations. Ann Intern Med 2013;159(4):JC9.
Murad MH, Altayar O, Bennett M, Wei JC, Claus PL, Asi N, Prokop LJ, Montori VM, Guyatt GH. Using GRADE for evaluating the quality of evidence in hyperbaric oxygen therapy clarifies evidence limitations. J Clin Epidemiol 2014;67(1):65–72.
Murao N, Oyama A, Yamamoto Y, Funayama E, Ishikawa K, Maeda T. Efficacy of hyperbaric oxygen after microtia reconstruction using costal cartilage: A retrospective case-control study. Undersea Hyperb Med 2023;50(4):413-419 (DOI 10.22462/01.01.2023.45).
Muroya D, Nadayoshi S, Yamada K, Kai Y, Masuda T, Miyazaki D, Sasaki S, Shimokobe H, Shimokobe H, Okamoto K, Hiramatsu T, Inoue M, Konno T, Okamoto K. The Effects of Hyperbaric Oxygen Therapy in Postoperative Patients with Ulcerative Colitis: A Retrospective Study. Kurume Med J 2026;72:13-19.
Murphy-Lavoie H, Butler FK. Notes on the use of HBO2 with optic neuritis. Undersea Hyperb Med 2011;38(6):561.
Murphy-Lavoie H, Butler F, Hagan C. Central retinal artery occlusion treated with oxygen: a literature review and treatment algorithm. Undersea Hyperb Med 2012;39(5):943-53.
Murphy-Lavoie H, Piper S, Moon RE, Legros T. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss. Undersea Hyperb Med 2012;39(3):777–792.
Murray RA. A Critical Look at Soft-Sided and Hard-Sided "Mild" Hyperbaric Chambers - Risks, Regulations, and Ethical Oversights. Undersea Hyperb Med 2026;53(3):523-534.
Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Free Radic Res 2004;38(9):927-32.
Muth CM. Hyperbaric oxygen, oxidative stress and comets --an editorial perspective. Undersea Hyperb Med 2014;41(3):169-70.
Mutluoglu M, Metin S, Arziman I, Uzun G, Yildiz S. The use of hyperbaric oxygen therapy for carbon monoxide poisoning in Europe. Undersea Hyperb Med 2016;43(1):49-56.
Mutluoglu M, Uzun G, Bennett M, Germonpré P, Smart D, Mathieu D. Poorly designed research does not help clarify the role of hyperbaric oxygen in the treatment of chronic diabetic foot ulcers. Diving Hyperb Med 2016;46(3):133-134.
Mutzbauer TS, Mueller PHJ, Tetzlaff K, Neubauer B, Sigg O. Is Eustachian tube ventilatory function (ETVF) impairment after oxygen diving mediated by free radicals? Undersea Hyperb Med 2000;27(suppl):16 — UHMS ASM abstract.
ME impedance decreased overnight after the first dive (p=0.015) but not after the second (p=0.475), in No difference between vitamin and placebo groups after the first dive (p=0.827). ⚠️ Added 1 Sep 2026 — the page previously compressed this into "if anything the vitamin group had
Mutzbauer TS, Staps E. How delay to recompression influences treatment and outcome in recreational divers with mild to moderate neurological decompression sickness in a remote setting. Diving Hyperb Med 2013;43(1):42-45.
Mychaskiw G. Hyperbaric oxygen therapy and neurologic disease: the time has come. Undersea Hyperb Med 2010;37(2):xi-xiii.
Mychaskiw G. Neurologic applications of hyperbaric oxygen: a sad, slow story of smoke and fire. Undersea Hyperb Med 2011;38(5):305-7.
Mychaskiw G. Some people say a man is made out of mud. miners, miracles and the old red devil. Undersea Hyperb Med 2012;39(2):625-626.
Mychaskiw G. The second renaissance of hyperbaric medicine: indications revisited. Undersea Hyperb Med 2012;39(3):691-2.
Mychaskiw G. How many deaths will it take till they know? Monkeys, madmen and the standard of evidence. Undersea Hyperb Med 2012;39(4):795-7.
Mychaskiw G. Known knowns, known unknowns and unknown unknowns: the science and the passion of HBO2 therapy and traumatic brain injury: an editorial perspective. Undersea Hyperb Med 2013;40(5):371-2.
Mychaskiw G. Pens, swords and scientific journals: don't believe the hype: an editorial perspective. Undersea Hyperb Med 2013;40(3):221-2.
Mychaskiw G. Anecdotes and desperate hopes--when does off-label become investigational? An editorial perspective. Undersea Hyperb Med 2013;40(1):1-2.
Myers RAM, Snyder SK, Linberg S, Cowley RA. Value of hyperbaric oxygen in suspected carbon monoxide poisoning. JAMA 1981;246:2478-2480.
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Myers DE, Myers RA. A preliminary report on hyperbaric oxygen in the relief of migraine headache. Headache 1995;35(4):197-9.
Myking O, Schreiner A. Hyperbaric oxygen in hemolytic crisis. JAMA 1974;227(10):1161-2.
Single case report from the University of Bergen, Norway. A 55-year-old woman in previously good health developed acute autoimmune haemolytic anaemia with warm antibodies of unknown cause. The haemoglobin fell to approximately 3 gm/100 ml with signs of cerebral hypoxia, and despite numerous attempts, compatible blood could not be obtained. She was transferred to the Royal Norwegian Naval Base in B
Naaji A, Ciobanu M, Popescu M. Advances in Hyperbaric Oxygen Therapy: Medical Benefits and Technical Perspectives. Ann Biomed Eng 2026;54(7):2318-2336.
Nabil S, Samman N (University of Hong Kong). Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg 2011;40(3):229–243.
Systematic review of ORN after post-radiation dental extraction. ORN incidence ~4% with hyperbaric-oxygen cover vs ~6% with antibiotics. Authors conclude HBO is effective in reducing the risk of ORN after post-radiation extractions. ⚠️ Full read 21 Oct 2026 (pages 1–15, Tables 1–11): the record's headline needs three qualifiers. The 4% vs 6% is not a comparison of groups (pages 7–8, Table 5). HBO-covered extractions (6 ORN in…
Nadella KR, Kodali RM, Guttikonda LK, Jonnalagadda A. Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update. J Maxillofac Oral Surg 2015;14(4):891-901.
Nagy ZZ, Vörös KM, Dormán P, Szolnoki N. Műtét utáni maculaoedema gyógyulásának gyorsítása túlnyomásos (hiperbárikus) oxigénterápiás módszerrel [Acceleration of postoperative macular edema recovery with hyperbaric oxygen therapy — Hungarian, English title as printed by the journal]. Orv Hetil 2026;167(28):1120-1126.
Nah S, Choi S, Na H, Han S. Neurological symptoms improved by hyperbaric oxygen therapy in a post-cardiac arrest patient due to carbon monoxide poisoning: a case report. Undersea Hyperb Med 2021;48(2).
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Post-treatment hearing improvement was statistically significant in BOTH groups (PTA, Siegel's criteria, Success 55% (group I) vs 63% (group II) — the increase with added IT steroid was not statistically Profound loss (> 90 dB) subgroup: 0 of 6 succeeded in group I against 6 of 12 (50%) in group II
Naicker Y, Ahmed N, Davids R. Damage control surgery of the critical Jehovah's Witness patient — a narrative review. S Afr J Surg 2023;61(1):39–44.
Nair K, Nair S, Imbruce R. Treatment of chronic vertigo with hyperbaric oxygen. Lancet 1973;1(7796):184-185.
Najib B, Picard M, Kauert A, Dejode M, Schiappa R, Figl A, Dusquesne M, Barranger E, Delpech Y. Hyperbaric oxygen therapy after reconstructive breast surgery: A retrospective study. J Gynecol Obstet Hum Reprod 2026;55(7):103210.
Nakada T, Nakada H, Yoshida Y, Nakashima Y, Banya Y, Fujihira T, Karasawa K. Hyperbaric oxygen therapy for radiation cystitis in patients with prostate cancer: a long-term follow-up study. Urol Int 2012;89(2):208-214 (PMID 22797611. DOI 10.1159/000338910).
Nakahara K, Yamashita S, Ideo K, Shindo S, Suga T, Ueda A, Honda S, Hirahara T, Watanabe M, Yamashita T, Maeda Y, Yonemochi Y, Takita T, Ando Y. Drastic therapy for listerial brain abscess involving combined hyperbaric oxygen therapy and antimicrobial agents. J Clin Neurol 2014;10(4):358-62.
Nakao T, Hirata T, Adachi T, Fukuda J, Fukada T, Iino-Ohori K, Igarashi M, Yoshikawa K, Iwasa K, Saito A. Cognitive Processing Efficiency (Throughput) Improves with Aerobic Exercise and Is Independent of the Environmental Oxygenation Level: A Randomized Crossover Trial. Sports (Basel) 2026;14(1):30.
Nakao T, Saito A, Adachi T, Fukuda J, Fukada T, Iino-Ohori K, Igarashi M, Iwasa K, Yoshikawa K. Blood and Vascular Endothelial Responses to Mild Hyperbaric Oxygen During EPA-Supplemented Aerobic Exercise: A Randomised Crossover Trial. J Funct Morphol Kinesiol 2026;11(4):443 (open access, CC BY; published 23 Oct 2026; issue number from the DOI suffix).
Twenty-six men were assessed and two excluded (one could not adapt to the chamber, one smoked); 24 were enrolled and all completed (Fig. 1, p.3). Sixteen were randomised 1:1 by a lot-drawing procedure prepared by an independent third party to HBO→NN or NN→HBO, with allocation concealed from the principal investigator; eight further men took EPA under normobaric conditions without exercise and were
Nakao T, Hirata T, Saito A. Mild Hyperbaric Oxygen Exposure Is Associated with Calculation-Method-Dependent Changes in VE/VCO2 During Seated Rest. Biology (Basel) 2026;15(15):1254.
Narozny W, Sicko Z, Przewozny T, Stankiewicz C, Kot J, Kuczkowski J. Usefulness of high doses of glucocorticoids and hyperbaric oxygen therapy in sudden sensorineural hearing loss treatment. Otol Neurotol 2004;25(6):916-923.
Narozny W, Sicko Z, Kot J, Stankiewicz C, Przewozny T, Kuczkowski J. Hyperbaric oxygen therapy in the treatment of complications of irradiation in head and neck area. Undersea Hyperb Med 2005;32(2):103–110.
Nasole E, Zanon V, Marcolin P, Bosco G. Middle ear barotrauma during hyperbaric oxygen therapy; a review of occurrences in 5,962 patients. Undersea Hyperb Med 2019;46(2):101-106.
Nates JL, Cattano D, Costa FS, Chelly JE, Doursout MF. Thromboelastographic assessment of the impact of mexiletine on coagulation abnormalities induced by air or normal saline intravenous injections in conscious rats. Diving Hyperb Med 2017;47(4):228-232.
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Navarro RU, Ferguson CC. Treatment of experimental hemorrhagic shock by the combined use of hyperbaric oxygen and low-molecular weight dextran. Surgery 1968;63(5):775–781.
Navarro P, Bornstein S. Hyperbaric oxygen therapy for difficult wound healing in Newfoundland & Labrador. Newfoundland and Labrador Centre for Applied Health Research (NLCAHR) 2012 (Contextualized Health Research Synthesis Program report).
Department of the Navy, Naval Sea Systems Command (NAVSEA), Supervisor of Diving and Salvage. U.S. Navy General Specification for the Design, Construction, and Repair of Diving and Hyperbaric Equipment (NAVSEA TS500-AU-SPN-010), Revision 1. Naval Sea Systems Command technical publication TS500-AU-SPN-010 2006.
- Issuer and edition. US Navy, Naval Sea Systems Command, Supervisor of Diving and Salvage (SUPSALV, NAVSEA 00C). Revision 1, dated August 23, 2006; "supersedes NAVSEA TS500-AU-SPN-010, Dated March 25, 2005" (title page, PDF page 1). Its informal name is "GENSPEC for DLSS" (Foreword, page vi). - Purpose. To "authoritatively establish technical requirements for design, construction and repair for a
Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med 2011;38(5):345-66.
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Neel OF, Mousa AH, Al-Terkawi RA, Bakr MM, Mortada H. Assessing the efficacy of hyperbaric oxygen therapy on facelift outcomes: a case–control study comparing outcomes in patients with and without hyperbaric oxygen therapy. Aesthet Surg J Open Forum 2023;5:ojad065.
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Neiberger RJ, Waters ET. Hyperbaric oxygen treatment for paracentral acute middle maculopathy: a case study. Undersea Hyperb Med 2023;50(3):283-287 (DOI 10.22462/01.01.2023.9).
Neiman J, Nilsson BY, Barr PO, Perrins DJ. Hyperbaric oxygen in chronic progressive multiple sclerosis: visual evoked potentials and clinical effects. J Neurol Neurosurg Psychiatry 1985;48(6):497-500.
Nemiroff PM, Rybak LP. Applications of hyperbaric oxygen for the otolaryngologist head and neck surgeon. Am J Otolaryngol 1988;9(2):52-57.
Neto PH, Ribeiro ZB, Pinho AB, de Almeida CHR, Maranhão CAA, Goncalves JDCC. Hyperbaric oxygen therapy for the treatment of a crush injury of the hand: a case report. J Trauma Inj 2022;35(3):209–214.
Neubauer B, Tetzlaff K, Staschen CM, Bettinghausen E. Cardiac output changes during hyperbaric hyperoxia. Int Arch Occup Environ Health 2001;74(2):119–122.
Neuman TS, Thom SR, editors. Physiology and Medicine of Hyperbaric Oxygen Therapy. Philadelphia (PA): Saunders Elsevier 2008:607 pp (PDF).
Newcomb A, Frawley G, Fock A, Bennett M, d'Udekem Y. From the recent literature: Hyperbaric oxygenation in the management of cerebral arterial gas embolism during cavopulmonary connection surgery (summarised by Andrew Fock). Diving Hyperb Med 2008;38(4):219.
Newcomb A, Frawley G, Fock A, Bennett M, d'Udekem Y. Hyperbaric oxygenation in the management of cerebral arterial gas embolism during cavopulmonary connection surgery. J Cardiothorac Vasc Anesth 2008;22(4):576-80.
Newth A, Perleth M, Sherlock S, Romero L, Bennett MH. Hyperbaric oxygen therapy for acute idiopathic sudden sensorineural hearing loss; a systematic review with meta-analysis. Diving Hyperb Med 2025;55(4):398–406.
Chance of improvement (HBO + steroids vs steroids): ~~RR 1.6 (95% CI 1.3–2.0)~~ RR 1.5 (95% CI 1.2–1.7), NNT 4 (3–5), 7 trials, n = 562 (⚠️ corrected 21 Oct 2026: the struck figure appears only in the abstract; Results and Table 1 give RR 1.5). Mean audiometric gain: ~~+15.6 dB (95% CI 1.5–29.8)~~ +15.1 dB (95% CI 8.2–22.0) (4 trials, n = 245; ⚠️ corrected 21 Oct 2026, abstract-only figure struck). GRADE: moderate evidence tha…
Newton HB, Padilla W, Burkart J, Pearl DK. Neurological manifestations of decompression illness in recreational divers - the Cozumel experience. Undersea Hyperb Med 2007;34(5):349-57.
Newton HB, Burkart J, Pearl D, Padilla W. Neurological decompression illness and hematocrit: analysis of a consecutive series of 200 recreational scuba divers. Undersea Hyperb Med 2008;35(2):99-106.
Ng AWA, Muller R, Orton J. Incidence of middle ear barotrauma in staged versus linear chamber compression during hyperbaric oxygen therapy: a double blinded, randomized controlled trial. Undersea Hyperb Med 2017;44(2):101–107.
MEB incidence: staged 48% vs linear 62% (P=0.12) — not a statistically significant reduction. The staged protocol produced significantly less severe MEB deteriorations (severity, not incidence,
Nguyen NB, Nguyen Van T, Nguyen Thi Hai H, Nguyen Truong S. Results of treating patients with diabetic foot ulcers with hyperbaric oxygen. Int Marit Health 2025;76(4):259–267.
Granulation growth and infection control better with HBO (p<0.001); ulcer depth and diameter Amputation rate 4.6% (HBO) vs 11.7% (reference); treatment time 10.1 ± 4.6 vs 15.1 ± 7.8 days. ⚠️ Corrected 31 Aug 2026: this bullet previously read "The authors also report a significant odds
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for carbon monoxide poisoning (all ages). NHS England Reference 170048P. London: NHS England 2018:16 pp (published July 2018; for implementation from 1 April 2019; URL https://www.england.nhs.uk/publication/hbot-carbon-monoxide-poisoning-all-ages/).
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for decompression illness/gas embolism (all ages). NHS England Reference 170047P. London: NHS England 2018:22 pp (published 20 July 2018; for implementation from 1 April 2019; URL https://www.england.nhs.uk/publication/hbot-decompression-illness-gas-embolism-all-ages/).
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for malignant otitis externa (all ages). NHS England Reference 170045P. London: NHS England 2018:15 pp (published 20 July 2018; for implementation from 1 April 2019; URL https://www.england.nhs.uk/publication/hbot-malignant-otitis-externa-all-ages/).
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for necrotising soft tissue infections (adults). NHS England Reference 170070P. London: NHS England 2018:18 pp (published July 2018; for implementation from 1 April 2019; URL https://www.england.nhs.uk/publication/hbot-necrotising-soft-tissue-infections-adults/).
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for soft tissue radiation damage in patients with a history of pelvic irradiation for malignant disease (all ages). NHS England Reference 170046P. London: NHS England 2018:16 pp (published 20 July 2018; for implementation from 1 April 2019; URL https://www.england.nhs.uk/publication/hbot-soft-tissue-radiation-damage-in-patients-with-a-history-of-pelvic-irradiation-for-malignant-disease-all-ages/).
NHS England Specialised Commissioning Team. Clinical commissioning policy: Hyperbaric oxygen therapy for diabetic lower limb ulceration (diabetic foot ulcer) (all ages). NHS England Reference 170120P. London: NHS England 2019:15 pp (published 12 April 2019; URL https://www.england.nhs.uk/publication/hyperbaric-oxygen-therapy-for-diabetic-lower-limb-ulceration-diabetic-foot-ulcer-all-ages/).
NHS England Trauma Programme of Care. Hyperbaric oxygen therapy services (all ages). Service specification 170084–250116S. London: NHS England 2025:29 pp (published January 2025, for implementation October 2025; supersedes 170084S (2019) and D11/S/a (2014); URL https://www.england.nhs.uk/wp-content/uploads/2018/11/Hyperbaric-oxygen-therapy-services-all-ages-Service-specification-January-2025.pdf).
NHS Wales Joint Commissioning Committee. Hyperbaric Oxygen Therapy (all ages). Commissioning Policy CP07, version 12.0. Cardiff: NHS Wales Joint Commissioning Committee 2026:24 pp (published August 2026; URL https://jcc.nhs.wales/clinical-policies/other/hyperbaric-oxygen-therapy-commissioning-policy-cp07-august-2026-pdf/).
National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. NICE guideline NG19. London: NICE 2015:46 pp (published 26 August 2015, last updated 11 October 2019; URL https://www.nice.org.uk/guidance/ng19).
Nicolai M, Urkmez A, Sarikaya S, Fode M, Falcone M, Albersen M, Gul M, Hatzichristodoulou G, Capogrosso P, Russo GI. Penile Rehabilitation and Treatment Options for Erectile Dysfunction Following Radical Prostatectomy and Radiotherapy: A Systematic Review. Front Surg 2021;8:636974.
Nier H, Sailer R, Palomba P. Evaluation of hyperbaric oxygenation in gas gangrene [abstracted in J Trauma]. Deutsche Medizinische Wochenschrift [abstract in The Journal of Trauma] 1978;103:1958-1960.
Nier H, Kremer K. Gasbrand — immer noch ein diagnostisches und therapeutisches Problem [Gas gangrene — still a diagnostic and therapeutic problem]. Zentralbl Chir 1984;109(6):402-417.
Niezgoda JA, Cianci P, Folden BW, Ortega RL, Slade JB, Storrow AB. The effect of hyperbaric oxygen therapy on a burn wound model in human volunteers. Plast Reconstr Surg 1997;99(6):1620–1625.
On day 2, wound size, hyperaemia and exudation differed significantly (p<0.05). The HBO group showed a No significant difference in epithelialization. ⚠️ Full read 21 Oct 2026 (Results, page 1622; Figs. 1–3, pages 1622–1623, read from the page images):
Nik Ab Rahman NH, Wan Mohammad WMZ, Bajuri MY, Shafee R. Use of hyperbaric oxygen therapy (HBOT) in chronic diabetic wound - A randomised trial. Med J Malaysia 2019;74(5):418–424.
Wound-size trajectory over the four time points was significantly better with HBOT (repeated-measures On logistic regression, the HBOT group had ~44× higher odds of achieving ≥30% wound-size reduction
Nikolić D, Pasternak J, Manojlović V, Budinski S, Nikolić M, Batinić N. Hyperbaric Oxygen Therapy for Chronic Venous Leg Ulcers: A Prospective Randomised Controlled Trial. Int Wound J 2026;23(3):e70856.
Area reduction: 62.1% ± 22.1% (HBO) vs 41.7% ± 21.5% (control); MD 20.4% (95% CI 10.1–30.7), Complete healing at 90 days: 62.5% vs 30.0% (NNT 3). TcPO₂ rose 26.1 → 150.3 mmHg in the HBO group (p<0.001); pain improved significantly more.
Nilès C, Mathieu D, Parmentier-Decrucq E. Treating ARDS-associated air embolism: a question of priorities. Undersea Hyperb Med 2021;48(2):169-172.
Nishizaka T, Nomura T, Sano T, Higuchi K, Nagatomo F, Ishihara A. Hyperbaric oxygen improves ultraviolet B irradiation-induced melanin pigmentation and diminishes senile spot size. Skin Res Technol 2011;17(3):332-338.
Niu QY, Yang XQ, Liu XW, Yang F, He W. Comparative efficacy and safety of core decompression, cell-based therapy, hyperbaric oxygen therapy, extracorporeal shock wave therapy, and combined regimens for osteonecrosis of the femoral head: a network meta-analysis. Front Cell Dev Biol 2026;14:1876711.
National Oceanic and Atmospheric Administration. Operating Standards for NOAA Hyperbaric Chambers. NOAA 2017:1-109.
Nogueira-Filho GR, Rosa BT, David-Neto JR. Effects of hyperbaric oxygen therapy on the treatment of severe cases of periodontitis. Undersea Hyperb Med 2010;37(2):107-14.
Nöhl S, Burisch C, Gödde D, Sellmann T. 'Power under pressure' - defibrillation during hyperbaric oxygen therapy: a scoping review. Diving Hyperb Med 2025;55(4):407-418.
Norman JN. Haemodynamic studies in total blood replacement. Bibl Haematol 1975;(41):203-8.
Norton MN, Weaver LK. Decompression sickness with incidental pulmonary cyst. Undersea and Hyperbaric Medicine 2022;49(3):289-293.
Novitas Solutions. Local Coverage Determination (LCD) for Hyperbaric Oxygen (HBO) Therapy (L34794)(Posted for Notice) Contractor Information. unknown 2014:1-22.
Nowadly C, Johnson-Arbor K, Boyle A. Severe unintentional first trimester carbon monoxide poisoning: case report. Undersea Hyperb Med 2018;45(4):453-456.
Nukala N, Rao R, Nemeth D, Badam M. Hyperbaric Oxygenation Therapy as Adjunctive Treatment of Complex Wound Associated with Sterno-clavicular Septic Arthritis. Undersea Hyperb Med 2025;52(3):279-282.
Obradovic A, Nenadovic A, Mitovic N, Jeremic R, Brkic P, Vidonja Uzelac TF, Vujacic UJ, Ivanov M, Jankovic S, Vukovic A, De Luka SR, Kovacevic S, Nesovic Ostojic J. Organ-specific redox and trace element modulation following hyperbaric oxygenation and physical activity in rats. Front Med (Lausanne) 2026;13:1820821.
Öçbe M, Sümen SG, Altun BD, Dumlu A. Barodontalgia during hyperbaric oxygen therapy of an 8-year-old male: A case report. Undersea Hyperb Med 2024;51(1):47-51.
Oda T, Takeori M. Effect of viscosity of the blood on increase in cardiac output following acute hemodilution. In: Wada J, Iwa T, eds. Proceedings of the Fourth International Congress on Hyperbaric Medicine. Baltimore: Williams & Wilkins 1970:191–196.
Oguz H, Sobaci G. The use of hyperbaric oxygen therapy in ophthalmology. Surv Ophthalmol 2008;53(2):112-120.
Oh SH, Kang HD, Jung SK, Choi S. Successful treatment of decompression sickness complicated with acute hepatic infarction and acute kidney injury: a case report. Undersea Hyperb Med 2019;46(1):81-85.
Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Agustine, Faruk M, Kalangi JA. (verify). Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: A randomized controlled trial study. Int J Surg Open 2021;29:33–39.
Serum VEGF increased significantly in the HBO group vs control (p<0.05). n = 15 (7 HBO, 8 control; Table 1, page 35), not stated on this page before. Both arms were sampled at baseline and after debridement (no difference). Only the HBO arm was sampled
Oley MH, Oley MC, Kepel BJ, Faruk M, Wagiu AMJ, Sukarno I, Tulong MT, Sukarno V. Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers Based on Wagner Grading: A Systematic Review and Meta-analysis. Plast Reconstr Surg Glob Open 2024;12(3):e5692.
Wound healing (≥8 weeks after final treatment): RR 2.39 (95% CI 1.87–3.05; P<0.00001) favouring HBOT. Minor / distal amputation: RR 0.58 (95% CI 0.43–0.80; P<0.007). Major / proximal amputation: RR 0.31 (95% CI 0.18–0.52; P<0.00001).
Oley MH, Oley MC, Kepel BJ, Prasetyo E, Kalitouw F, Kalesaran L, Aling DMR, Tulong MT, Islam AA, et al. A descriptive retrospective study on the various uses of hyperbaric oxygen therapy. Int Marit Health 2025;76(4):254-258 (DOI 10.5603/imh.103441).
Oley MH, Oley MC, Iskandar AAA, Sukasah CL, Aulia I, Langi FLFG, Lampus HF, Sukarno I, Sukarno V, Faruk M. The effect of hyperbaric oxygen therapy on hypospadias reconstruction: a preliminary randomized controlled trial study of VEGF levels and HOPE score analysis. Arch Ital Urol Androl 2025;97(1):13342.
VEGF rose with successive HBO sessions — significant at 3 (p=0.038), 4 (p=0.002) and 5 (p=0.008) sessions. Total HOPE score improved (p=0.028) and penile-torsion sub-score (p=0.006) in the HBO group. Conclusion: HBO accelerates wound healing after urethroplasty; ≥3 sessions recommended.
Oley MH, Oley MC, Sukarno V, Suoth SC, Faruk M. Hyperbaric oxygen therapy in the reconstruction of giant rhinophyma: a case series. Dermatol Rep 2026:Epub ahead of print.
Oliveira P, Batista ME, Barbosa M, Vaz J, Borges A. Pan-Spinal Epidural Abcess: Multidisciplinary Management of a Rare and Life-Threatening Condition. Cureus 2026;18(1):e101533.
Olson KR, Seger D. Hyperbaric oxygen for carbon monoxide poisoning: does it really work? Annals of Emergency Medicine 1995;25(4):535-537.
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Omar AR, Ibrahim M, Hussein A. Acute ophthalmic artery occlusion in decompression illness with underlying anterior cerebral artery A1 segment hypoplasia. Diving and Hyperbaric Medicine 2018;48(2):112-113.
O’Neill WW, Martin JL, Dixon SR, Bartorelli AL, Trabattoni D, Oemrawsingh PV, et al. Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT). Journal of the American College of Cardiology 2007;50(5):397-405.
O'Neill OJ, Weitzner ED. The O'Neill grading system for evaluation of the tympanic membrane: a practical approach for clinical hyperbaric patients. Undersea Hyperb Med 2015;42(3):265-271.
O'Neill OJ, Smykowski E, Marker JA, Perez L, Gurash S, Sullivan J, et al. Proof of concept study using a modified Politzer inflation device as a rescue modality for treating Eustachian tube dysfunction during hyperbaric oxygen treatment in a multiplace (Class A) chamber. Undersea Hyperb Med 2019;46(1):55-61.
O'Neill OJ, Dayya D, Varughese L, Marker JA, Perez L, Dayya M. The effect of total compression time and rate (slope) of compression on the incidence of symptomatic Eustachian tube dysfunction and middle ear barotrauma: a Phase II prospective study. Undersea Hyperb Med 2021;48(3):209-219 (Phase II prospective study; 1,244 group patient-treatment exposures covering 5,072 individual patient-treatment exposures).
The longer 15-minute compression interval produced significantly fewer compression stops and holds than the 10-minute interval (Table 3D: OR 0.66, 95% CI 0.49–0.89, p = 0.006), reproducing the same unit's Phase I result. The non-linear slope showed a 17% lower risk but did not reach significance (Table 3E: OR 0.80, 95% CI 0.59–1.1, p = 0.14). Note that the abstract's claim to be "the first to demonstrate a statistically signif…
Onodera K, Ishikawa M, Homura M, Takahashi K, Hoshino K, Morimoto Y. Factors related to the prognosis of hyperbaric oxygen therapy for postoperative paralytic ileus. Undersea Hyperb Med 2025;52(2):93-99.
Medical Advisory Secretariat (Ontario). Hyperbaric oxygen therapy for non-healing ulcers in diabetes mellitus: an evidence-based analysis. Ont Health Technol Assess Ser 2005;5(11):1–28.
Citing the Cochrane analysis (3 studies, 118 patients): HBOT may prevent major amputation — RR 0.31 Evidence graded low quality (small trials, varying wound severity, HBOT regimens and endpoints);
Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser 2017;17(5):1-142.
Opasanon S, Pongsapich W, Taweepraditpol S, Suktitipat B, Chuangsuwanich A. Clinical effectiveness of hyperbaric oxygen therapy in complex wounds. J Am Coll Clin Wound Spec 2015;6(1-2):9–13 (Zotero gives 2014; PubMed and the PDF give 2015 (volume 6, 2014 issue published 2015)).
O'Reilly D, Pasricha A, Campbell K, Burke N, Assasi N, Bowen JM, Tarride JE, Goeree R. HYPERBARIC OXYGEN THERAPY FOR DIABETIC ULCERS: SYSTEMATIC REVIEW AND META-ANALYSIS. Int J Technol Assess Health Care 2013;29(3):269–281.
12 publications (6 RCTs + 6 comparative observational). Major amputation reduced 60% (RCTs, p=0.29 — NS) and 61% (observational, p=0.003) vs standard care. Unhealed-wound relative risk 0.54 (RCTs, p=0.10 — NS) and 0.24 (observational, p<0.001).
Oriani G, Marroni A, Wattel F, editors. Handbook on Hyperbaric Medicine. Milan: Springer-Verlag Italia 1996:xii + 902 pp (printed folios; the title verso states no extent; PDF 900 pp — printed page ≠ PDF page by a drifting offset, see the paging table on this page).
Oroglu B, Turker T, Aktas S, Olgac V, Alp M. Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves. Undersea Hyperb Med 2011;38(5):367-73.
Orozco-Gutierrez A, Rojas-Cerda L, Estrada RM, Gil-Rosales C. Hyperbaric oxygen in the treatment of asphyxia in two newborn infants. Diving Hyperb Med 2010;40(4):218-20.
Ortega MA, Fraile-Martinez O, García-Montero C, Callejón-Peláez E, Sáez MA, Álvarez-Mon MA, et al. A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities. Medicina (Kaunas) 2021;57(9).
Orwig D, Logue C, Hendriksen S, Westgard B, Walter J, Pullis M, Masters T. An approach to treating a patient with a HeartMate II™ left ventricularassist device in a multiplace hyperbaric chamber: a case report. Undersea Hyperb Med 2018;45(1):89-93.
Orwig DM, Wang J, Li Z, McGlynn JJ, HajAissa N, Davis A, Hovingh M, Packard L, Kooistra JS, Min J. The effects of hyperbaric oxygen treatment for non-arteritic central retinal artery occlusion (HBOT-CRAO). Am J Emerg Med 2025;98:1-5 (Epub 5 Aug 2025).
65 patients: full-course HBOT 17 (twice daily × 5 days = 10 treatments), partial 16, none 32. No Full-course HBOT: significant BCVA improvement at discharge (p = 0.01); no benefit with partial or no Conclusion: HBOT may be considered for CRAO presenting within 24 h, with the full course important.
Osborne CK, Carolla R, Jefferson D, Mengel CE. Effect of methemoglobin on in vivo RBC lipid peroxidation. Aerosp Med 1973;44(1):63-7.
Oscarsson N, Müller B, Rosén A, Lodding P, Mölne J, Giglio D, et al. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. Lancet Oncol 2019;20(11):1602–1614.
Difference in change of mean EPIC urinary total score: +10.1 points favouring HBOT Adverse events: transient grade 1–2 (sight/hearing) in 41%. ⚠️ Full read 21 Oct 2026 (all 13 pages of the Lancet Oncol paper): the primary result holds. Four points this page did not carry.
Oscarsson N, Rosén A, Müller B, Renström Koskela L, Giglio D, Kjellberg A, Ettala O, Seeman-Lodding H. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): long-term follow-up of a randomised controlled, phase 2–3 trial. EClinicalMedicine 2025;83:103214.
Mean EPIC urinary total score improved 18.0 points (95% CI 14.2–21.8) from baseline to 6 months Responders (n=48; 68.6%) — defined as ≥9-point improvement post-HBO₂ — maintained a mean increase 9/70 (12.8%) received additional HBO₂ for recurring symptoms over the 5 years.
Gafar Abubakir Osman H, Elbadri ME, Alhadi IAH, Ibrahim AS, Ayyub A, Mohamed A, Sahnon ASA, Alkhazendar JHJ, Alkhazendar AH, Awan M. Crush syndrome and systemic necrosis in trauma patients: a systematic review of pathophysiology, anatomical impact, and renal outcomes. Cureus 2025;17(8):e89592.
Osmani F, Thakkar S, Vigdorchik J. The Utility of Conservative Treatment Modalities in the Management of Osteonecrosis. Bull Hosp Jt Dis (2013) 2017;75(3):186–192.
The biophysical modalities (HBO, ESWT, PEMF) all produced delay and partial reversal of disease Stage-dependent: Ficat I–II (pre-collapse) can be approached conservatively (pharmacological + ⚠️ Full read 21 Oct 2026 — the HBO evidence is two studies (Results, pages 189–190; Table 5, page 188):
Osteen RT, Klebanoff G. The effects of hemodilution, hypothermia, and hyperbaric oxygenation on intact dogs. Cryobiology 1970;7(4):263-4.
Oter S, Korkmaz A. Relevance of hyperbaric oxygen to ozone therapy. Arch Med Res 2006;37(7):917-8; author reply 919.
Otón Sánchez C, González Lugo Y, Otón Sánchez L, Díaz-Flores Varela L, Jiménez Calero J, Puerto Romero P. Treatment of radiation-induced cervical fibrosis with pentoxifylline-tocoferol and hyperbaric oxygen. Rep Pract Oncol Radiother 2013;18(Suppl):S111 — SEOR/ESTRO congress abstract.
37 randomised, 26 completed (13 per arm); well tolerated (2 stopped for drug intolerance). Patients improving fibrosis by ≥1 LENT-SOMA grade: Arm 1 (drugs only): 1/13 at 3 months, 4/13 at 6 months.
O'Toole K. Hyperbaric oxygen therapy and chronic refractory osteomyelitis. Operative Techniques in Orthopaedics 2002;12(4):282–285.
Definition adopted (from Strauss): chronic osteomyelitis is bone infection which, when adequately treated, persists longer than six weeks; it becomes refractory when it does not respond to adequate therapeutic intervention including antibiotics and surgery. The Esterhai, Waldvogel and Cierny-Mader classification systems are named as aids to treatment choice.
Otsuka Y, Tomura S, Toyooka T, Takeuchi S, Tomiyama A, Omura T, et al. Hyperbaric hydrogen therapy improves secondary brain injury after head trauma. Undersea Hyperb Med 2023;50(4):403-411.
Otto GH, Buyukcakir C, Fife CE. Effects of smoking on cost and duration of hyperbaric oxygen therapy for diabetic patients with non-healing wounds. Undersea Hyperb Med 2000;27(2):83–89.
OuYang H, Yang J, Wan H, Huang J, Yin Y. Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis. Front Endocrinol (Lausanne) 2024;15:1452192.
Versus SOC, HBOT — along with PRP, TOT, ADM and SCs — significantly increases the complete-healing HBOT is not the top-ranked modality: PRP (esp. PRP+NPWT) and combination regimens ranked highest No significant between-treatment differences for ulcer-area reduction.
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A systematic review and meta-analysis of randomised trials of hypoxic modification added to curative-intent primary radiotherapy alone. - 32 randomised trials, 4,805 patients. - Inclusion criterion, stated: the treatment had to be curative intended primary radiotherapy alone, with randomisation to a hypoxic modifier known only to influence hypoxic radioresistance and having no other cytotoxic effe
Oyaizu T, Enomoto M, Tsujimoto T, Kojima Y, Okawa A, Yagishita K. Elimination of CT-detected gas bubbles derived from decompression illness with abdominal symptoms after a short hyperbaric oxygen treatment in a monoplace chamber: a case report. Undersea Hyperb Med 2017;44(2):167-171.
Oyaizu T, Enomoto M, Yamamoto N, Tsuji K, Horie M, Muneta T, Sekiya I, Okawa A, Yagishita K. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep 2018;8(1):1288.
Oedema/injury: HBO reduced early hindlimb volume and muscle wet weight (µCT volume lower at 6 h, Dual immuno-regenerative action: HBO suppressed the acute-phase rise in circulating macrophages, Pathway: early stimulation of the IL-6/STAT3 pathway in contused muscle.
Ozdemir A, Uzun G, Turker T, Ucar E, Yildiz S. Changes in pulmonary function in hyperbaric chamber inside attendants: a case-control study. Undersea Hyperb Med 2016;43(7):805-811.
Özdemir Ü, Akin M, Sözen I, Erkent M, Tatar S, Yasti AÇ. Effects of hyperbaric oxygen therapy on clinical and economic outcomes in patients with deep second-degree burns. Undersea Hyperb Med 2023;50(1):29-37 (DOI 10.22462/01.01.2023.18).
Özgök-Kangal MK, Karatop-Cesur I, Akcali G, Yildiz S, Uzun G. Requests for emergency hyperbaric oxygen treatment for carbon monoxide poisoning in Ankara, Turkey. Diving Hyperb Med 2016;46(3):176–180.
Ozgok-Kangal K. Long-term infant outcomes after hyperbaric oxygen treatment for acute carbon monoxide poisoning during pregnancy. Diving Hyperb Med 2021;51(3):248-255.
Ozgok Kangal K, Mirasoglu B. Hyperbaric oxygen treatment for infants: retrospective analysis of 54 patients treated in two tertiary care centres. Diving and Hyperbaric Medicine Journal 2024;54(1):9-15 (DOI 10.28920/dhm54.1.9-15).
Özkan R, Türkmen O, Yumbul Kardaş AS, Sivrikaya H. Evaluation of Responses Provided by Artificial Intelligence Chatbots to Questions on Hyperbaric Oxygen Therapy. Lokman Hekim Dergisi (Lokman Hekim Journal) 2026;16(3):952-960.
Özkan R, Kaya B. High-altitude decompression illness following recreational diving: a case report from Lake Van. Undersea Hyperb Med 2026;53(1):31-34.
Özkan R, Türkmen O, Yapici K, Kaya Z. Bilateral sudden sensorineural hearing loss following indirect lightning exposure successfully treated with hyperbaric oxygen therapy: a case report. Diving Hyperb Med 2026;56(3):371-375.
Özkan R, Kaya B, Kaya G. Vascular occlusion following hyaluronic acid injection: A case report. Undersea Hyperb Med 2026;53(1):47-50.
Özlü EBK, Aytekin Ş, Akar E, Çalışaneller AT. Hyperbaric Oxygen Therapy In Surgical Site Infections: A Clinical Experience. Undersea Hyperb Med 2025;52(2):73-79.
Öztopuz Ö, Türkön H, Sehitoglu MH, Büyük B, Uzun M, Ovali MA, et al. Hyperbaric oxygen treatment ameliorates gentamicin-induced nephrotoxicity and expression of kidney injury molecule 1 in the rat model. Undersea Hyperb Med 2019;46(2):125-133.
Ozturk H, Mirasoglu B, Aktas S. Hyperbaric oxygen treatment for refractory haemorrhagic cystitis occurring after chemotherapy and haematopoietic stem cell transplantation: retrospective analysis of 25 patients. Diving Hyperb Med 2022;52(1):27-34.
Paderno E, Zanon V, Vezzani G, Giacon TA, Bernasek TL, Camporesi EM, Bosco G. Evidence-Supported HBO Therapy in Femoral Head Necrosis: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health 2021;18(6):2888.
Overall clinical effect OR 3.84 (95% CI 2.10–7.02; P<0.00001) favouring HBO. Subgroup: Asian population OR 3.53 (95% CI 1.87–6.64; significant); non-Asian OR 7.41 (95% CI
Padhiyar V, Maitra A, Singh C, Tulara N. Nitrofurantoin-Induced Hemolytic Anemia and Methemoglobinemia in G6PD Deficiency Treated With Hyperbaric Oxygen Treatment. Undersea Hyperb Med 2026;53(2):235-242.
Paetow G, Logue C, TenBrink W, Zarzar R, Driehorst M, Brown L, et al. In-situ simulation for the detection of latent risk threats in a hyperbaric medicine department. Undersea Hyperb Med 2020;47(2):211-216.
Paganini M, Moon RE, Boccalon N, Melloni GEM, Giacon TA, Camporesi EM, Bosco G. Blood gas analyses in hyperbaric and underwater environments: a systematic review. J Appl Physiol (1985) 2022;132(2):283–293.
A systematic review of studies measuring blood gases in hyperbaric and underwater environments — a physiology and measurement-methodology synthesis.
Pagoldh M, Hultgren E, Arnell P, Eriksson A. Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study. Scand J Gastroenterol 2013;48(9):1033–1040.
No statistically significant difference between the groups in any of the assessed variables — The UNSW appraisal notes the study was underpowered.
Pak S, Valencia D, Lee C, Lach J, Ortiz G. Ingestion of food grade hydrogen peroxide with resultant gastrointestinal and neurologic symptoms treated with hyperbaric oxygen therapy: case report and review with emphasis on the therapeutic value of HBO2 in vascular gas embolism. Undersea Hyperb Med 2021;48(2):177-186.
Palmer A, Holdstock C, Watts D, Stokes RJ, Whiteley J. A case of severe multi-system decompression sickness requiring critical care, aggressive fluid resuscitation and hyperbaric oxygen therapy. Diving Hyperb Med 2026;56(3):376-380.
Pan JQ, Tian ZM, Xue LB. Hyperbaric oxygen treatment for long COVID: from molecular mechanism to clinical practice. Curr Med Sci 2023;43(6):1061-1065.
Pandey K, Teguh DN, van Hulst RA. Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patients. Diving Hyperb Med 2022;52(3):208-212.
Pang YC, Giacobbe P, Alam F. Hyperbaric oxygen therapy as a potential treatment for MDD: a narrative review. Front Med (Lausanne) 2026;13:1931426.
Pang Y, Yuan J, Yuan X, Chai X, Li S. Hyperbaric oxygen therapy for ischemic encephalopathy following occupational exposure to high-concentration toxic gases: two cases. Front Toxicol 2026;8:1782213.
Pangal DJ, Baertsch H, Kellman EM, Cardinal T, Brunswick A, Rutkowski M, Strickland B, et al. Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles. World Neurosurg 2021.
Paquette IM, Vogel JD, Abbas MA, Feingold DL, Steele SR. Reprint: The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Chronic Radiation Proctitis. Diving Hyperb Med 2019;49(1):66.
Park S, Marinov A, Clarke H, Schiavo S, Greer E, Djaiani G, Tarshis J, Katznelson R. Safety of hyperbaric oxygen therapy in non-emergent patients with a history of seizures: A retrospective cohort study. PLoS One 2025;20(1):e0317586.
Parker JN, Parker PM, editors. Hyperbaric Chamber: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications (ICON Group International) 2004:96 pp (PDF).
One of ICON Group's automatically assembled "medical dictionary, bibliography and research guide" series: chapters of study listings (from federal research databases), alternative-medicine listings, dissertations, patents, book lists and a glossary, with a disclaimer that the publisher makes no warranty about the contents. It contains no original review, data or recommendation, so nothing in it is
Parsons D, Utz E, Kidd G, Virgilio G. Inner ear decompression sickness after a routine dive and recompression chamber drill. Undersea Hyperb Med 2024;51(2):129-135.
Partrick M, Fiesseler F, Shih R, Riggs R, Hung O. Monthly variations in the diagnosis of carbon monoxide exposures in the emergency department. Undersea Hyperb Med 2009;36(3):161-7.
Pateria P, Chong A. A recurrent, ischaemic ileocolonic anastomosis ulcer refractory to surgery treated with hyperbaric oxygen. Diving Hyperb Med 2018;48(3):194–196.
Pathault E, Sanchez S, Husson B, Vanhaecke C, Georges P, Brazier C, Mourvillier B, Viguier M. Hyperbaric oxygen therapy enables pain reduction and healing in painful chronic wounds, including in calciphylaxis. Ann Dermatol Venereol 2024;151(4):103325.
Payne H, Adamson A, Bahl A, Borwell J, Dodds D, Heath C, Huddart R, McMenemin R, Patel P, Peters JL, Thompson A. Chemical‐ and radiation‐induced haemorrhagic cystitis: current treatments and challenges. BJU Int 2013;112(7):885–897.
Narrative/systematic overview of haemorrhagic-cystitis treatments (hydration, bladder irrigation, formalin, aluminium, hyperbaric oxygen, cystectomy). HBO presented as an effective option for RT-induced cystitis; hyperbaric protocols differ between reports and evidence is largely observational.
Pazin C, de Souza Mitidieri AM, Silva APM, Gurian MBF, Poli-Neto OB, Rosa-e-Silva JC. Treatment of bladder pain syndrome and interstitial cystitis: a systematic review. Int Urogynecol J 2016;27(5):697-708.
Pearl A, Pearl S. Hyperbaric oxygen therapy for avascular necrosis of the femoral head: A case report. Undersea Hyperb Med 2024;51(3):241-245 (DOI 10.22462/644).
Pekovic S, Dacic S, Krstic D, Jeremic R, Djelic M, Brkic P. Hyperbaric oxygen therapy in traumatic brain injury: cellular and molecular mechanisms. In: Hyperbaric Oxygen Treatment in Research and Clinical Practice — Mechanisms of Action in Focus. IntechOpen 2018 (book chapter 3. DOI 10.5772/intechopen.75025).
Peleg RK, Fishlev G, Bechor Y, Bergan J, Friedman M, Koren S, Tirosh A, Efrati S. Effects of hyperbaric oxygen on blood glucose levels in patients with diabetes mellitus, stroke or traumatic brain injury and healthy volunteers: a prospective, crossover, controlled trial. Diving Hyperb Med 2013;43(4):218-21.
Pell M, Saththasivam P, Stephens PL, Mychaskiw G. Therapeutic effect of hyperbaric oxygen on inclusion body myositis. Undersea Hyperb Med 2012;39(6):1111-4.
Peng ZR, Zhong WH, Liu J, Xiao PT. Effects of the combination of hyperbaric oxygen and 5-fluorouracil on proliferation and metastasis of human nasopharyngeal carcinoma CNE-2Z cells. Undersea Hyperb Med 2010;37(3):141-50.
Peng Z, Wang S, Huang X, Xiao P. Effect of hyperbaric oxygen therapy on patients with herpes zoster. Undersea Hyperb Med 2012;39(6):1083-7.
Peng Z, Fan J, Liu L, Kuang F, Xue F, Wang B. Research Report: Intermittent hypobaric hypoxia and hyperbaric oxygen on GAP-43 in the rat carotid body. Undersea Hyperb Med 2015;42(6):529-37.
Peng X, Gao B, Wang X, Qin X, Peng M, Zeng X. Hyperbaric oxygen and treadmill exercise partially prevented bone loss and bone microarchitecture deterioration in ovariectomized rats. Diving and Hyperbaric Medicine Journal 2023;53(2):111-119 (DOI 10.28920/dhm53.2.111-119).
Pennefather J. Now and then – tales from SUMU. Diving Hyperb Med 2007;37(2):90-93.
Perdrizet G, Rutland R, Shapter C, Keating K, Abbensetts K. Traumatic amputation in a Jehovah's Witness: options for enhancing oxygen delivery [abstract B11]. Undersea Hyperb Med 2007;34(4):240–241 (Abstracts from the UHMS ASM 2007).
Perdrizet GA. Type II DCS in an inside hyperbaric attendant: commentary. Undersea Hyperb Med 2012;39(5):869.
Pereira D, Ferreira C, Catarino R, Correia T, Cardoso A, Reis F, Cerqueira M, Prisco R, Camacho O. Hyperbaric oxygen for radiation-induced cystitis: a long-term follow-up. Actas Urol Esp 2020;44(8):561-567.
Perelman SI, Shander A, Mabry C, Ferraris VA. Preoperative anemia management in the coronavirus disease (COVID-19) era. JTCVS Open 2021;5:85-94.
Perez MFM, Ongkeko-Perez JV, Serrano AR, Andal MP, Aldover MCC. Delayed hyperbaric intervention in life-threatening decompression illness. Diving Hyperb Med 2017;47(4):257-259.
Perks S, Blake DF, Young DA, Hardman J, Brown LH, Lewis I, et al. An assessment of the performance of the Baxter elastomeric (LV10) Infusor™ pump under hyperbaric conditions. Diving Hyperb Med 2017;47(1):33-37.
Perren S, Gatt A, Papanas N, Formosa C (University of Malta; ⚠️ Papanas N is at the Democritus University of Thrace, Alexandroupolis, Greece — corrected 2 Sep 2026). Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial. Open Cardiovasc Med J 2018;12:80–85.
Both arms reduced ulcer area and depth (P<0.001). Group A (HBOT) showed superior improvement in both ulcer area (P<0.001) and depth (P<0.001)
Perrins DJ. Indexed as a Randomized Controlled Trial. Influence of hyperbaric oxygen on the survival of split skin grafts. Lancet 1967;1(7495):868–871.
Complete "take" (≥95% graft survival): 64% (≈15/24) HBO vs 17% (≈4/24) control — absolute increase ≥60% take: 100% (HBO) vs 64% (control) — no treated graft fell below 60% take; NNT ≈ 3. <br>⚠️ Corrected 31 Aug 2026: the control figure previously read 62.5%. The paper's table (Proportion of treated and control cases in relation to graft survival, p. 869) gives >60%: treated 100%, control 64% (verified against the printed table…
Persson BM. Effect of hyperbaric oxygenation on longitudinal growth of bones. Acta Orthopaedica Scandinavica 1967;38(1-4):23-34.
Peskin B, Shupak A, Levin D, Norman D, Jacob Z, Boss JH, Misselevich I, Reis DN, Zinman C. Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head. Undersea Hyperb Med 2001;28(4):187–194 (PubMed lists eight authors; the PDF adds Zinman C).
Peters N, Jansen S, Klußmann JP, Meyer MF. Intraindividual variability of the Eustachian tube function: a longitudinal study in a pressure chamber. Diving Hyperb Med 2023;53(1):24-30.
Peterson DE, Koyfman SA, Yarom N, Lynggaard CD, Ismaila N, Forner LE, et al. (ISOO-MASCC-ASCO). Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline. J Clin Oncol 2024;42(16):1975–1996.
A multi-society clinical practice guideline (International Society of Oral Oncology – Multinational Association of Supportive Care in Cancer – American Society of Clinical Oncology) on prevention and management of osteoradionecrosis (ORN) in head-and-neck cancer treated with radiotherapy. The most authoritative recent guideline touching HBO for ORN — and it is cautious.
Petri NM. Croatian indications for hyperbaric oxygenation: doubts of the world projected in a small country. Undersea Hyperb Med 2009;36(5):353-9.
Pham B, Edillor P. Relative brain perfusion differences in a patient with persistent fatigue and subjective cognitive symptoms: a case report. Cureus 2026;18(10):e118112.
Philipsen BB, Korsholm M, Rohde M, Wessel I, Forner L, Johansen J, Godballe C. The effect of hyperbaric oxygen therapy in head and neck cancer patients with radiation induced dysphagia — a systematic review. Clin Transl Oncol 2024;26(10):2594-2600.
Phillips TJ. Hyperbaric oxygen therapy [Controversies in Dermatologic Surgery]. Dermatol Surg 2000;26(12):1167-1169.
Phillips JC. Understanding hyperbaric oxygen therapy and its use in the treatment of compromised skin grafts and flaps. Plast Surg Nurs 2005;25(2):72-80.
Phillips JS, Jones SEM. Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa. Cochrane Database Syst Rev 2013;(5):CD004617 (current version pub3 (2013); supersedes pub2 (2005)).
No randomised controlled trials identified. No data to show adjunctive HBO improves outcome over ⚠️ Full read 21 Oct 2026: last search 14 January 2011, no language, date or status restrictions,
Pilgramm M, Schumann K. Hyperbaric oxygen therapy for acute acoustic trauma. Arch Otorhinolaryngol 1985;241(3):247–257.
HBO shortened the course of healing with respect to high-pitch (high-frequency) perception Timing-dependent: ⚠️⚠️ WITHDRAWN 2 September 2026 — ANOTHER SOURCE'S CLAIM, NOT THIS TRIAL'S RESULT. The sentence sat in the Discussion (p.254) as a general remark attributed to other authors: "Experience shows that when indicated, any therapy started as early as possible produces better results...", immediately after "Several studies do…
Pilgramm M, Lamm H, Schumann K. [Hyperbaric oxygen therapy in sudden deafness]. Laryngol Rhinol Otol (Stuttg) 1985;64(7):351–354.
Standard therapy (n=19): start 45.7 → end 25.5 dB, gain 20.2 dB (44%), P<0.01. HBO + standard (n=18): start 47.2 → end 18.1 dB, gain 29.1 dB (61%), P<0.01. Between-group difference (this appraiser's calculation): ≈ 8.9 dB favouring HBO (95% CI ≈ 0.3–17.5) —
Pisano TJ, Zotter B, Lambert DS, Prasad S. Decompression sickness myelopathy: case report and acute management review for the neurologist. Neurohospitalist 2026:19418744261500155 (online first, 16 Oct 2026).
Pitkin AD, on behalf of the RIBP Working Party. Double-blind randomised controlled trial of hyperbaric oxygen (HBO) therapy for treatment of radiation-induced brachial plexopathy (RIBP). Undersea Hyperb Med 2000;27(suppl):39 — UHMS ASM abstract.
No differences in mean warm sensory thresholds between groups — HBO did not reverse RIBP in the short Authors flagged that a possible effect on arm lymphoedema was being tested in a follow-up trial (→ that
Pittinger CB. Hyperbaric Oxygenation. Springfield (IL): Charles C Thomas 1966:136 pp (PDF; scan with OCR text layer); American Lecture Series no. 640.
Pitts S. 3 hyperbaric oxygen treatments reduced cognitive sequelae of acute carbon monoxide poisoning [commentary]. Evid Based Med 2003;8(3):87.
Plenk HP. Hyperbaric Radiation Therapy — Preliminary Results of a Randomized Study of Cancer of the Urinary Bladder and Review of the 'Oxygen Experience.' Am J Roentgenol Radium Ther Nucl Med January 1972.
A significant improvement in survival was reported in the HBO (hypofractionated) arm vs conventional Author's review claim: oxygen benefit appears only when 4–12 fractions are used; SCC of cervix and In the cited cervix series using conventional fractionation, the HBO-vs-air difference was not
Poff D, Wong R, Bulsara M. Acute decompression illness and serum s100beta levels: a prospective observational pilot study. Undersea Hyperb Med 2007;34(5):359-367.
Polzik P, Hansen MB, Olsen NV, Grøndal O, Hyldegaard O. Hyperbaric oxygen therapy may overcome nitric oxide blockage during cyanide intoxication. Undersea Hyperb Med 2017;44(3):221-234.
Polzik P, Johansson PI, Hyldegaard O. How biomarkers reflect the prognosis and treatment of necrotising soft tissue infections and the effects of hyperbaric oxygen therapy: the protocol of the prospective cohort PROTREAT study conducted at a tertiary hospital in Copenhagen, Denmark. BMJ Open 2017;7(10):e017805.
Popa D, Chin W, Huchim-Lara O, Grover I. Spinal decompression sickness in an artisanal diving fisherman in Yucatán, Mexico: a case report. Undersea and Hyperbaric Medicine 2017;44(5):415-419.
Popa D, Medak A, Chin W, Huchim-Lara O, Fliszar E, Hughes T, Grover I. Dysbaric osteonecrosis (DON) among the artisanal diving fishermen of Yucatan, Mexico. Diving and Hyperbaric Medicine 2020;50(4):391-398.
Popa D, Waterhouse L, Duchnick J, Neuman T, Witucki P. Performance of the Uni-Vent Eagle™ Model 754 ventilator under hyperbaric conditions. Undersea Hyperb Med 2021;48(4):409-416.
Popova J, Buravkova L. Blood biochemical parameters in women during long-term simulated hyperoxic diving up to 8 ATA. Undersea Hyperb Med 2006;33(3):211-6.
Posluszny JA Jr, Napolitano LM. How do we treat life-threatening anemia in a Jehovah's Witness patient? Transfusion 2014;54(12):3026–3034.
A narrative practice review in Transfusion's "HOW DO I…?" instructional series, setting out one American centre's protocol for severe anaemia in patients who decline transfusion, with an embedded uncontrolled case series of 6 patients treated under that protocol between 2012 and 2014. There is no search strategy, no database, no date range, no eligibility criteria, no screening or extraction proce
Poulton TJ, Witcofski RL. Hyperbaric oxygen therapy for radiation myelitis. Undersea Biomed Res 1985;12(4):453–458.
Pracyk JB, Stolp BW, Fife CE, Gray L, Piantadosi CA. Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning. Undersea Hyperb Med 1995;22(1):1-7.
Preheim B, Moayedi S, Chew KW, Sethuraman K. Myocardial Ischemia-Associated Arterial Embolism Management from Pulmonary Cryotherapy. Undersea Hyperb Med 2025;52(4):617-620.
Press OW, Ramsey PG. Central nervous system infections associated with hereditary hemorrhagic telangiectasia. Am J Med 1984;77(1):86-92.
Presti N, Huang E, Pryor JL, Hostler D. Effects of hyperbaric oxygen therapy on exercise-induced muscle damage. Undersea Hyperb Med 2022;49(3):315-327.
Price JC, Stevens DL. Hyperbaric oxygen in the treatment of rhinocerebral mucormycosis. Laryngoscope 1980;90(5 Pt 1):737-47.
Price WD, Price SM, Johnston M. Novel treatment of dihydrogen sulfide inhalation using hyperbaric oxygen during mass casualty. Undersea Hyperb Med 2021;48(2):153-156.
Price SM, Price WD, Johnston MJ. Pneumomediastinum and the use of hyperbaric oxygen treatment. Diving Hyperb Med 2021;51(1):119-123.
Pries-Heje MM, Lerche CJ, Fosbøl E, Forchhammer M, Hasselbalch RB, Schwartz F, Siebert ASL, Jensen PØ, Rottensten H, Iversen K, Bundgaard H, Hyldegaard O, Moser C. Hyperbaric Oxygen Treatment as a Novel Add-on in Selected Patients with Infective Endocarditis – A Safety and Feasibility Trial. Infect Drug Resist 2026;19:568123.
Pritchard J, Anand P, Broome J, Davis C, Gothard L, Hall E, Maher J, McKinna F, Millington J, Misra VP, Pitkin A, Yarnold JR (RAGE / Royal Marsden). Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2001;58(3):279–286 (PII S0167-8140(00)00309-8; DOI to confirm).
Pre-treatment neurophysiological tests were grossly abnormal in the affected hand in both groups (as No adverse effects of HBO were reported. The authors noted warm-sensory-threshold improvements offered only "some suggestion" of activity in a
Prost M, Eichhorn D, Strelow H, et al. Influence of the COVID-19 pandemic on causes for the development of carbon monoxide intoxications. Undersea Hyperb Med 2022;49(4):479-483.
Pucko EB, Godlewski J, Kaźmierczak N, Ostrowski RP. Anti-glioma agents and hyperbaric oxygen for prospective therapeutic approaches. Int J Mol Sci 2026;27(19):8504.
Pulsipher DT, Hopkins RO, Weaver LK. Basal ganglia volumes following CO poisoning: A prospective longitudinal study. Undersea Hyperb Med 2006;33(4):245-56.
Qi Y, Guo Z, Hu H, Meng X, Lv Y, Pan S, Guo D. Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning. Undersea Hyperb Med 2020;47(4):607-619.
Qin L, Chu M, Guo D, Wang L, Wang J, Ding X, Bi M, Zou Y. Efficacy of Combined XingZhi‐YiNao Granules and Hyperbaric Oxygen Therapy for Cognition and Motor Dysfunction in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. Evid Based Complement Alternat Med 2017;2017:1323297.
Both active arms improved cognition/motor scores and P300 amplitude (P<0.05); the XZYN group was ⚠️ Full read 21 Oct 2026 (pages 2–6): HBO dose not reported: "extra hyperbaric oxygen therapy once daily till 2 months" — no pressure,
Qingsong W, Yeming G, Xuechun L, Hongjuan L, Jing W. The free radical scavenger, edaravone, ameliorates delayed neuropsychological sequelae after acute carbon monoxide poisoning in rabbits. Undersea Hyperb Med 2013;40(3):223-9.
Qu C, Xu M, Lorenzo S, Huang P, Rao Z, Geng X, Zhao J. Mild hyperbaric oxygen therapy on subjective sleep quality, aerobic, anaerobic exercise test, brain and muscle tissue oxygenation response in Chinese University male athletes after muscle fatigue. BMC Sports Sci Med Rehabil 2026;18(1):181.
Quah B, Yong CW, Lai CWM, Islam I. Efficacy of adjunctive modalities during tooth extraction for the prevention of osteoradionecrosis: A systematic review and meta‐analysis. Oral Dis 2024;30(6):3732–3744.
The two controlled comparisons (review section 3.2), which are what the direction rests on: HBO vs no intervention: 2 studies, 108 patients (Beumer 1983, Vudiniabola 1999) — OR 0.27 HBO vs antibiotics: 3 studies, 281 patients (Marx 1985, Sulaiman 2003, Shaw 2019/HOPON) — OR 0.57
Rabinovich E, Johnson-Arbor K, Serrano M, Chao C, Eblan MJ, Rao AD, Terao M, Toretsky J, Sarangi S, Varela C, Hong D. The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient. JPGN Rep 2022;3(1):e144.
Racic G, Denoble PJ, Sprem N, Bojic L, Bota B. Hyperbaric oxygen as a therapy of Bell's palsy. Undersea Hyperb Med 1997;24(1):35-8.
Rahat MA, Brod V, Amit-Cohen BC, Henig O, Younis S, Bitterman H. Oxygen mitigates the inflammatory response in a model of hemorrhage and zymosan-induced inflammation. Shock 2016;45(2):198-208.
Rahman MM, Saif MSI, Beall J, Martin RL, Rockswold GL, Barsan WG, Korley FK, Silbergleit R, Stevenson V, Gajewski B. A Bayesian model with seasonal effects for predicting accrual in clinical trials: application to HOBIT and BOOST-3 trials for severe traumatic brain injury. Contemp Clin Trials Commun 2025;48:101586.
Rainer PP, Kaufmann P, Smolle-Juettner FM, Krejs GJ. Case report: Hyperbaric oxygen in the treatment of puff adder (Bitis arietans) bite. Undersea Hyperb Med 2010;37(6):395-8.
Rainolds D, Long R. Blinding the blinded - assessing the effectiveness of a sham treatment in a multiplace hyperbaric chamber trial. Diving Hyperb Med 2008;38(1):3-7.
Raizandha MA, Hidayatullah F, Kloping YP, Rahman IA, Djatisoesanto W, Rizaldi F. The role of hyperbaric oxygen therapy in Fournier’s Gangrene: A systematic review and meta-analysis of observational studies. Int Braz J Urol 2022;48(5):771–781.
10 studies (qualitative + quantitative synthesis). Mortality significantly lower with HBO: OR 0.29 (95% CI 0.12–0.69; p=0.005). No significant difference in mean length of stay (MD −0.18; 95% CI −7.68 to 7.33; p=0.96) or number of debridement procedures (MD 1.33; 95% CI −0.58 to 3.23; p=0.17). ⚠️ Corrected 31 Aug 2026 (denominators added): these two "no difference" results were previously quoted with no denominator, which read…
Rajpal N, Walters ET, Elmarsafi T, Pittman TA, Johnson-Arbor KK. Use of hyperbaric oxygen therapy for tissue ischemia after breast reconstruction. Undersea Hyperb Med 2019;46(4):461-465.
Raleigh G, Rivard R, Fabus S. Air-activated chemical warming devices: effects of oxygen and pressure. Undersea Hyperb Med 2005;32(6):445-449.
Ramchandani R, Devaney B, Jaison A, Banham N, Roehr S. Cerebral arterial oxygen embolism as a complication of hyperbaric oxygen treatment: a case report. Diving Hyperb Med 2026;56(2):198-202.
Ramchandani R, Lin ZC, Devaney B, Jeffree RL, Tsouras T. Evaluation of external ventricular drain performance under hyperbaric conditions: a bench study. Diving Hyperb Med 2026;56(3):323-328.
Ramdani M, El Moudane A, Tahri Y, Slimani O, Barki A. Fournier's gangrene and extensive abdominal necrotizing fasciitis secondary to perforated appendicitis within an inguinoscrotal hernia: a rare case report. Cureus 2026;18(8):e114723.
Ramdhun VS, Richards CE, Khan ZH, Manga A, Marsh R, Sudhir R, Mathew B, Das I, Bajaj A. Emergency management of cerebral air gas embolism as a complication of CT-guided lung biopsy. BJR Case Rep 2026;12(4):uaag026.
Raphael JC, Elkharrat D, Jars-Guincestre MC, Chastang C, Chasles V, Vercken JB, Gajdos P. Trial of normobaric and hyperbaric oxygen for acute carbon monoxide intoxication. Lancet 1989;2(8660):414–419.
Group A (no LOC): recovery 66% (A0/NBO) vs 68% (A1/HBO) — no benefit from HBO, irrespective of Group B (LOC): recovery 54% (one HBO) vs 52% (two HBO) — a second HBO session gave no benefit in All 4 deaths (2 B1, 2 B2) and 7 patients left with neuropsychiatric sequelae (3 B1, 4 B2) had
Raskin A, Gershon S, Crook TH, Sathananthan G, Ferris S. The effects of hyperbaric and normobaric oxygen on cognitive impairment in the elderly. Arch Gen Psychiatry 1978;35(1):50-6.
Rasmussen VM, Borgen AE, Jansen EC, Rotbøll Nielsen PH, Werner MU. Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans. Acta Anaesthesiol Scand 2015;59:749-762.
Statistically significant overall attenuation of SHA during HBO vs control (P=0.011). Order/carryover effect: in the 8 volunteers starting with HBO, no difference vs control was seen — i.e.
Ratliff NB, Hackel DB, Mikat E. The effect of hyperbaric oxygen on the myocardial lesions of hemorrhagic shock in dogs. Am J Pathol 1967;51(3):341-9.
Ratliff NB, Hackel DB, Mikat E. Myocardial carbohydrate metabolism and lesions in hemorrhagic shock. Effects of hyperbaric oxygen. Arch Pathol 1969;88(5):470-5.
Ravi P, Vaishnavi D, Gnanam A, Krishnakumar Raja VB. The role of hyperbaric oxygen therapy in the prevention and management of radiation-induced complications of the head and neck – a systematic review of literature. J Stomatol Oral Maxillofac Surg 2017;118(6):359–362.
Evidence that HBO improves subjective xerostomia, swallowing, speech and overall quality of life after head/neck radiotherapy. No conclusive evidence that HBO improves dental-implant survival, prevents osteoradionecrosis, or improves Scope excludes HBO used to treat established ORN (exclusion criterion 3, page 360), so the review says nothing
Ravindran E, von der Lippe N, Wennerstrøm K, Røed I, Stenehjem AE, Kepka A, Grzyb K, Øvrehus MA, Nordheim E. Kalsifylaksi [Calciphylaxis]. Tidsskr Nor Laegeforen 2026;146(1).
Ray K, Savaser D, Huang E. Hyperbaric oxygen therapy and fluorescence angiography in arterial insufficiency secondary to injection of crushed hydromorphone. Undersea Hyperb Med 2021;48(3):255-261.
Ray KL, Apsey RJ, Heltborg JL, Bliss CL, Huang ET. Performance characteristics of high-frequency percussive ventilation under hyperbaric conditions. Undersea Hyperb Med 2021;48(2):157-168.
Razdan PS, Buteau D, Pollock NW. A case of Löfgren's syndrome confused with decompression sickness. Diving and Hyperbaric Medicine 2019;49(4):306-310.
Rebel A, Beck A, Efron P, Bavry AA, Ang D. Successful rescue therapy for severe acute anemia: managing the critically ill Jehovah's Witness. Am Surg 2015;81(6):E263–E265.
Register SD, Aaron ME, Gelly HB. Hyperbaric oxygen therapy and optic neuritis: case report and literature review. Undersea Hyperb Med 2011;38(6):557-9.
Reid MP, Fock A, Doolette DJ. Decompressing recompression chamber attendants during Australian submarine rescue operations. Diving Hyperb Med 2017;47(3):168-172.
Reis ND, Schwartz O, Militianu D, Ramon Y, Levin D, Norman D, Melamed Y, Shupak A, Goldsher D, Zinman C. Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. J Bone Joint Surg Br 2003;85(3):371–375.
81% of HBO-treated hips returned to normal on MRI, vs 17% in the untreated comparison group. Benefit confined to pre-collapse (stage-I) disease; in the untreated group most lesions of this
Reis Aguiar AR, Noversa R, Queiroz I, Gaio-Lima C, Barata P, Camacho Ó. Hyperbaric Oxygen Therapy for Medication-Related Osteonecrosis of the Jaw: Retrospective Study. Undersea Hyperb Med 2026;53(3):495-504.
Rendell-Baker L, Jacobson JH 2nd. The present status and future possibilities of hyperbaric oxygen therapy. Anesth Analg 1964;43(5):520-526.
Rendina C. A historical review of the U.S. Navy's busiest recompression chamber in the Pacific theater with a current perspective on caring for civilian divers within its area of responsibility: short communication. Undersea Hyperb Med 2018;45(2):183-189.
Reust RS, Diener BC, Stroup JS, Haraway GD. Hyperbaric treatment of arterial CO2 embolism occurring after laparoscopic surgery: a case report. Undersea Hyperb Med 2006;33(5):317–320 (PubMed title spells 'occuring').
Revelli L, Vagnoni S, D'Amore A, Di Stasio E, Lombardi CP, Storti G, Proietti R, Balestra C, Ricerca BM. EPO modulation in a 14-days undersea scuba dive. Int J Sports Med 2013;34(10):856-60.
Rhee TM, Hwang D, Lee JS, Park J, Lee JM. Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg 2018;144(12):1153–1161.
Complete hearing recovery: OR 1.61 (95% CI 1.05–2.44); any hearing recovery: OR 1.43 (1.20–1.67); Dose/selection signal: benefit greater with severe-to-profound baseline loss, HBO as salvage, ⚠️ Full read 21 Oct 2026 (all 9 pages) — the effect measure is mislabelled throughout, and the GRADE rating is lowered.
Riansrithongkham T, Yongchareon P, Sivadechathep A, Likitvong A, Mahamongkol T, Pruksapong C. Efficacy of hyperbaric oxygen therapy combine with negative pressure wound therapy in chronic wound: A randomized controlled trial. JPRAS Open 2025;45(none — JPRAS Open carries no issue numbers; page 1 prints 'JPRAS Open 45 (2025) 61–75' and PubMed lists volume and pages only):61–75.
A randomised trial that asks whether adding HBOT to NPWT speeds wound contraction over the first two weeks . It is the only randomised HBOT-plus-NPWT against NPWT-alone trial read in full in this library; the related comparative evidence is the non-randomised three-arm evidence/matic-2019-hbo-npwt-dfu and the abstract-level meta-analysis evidence/yang-liehao-2024-hbo-npwt-hard-to-heal-wounds-sr. P
Ribeiro AF, Vieira JG, Moniz M, Escobar C, Abadesso C, Amaro C, Cavalheiro D, Guerreiro F, Luis C, Nunes P. Hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy in non-fatal drowning. Undersea Hyperb Med 2021;48(1):53–56.
Ring S, Pansuriya T, Rashid H, et al. Coronary Air Embolism Secondary to Percutaneous Lung Biopsy: A Systematic Review. Cureus 2024;16(2):e55234.
Characterises presentation, risk factors and management of iatrogenic coronary/arterial air embolism; Case-report-based literature — documents an uncommon procedural cause of AGE. ⚠️ Full read 21 Oct 2026 (pages 1–9; Tables 1–4): PubMed only, case reports January 2001–December
Ringenbach S, Airen S, Keeler J, Samy R, Nayak C, Ohlstein JF. A Comprehensive Review of the PENTOCLO Protocol and Its Applications in the Head and Neck. Ear Nose Throat J 2025;not yet assigned — published online 8 Oct 2025 as article 1455613251381176; the held PDF paginates 1–12 with '00(0)' in the running head. Re-check.(not yet assigned. Re-check.):1455613251381176 (online-first article number; 12 pages).
Risberg J, Englund M, Aanderud L, Eftedal O, Flook V, Thorsen E. Venous gas embolism in chamber attendants after hyperbaric exposure. Undersea Hyperb Med 2004;31(4):417-429.
Risberg J, Midtgaard H. Decompression sickness in surface decompression breathing air instead of oxygen. Diving and Hyperbaric Medicine 2024;54(3):242-248.
Risberg J, Phillips S, Sletteskog N, Grong K. Gastric barotrauma following submarine escape training. Diving Hyperb Med 2025;55(2):195-198.
Riseman JA, Zamboni WA, Curtis A, Graham DR, Konrad HR, Ross DS. Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for debridements. Surgery 1990;108(5):847-850.
Rits Y, Uzieblo M, Shanley CJ. Hyperbaric oxygen decreases intimal thickness and area after carotid artery balloon injury in a rat model. Ann Vasc Surg 2013;27(6):785–790.
Rivolta MC, Waisberg E, Ong J, Masalkhi M, Lee AG. Ocular effects of hyperbaric oxygen therapy. Eye (London) 2023;38(6):1031-1033.
Rizzato A, D'Alessandro N, Berenci E, Rinchi A, Enten G, Vezzani G, et al. Effect of mild hyperbaric oxygen therapy on children diagnosed with autism. Undersea Hyperb Med 2018;45(6):639-645.
Rocky Mountain Health Plans / UnitedHealthcare. Hyperbaric Oxygen Therapy and Topical Oxygen Therapy. unknown 2025:1-18.
Robertson JA, Shlim DR. Treatment of moderate acute mountain sickness with pressurization in a portable hyperbaric (Gamow) Bag. J Wilderness Med 1991;2(4):268-273.
Robins MS. Early treatment of frostbite with hyperbaric oxygen and pentoxifylline: a case report. Undersea Hyperb Med 2019;46(4):521-526.
Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen. J Neurosurg 1992;76(6):929-934.
Rockswold SB, Rockswold GL, Zaun DA, Liu J. A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. J Neurosurg 2013;118(6):1317-1328.
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005;41(5):634-53.
Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg 2005;92(1):24–32.
Major amputation in diabetic ulcers (3 trials, 118 patients): RR 0.31 (95% CI 0.13–0.71), ⚠️ Corrected 26 Oct 2026 (faithfulness audit f26): previously said "5 trials, 118 patients". The abstract Ulcer healing and minor-amputation rate were not significantly influenced by HBOT.
Rogatsky GG, Meilin S, Zarchin N, Thom SR, Mayevsky A. Hyperbaric oxygenation affects rat brain function after carbon monoxide exposure. Undersea Hyperb Med 2002;29(1):50–58.
Rogatsky GG, Mayevsky A. The life-saving effect of hyperbaric oxygenation during early-phase severe blunt chest injuries. Undersea Hyperb Med 2007;34(2):75-81.
Rogatsky GG, Stambler I. Hyperbaric oxygenation for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction. Front Biosci (Schol Ed) 2017;9(2):230-243.
Rojas A, Stewart FA, Smith KA, Soranson JA, Randhawa VS, Stratford MR, Denekamp J. Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions. Int J Radiat Oncol Biol Phys 1987;13(11):1681-9.
Rollins MD, Gibson JJ, Hunt TK, Hopf HW. Wound oxygen levels during hyperbaric oxygen treatment in healing wounds. Undersea Hyperb Med 2006;33(1):17–25.
Roloff MV, D'Addario AP, Buffum EJ. Pulmonary alveolar macrophage response to hyperbaric carbon monoxide exposure. Undersea Biomed Res 1978;5(1):15–23.
Roman Padilla JC, Ortiz Peces L, Alavedra Martinez P, Cebrian JL. Is Simple Reimplantation a Viable Option in Pediculated Auricular Avulsions? A Systematic Review of the Literature. Craniomaxillofac Trauma Reconstr 2025;18(3):36.
Romano-Ribeiro C, Gaio-Lima C, Ferreira AP, Oliveira B, Dias-Vaz M, Camacho Ó. Abnormal motor blockade after epidural analgesia caused by pneumorrhachis and the role of hyperbaric oxygen treatment: a case report. Diving Hyperb Med 2022;52(1):54-57.
Rosenberg S, Kaplan S, Rosario E. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke [poster abstract 3591]. Arch Phys Med Rehabil 2015;96(10):e46.
Rosenberg M, Ezra R, Arieli R, Barash U. Synergistic Neuroprotection by Caffeine and Astaxanthin Against CNS-OT. Undersea Hyperb Med 2025;52(4):599-606.
Rosenzweig SA, Thompson SR, Bennett MH. Hyperbaric oxygen therapy for late onset dropped head syndrome following mantle field radiation therapy for Hodgkin lymphoma: a case report and literature review. Diving Hyperb Med 2025;55(3):275-279 (DOI 10.28920/dhm55.3.275-279).
Rosignoli L, Chu ER, Carter JE, Johnson DA, Sohn JH, Bahadorani S. The Effects of Hyperbaric Oxygen Therapy in Patients with Central Retinal Artery Occlusion: A Retrospective Study, Systematic Review, and Meta-analysis. Korean J Ophthalmol 2021;36(2):108–113.
Meta-analysis: HBOT did NOT enhance final visual outcome (P=0.83). The authors' own retrospective cohort likewise showed no visual benefit in the HBOT group. Safety concerns noted: barotrauma and generalised seizures.
Ross ME, Yolton DP, Yolton RL, Hyde KD. Myopia associated with hyperbaric oxygen therapy. Optom Vis Sci 1996;73(7):487-94.
Ross JA, Sayer MDj. Emergency recompression: clinical audit of service delivery at a national level. Diving Hyperb Med 2009;39(1):33-7.
Rossignol DA, Rossignol LW. Hyperbaric oxygen therapy may improve symptoms in autistic children. Med Hypotheses 2006;67(2):216-28.
Rossignol DA, Rossignol LW, Smith S, Schneider C, Logerquist S, Usman A, Neubrander J, Madren EM, Hintz G, Grushkin B, Mumper EA. Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial. BMC Pediatr 2009;9:21.
Roth V, Herron MS, Bueno RA, Chambers CB, Neumeister MW. Stimulating angiogenesis by hyperbaric oxygen in an isolated tissue construct. Undersea Hyperb Med 2011;38(6):509-14.
Rozali A, Mohd Zin B, Sherina MS, Khairuddin H, Sulaiman A. Development of recompression chamber facilities in Malaysia. Diving Hyperb Med 2007;37(2):87-89.
Rozloznik M, Lochmanova A, Chmelar D, Hajek M, Korytkova K, Cisarikova M. Experimental use of flow cytometry to detect bacteria viability after hyperbaric oxygen exposure: Work in progress report. Diving Hyperb Med 2020;50(2):152-156.
Rozycki SW, Brown MJ, Camacho M. Inner ear barotrauma in divers: an evidence-based tool for evaluation and treatment. Diving Hyperb Med 2018;48(3):186-193.
Rudge FW. The role of hyperbaric oxygenation in the treatment of clostridial myonecrosis. Mil Med 1993;158(2):80-83.
Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws — 2009 update. J Oral Maxillofac Surg 2009;67(5 Suppl):2–12 (also reprinted in Aust Endod J 2009;35(3):119–30 (PMID 19961450); the file on hand is the AAOMS website version, 23 pages).
Ruiz E, Haglin JJ, Hitchcock CR. Anemia and hyperbaric oxygenation in dogs subjected to coronary artery ligations. J Surg Res 1972;13(6):339-48.
Ruiz-Mambrilla M, Duenas-Ruiz A, Perez-Castrillon JL, Usategui-Martin I, Duenas-Laita A. Speech therapy and hyperbaric oxygen for aphasia after carbon monoxide intoxication. Undersea Hyperb Med 2023;50(1).
Rusoke-Dierich O. Diving Medicine. Cham: Springer International Publishing 2018:XV + 437 pp.
Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ. Hyperbaric Oxygen Therapy in Acute Ischemic Stroke: Results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial (HOAIS) Pilot Study. Stroke 2003;34(2):571-574 (DOI 10.1161/01.STR.0000050644.48393.D0).
Sacchetti M, Mantelli F, Merlo D, Lambiase A. Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa. J Ophthalmol 2015;2015:737053.
Sack RA, Pikkel YY, Shemy OL, Ramon Y, Ullmann Y, Zeltzer AA. Transcutaneous oximetry values in chronic ulcer patients during Hyperbaric treatment at 1.4 ATA compared to 2 ATA. Undersea Hyperb Med 2024;51(1):1-5 (DOI 10.22462/587).
Sadler C, Latham E, Hollidge M, Boni B, Brett K. Delayed hyperbaric oxygen therapy for severe arterial gas embolism following scuba diving: a case report. Undersea Hyperb Med 2019;46(2):197-202.
Sadler C, Arefieva CAL, Duchnick J, Bermudez R, Witucki P, Shishlov K. Hyperbaric medicine simulation education curriculum: CNS toxicity during Treatment Table 6 and intubated ICU patient with mucous plugging. Undersea Hyperb Med 2019;46(4):467-481.
Sadler C. Response from Dr. Sadler. Undersea Hyperb Med 2019;46(5):725.
Saesen K, Loos E, Montagna C, Vanbrabant T, Goedhuys R, Lemkens N. Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss. B-ENT 2017;13:105–112.
Safai P, Farzaneh B, Fekrazad R. The effects of pressure in vitro on three methods of root canal obturation. Diving Hyperb Med 2019;49(1):16-20.
Sai Krishna MLV, Kar S, Kumar R, Singh H, Mittal R, Digge VK. The role of conservative management in the avascular necrosis of the femoral head: a review of systematic reviews. Indian J Orthop 2023;57(3):410-420.
Saito S, Aso C, Kanai M, Takazawa T, Shiga T, Shimada H. Experimental use of a transportable hyperbaric chamber durable for 15 psi at 3700 meters above sea level. Wilderness and Environmental Medicine 2000;11:21-24.
A feasibility report, not an efficacy study: a portable chamber rated to 15 psi, used at high altitude. The clinical target at altitude is altitude illness, where the chamber substitutes for descent by raising ambient pressure around the patient.
Salama SE, et al. Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone. Int J Low Extrem Wounds 2019.
Complete closure at end of treatment: 33.3% (5/15) HBOT vs 0% (0/15) conventional, P=0.014 — Complication frequency not significantly different between groups. ⚠️ Full read 21 Oct 2026 (all 6 pages, Table 2): the headline P value comes from the wrong test, though the result survives the right one.
Salameh M, Moghamis IS, Kokash O, Ahmed GO. Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review. Int Orthop 2021;45(10):2519-2523.
Salihoğlu M, Ay H, Cincik H, Cekin E, Cesmeci E, Memis A, Uzun G, Altundag A, Simsek K. Efficiency of hyperbaric oxygen and steroid therapy in treatment of hearing loss following acoustic trauma. Undersea Hyperb Med 2015;42(6):539–546 (author list on the PDF includes Simsek K; PubMed lists eight authors).
Sallam L, Rychlíková L, Mölne J, Bergo MO, Torinsson Naluai Å, Seeman-Lodding H, Oscarsson N, Giglio D. Hyperbaric oxygen treatment and toll-like receptor 5 in radioprotection of epithelial cells. PLoS One 2026;21(8):e0356247.
Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME. Oxygen Delivery during Severe Anemia When Blood Transfusion Is Refused on Religious Grounds. Ann Am Thorac Soc 2017;14(7):1216-1220.
Saltzman HA. Hyperbaric oxygen in cardiovascular disease: potential usages and hazards. Circulation 1965;31:454-462.
Sames C, Gorman DF, Sandiford P, Zhou L. Comparison of Australian and New Zealand referral rates for hyperbaric oxygen in oro-facial osteoradionecrosis: evidence-based, funding constraint or clinician whim? Diving Hyperb Med 2015;45(4):244–246.
Samson M, Masters T, Fastag-Guttman E, Logue C, Popa D. Cardiac and Thrombotic Effects of Severe Carbon Monoxide Poisoning: A Case Series. Undersea Hyperb Med 2026;53(2):271-278.
Sanchez EC. Hyperbaric oxygenation in peripheral nerve repair and regeneration. Neurol Res 2007;29(2):184-98.
Sanders RW. Controlling the rate of middle ear barotrauma: an editorial perspective. Undersea Hyperb Med 2014;41(5):355-6.
Sano H, Ichioka S, Sekiya N. Influence of oxygen on wound healing dynamics: assessment in a novel wound mouse model under a variable oxygen environment. PLoS One 2012;7(11):e50212.
Santema TB, Stoekenbroek RM, van Steekelenburg KC, van Hulst RA, Koelemay MJW, Ubbink DT. Economic outcomes in clinical studies assessing hyperbaric oxygen in the treatment of acute and chronic wounds. Diving Hyperb Med 2015;45(4):228–234.
1 RCT + 3 cohort studies reported both clinical and economic outcomes; only the RCT was of good methodological quality; outcome measures were heterogeneous and the effect of HBO on costs was variable. Little direct evidence on the cost-effectiveness of HBO for acute or chronic wounds; the authors call for economic endpoints in future studies. ⚠️ Full read 21 Oct 2026 (all 7 pages): the cost figures recorded in the direction: n…
Santema KTB, Stoekenbroek RM, Koelemay MJW, Reekers JA, van Dortmont LMC, Oomen A, Smeets L, Wever JJ, Legemate DA, Ubbink DT. Hyperbaric Oxygen Therapy in the Treatment of Ischemic Lower- Extremity Ulcers in Patients With Diabetes: Results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care 2018;41(1):112–119.
Limb salvage: 47/60 (78%) SC vs 53/60 (88%) SC+HBOT — RD 0.10 (95% CI −0.04 to 0.23), not Complete wound healing at 12 months: 28 vs 30 index wounds — RD 0.03 (95% CI −0.14 to 0.21), not Amputation-free survival (ITT): 41 vs 49 — RD 0.13 (95% CI −0.02 to 0.28), not significant (a
Santhanam P, Meehan A, Orrison WW, Wilson SH, Oakes TR, Weaver LK. Central auditory processing disorders after mild traumatic brain injury. Undersea Hyperb Med 2019;46(3):261-269.
Sanzi M, Aiolfi A, Marin JN, Darawsh AEH, Bona D. Hyperbaric oxygen treatment for late low colorectal anastomosis ischaemia: case report. Diving Hyperb Med 2021;51(1):116–118.
Saraoui W, Sivakumar BS, Forli A, Perruisseau-Carrier A. Frostbite to the upper limb: An updated review and management recommendations. Hand Surg Rehabil 2025;44(6):102302.
Sarrio-Sanz P, Sanchez-Caballero L, Martinez-Cayuelas L, Gori CF, Pacheco-Bru JJ, Nakdali-Kassab B, Gomez-Garberi M, Caballero-Perez P, Gomez-Perez L, Ortiz-Gorraiz MA. Efficacy, tolerance and predictors of response to the treatment with hyperbaric oxygen therapy for patients with hemorrhagic radiation cystitis. Arch Esp Urol 2022;75(4):354-360.
Sato T, Arai K, Ichioka S. Hyperbaric oxygen therapy for digital ulcers due to Raynaud's disease. Case Reports Plast Surg Hand Surg 2018;5(1):72–74.
SAUHMA HBO Committee — Cronje F, Meintjes J, Roberts C, Weir G, Rosenthal J. SAUHMA HBOT treatment protocols. Southern African Underwater and Hyperbaric Medical Association 2023:36 pp.
Southern African Underwater and Hyperbaric Medical Association; Undersea and Hyperbaric Medical Society. Position statement: low-pressure fabric hyperbaric chambers. Southern African Underwater and Hyperbaric Medical Association 2017.
Saunders M, Dische S. Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide. Br J Cancer Suppl 1996;27:S271-S278.
Saunders PJ (University of Birmingham). HYPERBARIC OXYGEN THERAPY IN THE MANAGEMENT OF CARBON MONOXIDE POISONING, OSTEORADIONECROSIS, BURNS, SKIN GRAFTS, AND CRUSH INJURY. Int J Technol Assess Health Care 2003;19(3):521–525.
From 154 full-text articles, 13 relevant RCTs were identified; little consistency across protocols, groups, timing and outcomes; no convincing evidence of effectiveness for CO poisoning, ORN, burns, skin grafts or crush injury. ⚠️ Four of the 13 included RCTs were positive, and the paper reports them (Discussion, pages 523–524): Marx 1985 27 foreign-language papers were not included (Results, page 523), and gangrene, osteomyel…
Sause WT, Plenk HP. Radiation therapy of head and neck tumors: a randomized study of treatment in air vs. treatment in hyperbaric oxygen. Int J Radiat Oncol Biol Phys 1979;5(10):1833-1836.
Savvidou OD, Kaspiris A, Bolia IK, Chloros GD, Goumenos SD, Papagelopoulos PJ, Tsiodras S. Effectiveness of Hyperbaric Oxygen Therapy for the Management of Chronic Osteomyelitis: A Systematic Review of the Literature. Orthopedics 2018;41(4):193–199.
Adjuvant HBO judged effective in 16/20 (80%) cohort studies and 19/20 (95%) case studies. Overall 308/419 (73.5%) patients with complete data had a successful outcome with no reported
Sayer MDj, Wilson CM, Laden G, Lonsdale P. The consequences of misinterpreting dive computers: three case studies. Diving Hyperb Med 2008;38(1):33-9.
Sayer MD, Ross JA, Wilson CM. Analysis of two datasets of divers with actual or suspected decompression illness. Diving Hyperb Med 2009;39(3):126-132.
Sayin O, Altinkaynak H. The effects of hyperbaric oxygen therapy on retinal layers in healthy eyes. Undersea Hyperb Med 2022;49(4):485-494.
Scarpa A, Granata G, Tedesco FP, Falchetta L, Montanino A, Gioacchini FM, Re M, Siglioccolo A, Salzano FA. Ten-year experience with combined hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss: a retrospective cohort of 332 patients. J Int Adv Otol 2026;22(5):1-6.
Hyperbaric oxygen during operative treatment [abstract]. The Journal of Trauma [Abstracts International] 1986;26:689.
Scheinkestel CD, Bailey M, Myles PS, Jones K, Cooper DJ, Millar IL, Tuxen DV. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust 1999;170(5):203–210.
No benefit from HBO; signal of harm. More HBO patients needed additional treatments (28% vs 15%, Worse learning-test scores at completion in the HBO group (P=0.01; severe P=0.005) and more Delayed neurological sequelae occurred only in HBO patients (P=0.03). No outcome measure was worse
Scher RL. Hyperbaric oxygen therapy for necrotizing cervical infections. Adv Otorhinolaryngol 1998;54:50-58.
Scheufler KM. Tissue oxygenation and capacity to deliver O2 do the two go together? Transfus Apher Sci 2004;31(1):45-54.
Schiavo S, Richardson D, Santa Mina D, Buryk-Iggers S, Uehling J, Carroll J, et al. Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke. Appl Physiol Nutr Metab 2020;45(12):1345-1352.
Schiavo S, Brenna CTA, Albertini L, Djaiani G, Marinov A, Katznelson R. Safety of hyperbaric oxygen therapy in patients with heart failure: A retrospective cohort study. PLoS One 2024;19(2):e0293484.
Schipke JD. Science and Statistics. Diving Hyperb Med 2021;51(2):230.
Schlimp CJ, Bothma PA, Brodbeck AE. Cerebral venous air embolism: what is it and do we know how to deal with it properly? [Comment and Response]. JAMA Neurol 2014;71(2):243.
Schmale M, Fichtner A, Pohl C, John E, Bucher M. Hyperbare Oxygenation bei nekrotisierenden Weichteilinfektionen: Pro. Chirurg 2012;83(11):973–979 (PMID 23108429. DOI 10.1007/s00104-012-2283-0. Published in German with an English abstract.).
A commissioned position article from the anaesthesiology/intensive care and hyperbaric unit at Universitätsklinikum Halle (Saale), with the general/visceral/vascular surgery clinic. It is structured as mechanism, then clinical studies, then practical protocol, then a service and cost argument. There is no search strategy, no databases, no date limits, no eligibility criteria, no selection or extra
Schmauss AK, Bahrmann E, Fabian W. Management of gas gangrene and hyperbaric oxygen [abstracted in J Trauma]. Zentralblatt für Chirurgie [abstract in The Journal of Trauma] 1973;98:912-925.
Schmidt CP, Vernon T, Bae JY, Chen CJ. Vision Loss following Tranexamic Acid Injection during an Elective Sinus Surgery. Am J Ophthalmol Case Rep 2026:102679 (journal pre-proof; no PMID at 2026-10-26).
Schmidt RC, Cooper JS. Hyperbaric Oxygen Therapy: A Quick Guide for Physicians and Surgeons. Global Surgery 2022;8(1).
Schmitz G, Aguero S. Bispectral index with density spectral array (BIS-DSA) monitoring in a patient with inner ear and cerebral decompression sickness. Diving and Hyperbaric Medicine 2024;54(3):237-241.
Schmitz G. Comparison of three infusion pumps as an option for intensive care treatments in monoplace hyperbaric chambers. Diving Hyperb Med 2025;55(2):145-153.
Schmitz G, Aguero S, Gabert LCH. Case of Broca's Aphasia as an expression of cerebral decompression sickness with advanced non-invasive monitoring during HBO₂ treatment. Undersea Hyperb Med 2026;53(1):91-97.
Schmitz G. Tension Pneumothorax During Hyperbaric Oxygen Therapy With Pigtail Pleural Catheter: A Case Report and Experimental Flow Analysis. Undersea Hyperb Med 2026;53(2):255-260.
St. Pierre Schneider B, Zhang L, Dombrowsky T, Wilson JR. A scoping review and evaluation of hyperbaric oxygen therapy for skeletal muscle injury in preclinical models. Med Gas Res 2026;16(2):125–132 (Epub 2025 Aug 18).
HBO promoted and quickened muscle regeneration after myotoxic and crush injury, and counteracted Benefits may persist, and early initiation of HBO is important — but more sessions do not always Evidence gaps: limited inclusion of females; milder pressures under-tested (potentially fewer
Schneidewind L, Anheuser P, Schönburg S, Wagenlehner FME, Kranz J. Hyperbaric Oxygenation in the Treatment of Fournier’s Gangrene: A Systematic Review. Urol Int 2021;105(3–4):247–256.
13 studies, 376 patients (no RCTs; 5 retrospective case-control studies totalling 319 patients, 145 HBO-treated). HBO-group mortality ~16.6%. Study quality moderate to high, but design observational. Conclusion cautious: a definitive recommendation is limited by the rarity of Fournier's gangrene and the lack of randomised evidence.
Schoen PJ, Raghoebar GM, Bouma J, Reintsema H, Vissink A, Sterk W, Roodenburg JLN. Rehabilitation of oral function in head and neck cancer patients after radiotherapy with implant-retained dentures: Effects of hyperbaric oxygen therapy. Oral Oncol 2007;43(4):379–388.
11 implants lost in 7 patients (8 before loading, 3 after). No significant difference in peri-implant health between HBO and non-HBO groups except plaque-index No differences between HBO and non-HBO groups in oral functioning / denture-problem impact / quality of
Schraibman IG. Gas gangrene after amputation for peripheral vascular disease. Postgrad Med J 1968;44(513):551-3 (AUTHOR and TITLE are printed in the scan. YEAR, VOLUME and ISSUE are NOT — the scan carries no journal name, no volume, no issue and no year anywhere on its three pages, only the running head 'Case reports' and the printed page numbers 551, 552 and 553. Year 1968, volume 44 and issue 513 were LOOKED UP in PubMed under PMID 5662196 and are recorded as a lookup, not as a reading of the source. See 'What could and could not be established from the PDF' below.).
Schugart RC, Friedman A, Zhao R, Sen CK. Wound angiogenesis as a function of tissue oxygen tension: a mathematical model. Proc Natl Acad Sci U S A 2008;105(7):2628-2633.
Sealy R. A preliminary clinical study in the use of misonidazole in cancer of the head and neck. Br J Cancer Suppl 1978;3:314–317.
With large fractions of irradiation, misonidazole appeared to confer no advantage; in previously The combination of hyperbaric oxygen and misonidazole did not appear to be toxic.
Sealy R, Cridland S, Barry L, Norris R. Irradiation with misonidazole and hyperbaric oxygen: final report on a randomized trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 1986;12(8):1343–1346.
The results favoured the combination (misonidazole + HBO) over conventional irradiation and
Sealy R, Jacobs P, Wood L, Levin W, Barry L, Boniaszczuk J, Blekkenhorst G. The treatment of tumors by the induction of anemia and irradiation in hyperbaric oxygen. Cancer 1989;64(3):646-52.
Sechrist JR, Warriner RA, Weninger AE, Ong R. Validation of hyperbaric oxygen treatment software for use with monoplace chambers. Undersea Hyperb Med 2008;35(3):219-25.
See HG, Tan YR, Au-Yeung KL, Bennett MH. Assessment of hyperbaric patients at risk of malnutrition using the Malnutrition Screening Tool - a pilot study. Diving Hyperb Med 2018;48(4):229-234.
Sehhati GH, Brost F. Hyperbaric oxygen in the management of gas gangrene [abstracted in J Trauma]. Arbeitsmedizin [abstract in The Journal of Trauma] 1974;9:171-173.
Seidel R, Carroll C, Thompson D, Diem RG, Yeboah K, Hayes AJ, et al. Risk factors for oxygen toxicity seizures in hyperbaric oxygen therapy: case reports from multiple institutions. Undersea Hyperb Med 2013;40(6):515-9.
Sen S, Sen S. 'Therapeutic effects of hyperbaric oxygen: integrated review' Medical Gas Research 2021;11(1):30-33.
Serena TE, Bullock NM, Cole W, Lantis J, Li L, Moore S, Patel K, Sabo M, Wahab N, Price P. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care 2021;30(Sup5):S7-S14.
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Mild (PTA ≤60), severe (60–80) and profound (≥81 dB) ISSNHL; 20 sessions HBO in both arms, with IT steroid IT + HBO: 19 dB gain, 78.9% success; IV + HBO: 18 dB, 70.5% — IT numerically better; benefit concentrated in Design (pages 2–3): 88 enrolled; 8 excluded after enrolment for comorbidity (Ménière's, diabetes,
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Shah SR, Wu A, Sindwani R, Tang D. Presentation and Optimal Management of Anterior and Central Skull Base Osteoradionecrosis: Systematic Review and Meta-Analysis. Laryngoscope 2025;135(3):982–990 (first published 15 Oct 2024).
Conservative therapy (including HBO): resolution 8/197 = 4.1%. Surgical treatment: 135/188 = 71.8%. Of these, vascularised tissue coverage: 104/114 = 91.2%. Surgery was superior to medical treatment alone; vascularised reconstruction was best. Authors
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Shander A, Javidroozi M. The approach to patients with bleeding disorders who do not accept blood-derived products. Semin Thromb Hemost 2013;39(2):182-90.
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A narrative practice review of "Bloodless Medicine and Surgery" (BMS), built around three illustrative case vignettes with commentary between them, plus the authors' institutional BMS protocol reproduced as a table. There is no methods section, no search strategy and no comparison of any kind.
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All 36 patients completed the study. Arms were UNEQUAL: HA n = 16, HBO n = 20 (Patients and At 6, 12 and 18 months the improvement rate showed no statistical difference between the two groups ⚠️⚠️ VOIDING FREQUENCY WAS NOT SUSTAINED IN EITHER ARM. By 18 months it had returned to baseline —
Shappell HW, Kislevitz M, Reddy G, Amirlak B, Morey A, Stone JA. Successful replantation of amputated penis with adjuvant hyperbaric oxygen therapy. Undersea Hyperb Med 2019;46(5):695-699.
Sharifi M, Fares W, Abdel-Karim I, Koch JM, Sopko J, Adler D; Hyperbaric Oxygen Therapy in Percutaneous Coronary Interventions Investigators. Usefulness of hyperbaric oxygen therapy to inhibit restenosis after percutaneous coronary intervention for acute myocardial infarction or unstable angina pectoris. Am J Cardiol 2004;93(12):1533-5.
Sharma R, Sharma SK, Mudgal SK, Jelly P, Thakur K. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials. Sci Rep 2021;11(1):2189.
Complete healing significantly favoured HBOT (pooled OR 0.29, 95% CI 0.14–0.61; I²=62%; authors Major amputation reduced: RR 0.60 (95% CI 0.39–0.92; I²=24%). Minor amputation not significantly reduced (RR 0.82, 95% CI 0.34–1.97); more adverse events in the
Shaw HA, Ezenwa E. Secondary abdominal pregnancy in a Jehovah's Witness. South Med J 2000;93(9):898–900.
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Shaw RJ, Butterworth C. Hyperbaric oxygen in the management of late radiation injury to the head and neck. Part II: prevention. Br J Oral Maxillofac Surg 2011;49(1):9-13.
Shaw JJ, Psoinos C, Emhoff TA, Shah SA, Santry HP. Not just full of hot air: hyperbaric oxygen therapy increases survival in cases of necrotizing soft tissue infections. Surg Infect (Larchmt) 2014;15(3):328-335 (PMID 24786980. DOI 10.1089/sur.2012.135).
Shaw R, Butterworth C, Tesfaye B, Bickerstaff M, Dodd S, Smerdon G, Chauhan S, Brennan P, Webster K, McCaul J, Nixon P, Kanatas A, Silcocks P. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial. Trials 2018;19(1):22.
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ORN at 6 months: 6.4% (HBO) vs 5.7% (control) — OR 1.13 (95% CI 0.14–8.92), p=1. Fewer acute symptoms with HBO; no significant difference in late pain or quality of life. Higher dropout in the HBO arm.
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Sheffield PJ, Pirone CJ. Decompression sickness in inside attendants (Section VI, Chapter 2). In: Hyperbaric Facility Safety - A Practical Guide (parent volume identified 23 Oct 2026 from the running head on every even page) 2002:643-663.
Sheffield R, Posey KI. Ear Barotrauma: What Chamber Operators Should Know. International ATMO Education (learn.hyperbaricmedicine.com) 2021.
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Sherlock S. ECHM Consensus Conference and levels of evidence. Diving Hyperb Med 2017;47(2):133.
Sherlock S, Way M, Tabah A. Audit of practice in Australasian hyperbaric units on the incidence of central nervous system oxygen toxicity. Diving Hyperb Med 2018;48(2):73-78.
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A systematic review and meta-analysis restricted to randomised trials of adjunctive hyperbaric oxygen in traumatic incomplete spinal cord injury (iSCI). Searches ran from January 2015 to June 2025 across PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang and VIP (p. 90). 783 records were screened and 15 RCTs (1158 patients) were included — 3 published in English and 12 in Chinese (p.
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HBO therapy was used in 34/197 (17.3%) and surgical debridement in 35 (17.8%). Mortality 4% (literature range 2–11%); late diagnosis, cranial-nerve involvement and inadequate The review states the evidence supporting HBO efficacy in FMOE is limited; the primary treatment is
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Higher arterial Hb saturation at discharge with HBO (94.74 ± 3.28% vs 92.60 ± 4.66%, p=0.009). Better distal pulse palpability (a. dorsalis pedis palpable in 27 vs 18 subjects; p<0.05). Fewer amputation-stump complications and significantly less time from admission to finishing the
Simayijiang H, Lin Y, Zhong T, Li Z, Zhang K, Long Y. Designing clinical research on hyperbaric oxygen therapy: a narrative review and practical methodological guide. Trials 2026:in press.
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Of the 32 patients with clostridial infections, 9 died — but none died from the clostridial infection HBO was associated with subsidence of systemic toxaemia, allowing surgery/amputation to be Reinforces the triad — HBO is adjunctive to surgical debridement and antibiotics, not a substitute;
Slade JB, Potts MV, Flower AM, Sky KM, Sit MT, Schmidt TW. Pain improvement in rheumatoid arthritis with hyperbaric oxygen: report of three cases. Undersea Hyperb Med 2016;43(4):467-472.
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Smart D. Critical appraisal: Does hyperbaric oxygen administration decrease side effects and improve quality of life after pelvic irradiation? Diving Hyperb Med 2011;41(4):233.
Smart D, Van der Broek C. Lithium batteries - intravenous infusion pumps used in hyperbaric facilities. Diving Hyperb Med 2011;41(3):165.
Smart D, Wallington M. A cost-analysis case study of radiation cystitis treatment including hyperbaric oxygen therapy. Diving Hyperb Med 2012;42(2):92-97.
Smart D. Critical appraisal: No evidence of benefit with hyperbaric oxygen therapy for sudden hearing loss. Diving Hyperb Med 2016;46(3):189.
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Smith RG. An appraisal of potential drug interactions regarding hyperbaric oxygen therapy and frequently prescribed medications. Wounds 2011;23(6):147-59.
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Outcomes: 64/94 (67.4%) positive, 16 (17.9%) ambiguous, 14 (14.7%) negative. The only factor independently associated with outcome was pressure: <3 ATA was significantly linked to
Soh CR, Pietrobon R, Freiberger JJ, Chew ST, Rajgor D, Gandhi M, Shah J, et al. Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample. Intensive Care Med 2012;38(7):1143–1151.
HBOT-treated patients had a significantly lower risk of death — adjusted OR 0.49 (95% CI 0.29–0.83). HBOT was associated with higher hospital cost and longer length of stay (expected for a sicker,
Soh CR, Kim SJ, Chong SJ. Hyperbaric oxygen therapy for chronic diabetic wounds. Trends Anaesth Crit Care 2013;3(5):279-282.
Sokolowski SA, Räisänen-Sokolowski AK, Tuominen LJ, Lundell RV. Delayed treatment for decompression illness: factors associated with long treatment delays and treatment outcome. Diving and Hyperbaric Medicine 2022;52(4):271-276.
The delay comparison is null. Patients with no residual symptoms had a median delay of 24 h A shorter delay was associated with needing fewer treatments. Patients needing only one HBOT had a Symptom type drove the delay, not the other way round. Cardiopulmonary symptoms had a shorter
Sokolowski SA, Räisänen-Sokolowski AK, Lundell RV (Helsinki University). Development of myopia in scuba diving and hyperbaric oxygen treatment: a case report and systematic review. Diving Hyperb Med 2024;54(4):328–337.
Hyperoxic myopia is a well-known, typically reversible side effect of repeated HBOT exposure (lens Safety/consent relevance: patients on a full HBOT course should be counselled about transient myopic shift
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119 patients: ITSI 73 vs HBOT + ITSI 46. Significant within-group pre-to-post improvement in PTA/SRT/WRS HBOT-responder audiogram improvement seen within 10.9 ± 6.5 (max 23) sessions; no benefit beyond 23 Conclusion: no additional benefit from concurrent adjunctive HBOT; HBOT may help steroid-refractory
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Spruijt NE, Hoekstra LT, Wilmink J, Hoogbergen MM. Hyperbaric oxygen treatment for mastectomy flap ischaemia: a case series of 50 breasts. Diving Hyperb Med 2021;51(1):2–9.
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Carbon monoxide poisoning is a leading precipitant of DPHL (alongside opioid/other overdose, anoxia, Treatment is largely supportive — amantadine, an antioxidant cocktail, and corticosteroids are the Prognosis is variable; many patients improve over months, but the evidence base is case reports/series
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Bench evaluation of IV pumps and related equipment under hyperbaric conditions, part of the same programme as evidence/stanga-2003-nedu-respiratory-support-devices-hyperbaric (TR 03-18, the ventilator report). The stated context: "Ventilators, cardiac monitors, intravenous (IV) pumps, and other equipment are being evaluated to meet a U.S. Navy-identified need to improve patient care levels in the
Stanga DF. Evaluation of respiratory support devices for use in the hyperbaric chamber (NEDU TR 03-18). Navy Experimental Diving Unit Technical Report 2003;TR 03-18.
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Stevens DL, Bryant AE, Adams K, Mader JT. Evaluation of therapy with hyperbaric oxygen for experimental infection with Clostridium perfringens. Clin Infect Dis 1993;17(2):231–237.
HBO alone did NOT improve survival at any inoculum tested. Early HBO plus penicillin or metronidazole showed significant additive efficacy (at ~10⁹ Clindamycin was the single most effective agent at high inocula (a protein-synthesis inhibitor that
Stevens SL, Narr AJ, Claus PL, Millman MP, Steinkraus LW, Shields RC, et al. The incidence of hypoglycemia during HBO2 therapy: A retrospective review. Undersea Hyperb Med 2015;42(3):191-6.
Stevens SL, Sorita A, Narr AJ, Claus PL, Tescher A, Millman MP, et al. Applying quality improvement methods in a hyperbaric oxygen program: reducing unnecessary glucose testing. Undersea Hyperb Med 2016;43(4):427-435.
Stevens G, Lewis I. A case of facial vascular occlusion after hyaluronic acid cosmetic filler injection treated with adjunctive hyperbaric oxygen. Diving Hyperb Med 2025;55(1):56-58 (PMID 40090027. DOI 10.28920/dhm55.1.56-58).
Stewart J, Gosine D, Kaleel M, Kurtev A. Hyperbaric oxygen and muscle performance in maximal sustained muscle contraction. Undersea Hyperb Med 2011;38(6):483-91.
Porubsky C, Stiegler P, Matzi V, Lipp C, Kontaxis A, Klemen H, Walch C, Smolle-Jüttner F. Hyperbaric Oxygen in Tinnitus: Influence of Psychological Factors on Treatment Results? ORL J Otorhinolaryngol Relat Spec 2006;69(2):107–112 (epub 8 Dec 2006; print 2007).
Outcomes overall: complete remission 12 (3.3%), intensity lessened 122 (33.9%), agreeable change of No statistically significant difference between the two HBO protocols (p>0.05). Outcome tracked expectation: improvement in 60.3% with positive expectation (n=68) vs 47.2%
Stirban A, Lentrodt S, Nandrean S, Pop A, Tschoepe D, Scherbaum WA. Functional changes in microcirculation during hyperbaric and normobaric oxygen therapy. Undersea Hyperb Med 2009;36(5):381-90.
Stirnemann J, Letellier E, Aras N, Borne M, Brinquin L, Fain O. Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease. Diving Hyperb Med 2012;42(2):82-84.
Stirnemann J, Serratrice J, Mann T, Louge P, Combescure C, Samii K, Pignel R, Agoritsas T, Ansari M, Cannas G, Chalandon Y, Cimasoni L, Cougoul P, Desgraz B, Gervaix A, Grosgurin O, Joffre T, Lae C, Magnan MA, Menager E, Momo Bona A, Panchard MA, Pellegrini M, Reny JL, Riu B, Sahyoun C, Boet S. Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study). BMJ Open 2024;14(11):e084825.
Stock C, Gukasyan N, Muniappan A, Wright C, Mathisen D. Hyperbaric oxygen therapy for the treatment of anastomotic complications after tracheal resection and reconstruction. J Thorac Cardiovasc Surg 2014;147(3):1030-1035.
Stoekenbroek RM, Santema TB, Legemate DA, Ubbink DT, van den Brink A, Koelemay MJW. Hyperbaric Oxygen for the Treatment of Diabetic Foot Ulcers: A Systematic Review. Eur J Vasc Endovasc Surg 2014;47(6):647–655.
RCT-only SR. Trials split by ulcer type: ~182 patients with ischaemic ulcers, 64 with non-ischaemic, 130 unspecified; only 2 trials of good methodological quality. Pooling judged inappropriate because of significant clinical heterogeneity. Some evidence HBO improves complete healing in ischaemic DFU (not non-ischaemic); no consistent effect on amputation; more trials needed to justify routine use. ⚠️ Full read 21 Oct 2026 (pag…
Stokes RJ, Watts D, Smerdon G, Hall SD, Bunn L, Marsden J. Vestibular rehabilitation and recovery in divers with inner ear decompression sickness: a case series. Diving and Hyperbaric Medicine 2025;55(3):236-245.
Stokes RJ, Marsden J, Watts D, Smerdon G, Hall SD, Bunn L. Outcomes in the treatment of inner ear decompression sickness with hyperbaric oxygen therapy, a systematic review. Diving Hyperb Med 2026;56(1):71–82.
Most IEDCS divers treated with recompression / HBOT improve, but a proportion have residual Practical recommendations: a standardised examination and symptom-assessment method, vestibular
Strauss MB, Hargens AR, Gershuni DH, Greenberg DA, Crenshaw AG, Hart GB, Akeson WH. Reduction of skeletal muscle necrosis using intermittent hyperbaric oxygen in a model compartment syndrome. J Bone Joint Surg Am 1983;65(5):656–662.
Intermittent HBO reduced skeletal-muscle necrosis in the compartment-syndrome model, with benefit
Strauss MB, Bryant BJ, Hart GB. Transcutaneous oxygen measurements under hyperbaric oxygen conditions as a predictor for healing of problem wounds. Foot Ankle Int 2002;23(10):933-937.
Strauss MB. Hyperbaric oxygen as an intervention for managing wound hypoxia: its role and usefulness in diabetic foot wounds. Foot Ankle Int 2005;26(1):15-18.
Strauss MB. Contribution Orthopedic applications of hyperbaric oxygen therapy. Undersea Hyperb Med 2009;36(3):214-216.
Strauss MB. The effect of hyperbaric oxygen in crush injuries and skeletal muscle-compartment syndromes; with the companion editorial 'Why hyperbaric oxygen therapy may be useful in treating crush injuries and skeletal muscle-compartment syndrome' Undersea Hyperb Med 2012;39(4):847-855 (review); 799-800 (editorial).
Strauss MB. More on HBO2 for DFUs. Undersea Hyperb Med 2013;40(6):611-2.
Strauss MB. Concerns regarding Fedorko, et al.'s article: Hyperbaric oxygen does not reduce indications. Undersea Hyperb Med 2016;43(6):742-743.
Strauss MB, Lu LQ, Miller SS. The Gradient Perfusion Model Part 2: Substantiation of the GPM with clinical cases. Undersea Hyperb Med 2018;45(3):297-305.
UHMS member wound scoring system is receiving coverage. Undersea Hyperb Med 2018;45(4):483-485.
Strauss MB. The role of hyperbaric oxygen for acute traumatic ischemias. Undersea Hyperb Med 2022;49(2):233–248.
Strauss MB, Covington DB. Delayed recognition of Type II decompression sickness in a diver with chronic atrial fibrillation. Undersea and Hyperbaric Medicine 2022;49(2):227-231 (as printed in the article; PubMed records 563-568).
Strauss M, Sass A, Wilson K, Miller S. Mixed Compartment Syndromes and Neuropathy Resolution With Hyperbaric Oxygen. Undersea Hyperb Med 2026;53(2):227-234.
Stream JO, Grissom CK. Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment. Wilderness Environ Med 2008;19(4):293-303.
Stuhr LEB, Raa A, Øyan AM, Kalland KH, Sakariassen PO, Petersen K, Bjerkvig R, Reed RK. Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats. J Neurooncol 2007;85(2):191–202.
Sugiyama J, Takegami Y, Muto S. Negative Pressure Wound Therapy Versus Conventional Dressings After Debridement for Necrotizing Fasciitis or Gas Gangrene: Impact on Hospital Stay and Wound Closure Methods. Cureus 2026;18(5):e109563.
Suhaym O, Assari A. Osteoradionecrosis following dental extractions and implants in nasopharyngeal cancer patients treated with radiotherapy: a narrative review. Genet Mol Res 2026;25(21s) (Genetics and Molecular Research 25(21s):2026 as printed in the running footer; no page range printed; PDF supplied by Dr Weir).
A narrative review of 30 papers (1999–2025) on ORN after extraction or implant placement in irradiated jaws, focused on nasopharyngeal cancer (NPC) but mostly drawing on mixed head-and-neck cohorts. The Methods state that a systematic review was not feasible and that included studies were not quality-assessed (p 2).
Sukhotnik I, Krausz MM, Brod V, Balan M, Turkieh A, Siplovich L, Bitterman H. Divergent effects of oxygen therapy in four models of uncontrolled hemorrhagic shock. Shock 2002;18(3):277-84.
Sukoff MH, Ragatz RE. Hyperbaric oxygenation for the treatment of acute cerebral edema. Neurosurgery 1982;10(1):29-38.
Summers M, Gawthorpe IC. Diaphragmatic injury a hidden issue for divers following trauma: Case report. Diving and Hyperbaric Medicine 2020;50(2):178-180.
Sun TB, Yang CCH, Kuo TBJ. Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications. Diabet Med 2006;23(4):360–366.
No baseline HRV difference between groups; after HBO, significant increases in RR (+82.7±16.0 ms), Local tissue oxygenation increased significantly with HBO. ⚠️ Full read 21 Oct 2026 (pages 361–366):
Sun Q, Wu D, Yu T, Yang Y, Wei L, Lv F, et al. Effects of positive end-expiratory pressure on intracranial pressure in mechanically ventilated dogs under hyperbaric oxygenation. Undersea Hyperb Med 2014;41(4):273-6.
Sun Q, Sun Z, Gao G. The sham control settings in hyperbaric oxygen trials. Undersea Hyperb Med 2016;43(7):855-856.
Sun M, Liang H, Chen Y, Duan S, Xu R, Cai Z. A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head. Medical Gas Research 2026;16(1):1-5.
Sun Y, Yang Y, Wang Z, Zhao H, Ge X, Pan S. Optimizing Hyperbaric Oxygen Therapy for Sudden Hearing Loss. Otolaryngol Head Neck Surg 2026;not yet assigned — published online 1 Oct 2026 as article ohn.70449; the held PDF prints '2026, Vol. 00(00) 1–9' Re-check.(not yet assigned. Re-check.):1-9 (online-first).
Sun X, Sun Q, Yao L, Han F, Song J, Bai G, Xiong L, Fang Z. High Flow Nasal Cannula Oxygen Therapy for Acute Carbon Monoxide Poisoning. Research Square (preprint) 2026:posted 22 Oct 2026, version 1, not peer reviewed (PREPRINT, not peer reviewed; CC BY 4.0).
Five patients with CO exposure "in an enclosed space" were admitted to one Shanghai hospital in July 2024 (p.3). All presented with headache and nausea, without loss of consciousness or raised lactate, and all had a first arterial COHb above 30%; the authors label this "moderate" poisoning (p.3). All five were men aged 22–25, all smokers, BMI 20.2–29.0, with no hypertension, diabetes or CNS diseas
Surrett GW, Vaughan WM. Arterial gas embolism in a Special Forces combat dive student during free-swimming ascent training: A case study. Undersea Hyperb Med 2015;42(2):167-172.
Sutkowy P, et al. The impact of hyperbaric oxygen therapy on the redox balance of patients with diabetic foot syndrome. Free Radic Res 2024.
Svalestad J, Thorsen E, Vaagbø G, Hellem S. Effect of hyperbaric oxygen treatment on oxygen tension and vascular capacity in irradiated skin and mucosa. Int J Oral Maxillofac Surg 2014;43(1):107–112.
TcPO₂ increased significantly in the irradiated cheek (P<0.05), but not at reference points outside No difference between the 3- and 6-month follow-ups → the gain is durable (not a transient Control group: no significant change. No major therapeutic complications.
Svalestad J, Hellem S, Thorsen E, Johannessen AC. Effect of hyperbaric oxygen treatment on irradiated oral mucosa: microvessel density. Int J Oral Maxillofac Surg 2015;44(3):301–307.
Microvessel density significantly increased after HBOT (P=0.002–0.041). D2-40-positive lymphatic vessels significantly increased in number and area in the sub-epithelial area No significant change in the control group.
Svendsen Juhl C, Hedetoft M, Bidstrup D, Jansen EC, Hyldegaard O. Decompression illness treated in Denmark 1999-2013. Diving Hyperb Med 2016;46(2):87-91.
Sward DG, Sethuraman KN, Wong JS, Rosenthal RE. Carbon monoxide and ST-elevation myocardial infarction: case reports. Undersea Hyperb Med 2016;43(1):63-9.
Sward DG, Austin TW. Hemiplegia and bilateral globus pallidus infarcts after carbon monoxide poisoning: case report. Undersea Hyperb Med 2018;45(1):95-100.
Swift PC, Turner JH, Oxer HF, O'Shea JP, Lane GK, Woollard KV. Myocardial hibernation identified by hyperbaric oxygen treatment and echocardiography in postinfarction patients: comparison with exercise thallium scintigraphy. Am Heart J 1992;124(5):1151-8.
Takac I, Kvolik S, Divkovic D, Kalajdzic-Candrlic J, Puseljic S, Izakovic S. Conservative surgical management of necrotic tissues following meningococcal sepsis: case report of a child treated with hyperbaric oxygen. Undersea Hyperb Med 2010;37(2):95–99.
Takemura A, Ishihara A. Mild hyperbaric oxygen inhibits growth-related decrease in muscle oxidative capacity of rats with metabolic syndrome. Journal of Atherosclerosis and Thrombosis 2017;24(1):26-38.
Takemura A, Egawa T, Takagi R, Zhao H, Iyama R, Suzuki S, Fujino R, Fukunaga T, Hayashi T, Fujita S. Mild hyperbaric oxygen enhanced the regeneration of the tibialis anterior muscle after the cardiotoxin-induced muscle injury. Biochem Biophys Rep 2026;46:102638.
Talanker MM, Basta AV, Do T, Tung R, Allen A, Martin M, Ruygrok BL, Kellam PJ, Trost JG, Bhadkamkar MA. Multidisciplinary Approach to Complex Lower Extremity Limb Salvage in Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome: A Case Report. Microsurgery 2026;46(4):e70224.
Talas DÜ, Beger O, Çömelekoglu Ü, Çakir S, Taghipour P, Vayisoglu Y. An insight to tympanic membrane perforation pressure through morphometry: A cadaver study. Diving Hyperb Med 2021;51(1):10-17.
Talbot Z, Lee A, Boet S. Hyperbaric medicine in Canadian undergraduate medical school curriculum. Diving Hyperb Med 2023;53(2):138-141.
Tamaki H, Kohshi K, Sajima S, Takeyama J, Nakamura T, Ando H, et al. Repetitive breath-hold diving causes serious brain injury. Undersea Hyperb Med 2010;37(1):7-11.
Tamura H, Takao K, Kawashima M. Six cases of hyperbaric oxygen therapy for crush wounds [Japanese]. Orthopedics & Traumatology (Nishi Nihon Seisai) 1986;34(3):1032-1035.
Tan IK, Lim JM. Anaemia in the critically ill--the optimal haematocrit. Ann Acad Med Singap 2001;30(3):293-9.
Tan VH, Chin K, Kumar AA, Chng J, Soh CR. Treatment preferences for decompression illness amongst Singapore dive physicians. Diving Hyperb Med 2017;47(2):118-122.
Tanaka HL, Medak AJ, Duchnick J, Lindholm P. Wireless point-of-care ultrasound in a multiplace hyperbaric chamber. Undersea Hyperb Med 2023;50(3):265-272.
Tanaka HL, Rees JR, Zhang Z, Ptak JA, Hannigan PM, Silverman EM, Peacock JL, Buckey JC; Multicenter Registry for Hyperbaric Oxygen Treatment Consortium. Emerging Indications for Hyperbaric Oxygen Treatment: Registry Cohort Study. Interact J Med Res 2024;13:e53821 (published 20 Aug 2024; open access CC BY 4.0; verified vs PubMed 26 Oct 2026).
- Registry inception 2011 through May 2024; centres in the USA, UK and Australia; IRB approval at every site, consent model varying by centre (some waivers) [src: pmid:39078624]. - Records coded "other" were isolated, free-text entries reclassified with MATLAB text recognition and manually double-checked in Excel; the study size is simply the number of "other" entries [src: pmid:39078624]. - Outco
Tang XP, Tan M, Zhang T, Peng H, Duan JW. Effects of early hyperbaric oxygen therapy on clinical outcome in postoperative patients with intracranial aneurysm. Undersea Hyperb Med 2011;38(6):493-501.
Tang X, Yin X, Zhang T, Peng H. The effect of hyperbaric oxygen on clinical outcome of patients after resection of meningiomas with conspicuous peritumoral brain edema. Undersea Hyperb Med 2011;38(2):109-15.
Tang Y, Zou YX, Fan W, Chen SH, Fang YQ, Liu LN, et al. Simulation stress model of the undersea environment activates the central nervous, neuroendocrine and immune systems and anxiety in rats. Undersea Hyperb Med 2020;47(3):445-453.
Tang M, Gong S, He J, Wu X, Shi M, Yang M, Shi L, Huang L, Li L, Zhou D, Zhao Y. Hyperbaric oxygen therapy upregulates neurotrophic factors to ameliorate post-stroke depression: a randomized sham-controlled trial. Neuropsychiatr Dis Treat 2026;22:573494.
Tang X, Song S, Wu S, Wang Y, Jin G, Ding C, Zeng Q. Hyperbaric oxygen therapy timing, early neurohemodynamic response and functional outcome in acute ischemic stroke. Exp Ther Med 2026;32(6):339.
Tang X, Hao Y, Yu Y, Lin K, Kang X. Perioperative central retinal artery occlusion after prone posterior cervical spine surgery treated with delayed hyperbaric oxygen therapy: a case report and targeted literature review. BMC Anesthesiol 2026:in press.
Taraldsøy T, Bolann BJ, Thorsen E. Reduced nitric oxide concentration in exhaled gas after exposure to hyperbaric hyperoxia. Undersea Hyperb Med 2007;34(5):321-7.
Tatar S, Orhan N, Yilmaz CU, Arican N, Ahishali B, Kucuk M, et al. Hyperbaric oxygen therapy for five days increases blood-brain barrier permeability. Undersea Hyperb Med 2017;44(4):345-355.
Tatucu-Babet OA, Ridley EJ. Malnutrition screening in outpatients receiving hyperbaric oxygen therapy: an opportunity for improvement? Diving Hyperb Med 2018;48(4):206-207.
Teguh DN, Levendag PC, Noever I, Voet P, van der Est H, van Rooij P, Dumans AG, de Boer MF, van der Huls MPC, Sterk W, Schmitz PIM (Erasmus MC, Rotterdam). Early Hyperbaric Oxygen Therapy for Reducing Radiotherapy Side Effects: Early Results of a Randomized Trial in Oropharyngeal and Nasopharyngeal Cancer. Int J Radiat Oncol Biol Phys 2009;75(3):711–716.
On all QoL items, better scores in the HBOT arm. The HBOT vs non-HBOT difference was significant for EORTC H&N35 Swallowing p=0.011 EORTC H&N35 Dry Mouth (xerostomia) p=0.009
Teguh DN, Bol Raap R, Struikmans H, Verhoef C, Koppert LB, Koole A, Huang Y, van Hulst RA. Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: prospectively patient-reported outcome measures in breast cancer patients. Radiat Oncol 2016;11(1):130.
Tekin V, Çiçek Z, Koç GE, Özler M. The effects of hyperbaric oxygen therapy and mitochondrial transplantation on cisplatin toxicity. Experimental and Molecular Pathology 2026;148:105076.
A bench study in bone-marrow-derived human mesenchymal stem cells, not an animal or clinical study. Cells were seeded at 5 × 10³ per well and exposed to cisplatin at an experimentally determined MTT-based LD50 (148 μM; 150 μM used), then given mitochondrial transplantation at a 10× or 100× cell-number-scaled dose for 4 hours, then three hyperbaric sessions of 90 minutes at 2.1 ATA or a matched inc
Tekkök IH, Erbengi A. Management of brain abscess in children: review of 130 cases over a period of 21 years. Childs Nerv Syst 1992;8(7):411-6.
Tempel R, Severance HW. Proposing short-term observation units for the management of decompression illness. Undersea Hyperb Med 2006;33(2):89-94.
Tenenhaus M, Gaid NA, Hayes S, Foubert P, Grover I. Injection of SVF combined with HBO2 improves viability of unfavorably designed flaps. Undersea Hyperb Med 2018;45(4):381-388.
Teoh SY, Vangaveti VN. Repeated hyperbaric exposure and glass ampoule safety. Diving Hyperb Med 2018;48(2):107-109.
Tepic S, Zivkovic M, Terzic N, Krivokuca R, et al. Effect of hyperbaric oxygen treatment on oxidative stress in patients having diabetes mellitus type 2. Medicinski Pregled 2009;62(5-6):225-230.
Tepic S, Petkovic A, Srejovic I, Jeremic N, Zivkovic V, Loncarevic S, Bradic J, Jakovljevic V. Impact of hyperbaric oxygenation on oxidative stress in diabetic patients. Undersea Hyperb Med 2018;45(1):9-17.
Thacker J, Pullis M, Masters T, Logue C. Laptop-style point-of-care ultrasound machines in the multiplace hyperbaric oxygen treatment chamber. Undersea Hyperb Med 2026;53(1):51-58.
Thaler J, Pignel R, Magnan MA, Pellegrini M, Louge P. Decompression illness treated at the Geneva hyperbaric facility 2010-2016: A retrospective analysis of local cases. Diving and Hyperbaric Medicine 2020;50(4):370-376.
Préterre C, Gaultier A, Obadia M, et al. Intravenous alteplase versus oral aspirin for acute central retinal artery occlusion within 4.5 h of severe vision loss (THEIA): a multicentre, double-dummy, patient-blinded and assessor-blinded, randomised, controlled, phase 3 trial. Lancet Neurology 2025;24(11):909–919.
70 patients randomised (35 alteplase, 35 aspirin). Mean onset-to-treatment 232 min. Primary endpoint: 19/29 (66%) alteplase vs 13/27 (48%) aspirin improved — not significant Interpretation: alteplase within 4.5 h not associated with significant benefit over aspirin; likely
Thenuwara K, Thomas J, Ibsen M, Ituk U, Choi K, Nickel E, Goodheart MJ. Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with life-threatening anemia following postpartum hemorrhage. Int J Obstet Anesth 2016;29:73–80.
The haemorrhage. Preoperative Hb was 12.2 g/dL (Hct 38%), improved in the anaemia clinic at 34 The nadir. On postoperative day one haemoglobin was 3.0 g/dL with a lactate of 5.6 mEq/L HBOT prescription. 2.4 ATA for 90 min at FiO₂ 1.0, in a 12-hourly cycle, begun on postoperative
Thistlethwaite KR, Finlayson KJ, et al. The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double‐blind, placebo‐controlled trial. Wound Repair Regen 2018;26(4):324–331.
Complete healing at 12 weeks: no significant difference between HBOT and placebo (primary outcome). Percent area reduction (PAR): 95% (HBOT) vs 54% (placebo) — significant (p=0.042; mean difference
Thom SR, Taber RL, Mendiguren II, Clark JM, Hardy KR, Fisher AB. Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 1995;25(4):474–480.
DNS developed in 7/30 (23%) of the ambient-pressure-oxygen group vs 0/30 (0%) after HBO (P<0.05). DNS appeared 6 ± 1 days after poisoning and persisted 41 ± 8 days. At 4-week follow-up, ambient-pressure patients who had not developed overt DNS still scored worse on
Thom SR, Bhopale VM, Fisher D, Zhang J, Gimotty P. Delayed neuropathology after carbon monoxide poisoning is immune-mediated. Proc Natl Acad Sci U S A 2004;101(37):13660-5.
A controlled laboratory experiment in male Wistar rats (Charles River Laboratories), 200–290 g, fed standard diet and water ad libitum, all care in accordance with institutional guidelines. Carbon monoxide poisoning protocol. In a 7-litre Plexiglas chamber, rats breathed 1,000 ppm CO for 40 min, then 3,000 ppm for up to 20 min until they lost consciousness, and were then removed to breathe room ai
Thom SR, Fisher D, Stubbs JM. Platelet function in humans is not altered by hyperbaric oxygen therapy. Undersea Hyperb Med 2006;33(2):81-3.
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. Journal of Applied Physiology 2009;106(3):988-995.
Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg 2011;127 Suppl 1(Suppl 1):131S-141S.
Thomas PS, Hakim TS, Trang LQ, Hosain SI, Camporesi EM. The synergistic effect of sympathectomy and hyperbaric oxygen exposure on transcutaneous PO2 in healthy volunteers. Anesth Analg 1999;88(1):67-71.
Thomas HS, Neu S, Hird A, Golding H, Wilton D, Saskin R, Tarshis J, Alam F, Nam RK, Herschorn S, Matta R. Hyperbaric oxygen therapy in patients with hemorrhagic radiation cystitis: A population-based, retrospective cohort study. Can Urol Assoc J 2026;not yet assigned — Epub ahead of print 25 Sep 2026(not yet assigned — Epub ahead of print):not yet assigned — Epub ahead of print (held PDF is the 16-page accepted manuscript).
The largest comparative dataset for this indication after evidence/feldmeier-2024-cms-data-cost-clinical-advantage-radiation-cystitis, and the first from a single-payer public system. ICES links the Ontario Cancer Registry to hospital, emergency, physician-billing and drug-benefit records for a population of about 16 million. The authors took every adult with a pelvic cancer (bladder cancer exclud
Thomas SJ, Bao JM, Ansari A, Kizilbash E, Langford JH, Kalafatis NE, Shughoury A, Gregory DM, Larson JR, Adams NJ, Marsee MK, Jordan CC, Johnson DM, Raza S, Wiarda A, Alizai AM, Walsh MM. Resolution of Pneumomediastinum, Cervicofacial Emphysema, and Internal Ophthalmoplegia with Hyperbaric Oxygen Therapy After Hip Arthroscopy: A Case Report. J Clin Med 2026;15(12):4634.
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Thornton SL, Gallagher R, Gallagher D, Hunter J, Castelli R, Scott M. Trends and characteristics of cases when serial carboxyhemoglobins are obtained. Undersea Hyperb Med 2019;46(5):655-658.
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Tian M, Du W, Yang S, Liao Q, Guo F, Li S. Application and progress of hyperbaric oxygen therapy in cardiovascular diseases. Med Gas Res 2025;15(3):427-434 (DOI 10.4103/mgr.MEDGASRES-D-24-00107).
Tibbles PM, Edelsberg JS. Hyperbaric-oxygen therapy. The New England Journal of Medicine 1996;334(25):1642-1648.
Tlapak J, Chmatal P, Oniscenko B, Pavlik V, Dosel P, Paral J, Lochman P. The effect of hyperbaric oxygen therapy on gene expression: microarray analysis on wound healing. Undersea Hyperb Med 2020;47(1):31-37.
Tlapák J, Tlapáková E, Pásler A, Chmelař D, Hájek M. Combined hyperbaric oxygen therapy and repetitive transcranial magnetic stimulation in depression and PTSD: future perspectives. Med Gas Res 2026;16(2):303-304.
Tobin DA, Vermund H. A randomized study of hyperbaric oxygen as an adjunct to regularly fractionated radiation therapy for clinical treatment of advanced neoplastic disease. Am J Roentgenol Radium Ther Nucl Med 1971;111(3):613-21.
Togawa S, Maruyama M, Yamami N, Nakayama H, Shibayama M, Kawashima M, et al. Dissociation of neurological deficits in spinal decompression illness. Undersea Hyperb Med 2006;33(4):265-70.
Toklu AS, Aktas S, Aydin S, Çimsit M. 37 decompression sickness cases treated in the Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine. SPUMS J 1999;29(4):227–230.
Toklu AS, Erelel M, Arslan A. Pneumomediastinum or lung damage in breath-hold divers from different mechanisms: a report of three cases. Diving Hyperb Med 2013;43(4):232-235.
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Tomiyama Y, Jansen K, Brian JE, Todd MM. Hemodilution, cerebral O2 delivery, and cerebral blood flow: a study using hyperbaric oxygenation. Am J Physiol 1999;276(4):H1190-6.
Tomoye EO, Park CL, Folke L, Moon RE. Reprinted from the 2023 Hyperbaric Indications Manual 15th Edition: Intracranial Abscess. Undersea Hyperb Med 2024;51(4):449–455.
Defines the indication (cerebral abscess, subdural/epidural empyema), aetiology, and the UHMS position; ⚠️ Full read 21 Oct 2026 (all 7 pages): the operative content, which the record had not carried. Selection criteria (PATIENT SELECTION CRITERIA). After diagnosis, adjunctive HBO₂ "should be considered" for multiple abscesses, an abscess in a deep or dominant location, a compromised host (particularly with fungal infection),…
Tomoye EO, Moon RE. Hyperbaric oxygen for intracranial abscess. Undersea Hyperb Med 2021;48(1):97–102.
Covers aetiology (contiguous spread, haematogenous seeding, trauma), the hypoxic-abscess mechanism, and Bottom line: given the high morbidity/mortality of intracranial abscess and that HBO is
Tong B, Niu K, Ku W, Xie W, Dai Q, Hellström S, Duan M. Comparison of Therapeutic Results with/without Additional Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Prospective Study. Audiol Neurootol 2021;26(1):11–16.
Overall success: 60.6% (40/66) HBO+P vs 42.9% (30/70) P (p = 0.038 as printed; ⚠️ corrected 31 Aug 2026 from "p<0.05" — the paper gives the exact value). Greater benefit in defined subgroups: mild–moderate baseline loss, age ≤50 y, treated ≤14 days, and ⚠️ Full read 21 Oct 2026 (all 6 pages): the worst-case reanalysis is now stated with its test. 144 consented (Anhui Medical University, May–December 2013). 8 withdrew (6 HBO+P,…
Toocheck C, Bahner D, Bachmann DJ. Carbon monoxide-induced atrial fibrillation resolved with hyperbaric oxygen. Undersea Hyperb Med 2020;47(1):145-149.
Toppen W, Cho NY, Sareh S, Kjellberg A, Medak A, Benharash P, Lindholm P. Contemporary national outcomes of hyperbaric oxygen therapy in necrotizing soft tissue infections. PLoS One 2024;19(3):e0300738.
HBOT group had lower mortality: <2% vs 5.9% (p<0.001) and lower amputation. HBOT is used in <1% of surgically-treated NSTI in the US — striking under-utilisation of a recognised
Topuz E, Yigit O, Cinar U, Seven H (Istanbul, Turkey). (received 2003). Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? Eur Arch Otorhinolaryngol 2004;261(7):393–396.
Between-group gains (Table 2, page 394): 250 Hz 12.9 vs 30.0 dB (p = 0.002), 500 Hz 19.5 vs 37.8 By initial severity (Table 3, page 394): ≤60 dB 22.3 vs 22.5 dB (p = 0.758, no difference); 61–80 dB 16.2 vs Age gradient in the HBO group: mean hearing gain 39.1 ± 18.3 dB in patients < 50 years vs 22.7 ± 11.3
Torp KD, Carraway MS, Ott MC, Stolp BW, Moon RE, Piantadosi CA, Freiberger JJ. Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients. Undersea Hyperb Med 2012;39(5):873-9.
Torres LN, Spiess BD, Torres Filho IP. Tissue oxygenation and microvascular hemodynamics in experimental arterial gas embolism. Undersea Hyperb Med 2011;38(6):537-48.
Torres Martínez FJ, Kuffler DP. Hyperbaric oxygen treatment to eliminate a large venous air embolism: a case study. Undersea Hyperb Med 2011;38(4):297–304.
Tran V, Smart D. Proliferative retinopathy during hyperbaric oxygen treatment. Diving Hyperb Med 2017;47(3):203.
Trevett AJ, Sheehan C, Forbes R. Decompression illness presenting as breast pain. Undersea Hyperb Med 2006;33(2):77-9.
Trevett A, Sheehan C, Wilkinson A, Moss I. Lion's mane jellyfish (Cyanea capillata) envenoming presenting as suspected decompression sickness. Diving and Hyperbaric Medicine 2019;49(1):57-60.
Trinks TP, Blake DF, Young DA, Thistlethwaite K, Vangaveti VN. Transcutaneous oximetry measurements of the leg: comparing different measuring equipment and establishing values in healthy young adults. Diving Hyperb Med 2017;47(2):82-87.
Tripathi KK, Moorthy A, Karai RC, Rao G, Ghosh PC. Effect of hyperbaric oxygen on bone healing after enucleation of mandibular cysts: a modified case control study. Diving Hyperb Med 2011;41(4):195-201.
Trytko BE, Bennett MH. Arterial gas embolism: a review of cases at Prince of Wales Hospital, Sydney, 1996 to 2006. Anaesth Intensive Care 2008;36(1):60-64.
Tsouras T. Test results for the evaluation of a glucometer for use under hyperbaric conditions: Technical report. Undersea Hyperb Med 2017;44(1):27-32.
Tsouras T, Devaney B, Lin ZC, Covelli C, Roberts L, Nanjayya VB, Millar I. Validation and clinical use of the Maquet (Getinge) original series Rotaflow extracorporeal membrane oxygenation device in hyperbaric conditions: a technical report. Diving Hyperb Med 2025;55(4):323-329.
Tsushima R, Mori K, Imaki S. Secondary deterioration in a patient with cerebral and coronary arterial gas embolism after brief symptom resolution: a case report. Diving Hyperb Med 2024;54(1):61-64.
Tucker A, Smart D. Technical validation of the EMMA capnometer under hyperbaric conditions. Diving Hyperb Med 2023;53(2):100-110.
Tueguem Moyo T, Jéhannin P, Le Pabic E, Le Faucheur A, Omarjee L, Mahe G. Test-retest reliability and minimal detectable change in exercise oximetry in claudicants. Ann Vasc Surg 2023;99:19-25.
Tuluy Y, Aksoy A, Sır E. Effects of external bleeding and hyperbaric oxygen treatment on Tamai zone 1 replantation. Diving and Hyperbaric Medicine Journal 2023;53(1):2-6 (DOI 10.28920/dhm53.1.2-6).
Tumanovskiĭ IuM, Leonov AN. [Activity of the afferent links in the reflex compensatory mechanisms of hemodynamic disorders in acute blood loss and hyperbaric oxygenation]. Anesteziol Reanimatol 1985;(2):39-42 (Russian).
Tumanovsky YM. Hemodynamics and gas exchange in hemorrhagic shock and hyperbaric oxygenation (experimental study). General Reanimatology 2007;3(6):43–47.
Tuominen LJ, Sokolowski S, Lundell RV, Räisänen-Sokolowski AK. Decompression illness in Finnish technical divers: a follow-up study on incidence and self-treatment. Diving and Hyperbaric Medicine 2022;52(2):78-84.
Turgut B, Canarslan Demir K, Sariyerli Dursun GB, Zaman T. Hemiplegia resulting from acute carbon monoxide poisoning. Diving Hyperb Med 2023;53(2):155-157.
Türkmen O, Özkan R, Özgök Kangal K, Dur İnce M, Arslan Y. Hyperbaric oxygen treatment and pulmonary air-containing lesions. Diving Hyperb Med 2025;55(4):343-351 (DOI 10.28920/dhm55.4.343-351).
Tutrone WD, Green K, Weinberg JM, Caglar S, Clarke D. Pyoderma gangrenosum: dermatologic application of hyperbaric oxygen therapy. J Drugs Dermatol 2007;6(12):1214–1219.
Tyrtyshnikov IM. Effect of acute massive blood loss during hyperbaric oxygen therapy on nucleic acid metabolism in the albino rat liver. Bull Exp Biol Med 1974;77(6):611-2.
Tyrtyshnikov IM, Pichugina TP, Zareva NIa. [Effect of hyperbaric oxygenation on nucleic acid metabolism in the brain and internal organs in acute massive blood loss]. Patol Fiziol Eksp Ter 1975;(1):43-7 (Russian).
Tyrtyshnikov IM. [Plastic processes in the myocardium during the use of hyperbaric oxygenation in the recovery period after acute massive blood loss]. Kardiologiia 1985;25(2):94-6 (Russian).
Tyrtyshnikov IM. [Dynamics of the plastic processes in the liver during the use of hyperbaric oxygenation in the recovery period following acute massive blood loss]. Biull Eksp Biol Med 1986;101(2):154-6 (Russian with English abstract).
Udayakumaran S, Onyia CU, Kumar RK. Forgotten? Not Yet. Cardiogenic Brain Abscess in Children: A Case Series-Based Review. World Neurosurg 2017;107:124-129.
Udayakumaran S, Joseph T. A proposal for a tailored protocol for focal suppurative infection of the central nervous system: analysis of an institutional experience in pediatric patients. Neurosurg Focus 2019;47(2):E11.
Udomkarnjananun S, Kongnatthasate K, Praditpornsilpa K, Eiam-Ong S, Jaber BL, Susantitaphong P. Treatment of Calciphylaxis in CKD: A Systematic Review and Meta-analysis. Kidney Int Rep 2018;4(2):231-244.
Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Shinchi H, Natsugoe S. Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy. Langenbecks Arch Surg 2011;396(1):99–106 (epub 11 Nov 2010).
Ueno T, Omi T, Uchida E, Yokota H, Kawana S. Evaluation of hyperbaric oxygen therapy for chronic wounds. J Nippon Med Sch 2014;81(1):4-11.
Uguen M, Pougnet R, Uguen A, Loddé B, Dewitte JD. Dysbaric osteonecrosis among professional divers: a literature review. Undersea Hyperb Med 2014;41(6):579-87.
Uguen M, Pougnet R, Uguen A, Cornec D, Quintin-Roué I, Dewitte JD, et al. Dysbaric osteonecrosis in professional divers: two case reports. Undersea Hyperb Med 2015;42(4):363-7.
Clarke R. HBO2 for radiation cystitis (letter concerning Oscarsson et al, randomised controlled trial). Undersea Hyperb Med 2019;46(5):725-727.
Huang ET (Chair & Editor). Hyperbaric Medicine Indications Manual, 15th ed. Undersea and Hyperbaric Medical Society / Best Publishing Company Undersea and Hyperbaric Medical Society / Best Publishing Company; 2023. ISBN 978-1-947239-42-5.
The Undersea and Hyperbaric Medical Society's reference manual of accepted indications for hyperbaric oxygen, 15th edition, edited by Huang ET — a multi-author bound volume in which each indication is a separate chapter by different authors. It is held here as a reference work and a discovery pool, not as appraised evidence. No risk-of-bias instrument is applied to the volume as a whole, because a
Undersea and Hyperbaric Medical Society. Adjunctive therapy for decompression illness (DCI): summary of Undersea and Hyperbaric Medical Society guidelines. Undersea and Hyperbaric Medical Society guideline summary (December 2002), 9 pp 2002.
UHMS Associates Facility Design Committee (Wood S, chair). Hyperbaric Facility Design Guidelines, Version 1.0. Undersea and Hyperbaric Medical Society Associates 2004;1.0:1-11.
Undersea and Hyperbaric Medical Society. Safe Design and Operation of Hyperbaric Chambers. Undersea Hyperb Med 2013:1-4.
Undersea and Hyperbaric Medical Society. Undersea and Hyperbaric Medical Society, HBO2 Safety Committee: Commentary on the current status of IV pumps for monoplace chambers 2-17-2015. Undersea Hyperb Med 2015:1.
MEDFAQs: Compensating for hyperbaric treatments at altitude. Undersea Hyperb Med 2017;44(4):371-372.
MEDFAQs: radiation cystitis, radiation seed implant, screening prior to HBO2. Undersea Hyperb Med 2017;44(3):297-298.
MEDFAQs [surface interval between same-day treatments and pulmonary oxygen dose]. Undersea Hyperb Med 2017;44(5):495-496.
Undersea and Hyperbaric Medical Society. UHMS announces position statement on low-pressure, soft-sided hyperbaric chambers. Undersea Hyperb Med 2017;44(6):612.
Undersea and Hyperbaric Medical Society. UHMS Position Statement: The role of hyperbaric oxygen for acute traumatic ischemias. Undersea Hyperb Med 2018;45(5):617-620.
Undersea and Hyperbaric Medical Society. Clinical Hyperbaric Facility Accreditation Manual, Fourth Edition. Undersea and Hyperbaric Medical Society, Inc. (accreditation manual), North Palm Beach, FL 2018.
- Issuer and edition. UHMS, Fourth Edition, © 2018 (title page p.1; copyright p.2). The title page carries no month. The PDF metadata gives 4 June 2018, and the Zotero title says "Final 6-4-2018". That date comes from the file, not from the printed document. - What it is for. It is the probe set UHMS surveyors use to accredit a clinical hyperbaric facility. It is not a clinical guideline. UHMS sta
Undersea and Hyperbaric Medical Society. UHMS guidelines for credentialing, privileging and supervision of hyperbaric oxygen therapy in the U.S.A. Undersea Hyperb Med 2018;45(1):117-127 (created March 2009; revised June 2014 and January 2018).
Undersea and Hyperbaric Medical Society. UHMS Medical Fitness to Work Guidelines for Multiplace Inside Attendants 1st edition. Undersea Hyperb Med 2018;45(2):231-247.
MEDFAQs. Undersea Hyperb Med 2018;45(4):481-482.
Undersea and Hyperbaric Medical Society. UHMS position statement: low-pressure fabric hyperbaric chambers. Undersea Hyperb Med 2018;45(4):486-487.
Undersea and Hyperbaric Medical Society. UHMS Position Statement: Topical Oxygen for Chronic Wounds. Undersea Hyperb Med 2018;45(3):379-380.
Undersea and Hyperbaric Medical Society. position statement - uhms associates hyperbaric certification recognition v.10.05.2019 v6 1. Undersea Hyperb Med 2019.
The Editors. The issue: 24/7 access to hyperbaric care. Undersea Hyperb Med 2019;46(5):724.
Undersea and Hyperbaric Medical Society. uhms-position-statement-10-05-2019. Undersea Hyperb Med 2019.
Undersea and Hyperbaric Medical Society. UHMS Position Statement: Minimum-staffing guidelines for multiplace hyperbaric facilities. Undersea Hyperb Med 2019;46(1):93-94.
Undersea and Hyperbaric Medical Society Research Committee (Feldmeier JJ, Kirby JP, Buckey JC, co-chairs). Rationale, study design considerations, and protocol recommendations for treating COVID-19 patients with hyperbaric oxygen. Undersea and Hyperbaric Medical Society (society document; no journal) 2020 (no date printed; cites a UHMS webinar of 20 July 2020 and a paper online 22 July 2020, so issued late July 2020 or after; file received via Milpark).
Undersea and Hyperbaric Medical Society. HBO2 for COVID-19: Clinical trials at clinicaltrials.gov. Undersea Hyperb Med 2020;47(2):299-307.
Undersea and Hyperbaric Medical Society. UHMS Position Statement: Hyperbaric Oxygen (HBO2) for COVID-19 Patients. Undersea Hyperb Med 2020;47(2):297-298.
Shapshak D, Kelly M. UHMS Position Statement: HBO2 departments offering services for emergent and urgent HBO2 indications. Undersea Hyperb Med 2022;49(3):391-392.
Moon RE, Mitchell SJ. Hyperbaric treatment of air or gas embolism: current recommendations. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 1 (manual PDF pp 44–64).
The governing UHMS chapter for arterial and venous gas embolism, which the 14th-edition chapter previously filled. It covers mechanisms, presentation, first aid, recompression, adjunctive drugs, outcome data and a management flow chart.
Murphy-Lavoie H, Butler F, Hagan C. Arterial insufficiencies: central retinal artery occlusion. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 2A (manual PDF pp 65–89).
Huang ET, Heyboer M 3rd, Savaser DJ. Hyperbaric oxygen therapy for selected problem wounds. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 2B (manual PDF pp 90–168).
Weenink RP, Giannakopoulos GF, van Hulst RA. Clostridial myonecrosis (gas gangrene). In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 4 (manual PDF pp 211–222).
Childers EJ, Baynosa RC. The effect of hyperbaric oxygen on compromised grafts and flaps. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 5 (manual PDF pp 223–251).
Strauss MB. Acute traumatic ischemias: roles of hyperbaric oxygen. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 6 (manual PDF pp 252–278).
Moon RE, Mitchell SJ. Decompression sickness. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 7 (manual PDF pp 279–295).
Feldmeier JJ, Gesell LB. Delayed radiation injuries (soft tissue and bony necrosis) and potential for future research. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 8 (manual PDF pp 296–369).
Anderson CA, Jacoby I. Necrotizing soft tissue infections. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 11 (manual PDF pp 422–445).
Tettelbach WH, Hart BB. Refractory osteomyelitis. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 12 (manual PDF pp 446–494).
Van Meter KW. Severe anemia. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 13 (manual PDF pp 495–509).
Cianci P, Sato RM, Faulkner J. Adjunctive hyperbaric oxygen in the treatment of thermal burns. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 14 (manual PDF pp 510–563).
Camporesi EM, Zanon V, Vezzani G, Bosco G. Undersea and Hyperbaric Medical Society; 2023. Chapter 15. Avascular Necrosis (Aseptic Osteonecrosis). Avascular Necrosis (Aseptic Osteonecrosis). In: Hyperbaric Oxygen Therapy Indications, 15th ed.
Acceptance & grade: "Published evidence of the beneficial effects of HBO₂ on osteonecrosis led to its Recommendation: "we recommend that HBO₂ be included amongst the possible therapeutic options for Mechanism: raises tissue O₂, reduces marrow oedema and intraosseous pressure via vasoconstriction,
Bosco G, Vezzani G, Camporesi EM. Mechanisms of action of hyperbaric oxygen therapy. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 16 (manual PDF pp 577–592).
Heyboer M 3rd, Santiago W. Side effects of hyperbaric oxygen therapy. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 17 (manual PDF pp 593–621).
Huang E. Hyperbaric oxygen dosing. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 18 (manual PDF pp 622–636).
Camporesi EM, Paganini M, Bosco G. Oxygen pretreatment and preconditioning. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 19 (manual PDF pp 637–650).
Bennett MH, Mitchell SJ, Buckey JC, Robins M. Emerging indications. In: Huang ET, editor. UHMS Hyperbaric Medicine Indications Manual. 15th ed. North Palm Beach (FL): Best Publishing Company 2023:Chapter 21 (manual PDF pp 702–730).
UHMS Equipment Subcommittee. Description of Medical Device Approval Process - Class A Multiplace Chambers (Medical Device Approval Form, updated September 2023). Undersea and Hyperbaric Medical Society 2023:1-17.
The current formal instrument through which a testing facility documents a medical device for use in Class A (multiplace) chambers: facility identification, device description, and the structured safety data the Equipment Subcommittee requires. It is the institutionalised version of the risk-assessment thinking in evidence/burman-2009-decision-process-medical-equipment-hyperbaric, and the pathway
Undersea and Hyperbaric Medical Society. UHMS Position Statement: Increasing participation of hyperbaric medicine centers in hyperbaric medicine registries. Undersea Hyperb Med 2023:1-2.
Undersea and Hyperbaric Medical Society. UHMS Position Statement: The potential impact of UV-C Disinfection on acrylic surfaces of hyperbaric chambers. Undersea Hyperb Med 2023:1-2.
Undersea and Hyperbaric Medical Society. UHMS Ten Guidelines for Patients and Referring Physicians. Undersea Hyperb Med 2025:1-4.
O'Neill OJ, Kelly M, Shapshak D. UHMS Position Statement: Standardization of Terminology in Undersea and Hyperbaric Medicine: Adoption of "Hyperbaric Oxygen Treatment". Undersea Hyperb Med 2026;53(3):541-542.
MEDFAQs: Q&As on current UHM topics. Undersea Hyperb Med 2017;44(6):613-614.
Uittenbogaard D, Lansdorp CA, Bauland CG, Boonstra O. Hyperbaric oxygen therapy for dermal ischemia after dermal filler injection with calcium hydroxylapatite: a case report. Undersea Hyperb Med 2019;46(2):207–210.
Umapathy D, Amin KN, Dornadula S, Alladi V, Arumugam S, Kesavan R, Mohanram RK. Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy. Free Radic Biol Med 2019;138:53–62.
Umemura H, Kuyama T, Matsuda S, Kinoshita K, Satomura K. [The role of antioxidants (synthetic reductive type of glutathione, Tachione) in inducing morality in mice and dogs due to the radioactive isotope Au 198 and hemorrhagic shock in the hyperbaric environment]. Nihon Geka Hokan 1967;36(2):174-9 (Japanese).
Unfirer S, Mihalj M, Novak S, Kibel A, Cavka A, Mijalevic Z, Gros M, Brizic I, Budimir D, Cosic A, Boban M, Drenjancevic I. Hyperbaric oxygenation affects the mechanisms of acetylcholine-induced relaxation in diabetic rats. Undersea Hyperb Med 2016;43(7):787-803.
Uniyal M, Ahmad I, Dhiman AK, Kumar A, Sarkar B, Jagne N, Mago V, Azam MQ. The Effect of Hyperbaric Oxygen Therapy on Split-Thickness Skin Graft Uptake in Posttraumatic Wounds and Donor Site Healing: A Randomized Controlled Trial. Wounds 2025;37(3):134–140.
Graft uptake POD 4: 92.44% (SD 5.98) HBOT vs 88.12% (8.92) control, P=.036. Graft uptake POD 7: 91.69% (8.71) vs 83.12% (14.94), P=.026. Donor-site recovery faster: 15.16 (0.88) days vs 17.97 (2.49) days, significant. Graft-site infection
Uteshev NS, Isakov IuV, Pakhomova GV, Rasshchepkina NA, Kusova NN. [Hyperbaric oxygenation in gastrointestinal hemorrhage of nontumor etiology]. Khirurgiia (Mosk) 1983;(10):95–99 (Russian).
Uzun G, Kardesoglu E, Uz O, Mutluoglu M, Sen H. Sudden death during hyperbaric oxygen therapy: rare but it may occur. Undersea Hyperb Med 2010;37(1):49-50.
Uzun G, Mutluoğlu M, Bakir A, Senocak MS. Fate of abstracts presented at the annual scientific meeting of the Undersea and Hyperbaric Medical Society. Undersea Hyperb Med 2013;40(5):387-93.
Uzun G, Mutluoglu M, Ersen O, Yildiz S. Hyperbaric oxygen therapy in the treatment of osteonecrosis of the femoral head: a review of the current literature. Undersea Hyperb Med 2016;43(3):189–199.
Uzun G, Mutluoglu M, Metin S. The use of hyperbaric oxygen treatment for sudden sensorineural hearing loss in Europe. Diving Hyperb Med 2016;46(1):43–46.
Vadas D, Kalichman L, Hadanny A, Efrati S. Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance. Front Integr Neurosci 2017;11:25.
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Valadão J, Pearl J, Verma S, Helms A, Whelan H. Hyperbaric oxygen treatment for post-radiation central nervous system injury: a retrospective case series. Undersea Hyperb Med 2014;41(2):87–96.
Valente Aguiar P, Carvalho B, Monteiro P, Linhares P, Camacho Ó, Vaz R. Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosis. Diving Hyperb Med 2021;51(1):86-93.
Valian A, Allahdadi M. The effect of atmospheric pressure on the bond strength of composites. Undersea Hyperb Med 2022;49(4):415-423.
van den Brenk HAS. Hyperbaric oxygen in radiation therapy. An investigation of dose-effect relationships in tumor response and tissue damage. Am J Roentgenol Radium Ther Nucl Med 1968;102(1):8-26.
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van Hulst RA, van der Kamp W. Decompression sickness in a vegetarian diver: are vegetarian divers at risk? A case report. Undersea Hyperb Med 2010;37(3):181-4.
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Chronic suppurative osteomyelitis (5 patients): all remained free of symptoms during follow-up. In Diffuse sclerosing type A (5 patients): 2 arrested, 2 markedly improved, 1 not improved at all. One Diffuse sclerosing type B (6 patients): 1 arrested, 2 improved, 3 not improved. The 3 non-improved
Van Meter KW, Harch PG. HBO in emergency medicine. In: Jain KK, ed. Textbook of Hyperbaric Medicine. 2nd ed. Seattle: Hogrefe & Huber 1996:453–481.
Van Meter KW, Weiss LD, Harch PG. Hyperbaric oxygen in emergency medicine. In: Jain KK, ed. Textbook of Hyperbaric Medicine. 3rd ed. Seattle: Hogrefe & Huber 1999:557–588.
Van Meter KW. A systematic review of the application of hyperbaric oxygen in the treatment of severe anemia: an evidence-based approach. Undersea Hyperb Med 2005;32(1):61–83.
All 35 publications reported a positive result when HBO₂ was delivered as treatment for severe ⚠️ Corrected 31 Aug 2026 — THE MOST CONSEQUENTIAL CORRECTION ON THIS PAGE. The bullet above The human evidence is case reports and series — there is no randomised controlled trial,
Van Meter K. Hyperbaric Oxygen Therapy as an Adjunct to Pre-hospital Advanced Trauma Life Support. Surg Technol Int 2011;21:61-73.
Van Meter KW. The effect of hyperbaric oxygen on severe anemia. Undersea Hyperb Med 2012;39(5):937–942.
HBO dissolves oxygen in red-cell-poor plasma/resuscitation fluids to emergently supply tissue oxygen; and Cost/health-system argument: one HBO treatment is roughly the wholesale cost of a unit of packed red
Van Meter KW. Hyperbaric oxygen clinical application in resuscitation from insult of acute severe anemia. Wound Care Hyperbar Med 2014;5(4):27–32.
Van Meter KW. Hyperbaric oxygen in resuscitation. In: Jain KK, ed. Textbook of Hyperbaric Medicine. 6th ed. Cham: Springer 2017:551–566.
Van Meter KW. Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review. Front Med (Lausanne) 2024;11:1408816.
For short periods, plasma-dissolved oxygen at pressure can meet resting oxygen requirements without red Intermittent HBO averts oxygen toxicity while resupplying ATP for gene expression and reparative/ HBO ameliorates reperfusion injury after ischaemia; complication rate is very low; modern chambers can
Van Meter KW. Severe Anemia. Undersea Hyperb Med 2026;53(1):199-208.
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van de Wetering FT, Verleye L, Andreyev HJN, Maher J, Vlayen J, Pieters BR, van Tienhoven G, Scholten RJPM. Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis. Cochrane Database Syst Rev 2016;(4):CD003455.
Hyperbaric oxygen vs placebo — clinical evaluation healed or improved: RR 1.42 (95% CI 1.14–1.77), favouring HBO (single double-blind RCT, Clarke 2008, HBO at ~2.0–2.4 ATA). The review covered many non-surgical modalities (rectal sucralfate, formalin, short-chain-fatty-acid enemas, argon plasma coagulation, anti-inflammatories, HBO); heterogeneity precluded pooling across modalities and no standard could be recommended.
Vann RD, Butler FK, Mitchell SJ, Moon RE. Decompression illness. Lancet 2011;377(9760):153-64.
van Ooij PJAM, van Hulst RA, Kulik W, Brinkman P, Houtkooper A, Sterk PJ. Hyperbaric oxygen diving affects exhaled molecular profiles in men. Respir Physiol Neurobiol 2014;198:20–24.
van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial. J Urol 2006;176(4 Pt 1):1442-1446.
Varichon A, Pignel R, Boet S. Hyperbaric medicine and climate footprint. Diving Hyperb Med 2024;54(3):252.
Varughese L, O'Neill OJ, Marker J, Smykowski E, Dayya D. The effect of compression rate and slope on the incidence of symptomatic Eustachian tube dysfunction leading to middle ear barotrauma: a Phase I prospective study. Undersea Hyperb Med 2019;46(2):95-100.
Vas P, Rayman G, Dhatariya K, Driver V, Hartemann A, Löndahl M, Piaggesi A, Apelqvist J, Attinger C, Game F. Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review. Diabetes Metab Res Rev 2020;36(S1):e3284.
The graded HBO statement is the finding to cite. "In nonhealing ischaemic ulcers, the use of hyperbaric Major amputation: the earlier RCTs "provided some evidence to suggest that systemic HBOT may reduce the What remains uncertain, in the review's own words: "the type of ulcer that would benefit and the optimal
Vazquez RL, Spahr RC. Hyperbaric oxygen use in neonates: a report of four patients. Am J Dis Child 1990;144(9):1022-1024.
Vceva A, Zubcic Z, Mihalj H, Males J, Mendes T, Sestak A. Pretreatment hearing grades and hearing recovery outcomes after primary hyperbaric oxygen treatment in patients with idiopathic sudden sensorineural hearing loss. Diving Hyperb Med 2022;52(3):191-196.
Venter M. Hyperbaric Oxygen Therapy in Plastic and Reconstructive Surgery. Wound Care and Hyperbaric Medicine 2018:9-10.
Vera-Cruz P, Croca J, Zagalo C. Hyperbaric oxygen improves nasal air flow. Undersea Hyperb Med 2009;36(3):147-54.
Vera-Cruz P, Ferreira M, Zagalo C, dos Santos JM, Aguas AP. Structure of the rat nasal mucosa after acute and chronic hyperbaric oxygen therapy. Undersea Hyperb Med 2010;37(2):125-32.
Vezzani G, Zanon V, Manelli D, Camporesi EM, Bosco G. Report on HyperBaric Oxygen (HBO2) in femoral head necrosis. Expert report to the 10th European Consensus Conference on Hyperbaric Medicine, Lille (European Committee for Hyperbaric Medicine) 2016 (Undated PDF; year from Zotero (2016) and the Lille 2016 conference whose recommendations it carries (Mathieu 2017); not peer-reviewed as a stand-alone paper).
Vilenskii IT. [Hyperbaric oxygenation in the complex treatment of the sequelae of prolonged hypotension caused by acute blood loss]. Eksp Khir Anesteziol 1972;17(5):83-7 (Russian).
Villanueva E, Bennett MH, Wasiak J, Lehm JP. Hyperbaric oxygen therapy for thermal burns. Cochrane Database Syst Rev 2004;(3):CD004727.
One trial: no difference in length of stay, mortality, or number of surgeries once adjusted for The other trial: shorter mean healing time with HBOT (19.7 vs 43.8 days). Poor trial quality precluded confidence in either result.
Villeirs L, Tailly T, Ost P, Waterloos M, Decaestecker K, Fonteyne V, Van Praet C, Lumen N. Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature. Int J Urol 2020;27(2):98–107.
Systematic review of recent literature on HBO for radiation cystitis; overall response 64.8–100% and complete response 20–100% across studies, with high pooled weighted averages. Consistent with a real, clinically useful effect; heterogeneity in response definitions and mostly observational designs limit certainty. ⚠️ Full read 21 Oct 2026 (pages 98–106; Tables 1–4):
Villela A, Weaver LK, Ritesh D. Coronary gas embolism during a dive: a case report. Undersea Hyperb Med 2015;42(6):613-7.
Vincent J, Ross MK, Pollock NW. Effect of hyperbaric oxygen treatment on patients with reduced left ventricular ejection fraction. Diving Hyperb Med 2021;51(3):256-263.
Vingolo EM, Pelaia P, Forte R, Rocco M, Giusti C, Rispoli E. Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa? Doc Ophthalmol 1999;97(1):33–39 (Kluwer).
ERG b-wave amplitude rose in the HBO cases (T0 4.68 ± 3.81 µV → T1 8.46 ± 5.71 → T2 10.7 ± 7.6 → Controls declined (T0 4.92 ± 3.05 µV → T3 2.97 ± 3.61 µV) — a slight but significant decrease Authors' own caution: the study demonstrates an increase in electroretinographic responses only,
Vingolo EM, Rocco M, Grenga PL, Salvatore S, Pelaia P. Slowing the degenerative process, long lasting effect of hyperbaric oxygen therapy in retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 2008;246(1):93–98.
Visual acuity preservation at 5 years: 87.5% of the HBO group retained 80% of initial VA vs a At 10 years: 63.3% (HBO) vs 40% (control) maintained residual VA (χ²=3.22, p=0.05); static ERG b-wave mean values at the end of the protocol were significantly higher in the HBO group
Vinkel J, Lohse N, Hyldegaard O. The clinical use of hyperbaric oxygen in the treatment of Danish patients with diabetic foot ulcers. Dan Med J 2019;66(2):A5528.
Vinkel J, Rib L, Buil A, Hedetoft M, Hyldegaard O. Investigating the Effects of Hyperbaric Oxygen Treatment in Necrotizing Soft Tissue Infection With Transcriptomics and Machine Learning (the HBOmic Study): Protocol for a Prospective Cohort Study With Data Validation. JMIR Res Protoc 2022;11(11):e39252.
Vinkel J, Rib L, Buil A, Hedetoft M, Hyldegaard O. Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study). Eur J Med Res 2023;28(1):507.
Vishwanath G. Hyperbaric oxygen therapy in free flap surgery: is it meaningful? Med J Armed Forces India 2011.
No significant difference in flap survival, time to resolution of venous congestion, resolution ⚠️ No statistical test was done — the author says the numbers are "too small to be subjected to statistical ⚠️ Table 5's averages are wrong: oedema days 3, 0, 0, 1 average 1.0 (printed 2) and 1, 3, 1, 0 average 1.25
Visonà A, Lusiani L, Rusca F, Barbiero D, Ursini F, Pagnan A. Therapeutic, hemodynamic, and metabolic effects of hyperbaric oxygenation in peripheral vascular disease. Angiology 1989;40(11):994-1000.
Voigt A, Laspro M, Thys E, Jethanamest D, Chiu ES. Systematic Review of Otologic Adverse Events in Hyperbaric Oxygen Therapy. Undersea Hyperb Med 2025;52(4):537-547.
Voĭtkevich VI, Volzhskaia AM, Miasnikov AP. [Erythropoietic function of the kidneys under conditions of abnormally high oxygen pressure]. Biull Eksp Biol Med 1975;79(4):44-6 (Russian with English abstract).
Voĭtkevich VI, Volzhskaia AM, Miasnikov AP. [Erythropoietic activity of human blood following exposure to hyperbaric hyperoxygenation]. Biull Eksp Biol Med 1976;82(11):1299-1300 (Russian with English abstract).
Voĭtkevich VI, Miasnikov AP, Shcherba MM. [Effect of hyperoxia on the rate of restoration of blood composition after blood loss]. Biull Eksp Biol Med 1976;82(10):1183-5 (Russian with English abstract).
Voĭtkevich VI, Volzhskaia AM, Korchinskiĭ LA. [Plasma erythropoiesis inhibitors in humans during hyperbaric hyperoxia]. Biull Eksp Biol Med 1979;87(2):122-3 (Russian with English abstract).
Volzhskaia AM, Troshikhin GV, Shumilova TE. [Indices of the oxygen-transport properties of the blood and of erythropoiesis in rats after being in a nitrogen-oxygen environment under elevated pressure]. Fiziol Zh SSSR Im I M Sechenova 1985;71(3):320-3 (Russian with English abstract).
Vomhof-DeKrey EE, Ajayi OD. A randomized placebo-controlled trial of mild hyperbaric oxygen on serum biomarkers in persistent post-concussive symptoms: analysis at 13-week follow-up. Trauma Care 2026;6:9 (DOI 10.3390/traumacare6020009; ClinicalTrials.gov NCT05173818).
Vrijdag XC, van Waart H, Sames C, Sleigh JW, Mitchell SJ. Comparing the EMMA capnograph with sidestream capnography and arterial carbon dioxide pressure at 284 kPa. Diving Hyperb Med 2023;53(4):327-332.
Wackett J, Devaney B, Chau R, Ho J, King N, Grewal J, Armstrong J, Mitra B. Reported outcome measures in necrotising soft tissue infections: a systematic review. Diving Hyperb Med 2024;54(1):47-56 (PMID 38507909. DOI 10.28920/dhm54.1.47-56).
Wada K, Nishi D, Kitamura T, Ono K, Takahara T, Shirotani T, Shimizu A. Hyperbaric oxygenation therapy enhances the protective effect of moderate hypothermia against forebrain ischemia in the gerbil hippocampus. Undersea Hyperb Med 2006;33(6):399–405.
Wadee AN, Aref MHF, Nassar AA, Abo-Bakr I, et al. The influence of low- intensity laser irradiation versus hyperbaric oxygen therapy on transcutaneous oxygen tension in chronic diabetic foot ulcers: a controlled randomized trial. J Diabetes Metab Disord 2021;20(2):1489–1497.
Control group: no significant TcPO₂ change; both LILI and HBOT: significant improvement vs baseline The percentage improvement in TcPO₂ was greater with HBOT than LILI — HBOT favoured on this ⚠️ Full read 21 Oct 2026 (pages 1489–1496; Tables 1–3, Figs 1–2):
Wafi J, Alshurafa A, Yassin MA. Adjunctive Hyperbaric Oxygen Therapy for a Refractory Sickle Cell-Associated Leg Ulcer: A Case Report. Clinical Case Reports 2026;14(9):e73320.
Wahl AM, Bidstrup D, Smidt-Nielsen IG, Werner MU, Hyldegaard O, Rotbøll-Nielsen P. A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial. J Pain Res 2019.
HBOT reduced BI-induced SHA vs control: 18.8 (95% CI 10.5–27.0) cm² vs 32.0 (20.1–43.9) cm² (P=0.021). Order/carryover (long-lasting) effect: in the AC→HBOT sequence a significantly larger SHA appeared in
Walker JM, James NT, Campbell H, Wilson SH, Churchill S, Weaver LK. Sleep assessments for a mild traumatic brain injury trial in a military population. Undersea Hyperb Med 2016;43(5):549-566.
Wang C, Schwaitzberg S, Berliner E, Zarin DA, Lau J. Hyperbaric Oxygen for Treating Wounds: A Systematic Review of the Literature. Arch Surg 2003;138(3):272–279.
57 studies — 7 RCTs, 16 nonrandomised, 34 case series; >2000 patients. HBO may be beneficial for hypoxic/ischaemic wounds, but methodological quality was limited. None used wound-tissue hypoxia as an inclusion criterion — so the reviews could not confirm HBO works specifically in the hypoxic wounds it is mechanistically meant to help; a persisting selection critique. ⚠️ Full read 21 Oct 2026 (pages 272–278; Tables 1–2):
Wang W, Li J, Chang Y, Xie X, Ren J, Wang X, et al. Effects of immune reaction in rats after acute carbon monoxide poisoning. Undersea Hyperb Med 2011;38(4):239-46.
Wang CJ, Wu RW, Yang YJ. Treatment of diabetic foot ulcers: A comparative study of extracorporeal shockwave therapy and hyperbaric oxygen therapy. Diabetes Res Clin Pract 2011;92(2):187–193.
Complete healing: 57% (ESWT) vs 25% (HBOT) (P=0.003). ≥50% improvement 32% vs 15% (P=0.071); unchanged ulcers 11% (ESWT) vs 60% (HBOT) (P<0.001); none Blood-flow perfusion and histology (cell proliferation, less apoptosis) favoured ESWT after treatment.
Wang CJ, Ko JY, Kuo YR, Yang YJ. Molecular changes in diabetic foot ulcers. Diabetes Res Clin Pract 2011;94(1):105–110.
Cohort: 39 patients (44 ulcers) ESWT (6 sessions) vs 38 patients (40 ulcers) HBOT (20 daily sessions); serial biopsies assessed molecular markers of angiogenesis, cell proliferation and apoptosis. Both modalities altered wound-healing molecular activity; the study characterises mechanism rather than comparing clinical healing endpoints. ⚠️ Full read 21 Oct 2026 (all 6 pages): three additions. This is very probably the same coh…
Wang C, Ye Z, Zheng J, Liu K, Sun X, Tao H, et al. Targeting reactive oxygen species by edaravone inhalation in a rat hyperoxic lung injury model: role of inflammasome. Undersea Hyperb Med 2013;40(6):505-11.
Wang YG, Zhan YP, Pan SY, Wang HD, Zhang DX, Gao K, Qi XL, Yu CJ. Hyperbaric oxygen promotes malignant glioma cell growth and inhibits cell apoptosis. Oncol Lett 2015;10(1):189–195.
Wang H, Li Y, Wu Q, Xu C, Liu Q. Combination of butylphthalide with umbilical mesenchymal stem cells for the treatment of delayed encephalopathy after carbon monoxide poisoning. Medicine (Baltimore) 2016;95(49):e5412.
42 DEACMP patients, 3 groups: MSC transplantation + butylphthalide (n=14); MSC alone; or HBOT. MSCs delivered by alternating subarachnoid and carotid-artery injection (self-made high-pressure injector — experimental). MMSE and Barthel index were significantly higher with combined MSC + butylphthalide than with MSC alone or HBOT (all P<0.0001); no significant adverse events. ⚠️ Full read 21 Oct 2026 (all 5 pages): the HBO arm i…
Wang W, Xue L, Li Y, Li R, Xie X, Bao J, Hai C, Li J. RNA sequencing analysis reveals new findings of hyperbaric oxygen treatment on rats with acute carbon monoxide poisoning. Undersea Hyperb Med 2016;43(7):759–770.
Wang W, Cheng J, Zhang J, Wang K. Effect of Hyperbaric Oxygen on Neurologic Sequelae and All-Cause Mortality in Patients with Carbon Monoxide Poisoning: A Meta-Analysis of Randomized Controlled Trials. Med Sci Monit 2019;25:7684–7693.
HBO lowered the risk of memory impairment vs NBO. Two HBO sessions were associated with higher memory-impairment risk than one session. HBO increased neuropsychological scores (block design, trail making); no other significant differences
Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, Zhao L, Yan Q, Deng Y, Wu N, Liao B. Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2. Cell Death Discov 2021;7(1):103.
Wang C, Xue L, Yu Q, Liu Y, Ren Z, Liu Y. Evaluation of a new hyperbaric oxygen ventilator during volume-controlled ventilation. Diving Hyperb Med 2023;53(2):129-137.
Wang Z, Xu H, Wang Z, Zhou H, Zhang L, Wang Y, Li M, Zhou Y. Efficacy and safety of multiple external therapies in patients with insomnia: a systematic review and network meta-analysis. Front Neurol 2024;15:1297767.
Wang C, Yu Q, Liu Y, Ren Z, Liu Y, Xue L. Evaluation of a new hyperbaric oxygen ventilator during pressure-controlled ventilation. Diving Hyperb Med 2024;54(3):212-216.
Wang Y, Yang X, Jiang M, Tang Z, Zhao L. Hyperbaric oxygen therapy for radiation enteritis and clinical parameters: a systematic review and meta-analysis. Front Med (Lausanne) 2025;12(none — Frontiers uses continuous article numbering):1632414.
A PROSPERO-registered (CRD42024618971, p.2) systematic review of HBOT for "radiation enteritis" (RE) after pelvic radiotherapy, searched across four Chinese and five international databases to 27 November 2024 (p.3, §2.4). 22 studies, 1,318 participants: 8 RCTs and 14 non-randomised intervention trials (NRITs); 6 RCTs entered the meta-analysis (p.4, §3.1; Figure 1). The NRITs are summarised narrat
Wang C, Zhang L, Yu Q, Liu Y, Ren Z, Xue L. Characteristic of volume-controlled ventilation with small tide volume in hyperbaric oxygen chamber. Undersea Hyperb Med 2025;52(3):305-312.
Wang H, Zhou H, Nie J, Du S, Ning W, Ding S, Zhang H. Effectiveness of hyperbaric oxygen in traumatic brain injury patients: a systematic review and meta-analysis. Complement Ther Med 2026;101:103417.
Wang X. Mechanism and application of hyperbaric oxygen therapy in neurosurgery. Med Gas Res 2026;16(2):156-160.
Wang H, Ma X, Sun Y, Guo Z, Wang J, Sun M. Hyperbaric oxygen therapy for osteoporosis: a systematic review of preclinical evidence and mechanisms. Bone 2026;205:117772.
Wang Y, Liu Y, Yang J, Peng D, Hua Q, Zhang C, Zhang Y, Wang W, Chen Y. Safety and efficacy of the combination of hyperbaric oxygen and 177Lu-DOTA-IBA in treating metastatic bone pain due to tumors. Sci Rep 2026 (DOI 10.1038/s41598-026-62346-0).
Warchol JM, Cooper JS, Diesing TS. Hyperbaric oxygen-associated seizure leading to stroke. Diving Hyperb Med 2017;47(4):260-262.
Ward AJ, Stubbs B, Dixon B. Carcinoma of the cervix: establishment of a hyperbaric oxygen trial associated with the use of the Cathetron. Br J Radiol 1974;47(558):319–325.
Describes the trial structure and technique; the initial patient response is reported as "encouraging" No definitive survival / local-control result in this paper.
Warner MA, Shore-Lesserson L, Shander A, Patel SY, Perelman SI, Guinn NR. Perioperative Anemia: Prevention, Diagnosis, and Management Throughout the Spectrum of Perioperative Care. Anesth Analg 2020;130(5):1364-1380.
Warren DC, Feehan P, Slade JB, Cianci PE. Chronic radiation proctitis treated with hyperbaric oxygen. Undersea Hyperb Med 1997;24(3):181–184.
Warriner RA 3rd, Hopf HW. The effect of hyperbaric oxygen in the enhancement of healing in selected problem wounds. Undersea Hyperb Med 2012;39(5):923-935 (PMID 23045921).
Watanabe T, Asai K, Fukuhara S, Uozumi R, Bessho K. Effectiveness of surgery and hyperbaric oxygen for antiresorptive agent-related osteonecrosis of the jaw: A subgroup analysis by disease stage. PLoS One 2021;16(1):e0244859.
Watson ER, Halnan KE, Dische S, Saunders MI, Cade IS, McEwen JB, Wiernik G, Perrins DJD, Sutherland I. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 1978;51(611):879–887.
Benefit in both local control and survival with HBO — "a true improvement in the therapeutic ratio." ⚠️ Added 23 Oct 2026 on full read — the survival benefit is a stage III subgroup result, not an all-patient one. Across all 320 patients actuarial 5-year survival was 33% vs 27%, P = 0.08 (Table V, p.882) — "close to a significant level", and in no single centre did it "approach statistical significance". In stage III (119 vs 1…
Weaver LK, Strauss MB (editors). Monoplace Hyperbaric Chamber Safety Guidelines. Report to the Hyperbaric Chamber Safety Committee of the Undersea and Hyperbaric Medical Society. Undersea and Hyperbaric Medical Society 1991:1-68.
Weaver LK, Howe S. Arterial oxygen tension of patients with abnormal lungs treated with hyperbaric oxygen is greater than predicted. Chest 1994;106(4):1134-1139.
Weaver LK, Churchill S. Pulmonary edema associated with hyperbaric oxygen therapy. Chest 2001;120(4):1407-1409.
Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF, Thomas FO, Morris AH. Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning. N Engl J Med 2002;347(14):1057–67.
Cognitive sequelae at 6 weeks: 19/76 (25.0%) HBOT vs 35/76 (46.1%) normobaric, P = 0.007. After adjustment for cerebellar dysfunction and stratification variables: adjusted OR 0.45 (95% CI 12 months: cognitive sequelae remained less frequent with HBOT (intention-to-treat, P = 0.04).
Weaver LK, Churchill SK. Hypoxemia with air breathing periods in U.S. NAVY Treatment Table 6. Undersea Hyperb Med 2006;33(1):11-5.
Weaver LK. Monoplace hyperbaric chamber use of U.S. Navy Table 6: a 20-year experience. Undersea Hyperb Med 2006;33(2):85-8.
Weaver LK, Churchill SK, Bell J, Deru K, Snow GL. A blinded trial to investigate whether 'pressure-familiar' individuals can determine chamber pressure. Undersea Hyperb Med 2012;39(4):801-5.
Weaver LK, Dicks C, Deru K, Miller RS. Regulatory considerations for a traumatic brain injury (TBI) indication for hyperbaric oxygen (HBO2). Undersea Hyperb Med 2013;40(5):439-41.
Weaver LK, Cifu D, Hart B, Wolf G, Miller RS. Reply: Department of Defense trials for hyperbaric oxygen and TBI: issues of study design and questionable conclusions. Undersea Hyperb Med 2013;40(5):471-2.
Weaver LK. Hyperbaric oxygen therapy for carbon monoxide poisoning. Undersea Hyperb Med 2014;41(4):339-354.
Weaver LK. Hyperbaric oxygen treatment for the critically ill patient. Diving Hyperb Med 2015;45(1):1.
Weaver LK, Chhoeu A, Lindblad AS, Churchill S, Wilson SH. Hyperbaric oxygen for mild traumatic brain injury: Design and baseline summary. Undersea Hyperb Med 2016;43(5):491-509.
Weaver LK, Chhoeu A, Lindblad AS, Churchill S, Deru K, Wilson SH. Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study. Undersea Hyperb Med 2016;43(5):485-489.
Weaver LK, Deru K, Churchill S, Legler J, Snow G, Grey T. Carbon monoxide poisoning in Utah: 1996-2013. Undersea Hyperb Med 2016;43(7):747-758.
Weaver LK, Deru K. Ischemic colitis associated with acute carbon monoxide poisoning--a case report. Undersea Hyperb Med 2016;43(2):175-80.
Weaver LK, Deru K. Carboxyhemoglobin half-life during hyperbaric oxygen in a patient with lung dysfunction: a case report. Undersea Hyperb Med 2017;44(2):173-177.
Weaver LK, Lindblad AS, Wilson SH, Churchill S, Deru K. TBI study questioned: Dr. Weaver response. Undersea Hyperb Med 2017;44(1):82-85.
Weaver LK, Wilson SH, Lindblad AS, Churchill S, Deru K, Price RC, et al. Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial. Undersea Hyperb Med 2018;45(2):129-156.
Weaver LK, Churchill S, Wilson SH, Hebert D, Deru K, Lindblad AS. A composite outcome for mild traumatic brain injury in trials of hyperbaric oxygen. Undersea Hyperb Med 2019;46(3):341-352.
Weaver LK, Oliver LC, Deru K, Stemmer-Rachamimov AO. Myositis associated with carbon monoxide poisoning. Undersea Hyperb Med 2019;46(1):63-67.
Weaver LK. Carbon monoxide poisoning. Undersea Hyperb Med 2020;47(1):151-169.
Weaver LK, Deru K, Foley J. Gunshot damage to monoplace hyperbaric chamber acrylic. Undersea Hyperb Med 2020;47(2):229-234.
Weaver LK, Deru K, Fletcher B, Daniel SD. Three cases of clinically significant inaccurate carboxyhemoglobin measurement. Undersea Hyperb Med 2022;49(2):171-177.
Weaver LK, Deru K. Vein discoloration after administration of hydroxocobalamin. Undersea Hyperb Med 2022;49(2):249-249.
Weaver LK, Deru K, Churchill S, Russo A. A randomized trial of one versus three hyperbaric oxygen sessions for acute carbon monoxide poisoning. Undersea Hyperb Med 2023;50(3):325–342.
No difference in the rate of neuropsychological sequelae between three HBO sessions and one HBO Overall sequelae rates were higher than in the 2002 trial, attributed by the authors to differences in ⚠️ Full read 21 Oct 2026 (all 18 pages, CONSORT diagram and tables): the record left out how the trial ended, and that changes its certainty.
Weaver LK. Carbon monoxide poisoning (reprinted from the 2023 Hyperbaric Indications Manual, 15th edition). Undersea Hyperb Med 2024;51(3):253-276.
Weaver LK, Ziemnik R, Deru K, Russo AA. A double-blind randomized trial of hyperbaric oxygen for persistent symptoms after brain injury. Sci Rep 2025;15(1):6885.
NSI at 13 weeks improved with HBO₂ vs sham — mean difference 7.0 (95% CI 1.7–12.3, p=0.01). HBO₂ group also improved on olfaction, anxiety, sleep difficulties, and vestibular complaints; both
Weber SU, Koch A, Siekmann U, Neitzel C, Stüber F, Hoeft A, et al. A single exposure to hyperbaric oxygen increases levels of circulating nucleosomes but does not induce mononuclear cell apoptosis in divers. Undersea Hyperb Med 2009;36(2):117-25.
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A narrative review from Xuanwu Hospital and Nantong University. It covers the mechanisms (angiogenesis, neurogenesis, BDNF/CREB, NF-κB suppression, SIRT1 and mitochondria; Table 1) and the clinical evidence in Alzheimer's disease, stroke, TBI and other conditions (Table 2, with self-assigned evidence levels I–IV). It proposes a "safety window" of 2.0–2.5 ATA, 60–90 min, 30–40 sessions (p 3197). No
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Five patients, symptom duration one to 12 days, each treated with six to 10 hyperbaric oxygen sessions, one hour at 1.5 ATA each (Table 1: 6, 6, 10, 6, 8 sessions). ⚠️ Corrected 31 Aug 2026: this previously read "each treated with hyperbaric oxygen for one hour at 1.5 ATA", which elided the course into a single session — the paper says "each patient underwent six to 10 treatments with 100% oxygen
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Wetzel PA, Lindblad AS, Mulatya C, Kannan MA, Villmar Z, Gitchel GT, et al. Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms. Undersea Hyperb Med 2019;46(3):299-311.
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Whalen RE, Moore GF, Mauney FM, et al. Hemodynamic responses to 'life without blood' In: Brown IW, Cox BG, eds. Proceedings of the Third International Conference on Hyperbaric Medicine. Washington DC: NAS–NRC 1966:402–408.
Whalen RE, Heyman A, Saltzman H. The protective effect of hyperbaric oxygenation in cerebral anoxia. Arch Neurol 1966;14(1):15-20.
Smart H, et al. Multidisciplinary approach in hyperbaric oxygen therapy: application of the WHASA wheel on the diabetic foot. Wound Healing Southern Africa 2008;1(2):42-44.
Whelan HT, Kindwall EP, editors. Hyperbaric Medicine Practice. 4th ed. North Palm Beach (FL): Best Publishing Company 2017:1825 pp (PDF).
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Wideröe R. A critical review of radiation therapy using hyperbaric oxygen treatment. Fortschr Geb Rontgenstr Nuklearmed 1969;110(5):738-744.
Wilcox JW, Kolodny SC. Acceleration of healing of maxillary and mandibular osteotomies by use of hyperbaric oxygen: a preliminary report. Oral Surg Oral Med Oral Pathol 1976;41(4):423-429.
Wiles CM, Clarke CR, Irwin HP, Edgar EF, Swan AV. Hyperbaric oxygen in multiple sclerosis: a double blind trial. Br Med J (Clin Res Ed) 1986;292(6517):367-71.
Wilkinson D, Doolette D. Hyperbaric oxygen treatment and survival from necrotizing soft tissue infection. Arch Surg 2004;139(12):1339–1345.
44 patients, 6 deaths (14%). Survival was less likely with increased age, renal dysfunction, idiopathic aetiology, and NOT receiving For extremity NSTI, HBO₂ significantly reduced amputation (P=0.05).
Wilkinson D, Chapman IM, Heilbronn LK. Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans. Diabet Med 2012;29(8):986-989.
Wilkinson D, Nolting M, Mahadi MK, Chapman I, Heilbronn L. Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes. Diving Hyperb Med 2015;45(1):30-6.
Wilkinson DC, Chapman IM, Heilbronn LK. Hyperbaric oxygen but not hyperbaric air increases insulin sensitivity in men with type 2 diabetes mellitus. Diving Hyperb Med 2020;50(4):386-390.
Wilkinson D, Szekely S, Gue B, Tam CS, Chapman I, Heilbronn LK. Assessment of insulin sensitivity during hyperbaric oxygen treatment. Diving Hyperb Med 2020;50(3):238-243.
Williams BT, Roding B, Winters PM, Schenk WG Jr. Hyperbaric oxygenation: influence on coronary blood flow and oxygen delivery to the myocardium. Arch Surg 1969;99(6):758-763.
Williams RL. Hyperbaric oxygen therapy and the diabetic foot. J Am Podiatr Med Assoc 1997;87(6):279-292.
Williams R, Feste M, Pontani B. Hyperbaric oxygen therapy used to treat intractable anemia due to radiation induced esophagitis and gastritis [abstract]. Undersea Hyperb Med 2007;34(4):304–305 (Abstracts from the UHMS ASM 2007).
Williams CS, Spitz MC, Foley JF, Weaver LK, Lindblad AS, Wierzbicki MR. Baseline EEG abnormalities in mild traumatic brain injury from the BIMA study. Undersea Hyperb Med 2016;43(5):521-530.
Williams CS, Weaver LK, Lindblad AS, Kumar S, Langford DR. Baseline neurological evaluations in a hyperbaric trial of post-concussive syndrome. Undersea Hyperb Med 2016;43(5):511-519.
Williamson J, Sharma A, Murray-Douglass A, et al. Outcomes of hyperbaric oxygen treatment for central and branch retinal artery occlusion at a major Australian referral hospital. Diving Hyperb Med 2023;53(3):224–229.
Central RAO: 71% (12/17) improved (objective BCVA in 8/17 = 47%, plus subjective in 4 more); mean Branch RAO: no improvement in any of the 5 patients (numbers small). Limited side effects; no irreversible adverse events.
Willy C, Rieger H, Vogt D. [Hyperbaric oxygen therapy for necrotizing soft tissue infections: contra]. Chirurg 2012;83(11):960–972 (PMID 23138865. DOI 10.1007/s00104-012-2284-z. Published in German with an English abstract.).
The search returned 250 hits after removal of duplicates. Those 250 peer-reviewed articles Half of the 250 reports are case series or case reports (OCEBM level 4 and 5; n=125). About 33% Only ten of the 250 articles report a retrospective HBOT versus non-HBOT group comparison, all
Wilmshurst PT, Edge CJ. Recurrent cutaneous decompression sickness in a hyperbaric chamber attendant with a large persistent foramen ovale. Diving Hyperb Med 2024;54(4):354-359 (DOI 10.28920/dhm54.4.354-359).
Wilmshurst P, Griffiths T, Stokes N, Heatlie G. Cutaneous decompression sickness after an air dive with oxygen breathed during decompression in a commercial diver with a persistent foramen ovale. Diving and Hyperbaric Medicine 2025;55(4):427-429.
Wilson JR, Foresman BH, Gamber RG, Wright T. Hyperbaric oxygen in the treatment of migraine with aura. Headache 1998;38(2):112-5.
Wilson HD, Wilson JR, Fuchs PN. Hyperbaric oxygen treatment decreases inflammation and mechanical hypersensitivity in an animal model of inflammatory pain. Brain Res 2006;1098(1):126-128.
Wilson CM, Sayer MDJ, Murchison AG. Transient prosopagnosia resulting from a cerebral gas embolism while diving. Diving Hyperb Med 2007;37(3):139-142.
Wilson CM, Sayer MDj. Two case reports of epileptic seizures related to probable cerebral arterial gas embolism. Diving Hyperb Med 2008;38(1):43-6.
Wilson CM, Ross JA, Sayer MDj. Saturation treatment in shore-based chambers for divers with deteriorating cerebro-spinal decompression sickness. Diving Hyperb Med 2009;39(3):170-4.
Wilson CM, Sayer MD. Transportation of divers with decompression illness on the west coast of Scotland. Diving Hyperb Med 2011;41(2):64-9.
Wilson CM, Sayer MD. Cerebral arterial gas embolism in a professional diver with a persistent foramen ovale. Diving Hyperb Med 2015;45(2):124-126.
Wilson SH, Weaver LK, Lindblad AS. Neuropsychological assessments in a hyperbaric trial of post-concussive symptoms. Undersea Hyperb Med 2016;43(5):585-599.
Wilson SH, Roth M, Lindblad AS, Weaver LK. Review of recent non-hyperbaric oxygen interventions for mild traumatic brain injury. Undersea Hyperb Med 2016;43(5):615-627.
Winn A, Billingsley M, Pullis M, Popa D, Logue C. Predictive modeling of the performance of the Zoll Z Vent® under hyperbaric conditions. Undersea Hyperb Med 2025;52(2):65-72.
Winstead-Derlega C, Allen JD. Hyperbaric oxygen for the treatment of severe subcutaneous and mediastinal emphysema after Renuvion/J-Plasma therapy®. Undersea Hyperb Med 2022;49(1):77-82.
Wiseman DH, Grossman AR. Hyperbaric oxygen in the treatment of burns. Crit Care Clin 1985;1(1):129-145.
A narrative review of burn pathogenesis and the possible roles of HBO, drawing on the authors' observational experience using HBO routinely for burns since 1972, plus animal and small human studies.
Ríos-Gómez M, Gómez-Ortega V, Cardona C, De La Hoz-Valle JA. WITHDRAWN — DO NOT CITE. Hyperbaric Oxygen Therapy in Plastic, Aesthetic, and Reconstructive Surgery: Systematic Review. 2023:43-52 (record withdrawn 2026-08-04; the paper itself has never been obtained or read, and no appraisal of it stands).
Witte J, Kähler W, Wunderlich T, Radermacher P, Wohlrab C, Koch A. Dose-time dependency of hyperbaric hyperoxia-induced DNA strand breaks in human immune cells visualized with the comet assay. Undersea Hyperb Med 2014;41(3):171-81.
Witucki P, Duchnick J, Neuman T, Grover I. Incidence of DCS and oxygen toxicity in chamber attendants: a 28-year experience. Undersea Hyperb Med 2013;40(4):345-350.
Wolf SJ, Lavonas EJ, Sloan EP, Jagoda AS, American College of Emergency Physicians. Clinical policy: Critical issues in the management of adult patients presenting to the emergency department with acute carbon monoxide poisoning. Ann Emerg Med 2008;51(2):138-52.
Wolf EG, Prye J, Michaelson R, Brower G, Profenna L, Boneta O. Hyperbaric side effects in a traumatic brain injury randomized clinical trial. Undersea Hyperb Med 2012;39(6):1075–1082.
No major adverse events — no pulmonary barotrauma, pulmonary oedema or seizure. Side effects were infrequent and mild; HBO at 2.4 atm abs was well tolerated.
Wolf G, Cifu D, Baugh L, Carne W, Profenna L. The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury. J Neurotrauma 2012;29(17):2606-2612.
Wölfel C, Schüpfer G, Konrad C, Knessl P, Wendling J. Telemedicine in the management of diving accidents: correlation of phone-assessed symptom severity with clinical findings. Diving Hyperb Med 2011;41(4):189-94.
Wolfers DL, Bennett MH. Performance of mainstream capnography under hyperbaric (243 kPa) oxygen conditions. Diving Hyperb Med 2006;36(4):174-178.
Wondmeneh TG, Ebrahim OA. Systematic review and meta-analysis of diabetic foot ulcers and associated factors among adults in Ethiopia. Arch Public Health 2025;83(1):309.
Wong RM. Decompression sickness in breath-hold diving. Diving Hyperb Med 2006;36(3):139-144.
Wong R. Decompression sickness following breath-hold diving. Diving Hyperb Med 2006;36(4):231-232.
Wong ZKR, Teo CKA, Kwek JWM, Kim SJ, See HG. Hyperbaric oxygen for the treatment of carbon monoxide-induced delayed neurological sequelae: a case report and review of the literature. Diving Hyperb Med 2024;54(1):65-68 (PMID 38507912. DOI 10.28920/dhm54.1.65-68).
Woo J, Min JH, Lee YH, Roh HT. Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study. Int J Environ Res Public Health 2020;17(20):7377.
Wood J, Stell R, Unsworth I, Lance JW, Skuse N. A double-blind trial of hyperbaric oxygen in the treatment of multiple sclerosis. Med J Aust 1985;143(6):238-40.
Wood FNR, Bowen K, Hartley R, Stevenson J, Warner M, Watts D. Dive medicine capability at Rothera Research Station (British Antarctic Survey), Adelaide Island, Antarctica. Diving Hyperb Med 2024;54(4):320-327.
Wood D, Bennett M. Pre-emptive treatment with hyperbaric oxygen following radiation therapy for head and neck cancer may prevent the onset of late radiation tissue injury (Critical Appraisal). Diving Hyperb Med 2016;46(2):124.
Workman T. Hyperbaric oxygen therapy: a high-risk procedure? An update II. Undersea Hyperb Med 2006;33(6):473.
Workman WT. Hyperbaric oxygen therapy: a high-risk procedure? An update. Undersea Hyperb Med 2006;33(4):310-1.
Workman WT, Calcote RD. Hyperbaric oxygen therapy and combat casualty care: a viable potential. Mil Med 1989;154(3):111-115.
Worth ER, Carver JA. Age-related macular degeneration and hyperbaric oxygen. Undersea Hyperb Med 2010;37(5):375; author reply 376-8.
Wreford-Brown CE, Hampson NB. Hyperbaric oxygen treatment protocols for mandibular osteoradionecrosis. Undersea Hyperb Med 2003;30(3):175–179.
Wright SE, Jenkinson SG. Clinical use of hyperbaric oxygen. Clinical Pulmonary Medicine 1994;1(4):237-249.
Wright JK, Ehler W, McGlasson DL, Thompson W. Facilitation of recovery from acute blood loss with hyperbaric oxygen. Arch Surg 2002;137(7):850-3.
A controlled laboratory experiment from the Davis Hyperbaric Laboratory, US Air Force School of Aerospace Medicine. The stated hypothesis is that hyperbaric oxygen up-regulates haemoglobin synthesis after acute blood loss in an animal model of moderate (30%) blood loss — that is, the question is whether hyperbaric oxygen might spare transfusion at blood losses far below the life-threatening levels
Wright JK, Zant E, Groom K, Schlegel RE, Gilliland K. Case report: Treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb Med 2009;36(6):391-399.
Wright KT, Praske SP, Bhatt NA, Magalhaes RM, Quast TM. Treatment of cardiac arrest in the hyperbaric environment: key steps on the sequence of care--case reports. Undersea Hyperb Med 2016;43(1):71-8.
Wright B, Guilliod R, Thakur B, Kundig C, Morales J, Tessler J, et al. Hyperbaric oxygen therapy versus placebo for post-concussion syndrome (HOT-POCS): a randomized, double-blinded controlled pilot study. Contemp Clin Trials Commun 2023;34:101176 (TRIAL PROTOCOL, not a results paper; ClinicalTrials.gov NCT05643482. PMID 37416626; DOI 10.1016/j.conctc.2023.101176).
Wu Z, Cai J, Chen J, Huang L, Wu W, Luo F, Wu C, Liao L, Tan J. Autologous bone marrow mononuclear cell infusion and hyperbaric oxygen therapy in type 2 diabetes mellitus: an open-label, randomized controlled clinical trial. Cytotherapy 2014;16(2):258-65.
Wu Q. Hyperbaric oxygen for treatment of diabetic foot ulcers: love you more than I can say. Ann Transl Med 2018;6(11):228.
Wu X, Chen S, Li S, Zhang J, Luan D, Zhao S, Chu Z, Xu Y. Oxygen therapy in patients with retinal artery occlusion: A meta-analysis. PLoS One 2018;13(8):e0202154.
Meta-analysis comparing best-corrected visual acuity in oxygen-therapy vs non-oxygen-therapy RAO patients. Oxygen therapy improved VA, with the benefit greatest for 100% hyperbaric oxygen and treatment durations >9 hours. ⚠️ Full read 21 Oct 2026 (all 11 pages): the "100% oxygen" and "hyperbaric oxygen" subgroup findings are the same single-study contrast. In Table 1, six of the seven studies used 100% oxygen at 2.0–2.8 ATA. T…
Wu S, Wei Y, Yu X, Peng Y, He P, Xu H, Qian C, Chen G. Retrospective analysis of brain abscess in 183 patients: A 10-year survey. Medicine (Baltimore) 2019;98(46):e17670.
Wu P, Tang KB, Yan WW. Periorbital emphysema after a dry hyperbaric chamber exposure. Diving Hyperb Med 2025;55(3):280-283 (DOI 10.28920/dhm55.3.280-283).
Wu Z, Yang X, Li C, Lai H, Liu Y, Zhang C, et al. Evaluation of the Effect of Hyperbaric Oxygen Preconditioning in Spinal Cord Injury Rats Using Diffusion Tensor Imaging. Undersea Hyperb Med 2026;53(3):455-466.
Wukich DK, Armstrong DG, Attinger CE, Boulton AJM, Burns PR, Frykberg RG, Hellman R, Kim PJ, Lipsky BA, Pile JC, Pinzur MS, Siminerio L. Inpatient management of diabetic foot disorders: a clinical guide. Diabetes Care 2013;36(9):2862-2871.
Wunderlich T, Frey N, Kähler W, Lutz M, Radermacher P, Klapa S, et al. Influence of hyperoxia on diastolic myocardial and arterial endothelial function. Undersea Hyperb Med 2017;44(6):521-533.
Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, Liang F, Pang J, Yu L. Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning. Drug Des Devel Ther 2017;11:513–519.
At 4 weeks, the dexamethasone + HBO group had a significantly higher remission rate (P=0.032), CSF MBP was significantly lower with added dexamethasone (P<0.0001), consistent with reduced ⚠️ Full read 21 Oct 2026 (all PDF pages): the remission result is borderline, and the blinding claim has no placebo behind it.
Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, Pang J. Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning. Med Sci Monit 2017;23:1501–1506.
Total remission rate 47.9% (NBP + HBO) vs 33.3% (HBO alone) — significantly higher with added NBP. Significantly more experimental-group patients reached MMSE 24–30, and NIHSS was lower
Xiang Y, Peng Z, Fu B, Qian Y, Ma T, Gao B, Zhu H. Effects of Hyperbaric Oxygen Combined with Lycopene on Oxidative Stress and Inflammation in Collegiate Badminton Players After High-Intensity Training. Nutrients 2026;18(17):2861.
Xiao XM, Ye ZH, Long Y, Chen SL. The effects of hyperbaric oxygen treatment on lipid peroxidation of pregnant rabbits and their fetus during late pregnancy. Undersea Hyperb Med 2006;33(4):299-303.
Xiao Y, Wang J, Jiang S, Luo H. Hyperbaric oxygen therapy for vascular dementia. Cochrane Database Syst Rev 2012;2012(7):CD009425.
Xiao X, Jing X, Zhao Y, Yao F, Sun Q. Stroke on ECG: a cerebral T-wave change secondary to acute carbon monoxide poisoning. Undersea Hyperb Med 2024;51(3):237-240.
Xie R, Zhong A, Wu J, Cen Y, Chen J. Could hyperbaric oxygen be an effective therapy option for pathological scars? A systematic review and meta-analysis. J Plast Surg Hand Surg 2023;57(1–6):330–335.
Only 4 comparative studies (1 RCT, 1 controlled clinical trial, 2 retrospective cohorts). HBO reduced scar recurrence after surgery/radiotherapy — OR 0.26 (95% CI 0.13–0.52, p=0.0001), with higher
Xie S, Hong W, Huang L, Hong Y. Impact of hyperbaric oxygen as initial treatment on idiopathic sudden sensorineural hearing loss prognosis: a propensity scores matching analysis. Braz J Otorhinolaryngol 2026;92:101775.
Xie Y, Li Y, Li Y, Chen S, Song G, Wang H. Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges. Front Cell Neurosci 2026;20:1941147.
Xing Y, Chen F, Liu G, Bao S, Zhang X, Guo Z, Shou Z, Guo J. Application of medical gases in prevention and treatment of electromagnetic radiation injury. Medical Gas Research 2027;17(1):251–260.
A narrative review proposing a "gas-centric, origin-based framework" for radioprotection, covering five agents: molecular hydrogen (H₂), hydrogen sulfide (H₂S), carbon monoxide (CO), nitric oxide (NO) and hyperbaric oxygen (HBO). The authors distinguish endogenous gasotransmitters (CO, NO, H₂S), which modulate existing signalling networks, from exogenous interventions (H₂ and HBO), which act by di
Xiong L. Hyperbaric oxygen: a new adjunctive therapy for surgical-related complications in irradiated advanced cancer patients. Undersea Hyperb Med 2011;38(3):157–158.
Xiong L. Recent focus of hyperbaric oxygen therapy study: an editorial perspective. Undersea Hyperb Med 2012;39(6):1051-2.
Xu Q, Fan SB, Wan YL, Liu XL, Wang L. The potential long-term neurological improvement of early hyperbaric oxygen therapy on hemorrhagic stroke in the diabetics. Diabetes Res Clin Pract 2018;138:75-80.
Xu XM, Luo H, Rong BB, Zheng XM, Wang FT, Zhang SJ, Li ZX. Management of delayed encephalopathy after CO poisoning: An evidence-based narrative review. Medicine (Baltimore) 2019;98(49):e18199.
Surveys the candidate therapies — hyperbaric oxygen, corticosteroids, N-butylphthalide, edaravone, Frames HBO as part of the standard DEACMP management background rather than a proven cure — consistent ⚠️ Full read 21 Oct 2026 (all PDF pages): the review is narrower than the Key points suggest. It includes only 4 RCTs. These are the dexamethasone + HBO and N-butylphthalide + HBO trials (evidence/xiang-2017-deacmp, evidence/xia…
Xu Y, Wang Q, Qu Z, Yang J, Zhang X, Zhao Y. Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Patients with Vascular Dementia. Cell Transplant 2019;28(8):1071-1075.
Xu Y, Huang C. Hyperbaric oxygen therapy for necrotizing fasciitis: a narrative review of mechanisms, clinical evidence, controversies, and practical considerations. Front Cell Infect Microbiol 2026;16:1842036 (Volume 16 and article number 1842036 are printed in the PDF's own citation block. Frontiers journals paginate by article number, so there is no page RANGE to record. Received 29 March 2026; revised 7 June 2026; accepted 15 June 2026; published 17 July 2026 — all four dates printed on page 1.).
Xue L, Wang WL, Li Y, Gong X, Bao JX, Zhang HJ, Xie XP, Chang YM, Li JS. Effects of hyperbaric oxygen on hippocampal neuronal apoptosis in rats with acute carbon monoxide poisoning. Undersea Hyperb Med 2017;44(2):121-131.
Yacono D, Allen MW. Hyperbaric oxygen therapy (HBO2) as an adjunct in the treatment of idiopathic sudden sensorineural hearing loss (ISSHL): a case report on two patients. Undersea Hyperb Med 2014;41(5):401–405.
Yagishita K, Jinno T, Koga D, Kato T, Enomoto M, Kato T, et al. Transient osteoporosis of the hip treated with hyperbaric oxygen therapy: a case series. Undersea Hyperb Med 2016;43(7):847-854.
Yagishita K, Enomoto M, Takazawa Y, Fukuda J, Koga H. Effects of hyperbaric oxygen therapy on recovery acceleration in Japanese professional or semi-professional rugby players with grade 2 medial collateral ligament injury of the knee: A comparative non-randomized study. Undersea Hyperb Med 2019;46(5):647-654.
Yakovlev VN, Savilov PN. Oxygen regime and exchange of ammonia in the sensomotor cortex of cats during blood loss and hyperbaric oxygenation. General Reanimatology 2020;16(2):64–76.
Yalcin M, Yiğiner O, Eroğlu M, Sehirli O, Berber U, Ozçelik F, et al. Effect of hyperbaric oxygen treatment in a rat model of abdominal aortic aneurysm. Undersea Hyperb Med 2014;41(1):9-15.
Yamada N, Toyoda I, Doi T, Kumada K, Kato H, Yoshida S, Shirai K, Kanda N, Ogura S. Hyperbaric oxygenation therapy for crush injuries reduces the risk of complications: research report. Undersea Hyperb Med 2014;41(4):283–289.
Yamada N, Toyoda I, Ogura S. Hyperbaric Oxygen Therapy in the Management of Severe Soft Tissue Injuries. 2020:81–103.
A textbook chapter, and it must be cited as one. Written by the hyperbaric and critical-care team at Gifu University Hospital, it sets out normal wound-healing physiology, the role of oxygen and reactive oxygen species in it, the pathophysiology of crush injury, the mechanisms by which hyperbaric oxygen is held to act, and then the clinical literature — nine studies collected in Table 6.2. It has
Yamamoto N, Oyaizu T, Yagishita K, Enomoto M, Horie M, Okawa A. Multiple and early hyperbaric oxygen treatments enhance muscle healing after muscle contusion injury: a pilot study. Undersea Hyperb Med 2021;48(3):227-238.
Yamamoto N, Takada R, Maeda T, Yoshii T, Okawa A, Yagishita K. Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment. Diving Hyperb Med 2021;51(4):338-344.
Yamashita M, Yamashita M. Hyperbaric oxygen treatment attenuates cytokine induction after massive hemorrhage. Am J Physiol Endocrinol Metab 2000;278(5):E811-6.
Yamashita M, Taniyama M, Tamai M. Cellular localization of tumor necrosis factor-alpha mRNA and interleukin-6 mRNA in the rat liver after hemorrhagic shock. Surg Today 2002;32(8):701-6.
Yan L, Liang T, Cheng O. Hyperbaric oxygen therapy in China. Med Gas Res 2015;5:3.
Yanagawa Y, Omori K, Takeuchi I, Jitsuiki K, Ohsaka H, Ishikawa K. The on-site differential diagnosis of decompression sickness from endogenous cerebral ischaemia in an elderly Ama diver using ultrasound. Diving and Hyperbaric Medicine 2018;48(4):262-263.
Yanagawa Y, Ohsaka H, Yatsu S, Suwa S. Acute aortic dissection during scuba diving. Undersea Hyperb Med 2024;51(2):185-187.
Yanagawa Y. Emergency use of monoplace hyperbaric chamber to treat two patients simultaneously. J Rural Med 2026;21(4):505-508.
Yanagida K, Watanabe D, Yoshida T, Nakagawa T, Mizushima A, Miura K, et al. Successful management of renal abscess secondary to diabetes mellitus with surgical treatment and hyperbaric oxygen therapy. Undersea Hyperb Med 2024;51(3):231-235 (DOI 10.22462/614).
Yang YJ, Wang XL, Yu XH, Wang X, Xie M, Liu CT. Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats. Undersea Hyperb Med 2008;35(2):113–129.
Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H, Zhan S. Interventions for treating gas gangrene. Cochrane Database Syst Rev 2015;(12):CD010577.
Only two RCTs met inclusion (90 participants total). Trial 1: standard treatment + Chinese herbs (n=26) vs standard alone (n=20) — RR 3.08 (95% CI Trial 2: standard + topical HBOT (n=21) vs standard + systemic HBOT (n=23) — RR 1.10
Yang TK, Wang YJ, Li HJ, Yu YF, Huang KW, Cheng JCH. Efficacy and Safety of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis: A Systematic Review and Meta-Analysis. J Clin Med 2024;13(16):4724.
14 studies, 556 patients. Symptom improvement in 500/556 (89.9%). Pooled complete remission of haematuria: 55% (95% CI 51–59%; random-effects).
Yang J, Ning P, Huang J, Ouyang H, Zhang J, Yang F, Cao H, Zhang F. Comparative efficacy of gas therapy for diabetic foot ulcers using network meta-analysis. PeerJ 2025;13:e19571.
34 RCTs, 2,268 DFUs, comparing gas therapies (HBOT, topical/continuous oxygen, ozone, NO, CO2, cold atmospheric plasma, standard care). HBOT ranked SECOND for healing rate (SUCRA = 0.814), behind CO2 therapy (SUCRA 0.998, a single RCT the authors discount); it beat SOC for healing rate (MD −2.71, 95% CI −4.85 to −1.34) and for area reduction (MD 0.39, 95% CI 0.11–0.67). ⚠️ HBOT also carried the second-highest amputation rankin…
Yang B, Liu J, Ding L, Li M, Fu X, Li Z, et al. Hyperbaric Oxygen Treatment Attenuates Renal Ischemia/Reperfusion Injury in Rats. Undersea Hyperb Med 2026;53(2):279-290.
Yang WZ, Yang M, Yang T, Wang Z, Lin W, Pan SY, et al. Recovery Patterns During Extended Hyperbaric Oxygen Treatment Combined With Steroids in Severe Sudden Sensorineural Hearing Loss: A Multi-Center Study. Undersea Hyperb Med 2026;53(2):261-270.
Yang IF, Yin CY, Chang KH, Xiao FY, Yang FC. Ventral Cervical Epidural Abscess Presenting as a Stroke Mimic With Paradoxical Thoracic Sensory Level: Diagnostic Challenges and Multimodal Management. Am J Case Rep 2026;27:e952372.
Yang L, Kong J, Xing Y, Pan L, Li C, Wu Z, Li M, Zhang L. Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy for hard-to-heal wounds: a systematic review and meta-analysis. J Wound Care 2024;33(12):950–957.
15 studies (9 RCTs + 6 retrospective). HBO+NPWT superior on: wound healing rate OR 6.77 (95% CI Authors conclude HBO+NPWT is safe and effective but findings should be interpreted with great caution given
Yarnold JR et al. Double-blind randomised phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2005;77(3):327 — Letter to the Editor.
McGill Pain Questionnaire: no evidence of difference between the randomised groups. MOS SF-36: no evidence of a treatment effect missed in the main analysis. The authors judged it unlikely a treatment effect had been missed; no further neurophysiological
Yasuhara H, Naito H, et al. Emphysematous cystitis successfully treated with hyperbaric oxygen therapy: case report. Undersea Hyperb Med 2018;45(6):701-703.
Ye ZH, Zheng J, Liu K, Xj Sun XJ, Liu WW. Prolongation of latency is not enough in prevention of central nervous system oxygen toxicity. Undersea Hyperb Med 2013;40(5):473-4.
Yeh HT, Lee CH. Hyperbaric oxygen therapy research: an analysis of the 100 most-cited publications from 2011 to 2020. Undersea Hyperb Med 2022;49(4):519-532.
Yi H, Yu S, Zhang Y, Li R, Zhang D, Xu W. Preventive effects of ketone ester BD-AcAc2 on central nervous system oxygen toxicity and concomitant acute lung injury. Diving Hyperb Med 2018;48(4):235-240.
Yigider AP, Ovunc O, Arslan E, Sunter AV, Cermik TF, Yigit O. Malignant Otitis Externa: How to Monitor the Disease in Outcome Estimation? Medeni Med J 2021;36:23–9.
The HBOT result is null and stated as such in the abstract: "Duration of symptoms before the "There were no significant relationships between the outcome measures with HBOT status and the duration "Neither the duration between the first symptom and the initiation of the treatment nor addition of
Yildiz H, Senol L, Ercan E, Bilgili ME, Karabudak Abuaf O (Turkey). A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa. Int J Dermatol 2016;55(2):232–237 (epub 2015; verified vs PubMed 2026-07-27).
At week 10, more HBOT patients achieved a ≥50% decrease from baseline — SS in 100% and HSSI in Significant improvements from baseline in HSSI at weeks 4 and 10 with HBOT; adjunctive HBOT judged
Yilmaz HB, Erdogan RB, Paksoy M, Sanli A. Sudden hearing loss and vertigo after tooth extraction successfully treated with combined therapy including HBO2: a case report. Undersea Hyperb Med 2015;42(6):603–606.
Yilmaz M, Cakmak T, Yenilmez A, Baseskioglu B, Metin S. Effects of hyperbaric oxygen therapy on hydrochloric acid-induced interstitial cystitis in rats: a histological and ultrastructural study. Undersea Hyperb Med 2016;43(3):181-8.
Yin Y, Zeng W, Jing W, Tang W, Guo W. 高压氧治疗放射性颌骨骨坏死效果的系统评价. Hua Xi Kou Qiang Yi Xue Za Zhi 2021;39(6):690–697.
Meta-analysis of RCTs and cohort studies of HBO (± antibiotics/surgery) for ORNJ. No significant difference between: HBO+antibiotics+surgery vs surgery+antibiotics (RR 1.16, 95% CI 0.86–1.58); HBO vs antibiotics (RR 0.83, 95% CI 0.63–1.09); HBO vs antifibrotic drugs (RR 0.07, 95% CI 0.00–155.86 — an interval that carries no information); and HBO alone or combined vs other methods (RR 0.89, 95% CI 0.67–1.19), all P>0.05. ⚠️ Ful…
Yogaratnam JZ, Laden G, Madden LA, Guvendik L, Cowen M, Greenman M, Seymour AM, Cale A, Griffin S. Hyperbaric oxygen preconditioning promotes cardioprotection following ischemic reperfusion injury by improving myocardial function, limiting necrosis and enhancing the induction of Hsp72. Undersea Hyperb Med 2007;34(4):301-302.
Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Hyperbaric oxygen preconditioning improves myocardial function, reduces length of intensive care stay, and limits complications post coronary artery bypass graft surgery. Cardiovasc Revasc Med 2010;11(1):8-19.
Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Research report: the effects of hyperbaric oxygen preconditioning on myocardial biomarkers of cardioprotection in patients having coronary artery bypass graft surgery. Undersea Hyperb Med 2011;38(3):175–185 (PubMed lists the authors as 'Jeysen ZY, Gerard L, Levant G' (first names indexed as surnames); the byline on page 175 reads Jeysen Zivan Yogaratnam, Gerard Laden, Levant Guvendik).
Yoo Y, Cléroux A, Pollock NW, Boet S. Quality of reporting in hyperbaric medicine clinical trials: a cross-sectional study. Diving Hyperb Med 2025;55(4):352-368 (DOI 10.28920/dhm55.4.352-368).
Yoshida T, Kawashima A, Ujike T, Uemura M, Nishimura K, Miyoshi S. Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis. Int J Urol 2008;15(7):639–641.
You P, Fang Y, Bao X, Ma J, Zhang S, Yao J. Effects of hyperbaric oxygen on the expression of endogenous matrix metalloproteinase 9 in rat lung tissue. Undersea Hyperb Med 2014;41(1):1-7.
You Q, Li L, Xiong SQ, Yan YF, Li D, Yan NN, Chen HP, Liu YP. Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia. Front Aging Neurosci 2019;11:86.
Youn BA, Burns JR. Management of the severely anemic Jehovah's Witness. Ann Intern Med 1993;119(2):170.
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Youngberg JT, Myers RA. Complications from hyperbaric oxygen therapy? Ann Emerg Med 1990;19(11):1356-7.
Ypma RE, Pollack GH. Effect of hyperbaric oxygen conditions on the ordering of interfacial water. Undersea Hyperb Med 2015;42(3):257-64.
Yu T, Liu L, Xu F, Wu D, Su Y, Sun Q. Branch-like gas in a commercial diver's liver: a case report. Undersea and Hyperbaric Medicine 2020;47(2):267-270.
Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen T-D, Lu Q (China). Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. Int Urol Nephrol 2011;43(3):755–761.
At 3 months post-op, total IIEF and the EF, OS and IS domain scores were significantly higher in the
Yüceer Ö. Neurological and Cardiac Determinants of Hyperbaric Oxygen Therapy in Carbon Monoxide Poisoning: A Retrospective Cohort Study. Int J Gen Med 2026;19:604040.
Yusa T, Sunagawa M. Involvement of nitric oxide in hemorrhagic shock — effect of hyperbaric oxygen and dexamethasone [abstract]. Anesthesiology 1998;89(3A Suppl):398A.
Zaher E, Masalha L, Abu Ahmad W, Allon G, Gur I, Beiran I, Duvdevan-Strier N. Hyperbaric oxygen therapy and visual outcomes in retinal artery occlusion: a retrospective 24-year cohort study. Research Square (preprint) 2026:posted 14 Oct 2026, version 1, not peer reviewed.
Zaman T, Celebi A, Mirasoglu B, Toklu AS. The evaluation of in-chamber sound levels during hyperbaric oxygen applications: Results of 41 centres. Diving Hyperb Med 2020;50(3):244-249.
Zamboni WA, Wong HP, Stephenson LL, Pfeifer MA. Evaluation of hyperbaric oxygen for diabetic wounds: a prospective study. Undersea Hyperb Med 1997;24(3):175–179.
Zamora FV, Santos ACFF, Zamora AV, Galvao LKCS, Pimenta NDS, Salles JPCEA, et al. Hyperbaric Oxygen Treatment for Long-COVID syndrome: A Systematic Review of Current Evidence on Cognitive Decline. Undersea Hyperb Med 2025;52(3):327-335.
Zanesco L, Mena LAP, Beraldo R, De Freitas FA, Levy D, Sousa Sevivas NE, Kawamura Demange M, Malavolta EA. Hyperbaric oxygen therapy (HBOT) as an adjuvant to surgical treatment of musculoskeletal injuries: a scoping review. The Hive - Musculoskeletal Journal 2026 (DOI 10.70885/hmsj.2026.07.003 — venue resolved 2026-08-06 from the article PDF now on file (raw/papers/Zanesco-2026-Hyperbaric-oxygen-therapy-HBOT-as-an-adjuvant-to-surgi.pdf); volume and page numbers are not printed on it).
Zanon V, Morri A, Lonati D, Paoli A, Camporesi EM, Bosco G. HBO₂ in snake envenomation (atrox albinus rattlesnake): a case report in a human. Undersea Hyperb Med 2016;43(4):473-476.
Zant AE, Figueroa XA, Paulson CP, Wright JK. Hyperbaric oxygen therapy to treat lingering COVID-19 symptoms. Undersea Hyperb Med 2022;49(3):333-339.
Zeindler PR, Freiberger JJ. Triage and emergency evacuation of recreational divers: a case series analysis. Undersea Hyperb Med 2010;37(2):133-9.
Zeng S, Li Y, Yao Z, et al. Edaravone combined with hyperbaric oxygen therapy in delayed encephalopathy after acute carbon monoxide poisoning: A meta-analysis. J Clin Neurosci 2024;126:270–283.
Adding edaravone to HBO improved total effective rate (RR 1.25, 95% CI 1.20–1.31), MMSE, MoCA, Authors rate the evidence low-quality.
Zenjaya KT, Leoni, Handoko L, Rosyadi RN. Revisiting hyperbaric oxygen therapy in acute myocardial infarction: a systematic review and meta-analysis of cardiac recovery and survival outcomes. Eur Heart J Suppl 2026;28(Suppl 11):xi12 (abstract suag119.032).
Zeybek B, Childress AM, Kilic GS, Phelps JY, Pacheco LD, Carter MA, Borahay MA. Management of the Jehovah's Witness in Obstetrics and Gynecology: A Comprehensive Medical, Ethical, and Legal Approach. Obstet Gynecol Surv 2016;71(8):488-500.
Zhang Q, Chang Q, Gould L. Hyperbaric oxygen protects against oxidative stress in an ischemic wound model [meeting abstract]. J Am Coll Surg 2006;203(3 Suppl):S56.
Zhang JH. Editorial: hyperbaric oxygen in neurological diseases. Neurol Res 2007;29(2):113-115.
Zhang T, Gong W, Li Z, Yang S, Zhang K, Yin D, Xu P, Jia T. Efficacy of hyperbaric oxygen on survival of random pattern skin flap in diabetic rats. Undersea Hyperb Med 2007;34(5):335–339.
Zhang PX, Han CH, Zhou FJ, Li L, Zhang HM, Liu WW. Renin-angiotensin system and its role in hyperoxic acute lung injury. Undersea Hyperb Med 2016;43(3):239-46.
Zhang H, Zhang P, Han C, Zhou F, Li L, Liu W. Treatment of hyperoxic acute lung injury with stem cell transplantation in murine models: a brief review. Undersea Hyperb Med 2016;43(4):437-445.
Zhang L, Sun Q, Wu D, Yang Y, Yu T, Gao G. Hyperbaric oxygen suppresses growth of Klebsiella pneumoniae and enhances effect of tigecycline in vitro. Undersea Hyperb Med 2017;44(6):543-549.
Zhang Z, Zhang W, Xu Y, Liu D. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis. Asian J Surg 2022;45(1):68–78.
Healing rate increased: RR 1.90 (95% CI 1.48–2.44; P<0.0001). Healing time shortened by ~19 days: MD −19.36 (95% CI −28.75 to −9.97; P<0.001). Major amputation reduced: RR 0.52 (95% CI 0.32–0.83; P<0.01).
Zhang Y, Yang J, Li J. Clinical application of hyperbaric oxygen therapy in China: A 2020 baseline survey. Undersea Hyperb Med 2022;49(2):179-190.
Zhang Y, Zhou Y, Jia Y, Wang T, Meng D. Adverse effects of hyperbaric oxygen therapy: a systematic review and meta-analysis. Front Med (Lausanne) 2023;10:1160774.
Zhang B, Yi H, Jiang Y, Zheng C. A comparison of the treatment outcomes of cerebral gas embolism at 2.8 ATA in comparison with 6 ATA. Undersea Hyperb Med 2024;51(4):341-346.
Zhang Y, Huang B, Wang T, Dong H, Huang X, Li X. A systematic review and meta-analysis of treatment modalities and their impact on the healing progression of diabetic foot ulcers. Int J Burns Trauma 2025;15(2):41-52.
Zhang Z, Li Z, Li S, Xiong B, Zhou Y, Shi C. Hyperbaric oxygen for moderate-to-severe traumatic brain injury: outcomes 5-8 years after injury. Med Gas Res 2025;15(1):156-163.
Zhang R, Guo H, Tang S, Zuo J, Shi X. Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial. Sci Rep 2025;15(1):22039.
Zhang X, Yang X, Hu J, Zhang W, Shen W. Treatment of brain abscess rupturing into ventricle: a case report and literature review. Front Surg 2026;13:1782105.
Zhang W, Li X, Ma H, Li Y, Xi Y, Wang W, Liu Y, Han P. The Adjunctive Role of Hyperbaric Oxygen Therapy in Microbial Infection-Related Conditions. Int J Med Sci 2026;23(6):2154-2165.
An open-access narrative review from an aerospace-medicine department, funded by the National Natural Science Foundation of China and Shaanxi provincial programmes (Funding, p. 2162). The mechanism section — plasma-dissolved oxygen, reactive oxygen species against anaerobes, restoration of neutrophil oxidative killing in hypoxic tissue, biofilm oxygen penetration and antibiotic potentiation (pp. 2
Zhang L, Hu Y, Han X, Fan L, Zhang H, Zhang Q, et al. The efficacy of hyperbaric oxygen therapy in stroke patients: a real-world study. Journal of Neurorestoratology 2026:100315.
Zhang NW, Jiang M, Zhang CJ, Pan YJ, Xu RB, et al. The effectiveness of different treatment methods in the treatment and prevention of medication-related osteonecrosis of the jaw: A systematic review and Bayesian network meta-analysis. J Craniomaxillofac Surg 2026;54:104467.
Bayesian network meta-analysis with SUCRA ranking of MRONJ-healing interventions: PRP-2 + L-PRF (89.3%)
Zhang H, Zheng H, Wang S, Xu S. Factors influencing therapeutic efficacy in patients with sudden sensorineural hearing loss: Development and validation of a nomogram prediction model. American Journal of Otolaryngology — Head and Neck Medicine and Surgery 2026:104936 (journal pre-proof).
Zhao D, Luo S, Xu W, Hu J, Lin S, Wang N. Efficacy and Safety of Hyperbaric Oxygen Therapy Used in Patients With Diabetic Foot: A Meta-analysis of Randomized Clinical Trials. Clin Ther 2017;39(10):2088–2094.e2.
9 RCTs. No significant difference between HBO and standard therapy for: healed ulcers RR 2.22 (95% CI 0.87–5.62; P=0.32; I²=81%), minor amputation RR 0.95 (0.39–2.29; P=0.91), major amputation RR 0.47 (0.17–1.28; P=0.14; I²=61%), adverse events RR 1.00 (0.64–1.56; P=0.99). Only ulcer-area reduction favoured HBO (standardised mean difference 1.12; 95% CI 0.20–2.04; P=0.04; I²=70%). High heterogeneity throughout. ⚠️ Full read 21…
Zhao Y, Zheng Y, Xiao Z, Liu J, Yang L, Liu F, et al. Diffusion tensor imaging in the evaluation of the long-term efficacy of HBO2 therapy in rats after traumatic spinal cord injury. Undersea Hyperb Med 2020;47(3):435-443.
Zheng J, Liu K, Kang Z, Cai J, Liu W, Xu W, et al. Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med 2010;37(3):185-92.
Zheng X, Li T, Wang J, Gao L. Gas Therapies for Chronic Wounds: Comparative Effectiveness, Safety, and Evidence Certainty—A Systematic Review and Network Meta-Analysis. J Clin Med 2026;15(7):2783.
Class effect: gas therapies increased complete healing vs standard care — RR 2.17 (95% CI 1.61–2.94), SUCRA ranking: standard care highest (93.9%) — attributed by the authors to network structure and Certainty: small-study effects likely (Egger p<0.001; Begg p=0.013). The authors grade overall certainty as moderate (abstract, page 1), limited by heterogeneity, imprecision and potential publication bias. Our own rating is GRADE…
Zheng XL, Zhan XZ, Liu JJ, Leng CY, Ling LW, Huang Q, Chen TY, Li JY, Zhao QT. Emerging therapeutic strategies for medication-related osteonecrosis of the jaw: From microenvironmental modulation to precision medicine (Review). Exp Ther Med 2026;32(6):330 (PMCID PMC13688155; open access CC BY-NC-ND 4.0; published 5 Oct 2026).
- A narrative review from Jinan University (Guangzhou and Dongguan, China) of pharmacological, regenerative, biomaterial and "physical or adjunctive" treatments for MRONJ, plus a section on precision medicine (machine-learning risk prediction, genetic susceptibility). - Search: PubMed and Web of Science Core Collection, English only, January 2010 to March 2026, last run 31 March 2026, with "hyperb
Zhong X, Shan A, Xu J, Liang J, Long Y, Du B. Hyperbaric oxygen for severe traumatic brain injury: a randomized trial. J Int Med Res 2020;48(10):300060520939824.
Zhou YY, Liu W, Yang YJ, Lu GD. Use of hyperbaric oxygen on flaps and grafts in China: analysis of studies in the past 20 years. Undersea Hyperb Med 2014;41(3):209–216.
Zhou W, Shao X, Jiang X. A clinical report of two cases of cryptogenic brain abscess and a relevant literature review. Front Neurosci 2018;12:1054.
Zhou YY, Ren RR, Cen Y, Liu WW, Chen H. Advances in the treatment of neuropathic pain with hyperbaric oxygen. Undersea Hyperb Med 2021;48(1):13-23.
Zhou M, Chen X, Li D, Luo J, Song S, You J, Ma H, Huang C. Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022. Front Neurol 2025;16:1455545.
Zhou X, Liang H, Liu H, Sun M, Cai Z. Hyperbaric oxygen therapy for knee osteoarthritis: treatment mechanism, potential advantages, and limitations. Med Gas Res 2026;16(4):501-507.
Zhu J, Hullett JB, Somera L, Barbee RW, Ward KR, Berger BE, et al. Intravenous perfluorocarbon emulsion increases nitrogen washout after venous gas emboli in rabbits. Undersea Hyperb Med 2007;34(1):7-20.
Zhu W, Moayedi S, Sethuraman K. Arterial Gas Embolism After CT-Guided Lung Biopsy. Undersea Hyperb Med 2025;52(2):117-120.
Zirkle LG, Mengel CE, Butler SA, Fuson R. Effects of in vivo hyperoxia on erythrocytes. IV. Studies in dogs exposed to hyperbaric oxygenation. Proc Soc Exp Biol Med 1965;119:833-7.
Zozulya OO, Klygunenko OM. The effect of an early course of hyperbaric oxygenation on blood rheology, the erythron and outcomes of severe traumatic brain injury. Emerg Med (Ukraine) 2026;22(6):624-630 (in Ukrainian, English abstract; original title 'Вплив раннього курсу гіпербаричної оксигенації на реологічні властивості крові, еритрон та результати тяжкої черепно-мозкової травми'; author names as transliterated by the journal (Zozulya, Klygunenko; national transliteration Zozulia, Klyhunenko); open access CC BY 4.0; received 26 Jun 2026, accepted 13 Aug 2026).
A single-centre two-arm study from Dnipro of 165 men with isolated severe TBI (GCS ≤9, CT-confirmed, age 20–60, BMI ≤29.9, no decompensated comorbidity, admitted within 6 h of injury) (p.625). Allocation, translated in full: "Depending on the intensive-care variant, patients were divided into two groups by the envelope method" ("Залежно від варіанта інтенсивної терапії хворі методом конвертів були
Zulec M, Volf A, Puharić Z. Hyperbaric oxygen therapy in treating post-ischemic pain caused by polycythemia vera complications: a case report. Undersea Hyperb Med 2015;42(6):607–611.
Zulfiqar A, Spindari K. Hyperbaric Oxygen Therapy Enhances Autologous Bone Graft Integration: A Meta-Analysis. Undersea Hyperb Med 2025;52(4):549–564.
Primary pooled effect SMD 1.476 (95% CI 0.814–2.138) — moderate-to-strong — but substantial heterogeneity (I²≈77%). Orthopaedic subgroup: SMD 1.995 (1.117–2.873), I²=3.4% — stronger and consistent. Maxillofacial data mostly small/uncontrolled/observational; one cranial study negative. Heavy reliance on
Zumberg M, Gorlin J, Griffiths EA, Schwartz G, Fletcher BS, Walsh K, Dao KH, Vansandt A, Lynn M, Shander A. A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option. Transfusion 2020;60(5):932-939.
Zumstein V, Parsons BA, Dabestani S, et al. The Benefits and Harms of Pharmacological Treatment for Postradiation Pelvic Pain: A Systematic Review by the European Association of Urology Chronic Pelvic Pain Panel with Recommendations for Clinical Practice. Eur Urol Open Sci 2023;56:29–38.
HBO (and formalin) produced beneficial effects on pain, quality of life and functional symptoms in HBO for postradiotherapy anorectal pain "remains controversial"; adverse-event reporting was